RU96117381A - NEUROPROTECTIVE COMPOUNDS - Google Patents
NEUROPROTECTIVE COMPOUNDSInfo
- Publication number
- RU96117381A RU96117381A RU96117381/04A RU96117381A RU96117381A RU 96117381 A RU96117381 A RU 96117381A RU 96117381/04 A RU96117381/04 A RU 96117381/04A RU 96117381 A RU96117381 A RU 96117381A RU 96117381 A RU96117381 A RU 96117381A
- Authority
- RU
- Russia
- Prior art keywords
- disease
- compound according
- condition
- hydroxypiperidin
- chroman
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 10
- 230000000324 neuroprotective Effects 0.000 title claims 4
- 201000010099 disease Diseases 0.000 claims 7
- JGYVZUCCBOVDJE-UHFFFAOYSA-N 3-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]-3,4-dihydro-2H-chromene-4,7-diol Chemical compound C1OC2=CC(O)=CC=C2C(O)C1N(CC1)CCC1(O)C1=CC=C(F)C=C1 JGYVZUCCBOVDJE-UHFFFAOYSA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000000903 blocking Effects 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 206010027599 Migraine Diseases 0.000 claims 2
- 208000008085 Migraine Disorders Diseases 0.000 claims 2
- 102000004868 N-methyl-D-aspartate receptors Human genes 0.000 claims 2
- 108090001041 N-methyl-D-aspartate receptors Proteins 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 206010065040 AIDS dementia complex Diseases 0.000 claims 1
- 206010001897 Alzheimer's disease Diseases 0.000 claims 1
- 206010002855 Anxiety Diseases 0.000 claims 1
- 206010057666 Anxiety disease Diseases 0.000 claims 1
- 210000003169 Central Nervous System Anatomy 0.000 claims 1
- 208000008208 Craniocerebral Trauma Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 206010015037 Epilepsy Diseases 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 201000001971 Huntington's disease Diseases 0.000 claims 1
- 206010020993 Hypoglycaemia Diseases 0.000 claims 1
- SOXFTMPFIDLKSW-QAZHXLKKSA-L O.CC[O-].[O-]C(=O)C(O)C(O)C([O-])=O.C1CN([C@H]2[C@H](C3=CC=C(O)C=C3OC2)O)CCC1(O)C1=CC=C(F)C=C1 Chemical compound O.CC[O-].[O-]C(=O)C(O)C(O)C([O-])=O.C1CN([C@H]2[C@H](C3=CC=C(O)C=C3OC2)O)CCC1(O)C1=CC=C(F)C=C1 SOXFTMPFIDLKSW-QAZHXLKKSA-L 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010061536 Parkinson's disease Diseases 0.000 claims 1
- 206010061920 Psychotic disease Diseases 0.000 claims 1
- 208000008513 Spinal Cord Injury Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 210000000748 cardiovascular system Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000002218 hypoglycaemic Effects 0.000 claims 1
- 230000000302 ischemic Effects 0.000 claims 1
- 201000010901 lateral sclerosis Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003287 optical Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (17)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18947994A | 1994-01-31 | 1994-01-31 | |
US08/189,479 | 1994-01-31 | ||
PCT/IB1994/000365 WO1995020587A1 (en) | 1994-01-31 | 1994-11-21 | Neuroprotective chroman compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
RU96117381A true RU96117381A (en) | 1998-12-10 |
RU2126404C1 RU2126404C1 (en) | 1999-02-20 |
Family
ID=22697514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU96117381A RU2126404C1 (en) | 1994-01-31 | 1994-11-21 | 3r*,4s* 3-[4-(4-fluorophenyl)-4-hydroxypiperidin-1- yl)chrohan-4,7-diol, optical isomers thereof and pharmaceutical composition based thereon, and method of medical treatment |
