RU96111026A - 7 - ([1A, 5A, 6A] -6-AMINO-3-AZABICYCLO [3.1.0.] HEX-3-IL) -6-fluoro-1- (2,4-difluorophenyl) -1,4-dihydro -4-OXO-1,8- NAPHTHIRIDINE-3-CARBONIC ACID, METHANESULPHIC ACID SALT, METHOD FOR PRODUCING IT, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT - Google Patents
7 - ([1A, 5A, 6A] -6-AMINO-3-AZABICYCLO [3.1.0.] HEX-3-IL) -6-fluoro-1- (2,4-difluorophenyl) -1,4-dihydro -4-OXO-1,8- NAPHTHIRIDINE-3-CARBONIC ACID, METHANESULPHIC ACID SALT, METHOD FOR PRODUCING IT, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENTInfo
- Publication number
- RU96111026A RU96111026A RU96111026/04A RU96111026A RU96111026A RU 96111026 A RU96111026 A RU 96111026A RU 96111026/04 A RU96111026/04 A RU 96111026/04A RU 96111026 A RU96111026 A RU 96111026A RU 96111026 A RU96111026 A RU 96111026A
- Authority
- RU
- Russia
- Prior art keywords
- azabicyclo
- difluorophenyl
- hex
- dihydro
- oxo
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 150000003839 salts Chemical class 0.000 title claims 2
- 239000011780 sodium chloride Substances 0.000 title claims 2
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 3
- 206010060945 Bacterial infection Diseases 0.000 claims 2
- 230000000844 anti-bacterial Effects 0.000 claims 2
- -1 hex-3-yl Chemical group 0.000 claims 2
- 239000006184 cosolvent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000004682 monohydrates Chemical class 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
Claims (4)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1995/007211 WO1996039406A1 (en) | 1995-06-06 | 1995-06-06 | NOVEL CRYSTAL FORM OF ANHYDROUS 7-([1α, 5α, 6α]-6-AMINO-3-AZABICYCLO[3.1.0]HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, METHANESULFONIC ACID SALT |
USPCT/US95/07211 | 1995-06-06 | ||
USPCTUS95/07211 | 1995-06-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU96111026A true RU96111026A (en) | 1998-10-27 |
RU2125571C1 RU2125571C1 (en) | 1999-01-27 |
Family
ID=39431076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU96111026A RU2125571C1 (en) | 1995-06-06 | 1996-06-05 | 7-([-([1α,5α,6α]]-6-AMINO-3-AZABICYCLO-[3,1,0]-HEX-3-YL)-6-FLUORO-1- -(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3- -CARBOXYLIC AND METHANESULFONIC ACIDS SALT AND A METHOD OF ITS SYNTHESIS |
Country Status (38)
Country | Link |
---|---|
US (1) | US5763454A (en) |
EP (1) | EP0789697B1 (en) |
JP (1) | JP3145715B2 (en) |
KR (1) | KR100191989B1 (en) |
CN (1) | CN1055474C (en) |
AR (1) | AR002753A1 (en) |
AU (1) | AU703634B2 (en) |
BG (1) | BG62443B1 (en) |
BR (1) | BR9602630A (en) |
CA (1) | CA2223404C (en) |
CZ (1) | CZ285878B6 (en) |
DE (1) | DE69503066T2 (en) |
DK (1) | DK0789697T3 (en) |
DZ (1) | DZ2046A1 (en) |
ES (1) | ES2117426T3 (en) |
FI (1) | FI974441A (en) |
HR (1) | HRP960267B1 (en) |
HU (1) | HUP9601540A3 (en) |
IL (1) | IL118488A (en) |
IS (1) | IS4351A (en) |
LV (1) | LV11619B (en) |
MA (1) | MA23892A1 (en) |
NO (1) | NO305599B1 (en) |
NZ (1) | NZ286735A (en) |
OA (1) | OA10293A (en) |
PE (1) | PE38097A1 (en) |
PL (1) | PL314604A1 (en) |
RU (1) | RU2125571C1 (en) |
SG (1) | SG54339A1 (en) |
SI (1) | SI9600185A (en) |
SK (1) | SK280535B6 (en) |
TN (1) | TNSN96084A1 (en) |
TW (2) | TW580389B (en) |
UA (1) | UA44718C2 (en) |
UY (1) | UY25459A1 (en) |
WO (1) | WO1996039406A1 (en) |
YU (1) | YU34596A (en) |
ZA (1) | ZA964647B (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA24500A1 (en) | 1997-03-21 | 1998-10-01 | Lg Life Sciences Ltd | CARBOXYLIC ACID SALT DERIVATIVE FROM NAPHTHYRIDINE. |
US20020032216A1 (en) | 1997-03-21 | 2002-03-14 | Lg Chemical Ltd. | Salt of naphthyridine carboxylic acid derivative |
HN1998000106A (en) | 1997-08-01 | 1999-01-08 | Pfizer Prod Inc | PARENTERAL COMPOSITIONS OF ALATROFLAXACINO |
DE19800214A1 (en) * | 1998-01-06 | 1999-07-15 | Knoll Ag | Process for the preparation of doxazosin mcsylate in a crystal modification referred to as Form A and an intermediate therefor |
US7019142B2 (en) * | 1998-01-16 | 2006-03-28 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
GB9818258D0 (en) * | 1998-08-21 | 1998-10-14 | Pfizer Ltd | Antifungal compositions |
HN1999000141A (en) * | 1998-09-03 | 2000-06-19 | Pfizer Prod Inc | PROCEDURE FOR PREPARING SALTS OF TROVAFLOXACIN FOR ADDITION OF ACIDS. |
GB9820405D0 (en) | 1998-09-18 | 1998-11-11 | Smithkline Beecham Plc | Process |
ES2164520B1 (en) * | 1999-03-16 | 2003-04-01 | Medichem Sa | "PROCEDURE FOR OBTAINING THE DOXAZOSINE MESYLATE POLYMORPH A" |
