RU96118435A - CHLORPYRIMIDINE INTERMEDIATE COMPOUNDS - Google Patents

CHLORPYRIMIDINE INTERMEDIATE COMPOUNDS

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Publication number
RU96118435A
RU96118435A RU96118435/04A RU96118435A RU96118435A RU 96118435 A RU96118435 A RU 96118435A RU 96118435/04 A RU96118435/04 A RU 96118435/04A RU 96118435 A RU96118435 A RU 96118435A RU 96118435 A RU96118435 A RU 96118435A
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RU
Russia
Prior art keywords
formula
compounds
compound
obtaining
interaction
Prior art date
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RU96118435/04A
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Russian (ru)
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RU2140913C1 (en
Inventor
Сюзен Мэри Дэйлюдж
Майкл Толар Мартин
Мишелль Джоанн Ферри Фьюджетт
Original Assignee
Де Вэллкам Фаундейшн Лимитед
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Priority claimed from GB9402161A external-priority patent/GB9402161D0/en
Application filed by Де Вэллкам Фаундейшн Лимитед filed Critical Де Вэллкам Фаундейшн Лимитед
Publication of RU96118435A publication Critical patent/RU96118435A/en
Application granted granted Critical
Publication of RU2140913C1 publication Critical patent/RU2140913C1/en

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Claims (1)

1. Соединение формулы I
Figure 00000001

где R1 и R2, которые могут быть одинаковыми или различными, выбраны из C1-8-алкила, C3-8-циклоалкила и арильной группы, которая может быть замещена.1. The compound of formula I
Figure 00000001

where R 1 and R 2 , which may be the same or different, are selected from C 1-8 alkyl, C 3-8 cycloalkyl and aryl group, which may be substituted. 2. Соединение по п.1, отличающееся тем, что R1 и R2 оба представляют собой C1-8-алкил.2. The compound according to claim 1, wherein R 1 and R 2 are both C 1-8 -alkyl. 3. Соединение формулы II
Figure 00000002

где R1 и R2 определены, как в п.1 или 2.3. The compound of formula II
Figure 00000002

where R 1 and R 2 defined as in claim 1 or 2. 4. Соединение формулы III
Figure 00000003

5. Соединение формулы IV
Figure 00000004

где R3 может быть атомом водорода или другой группой, которая не присоединена посредством гликозидной связи.4. The compound of formula III
Figure 00000003

5. The compound of formula IV
Figure 00000004

where R 3 may be a hydrogen atom or another group that is not attached via a glycosidic bond. 6. Соединение по п. 5, отличающееся тем, что R3 представляет собой C3-7углеродный цикл, C2-8-углеводородную или C4-7гетероциклическую группу с условием, что подобные группы не присоединены посредством гликозидной связи.6. The compound according to claim 5, wherein R 3 is a C 3-7 carbon cycle, a C 2-8 hydrocarbon or C 4-7 heterocyclic group with the condition that such groups are not attached via a glycosidic bond. 7. Соединение по п.5, отличающееся тем, что R3 представляет собой группу, выбранную из
Figure 00000005

б.7. The compound according to claim 5, wherein R 3 is a group selected from
Figure 00000005

b.
Figure 00000006

г. (AcOCH2)2CHCH2CH2 -;
Figure 00000007

Figure 00000008

Figure 00000009

Figure 00000010

8. Соединение по п.7, отличающееся тем, что R3 представляет собой
Figure 00000011

9. Способ получения соединения формулы VII
Figure 00000012

где R3 определен, как в пп.5, 6, 7 или 8,
заключающийся в циклизации соединения формулы VI, определенного в п.5, в присутствии кислоты.
Figure 00000006

d. (AcOCH 2 ) 2 CHCH 2 CH 2 -;
Figure 00000007

Figure 00000008

Figure 00000009

Figure 00000010

8. The compound according to claim 7, wherein R 3 is
Figure 00000011

9. The method of obtaining the compounds of formula VII
Figure 00000012

where R 3 defined as in paragraphs.5, 6, 7 or 8,
consisting in the cyclization of the compounds of formula VI, defined in paragraph 5, in the presence of acid. 10. Способ получения соединения формулы I, определенного в п.1, заключающийся во взаимодействии 2,5-диамино-4,6-ди-гидроксипиримидина с соединением формулы V
Figure 00000013
где R1 и R2 определены, как в п.1 или 2.10. The method of obtaining the compounds of formula I, as defined in claim 1, consisting in the interaction of 2,5-diamino-4,6-di-hydroxypyrimidine with the compound of the formula V
Figure 00000013
where R 1 and R 2 defined as in claim 1 or 2. 11. Способ получения соединения формулы II
Figure 00000014