Country Status (27)
Country | Link |
---|---|
US (1) | US5744483A (en) |
EP (1) | EP0741724B1 (en) |
JP (1) | JP2866743B2 (en) |
CN (1) | CN1048247C (en) |
AT (1) | ATE183184T1 (en) |
AU (1) | AU684568B2 (en) |
BR (2) | BR9408506A (en) |
CA (1) | CA2182101C (en) |
CO (1) | CO4230161A1 (en) |
CZ (1) | CZ286757B6 (en) |
DE (1) | DE69420053T2 (en) |
DK (1) | DK0741724T3 (en) |
EG (1) | EG20672A (en) |
ES (1) | ES2134361T3 (en) |
FI (1) | FI113769B (en) |
GR (1) | GR3031356T3 (en) |
HU (1) | HU221633B1 (en) |
IL (1) | IL112415A (en) |
MY (1) | MY111623A (en) |
NO (1) | NO309190B1 (en) |
NZ (1) | NZ275151A (en) |
PE (1) | PE43795A1 (en) |
PL (1) | PL179448B1 (en) |
RU (1) | RU2126404C1 (en) |
TW (1) | TW449591B (en) |
WO (1) | WO1995020587A1 (en) |
ZA (1) | ZA95692B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2232059A1 (en) * | 1995-09-15 | 1997-03-20 | Bertrand Leo Chenard | Phenol derivatives with pharmaceutical activity |
TW498067B (en) * | 1996-07-19 | 2002-08-11 | Hoffmann La Roche | 4-hydroxy-piperidine derivatives |
ZA200108038B (en) * | 2000-10-02 | 2003-04-01 | Pfizer Prod Inc | Prophylactic use of n-methyl-d-asparrate (NMDA) antagonists. |
EP1674087A1 (en) | 2000-10-02 | 2006-06-28 | Pfizer Products Inc. | Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists |
SE0100902D0 (en) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
ATE473967T1 (en) * | 2003-11-26 | 2010-07-15 | Pfizer Prod Inc | AMINOPYRAZOLE DERIVATIVES AS GSK-3 INHIBITORS |
WO2007051735A1 (en) | 2005-11-03 | 2007-05-10 | F. Hoffmann-La Roche Ag | Arylsulfonylchromans as 5-ht6 inhibitors indolylmaleimide derivatives as protein kinase inhibitors |
CN102702044A (en) * | 2006-01-20 | 2012-10-03 | 先灵公司 | Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors |
EP2522647B1 (en) * | 2011-05-10 | 2014-04-30 | DSM IP Assets B.V. | Process of separating chiral isomers of chroman compounds and their derivatives and precursors |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3294804A (en) * | 1961-01-27 | 1966-12-27 | Sterling Drug Inc | 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine |
FR5733M (en) * | 1966-09-27 | 1968-01-22 | ||
GB1495526A (en) * | 1974-05-31 | 1977-12-21 | Beecham Group Ltd | Chroman derivatives |
US4016281A (en) * | 1975-02-22 | 1977-04-05 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Tetralone and indanone compounds |
US4082755A (en) * | 1977-02-14 | 1978-04-04 | Janssen Pharmaceutica N.V. | 1-[(Diarylmethyl)aminoalkyl]piperidimes |
WO1980000152A1 (en) * | 1978-07-03 | 1980-02-07 | Sandoz Ag | 3-aminopropoxy-aryl derivates,preparation and use thereof |
US4358456A (en) * | 1980-05-03 | 1982-11-09 | John Wyeth & Brother Limited | Antipsychotic piperidinomethyl-indole derivatives |
DE3045688A1 (en) * | 1980-12-04 | 1982-07-08 | C.H. Boehringer Sohn, 6507 Ingelheim | NEW 8-ARYLALKYL-3-PHENYL-3-NORTROPANOLE, THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF |
EP0076075B1 (en) * | 1981-09-25 | 1986-11-20 | Beecham Group Plc | Pharmaceutically active benzopyran compounds |
EP0093534A1 (en) * | 1982-04-28 | 1983-11-09 | Beecham Group Plc | Novel chromanols |
GB8308064D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
