RU96121563A - USE OF BISPHOSPHONATES FOR INHIBITION OF BONE RESORPTION ARISING FROM IMPLANTATION OF ORTHOPEDIC PROSTHESES - Google Patents
USE OF BISPHOSPHONATES FOR INHIBITION OF BONE RESORPTION ARISING FROM IMPLANTATION OF ORTHOPEDIC PROSTHESESInfo
- Publication number
- RU96121563A RU96121563A RU96121563/14A RU96121563A RU96121563A RU 96121563 A RU96121563 A RU 96121563A RU 96121563/14 A RU96121563/14 A RU 96121563/14A RU 96121563 A RU96121563 A RU 96121563A RU 96121563 A RU96121563 A RU 96121563A
- Authority
- RU
- Russia
- Prior art keywords
- bone resorption
- inhibitor
- bisphosphonates
- arising
- implantation
- Prior art date
Links
- 229940112871 Bisphosphonate drugs affecting bone structure and mineralization Drugs 0.000 title claims 3
- 150000004663 bisphosphonates Chemical class 0.000 title claims 3
- 230000000399 orthopedic Effects 0.000 title claims 2
- 238000002513 implantation Methods 0.000 title 1
- 230000030991 negative regulation of bone resorption Effects 0.000 title 1
- 208000006386 Bone Resorption Diseases 0.000 claims 6
- 230000024279 bone resorption Effects 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 229940062527 Alendronate Drugs 0.000 claims 2
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 2
- -1 BM21.0995 Chemical compound 0.000 claims 2
- 210000000988 Bone and Bones Anatomy 0.000 claims 2
- 229960002286 Clodronic Acid Drugs 0.000 claims 1
- ACSIXWWBWUQEHA-UHFFFAOYSA-N Clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 1
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Didronel Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims 1
- 229960004585 Etidronic Acid Drugs 0.000 claims 1
- LWRDQHOZTAOILO-UHFFFAOYSA-N Incadronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)NC1CCCCCC1 LWRDQHOZTAOILO-UHFFFAOYSA-N 0.000 claims 1
- 229950006971 Incadronic acid Drugs 0.000 claims 1
- WRUUGTRCQOWXEG-UHFFFAOYSA-N Pamidronic acid Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims 1
- 229940019375 Tiludronate Drugs 0.000 claims 1
- DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 229940046231 pamidronate Drugs 0.000 claims 1
- 230000003449 preventive Effects 0.000 claims 1
- 229960005324 tiludronic acid Drugs 0.000 claims 1
Claims (8)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/230,670 US5646134A (en) | 1994-04-21 | 1994-04-21 | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
US230,670 | 1994-04-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU96121563A true RU96121563A (en) | 1999-01-10 |
RU2161032C2 RU2161032C2 (en) | 2000-12-27 |
Family
ID=22866129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU96121563/14A RU2161032C2 (en) | 1994-04-21 | 1995-04-17 | Biphosphonate application for inhibiting bone resorption arising as a result of orthopedic prosthesis implantation |
Country Status (29)
Country | Link |
---|---|
US (3) | US5646134A (en) |
EP (2) | EP0756483B1 (en) |
JP (1) | JPH09512268A (en) |
CN (1) | CN1078073C (en) |
AT (1) | ATE236641T1 (en) |
AU (1) | AU2374895A (en) |
BG (1) | BG63102B1 (en) |
CA (1) | CA2188030C (en) |
CO (1) | CO4370025A1 (en) |
CZ (1) | CZ305596A3 (en) |
DE (1) | DE69530293T2 (en) |
DK (1) | DK0756483T3 (en) |
DZ (1) | DZ1873A1 (en) |
ES (1) | ES2194050T3 (en) |
FI (1) | FI964213A0 (en) |
HR (1) | HRP950239A2 (en) |
HU (1) | HUT74911A (en) |
IL (1) | IL113361A (en) |
MY (1) | MY114265A (en) |
NO (1) | NO312124B1 (en) |
NZ (1) | NZ284295A (en) |
PL (1) | PL318552A1 (en) |
PT (1) | PT756483E (en) |
