RU96111026A - 7 - ([1A, 5A, 6A] -6-AMINO-3-AZABICYCLO [3.1.0.] HEX-3-IL) -6-fluoro-1- (2,4-difluorophenyl) -1,4-dihydro -4-OXO-1,8- NAPHTHIRIDINE-3-CARBONIC ACID, METHANESULPHIC ACID SALT, METHOD FOR PRODUCING IT, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT - Google Patents

7 - ([1A, 5A, 6A] -6-AMINO-3-AZABICYCLO [3.1.0.] HEX-3-IL) -6-fluoro-1- (2,4-difluorophenyl) -1,4-dihydro -4-OXO-1,8- NAPHTHIRIDINE-3-CARBONIC ACID, METHANESULPHIC ACID SALT, METHOD FOR PRODUCING IT, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT

Info

Publication number
RU96111026A
RU96111026A RU96111026/04A RU96111026A RU96111026A RU 96111026 A RU96111026 A RU 96111026A RU 96111026/04 A RU96111026/04 A RU 96111026/04A RU 96111026 A RU96111026 A RU 96111026A RU 96111026 A RU96111026 A RU 96111026A
Authority
RU
Russia
Prior art keywords
azabicyclo
difluorophenyl
hex
dihydro
oxo
Prior art date
Application number
RU96111026/04A
Other languages
Russian (ru)
Other versions
RU2125571C1 (en
Inventor
А.Ханданьян Линне
Л.Хендриксон Роберт
Дж.Джонсон Филлип
А.Моррис Томас
Норрис Тимоти
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1995/007211 external-priority patent/WO1996039406A1/en
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of RU96111026A publication Critical patent/RU96111026A/en
Application granted granted Critical
Publication of RU2125571C1 publication Critical patent/RU2125571C1/en

Links

Claims (4)

1. 7-([1а, 5а, 6а] -6-амино-3-азабицикло[3.1.0] гекс-3-ил)-6-фтор- 1-(2,4-дифторфенил)-1,4-дигидро-4-оксо-1,8-нафтиридин-3-карбоновая кислота, соль метансульфоновой кислоты, характеризуемая следующими основными пиками в рентгенограмме порошковой дифракции, приведенной в таблице.1.7 - ([1a, 5a, 6a] -6-amino-3-azabicyclo [3.1.0] hex-3-yl) -6-fluoro-1- (2,4-difluorophenyl) -1,4- dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, a salt of methanesulfonic acid, characterized by the following main peaks in the x-ray powder diffraction shown in the table. 2. Фармацевтическая композиция, имеющая противобактериальную активность, включающая соединение по п. 1 в количестве эффективном для лечения бактериальной инфекции, и фармацевтически приемлемый носитель. 2. A pharmaceutical composition having antibacterial activity, comprising a compound according to claim 1 in an amount effective for treating a bacterial infection, and a pharmaceutically acceptable carrier. 3. Способ лечения бактериальной инфекции, который включает введение субъекту, нуждающемуся в лечении, противобактериального количества соединения по п. 1. 3. A method of treating a bacterial infection, which comprises administering to a subject in need of treatment an antibacterial amount of a compound according to claim 1. 4. Способ получения соединения по п. 1, который включает нагревание 7-([1а, 5а, 6а]-6-амино-3-азабицикло[3.1.0]гекс-3-ил)-6- фтор-1-(2,4-дифторфенил)-1,4-дигидро-4-оксо-1,8-нафтиридин-3- карбоновой кислоты, соли метансульфоновой кислоты или ее производного моногидрата в присутствии спирта или его смеси с апротонным сорастворителем. 4. The method of producing the compound according to claim 1, which includes heating 7 - ([1a, 5a, 6a] -6-amino-3-azabicyclo [3.1.0] hex-3-yl) -6-fluoro-1- ( 2,4-difluorophenyl) -1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt or its derivative monohydrate in the presence of alcohol or a mixture thereof with an aprotic cosolvent.
RU96111026A 1995-06-06 1996-06-05 7-([-([1α,5α,6α]]-6-AMINO-3-AZABICYCLO-[3,1,0]-HEX-3-YL)-6-FLUORO-1- -(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3- -CARBOXYLIC AND METHANESULFONIC ACIDS SALT AND A METHOD OF ITS SYNTHESIS RU2125571C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1995/007211 WO1996039406A1 (en) 1995-06-06 1995-06-06 NOVEL CRYSTAL FORM OF ANHYDROUS 7-([1α, 5α, 6α]-6-AMINO-3-AZABICYCLO[3.1.0]HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, METHANESULFONIC ACID SALT
USPCT/US95/07211 1995-06-06
USPCTUS95/07211 1995-06-06

