RU97107020A - COMPOSITION OF STEROLES FROM SOAP AS A PULPA - Google Patents

COMPOSITION OF STEROLES FROM SOAP AS A PULPA

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Publication number
RU97107020A
RU97107020A RU97107020/04A RU97107020A RU97107020A RU 97107020 A RU97107020 A RU 97107020A RU 97107020/04 A RU97107020/04 A RU 97107020/04A RU 97107020 A RU97107020 A RU 97107020A RU 97107020 A RU97107020 A RU 97107020A
Authority
RU
Russia
Prior art keywords
composition
stigmastanol
campesterol
sitosterol
beta
Prior art date
Application number
RU97107020/04A
Other languages
Russian (ru)
Other versions
RU2165431C2 (en
Inventor
Новак Эгон
П.Катни Джеймс
Дж.Джонс Питер
Original Assignee
Дзе Юниверсити оф Бритиш Колумбия
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Юниверсити оф Бритиш Колумбия filed Critical Дзе Юниверсити оф Бритиш Колумбия
Publication of RU97107020A publication Critical patent/RU97107020A/en
Application granted granted Critical
Publication of RU2165431C2 publication Critical patent/RU2165431C2/en

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Claims (13)

1. Способ выделения композиции фитостеролов из мыла растительного происхождения в виде пульпы, который включает на первом этапе, смешивание мыла в виде пульпы со смесью растворителей, содержащей кетон, выбранный из группы, имеющей общую структуру RCOR1, где R и R1 являются алкильными группами, алифатический углеводород, выбранный из C5-C10 углеводородов и воды, и не содержащей спирта, при температуре, обычно, от 25 до 150oC, с образованием кремообразного осадка; и на втором этапе, очистку кремообразного осадка с получением композиции фитостерола.1. The method of isolating the composition of phytosterols from soap of plant origin in the form of pulp, which includes, at the first stage, mixing soap in the form of pulp with a solvent mixture containing a ketone selected from the group having the general structure RCOR 1 , where R and R 1 are alkyl groups an aliphatic hydrocarbon selected from C 5 -C 10 hydrocarbons and water, and not containing alcohol, at a temperature of usually from 25 to 150 o C, with the formation of a creamy precipitate; and in a second step, purifying the creamy precipitate to obtain a phytosterol composition. 2. Способ по п. 1, отличающийся тем, что кремообразный осадок очищают кристаллизацией с получением композиции фитостерола. 2. The method according to p. 1, characterized in that the creamy precipitate is purified by crystallization to obtain a phytosterol composition. 3. Способ по п.1, отличающийся тем, что мыло в виде пульпы получают из древесных стружек, включающих стружки кедра, ели, сосны, пихты, дуба, тсуги и тополя. 3. The method according to claim 1, characterized in that the soap in the form of pulp is obtained from wood chips, including shavings of cedar, spruce, pine, fir, oak, tsuga and poplar. 4. Композиция, понижающая холестерин, содержащая не более 70% по весу бета-ситостерола по крайней мере 10% по весу кампестерола и дополнительно, содержащая стигмастанол. 4. A cholesterol lowering composition containing not more than 70% by weight of beta-sitosterol at least 10% by weight of campesterol and additionally containing stigmastanol. 5. Композиция по п.4, отличающаяся тем, что общее содержание кампестерола и стигмастанола составляет по крайней мере 50% от количества бета-ситостерола. 5. The composition according to claim 4, characterized in that the total content of campesterol and stigmastanol is at least 50% of the amount of beta-sitosterol. 6. Композиция по п.4, отличающаяся тем, что соотношение бета-ситостерола, кампестерола и стигмастанола составляет 1,0 к от 0,2 до 0,4, к от 0,2 до 0,5 соответственно. 6. The composition according to claim 4, characterized in that the ratio of beta-sitosterol, campesterol and stigmastanol is 1.0 to 0.2 to 0.4, to 0.2 to 0.5, respectively. 7. Композиция по п.4, отличающаяся тем, что соотношение бета-ситостерола, кампестерола и стигмастанола составляет 1,0 : 0,354 : 0,414 соответственно. 7. The composition according to claim 4, characterized in that the ratio of beta-sitosterol, campesterol and stigmastanol is 1.0: 0.354: 0.414, respectively. 8. Композиция по п.4, отличающаяся тем, что соотношение бета-ситостерола, кампестерола и стигмастанола составляет 1,0 : 0,330 : 0,203 соответственно. 8. The composition according to claim 4, characterized in that the ratio of beta-sitosterol, campesterol and stigmastanol is 1.0: 0.330: 0.203, respectively. 9. Композиция по п.4, содержащая следующее соотношение фитостеролов: - 1,0 бета-ситостерола к 0,268 кампестерола к 0,299 стигмастанола. 9. The composition according to claim 4, containing the following ratio of phytosterols: - 1.0 beta-sitosterol to 0.268 campesterol to 0.299 stigmastanol. 10. Композиция, полученная способом, по п.1. 10. The composition obtained by the method according to claim 1. 11. Использование композиции по п.4 для производства медикаментов для снижения концентрации липопротеина-холестерина низкой плотности в плазме. 11. The use of the composition according to claim 4 for the manufacture of medicines to reduce the concentration of low density lipoprotein-cholesterol in plasma. 12. Продукт терапевтически эффективный для предотвращения или лечения первичной и вторичной дислипидимии и атеросклероза, включающий композицию по п.4 и фармацевтически эффективный носитель. 12. The product is therapeutically effective for the prevention or treatment of primary and secondary dyslipidimia and atherosclerosis, comprising the composition according to claim 4 and a pharmaceutically effective carrier. 13. Композиция по п.10, которая дополнительно включает сопутствующие соединения. 13. The composition of claim 10, which further includes concomitant compounds.
RU97107020/04A 1994-09-29 1995-09-29 Method of isolation of phytosterol composition, compositions, therapeutic product RU2165431C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31494594A 1994-09-29 1994-09-29
US314,945 1994-09-29
US314.945 1994-09-29

Publications (2)

Publication Number Publication Date
RU97107020A true RU97107020A (en) 1999-05-20
RU2165431C2 RU2165431C2 (en) 2001-04-20

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RU97107020/04A RU2165431C2 (en) 1994-09-29 1995-09-29 Method of isolation of phytosterol composition, compositions, therapeutic product

Country Status (28)

Country Link
US (1) US5770749A (en)
EP (3) EP1707572B1 (en)
JP (1) JPH10506394A (en)
CN (1) CN1057768C (en)
AT (1) ATE216395T1 (en)
AU (1) AU3559795A (en)
BG (1) BG64054B1 (en)
BR (1) BR9509119A (en)
CA (1) CA2201328A1 (en)
CZ (1) CZ298622B6 (en)
DE (1) DE69526442T3 (en)
DK (2) DK1707572T3 (en)
EE (1) EE9700073A (en)
ES (2) ES2173966T5 (en)
GE (1) GEP20022657B (en)
HU (1) HUT77522A (en)
LT (1) LT4305B (en)
LV (1) LV11900B (en)
MD (1) MD1721C2 (en)
MX (1) MX9702308A (en)
NO (2) NO310293B1 (en)
NZ (1) NZ293210A (en)
PL (1) PL186441B1 (en)
PT (1) PT783514E (en)
RU (1) RU2165431C2 (en)
SK (1) SK284250B6 (en)
TJ (1) TJ302B (en)
WO (1) WO1996010033A1 (en)

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