где R1 и R2 определены, как в п.1 или 2,
заключающийся в гидролизе соединения формулы I.11. The method of obtaining the compounds of formula II
Figure 00000014

where R 1 and R 2 defined as in claim 1 or 2,
consisting in the hydrolysis of compounds of formula I. 12. Способ получения соединения формулы III
Figure 00000015

посредством гидролиза соединения формулы I или II.12. The method of obtaining the compounds of formula III
Figure 00000015

by hydrolysis of a compound of formula I or II. 13. Способ получения соединения формулы VI
Figure 00000016

где R3 определен, как в пп.5, 6, 7 или 8,
заключающийся во взаимодействии соединения формулы III, определенного в п.4, с амином формулы R3NH2.13. The method of obtaining the compounds of formula VI
Figure 00000016

where R 3 defined as in paragraphs.5, 6, 7 or 8,
consisting in the interaction of the compounds of formula III, defined in paragraph 4, with an amine of the formula R 3 NH 2 . 14. Способ по п. 13, отличающийся тем, что взаимодействие соединения формулы III с амином осуществляют в присутствии основания. 14. The method according to p. 13, characterized in that the interaction of the compounds of formula III with the amine is carried out in the presence of a base. 15. Способ получения 2,5-диамино-4,6-дихлорпиримидина посредством гидролиза соединения формулы I, II или III. 15. A method of producing 2,5-diamino-4,6-dichloropyrimidine by hydrolysis of a compound of formula I, II or III. 16. Способ получения 2,6-диаминопуринов, в которых 6-аминогруппа замещена остатками R4 и R5, которые могут быть одинаковыми или различными и выбраны из атома водорода, C1-8-алкила, C3-6-циклоалкила или фенила, заключающийся во взаимодействии соединения формулы VI, определенного в пп.5, 6 или 7, с избытком амина NHR4R5 в кипящем растворителе.16. The method of producing 2,6-diaminopurins in which the 6-amino group is substituted by residues R 4 and R 5 , which may be the same or different and selected from a hydrogen atom, C 1-8 alkyl, C 3-6 cycloalkyl or phenyl consisting in the interaction of the compounds of formula VI, as defined in paragraphs.5, 6 or 7, with an excess of amine NHR 4 R 5 in a boiling solvent. 17. Способ получения (1S,4R)-4-[2-амино-6-(циклопропиламино)-9H-пурин-9-ил] -2-циклопентен-1-метанола, заключающийся во взаимодействии соединения формулы VI, определенного в п. 8, с избытком циклопропиламина в кипящем растворителе. 17. The method of obtaining (1S, 4R) -4- [2-amino-6- (cyclopropylamino) -9H-purin-9-yl] -2-cyclopentene-1-methanol, which consists in the interaction of the compounds of formula VI, defined in p 8, with an excess of cyclopropylamine in boiling solvent.
RU96118435A 1994-02-04 1995-02-03 Chloropyrimidine intermediate compounds RU2140913C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9402161A GB9402161D0 (en) 1994-02-04 1994-02-04 Chloropyrimidine intermediates
GB9402161.5 1994-02-04
PCT/GB1995/000225 WO1995021161A1 (en) 1994-02-04 1995-02-03 Chloropyrimide intermediates

Publications (2)

Publication Number Publication Date
RU96118435A true RU96118435A (en) 1999-02-20
RU2140913C1 RU2140913C1 (en) 1999-11-10

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US (8) US6448403B1 (en)
EP (1) EP0741710B1 (en)
JP (1) JP3670012B2 (en)
KR (1) KR100355983B1 (en)
CN (2) CN1161343C (en)
AT (1) ATE192742T1 (en)
AU (1) AU690203B2 (en)
BR (1) BR9506667A (en)
DE (1) DE69516847T2 (en)
DK (1) DK0741710T3 (en)
ES (1) ES2148486T3 (en)
FI (1) FI112477B (en)
GB (1) GB9402161D0 (en)
GR (1) GR3033850T3 (en)
HK (1) HK1004087A1 (en)
HU (1) HU223096B1 (en)
IL (1) IL112539A (en)
MX (1) MX9603091A (en)
MY (1) MY113775A (en)
NO (1) NO310819B1 (en)
NZ (1) NZ278948A (en)
PL (1) PL183885B1 (en)
PT (1) PT741710E (en)
RU (1) RU2140913C1 (en)
SG (1) SG47918A1 (en)
TW (1) TW390877B (en)
WO (1) WO1995021161A1 (en)
ZA (1) ZA95884B (en)

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