RU97104486A - TROPHIC FACTORS FOR REGENERATION OF THE CENTRAL NERVOUS SYSTEM - Google Patents

TROPHIC FACTORS FOR REGENERATION OF THE CENTRAL NERVOUS SYSTEM

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Publication number
RU97104486A
RU97104486A RU97104486/14A RU97104486A RU97104486A RU 97104486 A RU97104486 A RU 97104486A RU 97104486/14 A RU97104486/14 A RU 97104486/14A RU 97104486 A RU97104486 A RU 97104486A RU 97104486 A RU97104486 A RU 97104486A
Authority
RU
Russia
Prior art keywords
bind
exchange resin
cells
anion exchange
regeneration
Prior art date
Application number
RU97104486/14A
Other languages
Russian (ru)
Other versions
RU2157223C2 (en
Inventor
И.Беновиц Ларри
А.Ирвин Карлин
Джексон Пол
Original Assignee
Чилдренз Медикал Сентер Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/296,661 external-priority patent/US5898066A/en
Application filed by Чилдренз Медикал Сентер Корпорейшн filed Critical Чилдренз Медикал Сентер Корпорейшн
Publication of RU97104486A publication Critical patent/RU97104486A/en
Application granted granted Critical
Publication of RU2157223C2 publication Critical patent/RU2157223C2/en

Links

Claims (4)

1. Изолированный нейротрофический пептид типа, который (а) присутствует в среде, в которой культивированы клетки глиальных оболочек, (b) стимулирует аксонный отросток не подвергнутых какому-либо воздействию клеток ганглия сетчатки серебряного карася, (с) проходит через центрифужный фильтр с отсечкой 1 кДа.1. An isolated neurotrophic peptide of the type that (a) is present in the medium in which the cells of the glial membranes are cultured, (b) stimulates the axon process of the silver carp retinal ganglion cells not exposed to any effect, (c) passes through a centrifuge filter with a cut-off 1 kDa. 2. Нейротрофический полипептид по п.1, который дополнительно (а) сохраняет активность после нагревания при 95°С в течение 15 мин или 56°С в течение 1 ч, (b) не связывается с покрытыми полилизином планшетами, (с) не связывается с DЕАЕ-анионообменной смолой при рН 8,4. 2. The neurotrophic polypeptide according to claim 1, which further (a) retains activity after heating at 95 ° C for 15 min or 56 ° C for 1 h, (b) does not bind to polylysine-coated tablets, (c) does not bind with DEAE anion exchange resin at pH 8.4. 3. Нейротрофический полипептид по п.1, который представляет АF-1 серебряного карася. 3. The neurotrophic polypeptide according to claim 1, which is a silver crucian AF-1. 4. Изолированный нейротрофический полипептид типа, который (а) присутствует в среде, в которой культивированы клетки глиальных оболочек серебряного карася, (b) стимулирует аксонный отросток не подвергнутых какому-либо воздействию клеток ганглия сетчатки серебряного карася, (с) имеет молекулярную массу около 8-15 кДа; (d) не связывается с покрытыми полилизином планшетами, (е) инактивируется нагреванием при 95°С в течение 15 мин, (f) инактивируется трипсином или протеиназой К, (g) связывается с DЕАЕ-анионообменной смолой при рН 10, а не рН 8,4, и элюируется из DЕАЕ-анионообменной смолы 0,2 М NаСl. 4. An isolated neurotrophic polypeptide of the type that (a) is present in the medium in which the cells of the glial shells of the goldfish are cultured, (b) stimulates the axon process of the silver carp retinal ganglion cells not exposed to any effect, (c) has a molecular weight of about 8 -15 kDa; (d) does not bind to polylysine-coated tablets, (e) is inactivated by heating at 95 ° C for 15 min, (f) is inactivated by trypsin or proteinase K, (g) binds to a DEAE anion exchange resin at pH 10 rather than pH 8 , 4, and elutes from the DEAE anion exchange resin 0.2 M NaCl.
RU97104486/14A 1994-08-26 1995-08-24 Trophic factors for stimulating nervous system regeneration RU2157223C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/296,661 US5898066A (en) 1994-08-26 1994-08-26 Trophic factors for central nervous system regeneration
US296,661 1994-08-26

Publications (2)

Publication Number Publication Date
RU97104486A true RU97104486A (en) 1999-03-20
RU2157223C2 RU2157223C2 (en) 2000-10-10

Family

ID=23142976

Family Applications (1)

Application Number Title Priority Date Filing Date
RU97104486/14A RU2157223C2 (en) 1994-08-26 1995-08-24 Trophic factors for stimulating nervous system regeneration

Country Status (10)

Country Link
US (1) US5898066A (en)
EP (1) EP0777686A1 (en)
JP (1) JPH10505238A (en)
KR (1) KR970705577A (en)
CN (1) CN1127517C (en)
AU (1) AU713028B2 (en)
CA (1) CA2198587A1 (en)
NZ (1) NZ293048A (en)
RU (1) RU2157223C2 (en)
WO (1) WO1996006859A1 (en)

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WO2002032437A1 (en) * 2000-10-17 2002-04-25 Diatranz Limited Preparation and xenotransplantation or porcine islets
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WO2003027270A1 (en) * 2001-09-28 2003-04-03 Diabcell Pty Limited Growing xenotransplant material in culture
NZ515310A (en) * 2001-11-07 2004-08-27 Diabcell Pty Ltd Methods of treatment and delivery modes
CA2529573A1 (en) * 2003-06-24 2004-12-29 Diabcell Pty Limited Porcine islets cultured with porcine sertoli cells for xenotransplantation
NZ540597A (en) * 2005-06-08 2007-02-23 Neurotrophincell Pty Ltd A method for preventing the onset of type I diabetes comprising administering an implantable composition comprising living choroid plexus cells
US20090090214A1 (en) * 2007-10-04 2009-04-09 Chung Yuan Christian University Method for forming nano-scale metal particles
RU2459630C1 (en) * 2011-04-27 2012-08-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Method for stimulating neurogeneration by genetic make-ups
US20150190377A1 (en) * 2014-01-06 2015-07-09 The Regents Of The University Of California, A California Corporation Neuronal regeneration

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