RU96111684A - METHOD FOR PRODUCING 10- (3-MORPHOLYL PROPIONYL) Phenothiazinecarbamic Acid-2 Acid Hydrochloride - Google Patents

METHOD FOR PRODUCING 10- (3-MORPHOLYL PROPIONYL) Phenothiazinecarbamic Acid-2 Acid Hydrochloride

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Publication number
RU96111684A
RU96111684A RU96111684/04A RU96111684A RU96111684A RU 96111684 A RU96111684 A RU 96111684A RU 96111684/04 A RU96111684/04 A RU 96111684/04A RU 96111684 A RU96111684 A RU 96111684A RU 96111684 A RU96111684 A RU 96111684A
Authority
RU
Russia
Prior art keywords
ethyl ester
phenothiazinecarbamic
acid ethyl
acid
aminodiphenylamine
Prior art date
Application number
RU96111684/04A
Other languages
Russian (ru)
Other versions
RU2102394C1 (en
Inventor
Н.Н. Артамонова
В.Ф. Шнер
Б.В. Салов
Г.А. Горелова
Н.Ф. Максимова
А.П. Никитенкова
Original Assignee
Государственный научный центр РФ "НИОПИК"
Filing date
Publication date
Application filed by Государственный научный центр РФ "НИОПИК" filed Critical Государственный научный центр РФ "НИОПИК"
Priority to RU96111684A priority Critical patent/RU2102394C1/en
Priority claimed from RU96111684A external-priority patent/RU2102394C1/en
Application granted granted Critical
Publication of RU96111684A publication Critical patent/RU96111684A/en
Publication of RU2102394C1 publication Critical patent/RU2102394C1/en

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Claims (1)

Способ получения гидрохлорида этилового эфира 10-(3-морфолилпропионил)фенотиазинкарбаминовой-2 кислоты из 3-аминодифениламина, включающий следующие основные стадии: взаимодействие 3-аминодифениламина с этиловым эфиром хлоругольной кислоты с получением этилового эфира дифениламинокарбаминовой-3 кислоты; обработка этилового эфира дифениламинокарбаминовой-3 кислоты серой в присутствии йода с получением этилового эфира фенотиазинкарбаминовой-2 кислоты; последующее ацилирование вышеназванного этилового эфира 3-хлорпропионилхлоридом с получением этилового эфира 10-(3-хлорпропионил)фенотиазинкарбаминовой-2 кислоты, обработкой этого эфира морфолином, затем хлористым водородом с последующим выделением целевого продукта, отличающийся тем, что взаимодействие 3-аминодифениламина с этиловым эфиром хлоругольной кислоты проводят в двухфазной системе: толуол - водный раствор кислого углекислого натрия, по окончании реакции из реакционной массы удаляют воду и избыток толуола и в полученную массу добавляют серу и йод; суспензию продукта реакции направляют на ацилирование; продукт со стадии ацилирования кристаллизуют и направляют на стадию обработки морфолином.A method for producing 10- (3-morpholylpropionyl) phenothiazinecarbamic-2 acid ethyl ester hydrochloride from 3-aminodiphenylamine, the process comprising the following main steps: reacting 3-aminodiphenylamine with chlorocarbonyl ethyl ester to produce diphenylaminocarbamic-3 acid ethyl ester; treating diphenylaminocarbamic-3 acid ethyl ester with sulfur in the presence of iodine to obtain phenothiazinecarbamic-2 acid ethyl ester; subsequent acylation of the above ethyl ester with 3-chloropropionyl chloride to obtain 10- (3-chloropropionyl) phenothiazinecarbamic-2 acid ethyl ester, treatment of this ester with morpholine, then with hydrogen chloride followed by isolation of the target product, characterized in that the interaction of 3-aminodiphenylamine acids are carried out in a two-phase system: toluene - an aqueous solution of sodium hydrogencarbonate, at the end of the reaction, water and excess toluene are removed from the reaction mass and into the resulting mass add sulfur and iodine; a suspension of the reaction product is directed to acylation; the product from the acylation step is crystallized and sent to the morpholine treatment step.
RU96111684A 1996-06-10 1996-06-10 Method for production of hydrochloride of ethyl ester of 10-(3-morpholyl propyonyl)phenothiazine carbamine-2 acid RU2102394C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU96111684A RU2102394C1 (en) 1996-06-10 1996-06-10 Method for production of hydrochloride of ethyl ester of 10-(3-morpholyl propyonyl)phenothiazine carbamine-2 acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU96111684A RU2102394C1 (en) 1996-06-10 1996-06-10 Method for production of hydrochloride of ethyl ester of 10-(3-morpholyl propyonyl)phenothiazine carbamine-2 acid

Publications (2)

Publication Number Publication Date
RU96111684A true RU96111684A (en) 1998-01-20
RU2102394C1 RU2102394C1 (en) 1998-01-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU96111684A RU2102394C1 (en) 1996-06-10 1996-06-10 Method for production of hydrochloride of ethyl ester of 10-(3-morpholyl propyonyl)phenothiazine carbamine-2 acid

Country Status (1)

Country Link
RU (1) RU2102394C1 (en)

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