RU96111436A - HETEROCYCLIC DERIVATIVES OF PYRAZINAMIDE, MANIFESTING ANTI-SPEED, ANTI-TURBUS AND IMMUNOTROPIC ACTIVITY AND METHOD FOR THEIR PRODUCTION - Google Patents

HETEROCYCLIC DERIVATIVES OF PYRAZINAMIDE, MANIFESTING ANTI-SPEED, ANTI-TURBUS AND IMMUNOTROPIC ACTIVITY AND METHOD FOR THEIR PRODUCTION

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Publication number
RU96111436A
RU96111436A RU96111436/04A RU96111436A RU96111436A RU 96111436 A RU96111436 A RU 96111436A RU 96111436/04 A RU96111436/04 A RU 96111436/04A RU 96111436 A RU96111436 A RU 96111436A RU 96111436 A RU96111436 A RU 96111436A
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RU
Russia
Prior art keywords
pyrazinamide
turbus
production
speed
manifesting
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RU96111436/04A
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Russian (ru)
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RU2102390C1 (en
Inventor
Н.М. Голощапов
Т.Т. Сударева
Л.Е. Костюк
Т.П. Филипских
Е.Н. Голощапова
Г.Ф. Заика
В.А. Кузнецов
Original Assignee
Научно-исследовательская лаборатория иммунохимиотерапии лепры и иммунотропных средств с клиникой и опытно-экспериментальным производством МЗМП России
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Application filed by Научно-исследовательская лаборатория иммунохимиотерапии лепры и иммунотропных средств с клиникой и опытно-экспериментальным производством МЗМП России filed Critical Научно-исследовательская лаборатория иммунохимиотерапии лепры и иммунотропных средств с клиникой и опытно-экспериментальным производством МЗМП России
Priority to RU96111436A priority Critical patent/RU2102390C1/en
Priority claimed from RU96111436A external-priority patent/RU2102390C1/en
Publication of RU96111436A publication Critical patent/RU96111436A/en
Application granted granted Critical
Publication of RU2102390C1 publication Critical patent/RU2102390C1/en

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Claims (2)

1. Гетероциклические производные пиразинамида общей формулы
Figure 00000001

где R
Figure 00000002

Figure 00000003

Figure 00000004

обладающие противолепрозной, противотуберкулезной и иммунотропной активностью.1. Heterocyclic pyrazinamide derivatives of the general formula
Figure 00000001

where r
Figure 00000002

Figure 00000003

Figure 00000004

possessing antileprotic, anti-tuberculosis and immunotropic activity. 2. Способ получения гетероциклических производных пиразинамида взаимодействием пиразин-2-карбоксамида с соответствующим сульфохлоридом, отличающийся тем, что с целью повышения выхода продукта, получают в жидком аммиаке натриевую соль пиразинамида, а затем вводят соответствующий сульфохлорид. 2. A method of obtaining heterocyclic pyrazinamide derivatives by reacting pyrazin-2-carboxamide with the corresponding sulfonyl chloride, characterized in that in order to increase the yield of the product, pyrazinamide sodium salt is obtained in liquid ammonia, and then the corresponding sulfonic chloride is introduced.
RU96111436A 1996-06-06 1996-06-06 N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidinyl-5-sulfonyl)pyrazine- -2-carboxamide possessing anti leprotic and antituberculosis and immunotropic activity, method for their production RU2102390C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU96111436A RU2102390C1 (en) 1996-06-06 1996-06-06 N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidinyl-5-sulfonyl)pyrazine- -2-carboxamide possessing anti leprotic and antituberculosis and immunotropic activity, method for their production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU96111436A RU2102390C1 (en) 1996-06-06 1996-06-06 N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidinyl-5-sulfonyl)pyrazine- -2-carboxamide possessing anti leprotic and antituberculosis and immunotropic activity, method for their production

Publications (2)

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RU96111436A true RU96111436A (en) 1998-01-10
RU2102390C1 RU2102390C1 (en) 1998-01-20

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RU96111436A RU2102390C1 (en) 1996-06-06 1996-06-06 N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidinyl-5-sulfonyl)pyrazine- -2-carboxamide possessing anti leprotic and antituberculosis and immunotropic activity, method for their production

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY149180A (en) * 2008-06-03 2013-07-31 Taiho Pharmaceutical Co Ltd Uracil compound having inhibitor activity on human deoxyuridine triphosphatase or salt thereof
MY161094A (en) * 2009-11-30 2017-04-14 Taiho Pharmaceutical Co Ltd Anti-tumor effect potentiator

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