FR2581993B1 (en) * | 1985-05-14 | 1988-03-18 | Synthelabo | (BENZOYL-4 PIPERIDINO) -2 PHENYL-1 ALCANOLS DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
US4957928A (en) * | 1986-06-26 | 1990-09-18 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds |
US4968678A (en) * | 1988-02-19 | 1990-11-06 | Eli Lilly And Company | Tetrazole excitatory amino acid receptor antagonists |
FR2640266B2 (en) * | 1988-07-12 | 1992-07-10 | Synthelabo | INDOLONES-2, QUINOLEINONES-2, BENZO (B) AZEPINONES-2 AND BENZIMIDAZOLONES-2 DERIVATIVES OF (HYDROXY-1 PIPERIDINYL-2 ALKYL), THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
US4968878A (en) * | 1989-02-07 | 1990-11-06 | Transitions Research Corporation | Dual bumper-light curtain obstacle detection sensor |
US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
SK232890A3 (en) * | 1989-05-17 | 1998-11-04 | Pfizer | 2-piperidino and 2-pyrrolidino-1-alkanols derivatives and preparation method thereof |
RU2099339C1 (en) * | 1990-02-06 | 1997-12-20 | Пфайзер Инк. | Piperidine derivative |
US5192751A (en) * | 1992-07-24 | 1993-03-09 | Eli Lilly And Company | Use of competitive NMDA receptor antagonists in the treatment of urinary incontinence |
-
1994
- 1994-11-21 AT AT94931668T patent/ATE183184T1/en not_active IP Right Cessation
- 1994-11-21 DE DE69420053T patent/DE69420053T2/en not_active Expired - Fee Related
- 1994-11-21 ES ES94931668T patent/ES2134361T3/en not_active Expired - Lifetime
- 1994-11-21 WO PCT/IB1994/000365 patent/WO1995020587A1/en active IP Right Grant
- 1994-11-21 EP EP94931668A patent/EP0741724B1/en not_active Expired - Lifetime
- 1994-11-21 CA CA002182101A patent/CA2182101C/en not_active Expired - Fee Related
- 1994-11-21 NZ NZ275151A patent/NZ275151A/en unknown
- 1994-11-21 DK DK94931668T patent/DK0741724T3/en active
- 1994-11-21 US US08/687,542 patent/US5744483A/en not_active Expired - Fee Related
- 1994-11-21 HU HU9602100A patent/HU221633B1/en not_active IP Right Cessation
- 1994-11-21 CN CN94194940A patent/CN1048247C/en not_active Expired - Fee Related
- 1994-11-21 JP JP7519959A patent/JP2866743B2/en not_active Expired - Lifetime
- 1994-11-21 RU RU96117381A patent/RU2126404C1/en not_active IP Right Cessation
- 1994-11-21 AU AU80663/94A patent/AU684568B2/en not_active Ceased
- 1994-11-21 PL PL94315681A patent/PL179448B1/en unknown
- 1994-11-21 BR BR9408506A patent/BR9408506A/en not_active Application Discontinuation
- 1994-11-21 CZ CZ19962256A patent/CZ286757B6/en not_active IP Right Cessation
- 1994-11-22 TW TW083110873A patent/TW449591B/en active
-
1995
- 1995-01-18 PE PE1995259688A patent/PE43795A1/en not_active Application Discontinuation
- 1995-01-23 IL IL11241595A patent/IL112415A/en not_active IP Right Cessation
- 1995-01-27 MY MYPI95000224A patent/MY111623A/en unknown
- 1995-01-27 CO CO95003001A patent/CO4230161A1/en unknown
- 1995-01-28 EG EG6795A patent/EG20672A/en active
- 1995-01-30 BR BR9500380A patent/BR9500380A/en not_active IP Right Cessation
- 1995-01-30 FI FI950403A patent/FI113769B/en not_active IP Right Cessation
- 1995-01-30 ZA ZA95692A patent/ZA95692B/en unknown
-
1996
- 1996-07-30 NO NO963186A patent/NO309190B1/en unknown
-
1999
- 1999-09-29 GR GR990402449T patent/GR3031356T3/en unknown
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