RU (1) | RU2161032C2 (en) |
SK (1) | SK133396A3 (en) |
TW (1) | TW406021B (en) |
WO (1) | WO1995028936A1 (en) |
YU (1) | YU25295A (en) |
ZA (1) | ZA953185B (en) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5646134A (en) * | 1994-04-21 | 1997-07-08 | Merck & Co., Inc. | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
GB9408775D0 (en) * | 1994-05-04 | 1994-06-22 | Ciba Geigy Ag | Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration |
WO1997029754A1 (en) * | 1996-02-14 | 1997-08-21 | Itzhak Binderman | Topical bisphosphonates for prevention of bone resorption |
US6117856A (en) * | 1996-02-14 | 2000-09-12 | Binderman; Itzhak | Topical bisphosphonates for prevention of bone resorption |
US5853759A (en) * | 1996-05-17 | 1998-12-29 | Merck & Co.. Inc. | Effervescent alendronate formulation |
US20010031244A1 (en) | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
US6432932B1 (en) | 1997-07-22 | 2002-08-13 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US5994329A (en) * | 1997-07-22 | 1999-11-30 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US6015801A (en) * | 1997-07-22 | 2000-01-18 | Merck & Co., Inc. | Method for inhibiting bone resorption |
SI0998292T1 (en) * | 1997-07-22 | 2002-04-30 | Merck & Co., Inc. | Method for inhibiting bone resorption |
IT1296495B1 (en) * | 1997-11-21 | 1999-06-25 | Prodotti Antibiotici Spa | USE OF BISPHOSPHONATES IN THE PREPARATION OF PHARMACEUTICAL FORMS FOR INTRAMUSCULAR ADMINISTRATION |
US6414006B1 (en) | 1998-10-15 | 2002-07-02 | Merck Frosst Canada & Co. | Methods for inhibiting bone resorption |
US6331533B1 (en) | 1998-11-16 | 2001-12-18 | Merck & Co., Inc. | Method for inhibiting dental resorptive lesions |
WO2000033849A1 (en) | 1998-12-04 | 2000-06-15 | Roche Diagnostics Gmbh | Use of ibandronate for promoting osseointegration of endoprostheses |
CN1151793C (en) | 1998-12-25 | 2004-06-02 | 山之内制药株式会社 | Medicinal compsns. for treating osseous lesion in multiple myeloma |
EP1210138A4 (en) * | 1999-04-22 | 2003-05-07 | Hydro Med Sciences Inc | Controlled delivery of bisphosphonates |
AUPQ232599A0 (en) * | 1999-08-19 | 1999-09-09 | Royal Alexandra Hospital For Children, The | Drug for treating fractures |
AU781068B2 (en) * | 1999-08-19 | 2005-05-05 | Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexandra Hospital for Children), The | Drug for treating fractures |
AU2001287260A1 (en) * | 2000-07-12 | 2002-01-21 | Ecole Polytechnique Federale De Lausanne (Epfl) | Active biocoating for bone implant |
CH694935A5 (en) * | 2000-07-26 | 2005-09-30 | Straumann Holding Ag | Oberflaechenmodifizierte implants. |
AU2001221607A1 (en) * | 2000-11-20 | 2002-05-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Endosseous implant |
GB0029111D0 (en) * | 2000-11-29 | 2001-01-10 | Novartis Ag | Organic compounds |
EP1365769B1 (en) | 2001-02-06 | 2011-01-26 | The Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexandra Hospital for Children) | A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis |
NZ528659A (en) * | 2001-04-03 | 2005-02-25 | Royal Alexandra Hosp Children | A drug for use in bone grafting |
KR20020080018A (en) * | 2001-04-10 | 2002-10-23 | 한국화학연구원 | A controlled/sustained implant delivery containing bisphosphonate |
CA2347330C (en) * | 2001-05-10 | 2002-03-12 | Pharmaceutical Partners Of Canada Inc. | Liquid injectable formulation of disodium pamidronate |