Publications (2)

Publication Number Publication Date
RU96111026A true RU96111026A (en) 1998-10-27
RU2125571C1 RU2125571C1 (en) 1999-01-27

Family

ID=39431076

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96111026A RU2125571C1 (en) 1995-06-06 1996-06-05 7-([-([1α,5α,6α]]-6-AMINO-3-AZABICYCLO-[3,1,0]-HEX-3-YL)-6-FLUORO-1- -(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3- -CARBOXYLIC AND METHANESULFONIC ACIDS SALT AND A METHOD OF ITS SYNTHESIS

Country Status (38)

Country Link
US (1) US5763454A (en)
EP (1) EP0789697B1 (en)
JP (1) JP3145715B2 (en)
KR (1) KR100191989B1 (en)
CN (1) CN1055474C (en)
AR (1) AR002753A1 (en)
AU (1) AU703634B2 (en)
BG (1) BG62443B1 (en)
BR (1) BR9602630A (en)
CA (1) CA2223404C (en)
CZ (1) CZ285878B6 (en)
DE (1) DE69503066T2 (en)
DK (1) DK0789697T3 (en)
DZ (1) DZ2046A1 (en)
ES (1) ES2117426T3 (en)
FI (1) FI974441A (en)
HR (1) HRP960267B1 (en)
HU (1) HUP9601540A3 (en)
IL (1) IL118488A (en)
IS (1) IS4351A (en)
LV (1) LV11619B (en)
MA (1) MA23892A1 (en)
NO (1) NO305599B1 (en)
NZ (1) NZ286735A (en)
OA (1) OA10293A (en)
PE (1) PE38097A1 (en)
PL (1) PL314604A1 (en)
RU (1) RU2125571C1 (en)
SG (1) SG54339A1 (en)
SI (1) SI9600185A (en)
SK (1) SK280535B6 (en)
TN (1) TNSN96084A1 (en)
TW (2) TW580389B (en)
UA (1) UA44718C2 (en)
UY (1) UY25459A1 (en)
WO (1) WO1996039406A1 (en)
YU (1) YU34596A (en)
ZA (1) ZA964647B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA24500A1 (en) 1997-03-21 1998-10-01 Lg Life Sciences Ltd CARBOXYLIC ACID SALT DERIVATIVE FROM NAPHTHYRIDINE.
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
HN1998000106A (en) 1997-08-01 1999-01-08 Pfizer Prod Inc PARENTERAL COMPOSITIONS OF ALATROFLAXACINO
DE19800214A1 (en) * 1998-01-06 1999-07-15 Knoll Ag Process for the preparation of doxazosin mcsylate in a crystal modification referred to as Form A and an intermediate therefor
US7019142B2 (en) * 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
GB9818258D0 (en) * 1998-08-21 1998-10-14 Pfizer Ltd Antifungal compositions
HN1999000141A (en) * 1998-09-03 2000-06-19 Pfizer Prod Inc PROCEDURE FOR PREPARING SALTS OF TROVAFLOXACIN FOR ADDITION OF ACIDS.
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
ES2164520B1 (en) * 1999-03-16 2003-04-01 Medichem Sa "PROCEDURE FOR OBTAINING THE DOXAZOSINE MESYLATE POLYMORPH A"
US6239141B1 (en) 1999-06-04 2001-05-29 Pfizer Inc. Trovafloxacin oral suspensions
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
KR100517638B1 (en) 2002-04-08 2005-09-28 주식회사 엘지생명과학 New process for preparing acid salts of Gemifloxacin
CN102512364A (en) * 2011-12-30 2012-06-27 天津市嵩锐医药科技有限公司 Alatrofloxacin mesylate medicine composition for injection
TWI608970B (en) * 2013-01-11 2017-12-21 參天製藥股份有限公司 Inner plug and liquid storage container with the plug, tip portion structure of nozzle and liquid storage container with the structure

