RU96121791A - APPLICATION OF Xanthine derivatives to reduce the pathological hyperactivity of eosinophilic granulocytes, new xanthine derivatives and a method for their preparation - Google Patents
APPLICATION OF Xanthine derivatives to reduce the pathological hyperactivity of eosinophilic granulocytes, new xanthine derivatives and a method for their preparationInfo
- Publication number
- RU96121791A RU96121791A RU96121791/14A RU96121791A RU96121791A RU 96121791 A RU96121791 A RU 96121791A RU 96121791/14 A RU96121791/14 A RU 96121791/14A RU 96121791 A RU96121791 A RU 96121791A RU 96121791 A RU96121791 A RU 96121791A
- Authority
- RU
- Russia
- Prior art keywords
- xanthine derivatives
- methyl
- general formula
- hydrogen atom
- ethyl
- Prior art date
Links
- LRFVTYWOQMYALW-UHFFFAOYSA-N Xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title claims 7
- 229940053550 agents used for ADHD and nootropics psychostimulants Xanthine derivatives Drugs 0.000 title claims 7
- 229940083747 low-ceiling diuretics Xanthine derivatives Drugs 0.000 title claims 7
- 206010037211 Psychomotor hyperactivity Diseases 0.000 title claims 2
- 210000000222 eosinocyte Anatomy 0.000 title claims 2
- 230000001575 pathological Effects 0.000 title claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004432 carbon atoms Chemical group C* 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (5)
где R1 - метил или этил,
R2 - алкил с 1 - 4 атомами углерода,
X - атом водорода или гидроксил,
n - целое число от 1 до 5,
и/или его стереоизомер и/или его физиологически переносимую соль в эффективном количестве.1. A pharmaceutical composition having activity reducing eosinophilic granulocyte pathological hyperactivity, containing an active substance based on xanthine derivatives and at least one target additive, characterized in that it contains at least one compound of the general formula (I) as an active substance
where R 1 is methyl or ethyl,
R 2 is alkyl with 1 to 4 carbon atoms,
X is a hydrogen atom or hydroxyl,
n is an integer from 1 to 5,
and / or its stereoisomer and / or its physiologically tolerated salt in an effective amount.
где R1 - метил или этил,
R2 - алкил с 1 - 4 атомами углерода,
X - атом водорода или гидроксил,
n - целое число от 1 до 5,
причем соединение, у которого и R1 и R2 означают метил, X - означает атом водорода и n означает число 4, исключено,
его стереоизомер и физиологические переносимые соли.2. Xanthine derivatives of the general formula (I)
where R 1 is methyl or ethyl,
R 2 is alkyl with 1 to 4 carbon atoms,
X is a hydrogen atom or hydroxyl,
n is an integer from 1 to 5,
moreover, a compound in which both R 1 and R 2 mean methyl, X - means a hydrogen atom and n means the number 4, excluded,
its stereoisomer and physiological tolerated salts.
R2 - метил или этил,
X - атом водорода,
n - целое число от 1 до 5.5. Xanthine derivatives of the general formula (I) according to claim 1, wherein R 1 is methyl,
R 2 is methyl or ethyl,
X is a hydrogen atom,
n is an integer from 1 to 5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4411660.8 | 1994-04-05 | ||
| DE4411660A DE4411660A1 (en) | 1994-04-05 | 1994-04-05 | Use of xanthine derivatives to reduce the pathological hyperreactivity of eosinophilic granulocytes, new xanthine compounds and processes for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU96121791A true RU96121791A (en) | 1999-02-10 |
| RU2159617C2 RU2159617C2 (en) | 2000-11-27 |
Family
ID=6514636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU96121791/14A RU2159617C2 (en) | 1994-04-05 | 1995-03-21 | Xanthine derivatives, their stereoisomers and physiologically tolerable salts, pharmaceutical composition diminishing pathologic hyperactivity of eosinophilic granulates |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0758239A1 (en) |
| JP (1) | JPH09510983A (en) |
| KR (1) | KR100373948B1 (en) |
| CN (1) | CN1098686C (en) |
| AU (1) | AU695488B2 (en) |
| CA (1) | CA2187081A1 (en) |
| DE (1) | DE4411660A1 (en) |
| HU (1) | HUT74732A (en) |
| RU (1) | RU2159617C2 (en) |
| UA (1) | UA39136C2 (en) |
| WO (1) | WO1995026727A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
| US5985592A (en) * | 1997-06-05 | 1999-11-16 | Dalhousie University | Uses for pentoxifylline or functional derivatives/metabolites thereof |
| AU3370099A (en) * | 1998-03-31 | 1999-10-18 | Mayo Foundation For Medical Education And Research | Use of platelet activating factor (paf) inhibitors to inhibit il-5 induced eosinophil activation or degranulation |
| CN101538224A (en) | 2002-05-31 | 2009-09-23 | 先灵公司 | Process for preparing xanthine phosphodiesterase V inhibitors and precursers thereof |
| EP1719772A1 (en) * | 2002-05-31 | 2006-11-08 | Schering Corporation | Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8918297D0 (en) * | 1989-08-10 | 1989-09-20 | Beecham Group Plc | Novel treatment |
| DD298051A5 (en) * | 1989-08-16 | 1992-02-06 | ��@���������@�������k�� | PROCESS FOR THE PREPARATION OF A THERAPEUTIC AGENT FOR THE TREATMENT OF DIGESTIVE DISEASES |
| GB9023783D0 (en) * | 1990-11-01 | 1990-12-12 | Celltech Ltd | Pharmaceutical product |
| IL100195A0 (en) * | 1990-11-30 | 1992-08-18 | Hoechst Roussel Pharma | Use of xanthines for the preparation of a medicament having immuno suppressing activity |
| WO1993003728A1 (en) * | 1991-08-27 | 1993-03-04 | Temple University Of The Commonwealth System Of | Xanthine suppression of antigen activation of t- or b-cells |
| IL99368A (en) * | 1991-09-02 | 1996-01-19 | Teva Pharma | Compositions for topical treatment of psoriasis and atopic dermatitis comprising a xanthine derivative |
| US5473070A (en) * | 1992-11-16 | 1995-12-05 | Cell Therapeutics, Inc. | Substituted long chain alcohol xanthine compounds |
-
1994
- 1994-04-05 DE DE4411660A patent/DE4411660A1/en not_active Withdrawn
-
1995
- 1995-03-21 HU HU9602712A patent/HUT74732A/en unknown
- 1995-03-21 WO PCT/EP1995/001060 patent/WO1995026727A1/en not_active Application Discontinuation
- 1995-03-21 EP EP95912260A patent/EP0758239A1/en not_active Withdrawn
- 1995-03-21 CA CA002187081A patent/CA2187081A1/en not_active Abandoned
- 1995-03-21 CN CN95192342A patent/CN1098686C/en not_active Expired - Fee Related
- 1995-03-21 AU AU19510/95A patent/AU695488B2/en not_active Ceased
- 1995-03-21 KR KR1019960705541A patent/KR100373948B1/en not_active IP Right Cessation
- 1995-03-21 UA UA96114334A patent/UA39136C2/en unknown
- 1995-03-21 JP JP7525385A patent/JPH09510983A/en not_active Abandoned
- 1995-03-21 RU RU96121791/14A patent/RU2159617C2/en active
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