AUPR553701A0 (en) * | 2001-06-07 | 2001-07-12 | Royal Alexandra Hospital For Children, The | A device for the delivery of a drug to a fractured bone |
US20050070504A1 (en) * | 2001-12-21 | 2005-03-31 | The Procter & Gamble Co. | Risedronate compositions and their methods of use |
KR100638122B1 (en) * | 2001-12-21 | 2006-10-24 | 더 프록터 앤드 갬블 캄파니 | Method for the treatment of bone disorders |
US7488496B2 (en) * | 2002-03-06 | 2009-02-10 | Christer Rosen | Effervescent compositions comprising bisphosphonates and methods related thereto |
WO2003093314A2 (en) | 2002-05-03 | 2003-11-13 | Millenium Biologix Inc. | Connective tissue stimulating peptides |
US20040137058A1 (en) * | 2002-07-09 | 2004-07-15 | Katdare Ashok V. | Effervescent bisphosphonate formulation |
EP1508343B1 (en) * | 2003-08-21 | 2015-11-04 | AddBIO AB | Bisphosponate coated implant device and method therefor |
US20050181043A1 (en) * | 2004-02-12 | 2005-08-18 | Indranil Nandi | Alendronate salt tablet compositions |
US7674454B2 (en) * | 2004-03-06 | 2010-03-09 | Innovata Limited | Enzyme-prodrug therapy for prosthetic joint repair |
KR100564628B1 (en) * | 2004-06-16 | 2006-03-28 | 삼성전자주식회사 | Split gate type flash mwmory device and method of manufacturing the same |
US20060134190A1 (en) * | 2004-12-16 | 2006-06-22 | Banner Pharmacaps Inc. | Formulations of bisphosphonate drugs with improved bioavailability |
US8071574B2 (en) * | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
WO2006100527A1 (en) * | 2005-03-24 | 2006-09-28 | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. | Effervescent tablet containing sodium alendronate and related use and process |
US20070087052A1 (en) * | 2005-10-19 | 2007-04-19 | Katdare Ashok V | Effervescent bisphosphonate formulation |
FR2904784B1 (en) * | 2006-08-10 | 2010-09-03 | Surfactis Technologies | PROCESS FOR RECOVERING METALLIC AND MINERAL SURFACES BY SELF-ASSEMBLED MONOMOUCHES OF BISPHOSPHONIC COMPOUNDS AND USES THEREOF |
US20100144679A1 (en) * | 2007-03-21 | 2010-06-10 | Duke University | Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture |
WO2009061516A1 (en) * | 2007-11-08 | 2009-05-14 | New York University School Of Medicine | Medical implants containing adenosine receptor agonists and methods for inhibiting medical implant loosening |
US9867838B2 (en) | 2009-09-01 | 2018-01-16 | Duke University | Methods for treating heart failure using bisphosphonate compositions |
US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
TR201903835T4 (en) | 2010-12-06 | 2019-04-22 | Effrx Pharmaceuticals Sa | Stable effervescent bisphosphonate formulations with fast dissolution properties. |
US8858979B1 (en) | 2011-01-28 | 2014-10-14 | Clemson University | Service induced byproducts for localized drug delivery in orthopaedic implants |
RU2661677C2 (en) * | 2011-05-27 | 2018-07-18 | Аблинкс Нв | Inhibition of bone resorption with rank-l binding peptides |
JP6261512B2 (en) | 2011-11-16 | 2018-01-17 | デューク ユニバーシティ | Bisphosphonate compositions and methods for treating and / or reducing cardiac dysfunction |
RU2653627C1 (en) * | 2016-11-09 | 2018-05-11 | Федеральное государственное автономное образовательное учреждение высшего образования "Крымский федеральный университет имени В.И. Вернадского" | Method for modeling aseptic aminobisphosphonate osteonecrosis of lower jaws in laboratory white rats |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4446052A (en) * | 1982-05-17 | 1984-05-01 | The Procter & Gamble Company | Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate |