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE66202B1 (en) * 1989-08-16 1995-12-13 Pfizer Azabicyclo quinolone carboxylic acids
US5164402A (en) * 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
CZ286896B6 (en) * 1994-01-18 2000-07-12 Pfizer Process for preparing pharmaceutically acceptable salts of naphthyridone carboxylic acid and intermediates for this preparation
GB2289674A (en) * 1994-05-23 1995-11-29 Pfizer Antibacterial naphthyridine

Similar Documents

Publication Publication Date Title
RU96111026A (en) 7 - ([1A, 5A, 6A] -6-AMINO-3-AZABICYCLO [3.1.0.] HEX-3-IL) -6-fluoro-1- (2,4-difluorophenyl) -1,4-dihydro -4-OXO-1,8- NAPHTHIRIDINE-3-CARBONIC ACID, METHANESULPHIC ACID SALT, METHOD FOR PRODUCING IT, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT
RU93058555A (en) Quinuclidine derivatives, a method for their production, a pharmaceutical composition, a method for the treatment or prevention
RU94027569A (en) ORGANIC SALTS N, N'-DIACETHILTSISTINA, METHOD OF PRODUCTION, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT
FI913446A (en) Process for the preparation of therapeutically active 3- (2-substituted-3-oxo-2,3-dihydropyridazin-6-yl) -2-phenylpyrazolo [1,5-a] pyridines
CA2396561A1 (en) Substituted oxazolidinones and their use in the field of blood coagulation
PH23256A (en) A process for the preparation of quinolone carboxylic acid derivatives
CA2455774A1 (en) Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain
HUT53368A (en) Process for producing pyrazolo-pyridine derivatives and pharmaceutical compositions containing them
CA2258548A1 (en) Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
RU96123410A (en) MONOHYDRATE OF HYDROCHLORIDE 1-CYCLOPROPIL-7 - ([S, S] -2,8-DIAZABICYCLO [4.3.0] NON-8-IL) - 6-Fluoro-1,4-DIHYDRO-8-METHOXY-4-OXO- 3-quinoline carboxylic acid and pharmaceutical composition with antibacterial activity
AU595631B2 (en) 7-((3-(aminomethyl)-3-alkyl)-1-pyrrolidinyl)- quinoline-carboxylic acids
RU93004860A (en) HETEROCYCLIC COMPOUNDS, METHOD FOR THEIR PRODUCTION, USE AND PHARMACEUTICAL COMPOSITION
GEP20022801B (en) Pyridazino [4,5-B]-Quinoline 5-Oxide Derivatives, Their Preparation and Their Use as Glycine Antagonists
RU94008616A (en) 2-THIOSUBLISHED CARBAPENES, INTERMEDIATE CONNECTIONS FOR OBTAINING, METHODS OF OBTAINING, PHARMACEUTICAL COMPOSITION, METHOD OF TREATING BACTERIAL INFECTIONS
CA2139385A1 (en) Products containing g-csf and tnf binding protein
RU95110937A (en) Quinoline and acrydine compounds, process for preparation thereof, pharmaceutical composition, and intermediates
AU631814B2 (en) Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
HUT66515A (en) Process for preparing piperidine derivatives and pharmaceutical compositions contg. them as active ingredients
HU893127D0 (en) Process for the preparation of novel spiro-(imidazolidino-naphtaline) derivatives and pharmaceutical compositions containing such compounds as active ingredient
CA2013136A1 (en) (s)-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
IL81337A (en) Heptanoyl-glu-asp-ala-amino acid immunostimulants,process for their preparation and pharmaceutical compositions containing them
HUT46214A (en) Process for producing medical preparation suitable for treatment of peptic ulcer
RU2002115270A (en) Compounds and method for treating pain
NZ503027A (en) Use of rifamycin derivative for treating mastitis in a domestic animal
BG106831A (en) Compound and method for the treatment of pain