US6239141B1 (en) | 1999-06-04 | 2001-05-29 | Pfizer Inc. | Trovafloxacin oral suspensions |
GB9920917D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel process |
GB9920919D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel compound |
US6657061B2 (en) | 2001-06-29 | 2003-12-02 | Grayson Walker Stowell | Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6573382B2 (en) | 2001-06-29 | 2003-06-03 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6531603B1 (en) | 2001-06-29 | 2003-03-11 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6388080B1 (en) | 2001-06-29 | 2002-05-14 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6660864B2 (en) | 2001-06-29 | 2003-12-09 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6596871B2 (en) | 2001-06-29 | 2003-07-22 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
KR100517638B1 (en) | 2002-04-08 | 2005-09-28 | 주식회사 엘지생명과학 | New process for preparing acid salts of Gemifloxacin |
CN102512364A (en) * | 2011-12-30 | 2012-06-27 | 天津市嵩锐医药科技有限公司 | Alatrofloxacin mesylate medicine composition for injection |
TWI608970B (en) * | 2013-01-11 | 2017-12-21 | 參天製藥股份有限公司 | Inner plug and liquid storage container with the plug, tip portion structure of nozzle and liquid storage container with the structure |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE66202B1 (en) * | 1989-08-16 | 1995-12-13 | Pfizer | Azabicyclo quinolone carboxylic acids |
US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
CZ286896B6 (en) * | 1994-01-18 | 2000-07-12 | Pfizer | Process for preparing pharmaceutically acceptable salts of naphthyridone carboxylic acid and intermediates for this preparation |
GB2289674A (en) * | 1994-05-23 | 1995-11-29 | Pfizer | Antibacterial naphthyridine |
-
1995
- 1995-06-06 EP EP95922240A patent/EP0789697B1/en not_active Expired - Lifetime
- 1995-06-06 US US08/849,300 patent/US5763454A/en not_active Expired - Fee Related
- 1995-06-06 CA CA002223404A patent/CA2223404C/en not_active Expired - Fee Related
- 1995-06-06 DE DE69503066T patent/DE69503066T2/en not_active Expired - Fee Related
- 1995-06-06 JP JP50037497A patent/JP3145715B2/en not_active Expired - Fee Related
- 1995-06-06 ES ES95922240T patent/ES2117426T3/en not_active Expired - Lifetime
- 1995-06-06 DK DK95922240T patent/DK0789697T3/en active
- 1995-06-06 SK SK719-96A patent/SK280535B6/en unknown
- 1995-06-06 WO PCT/US1995/007211 patent/WO1996039406A1/en active IP Right Grant
-
1996
- 1996-05-13 TW TW089107609A patent/TW580389B/en not_active IP Right Cessation
- 1996-05-13 TW TW085105632A patent/TW403751B/en not_active IP Right Cessation
- 1996-05-29 CN CN96110060A patent/CN1055474C/en not_active Expired - Fee Related
- 1996-05-30 IL IL11848896A patent/IL118488A/en not_active IP Right Cessation
- 1996-05-31 AR ARP960102817A patent/AR002753A1/en unknown
- 1996-06-03 IS IS4351A patent/IS4351A/en unknown
- 1996-06-04 BR BR9602630A patent/BR9602630A/en not_active Application Discontinuation
- 1996-06-04 LV LVP-96-172A patent/LV11619B/en unknown
- 1996-06-04 PL PL96314604A patent/PL314604A1/en unknown
- 1996-06-04 UA UA96062190A patent/UA44718C2/en unknown
- 1996-06-05 YU YU34596A patent/YU34596A/en unknown
- 1996-06-05 KR KR1019960020171A patent/KR100191989B1/en not_active IP Right Cessation
- 1996-06-05 AU AU54749/96A patent/AU703634B2/en not_active Ceased
- 1996-06-05 TN TNTNSN96084A patent/TNSN96084A1/en unknown
- 1996-06-05 BG BG100639A patent/BG62443B1/en unknown
- 1996-06-05 HU HU9601540A patent/HUP9601540A3/en unknown
- 1996-06-05 NO NO962321A patent/NO305599B1/en not_active IP Right Cessation
- 1996-06-05 CZ CZ961625A patent/CZ285878B6/en not_active IP Right Cessation
- 1996-06-05 DZ DZ960090A patent/DZ2046A1/en active
- 1996-06-05 ZA ZA9604647A patent/ZA964647B/en unknown
- 1996-06-05 SG SG1996009972A patent/SG54339A1/en unknown
- 1996-06-05 RU RU96111026A patent/RU2125571C1/en not_active IP Right Cessation
- 1996-06-05 NZ NZ286735A patent/NZ286735A/en unknown
- 1996-06-05 MA MA24262A patent/MA23892A1/en unknown
- 1996-06-06 OA OA60835A patent/OA10293A/en unknown
- 1996-06-06 HR HR960267A patent/HRP960267B1/en not_active IP Right Cessation
- 1996-06-06 PE PE1996000421A patent/PE38097A1/en not_active Application Discontinuation
- 1996-06-06 SI SI9600185A patent/SI9600185A/en not_active IP Right Cessation
-
1997
- 1997-12-05 FI FI974441A patent/FI974441A/en unknown
-
1999
- 1999-04-06 UY UY25459A patent/UY25459A1/en not_active Application Discontinuation
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