US4753652A (en) * | 1984-05-04 | 1988-06-28 | Children's Medical Center Corporation | Biomaterial implants which resist calcification |
CN1046853C (en) * | 1988-01-20 | 1999-12-01 | 山之内制药株式会社 | (Cycloalkyl amine) methylene di (phosphonic acid) and drug taking this compound as active component |
US5270365A (en) * | 1991-12-17 | 1993-12-14 | Merck & Co., Inc. | Prevention and treatment of periodontal disease with alendronate |
HUT69699A (en) * | 1992-05-29 | 1995-09-28 | Procter & Gamble Pharma | Sulfur-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism |
JPH08505142A (en) * | 1992-12-23 | 1996-06-04 | メルク エンド カンパニー インコーポレーテッド | Bisphosphonate / estrogen therapy for treating and preventing bone loss |
US5403829A (en) * | 1993-03-24 | 1995-04-04 | Leiras Oy | Use of bisphosphonates in endo-osteal bone surgery |
FI92465C (en) * | 1993-04-14 | 1994-11-25 | Risto Tapani Lehtinen | A method for handling endo-osteal materials |
US5646134A (en) * | 1994-04-21 | 1997-07-08 | Merck & Co., Inc. | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
GB9408775D0 (en) * | 1994-05-04 | 1994-06-22 | Ciba Geigy Ag | Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration |
-
1994
- 1994-04-21 US US08/230,670 patent/US5646134A/en not_active Expired - Lifetime
-
1995
- 1995-03-28 MY MYPI95000773A patent/MY114265A/en unknown
- 1995-03-30 TW TW084103056A patent/TW406021B/en not_active IP Right Cessation
- 1995-04-13 IL IL11336195A patent/IL113361A/en unknown
- 1995-04-17 AU AU23748/95A patent/AU2374895A/en not_active Abandoned
- 1995-04-17 JP JP7527678A patent/JPH09512268A/en active Pending
- 1995-04-17 RU RU96121563/14A patent/RU2161032C2/en not_active IP Right Cessation
- 1995-04-17 DK DK95916335T patent/DK0756483T3/en active
- 1995-04-17 EP EP95916335A patent/EP0756483B1/en not_active Expired - Lifetime
- 1995-04-17 DE DE69530293T patent/DE69530293T2/en not_active Expired - Fee Related
- 1995-04-17 WO PCT/US1995/004498 patent/WO1995028936A1/en active IP Right Grant
- 1995-04-17 NZ NZ284295A patent/NZ284295A/en unknown
- 1995-04-17 PT PT95916335T patent/PT756483E/en unknown
- 1995-04-17 EP EP01201914A patent/EP1197213A3/en not_active Withdrawn
- 1995-04-17 AT AT95916335T patent/ATE236641T1/en not_active IP Right Cessation
- 1995-04-17 CN CN95192675A patent/CN1078073C/en not_active Expired - Fee Related
- 1995-04-17 CZ CZ963055A patent/CZ305596A3/en unknown
- 1995-04-17 HU HU9602888A patent/HUT74911A/en unknown
- 1995-04-17 SK SK1333-96A patent/SK133396A3/en unknown
- 1995-04-17 CA CA002188030A patent/CA2188030C/en not_active Expired - Fee Related
- 1995-04-17 PL PL95318552A patent/PL318552A1/en unknown
- 1995-04-17 ES ES95916335T patent/ES2194050T3/en not_active Expired - Lifetime
- 1995-04-19 DZ DZ950041A patent/DZ1873A1/en active
- 1995-04-19 YU YU25295A patent/YU25295A/en unknown
- 1995-04-19 CO CO95015985A patent/CO4370025A1/en unknown
- 1995-04-20 HR HR08/230,670A patent/HRP950239A2/en not_active Application Discontinuation
- 1995-04-20 ZA ZA953185A patent/ZA953185B/en unknown
-
1996
- 1996-10-16 BG BG100910A patent/BG63102B1/en unknown
- 1996-10-18 FI FI964213A patent/FI964213A0/en unknown
- 1996-10-18 NO NO19964441A patent/NO312124B1/en not_active IP Right Cessation
-
1997
- 1997-06-16 US US08/876,898 patent/US5891863A/en not_active Expired - Fee Related
-
1998
- 1998-05-20 US US09/082,237 patent/US5972913A/en not_active Expired - Lifetime
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