RU96108914A - DERIVATIVE OF AZOL AND CONTAINING ITS PHARMACEUTICAL COMPOSITION - Google Patents

DERIVATIVE OF AZOL AND CONTAINING ITS PHARMACEUTICAL COMPOSITION

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Publication number
RU96108914A
RU96108914A RU96108914/04A RU96108914A RU96108914A RU 96108914 A RU96108914 A RU 96108914A RU 96108914/04 A RU96108914/04 A RU 96108914/04A RU 96108914 A RU96108914 A RU 96108914A RU 96108914 A RU96108914 A RU 96108914A
Authority
RU
Russia
Prior art keywords
group
azole
different
same
derived
Prior art date
Application number
RU96108914/04A
Other languages
Russian (ru)
Inventor
Окада Минору
Йоден Тору
Каваминами Еидзи
Симада Йосиаки
Исихара Цукаса
Кудоу Масафуми
Original Assignee
Яманоути Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Яманоути Фармасьютикал Ко., Лтд. filed Critical Яманоути Фармасьютикал Ко., Лтд.
Publication of RU96108914A publication Critical patent/RU96108914A/en

Links

Claims (1)

1. Производное азола формулы I
Figure 00000001

где R1 и R2 - одинаковые или различные, водород, низший алкил или фенил, который может быть замещен атомом галогена;
A, B и D - одинаковые или различные, группа формулы =CR3 или атом азота;
X и Y - одинаковые или различные, простая связь, метилен, атом кислорода, группа S(O)n или группа
Figure 00000002

R3 и R4 - одинаковые или различные, водород или низший алкил;
n = 0, 1 или 2,
его соль, гидрат или сольват.1. Derived azole formula I
Figure 00000001

where R 1 and R 2 are the same or different, hydrogen, lower alkyl or phenyl, which may be substituted by a halogen atom;
A, B and D are the same or different, a group of the formula = CR 3 or a nitrogen atom;
X and Y are the same or different, a simple bond, methylene, an oxygen atom, a group S (O) n or a group
Figure 00000002

R 3 and R 4 are the same or different, hydrogen or lower alkyl;
n = 0, 1 or 2,
its salt, hydrate or solvate. 2. Производное азола или его соль по п.1, где R1 и R2 - одинаковые или различные, каждый - водород или низший алкил, Х - простая связь или группа S(O)n и Y - метилен, группа S(O)n или группа
Figure 00000003

3. Производное азола или его соль по п.1, где Х - простая связь и Y - метилен.2. Derived azole or its salt according to claim 1, where R 1 and R 2 are the same or different, each is hydrogen or lower alkyl, X is a simple bond or a group S (O) n and Y is methylene, group S (O ) n or group
Figure 00000003

3. Derived azole or its salt according to claim 1, where X is a simple bond and Y is methylene. 4. Производное азола или его соль по п.1, которые представляют собой 1-[1-(9Н-флуорен-2-ил)-этил]-1Н-имидазол. 4. Derived azole or its salt according to claim 1, which are 1- [1- (9H-fluoren-2-yl) ethyl] -1H-imidazole. 5. Фармацевтическая композиция, содержащая производное азола по п.1 или его фармацевтически приемлемую соль в качестве активного компонента. 5. A pharmaceutical composition comprising the azole derivative according to claim 1 or a pharmaceutically acceptable salt thereof as an active ingredient. 6. Ингибитор 17-20-стероидлиазы, содержащий производное азола по п.1 или его фармацевтически приемлемую соль в качестве активного компонента. 6. An inhibitor of 17-20 steroid lyase containing the azole derivative according to claim 1 or a pharmaceutically acceptable salt thereof as an active ingredient. 7. Ингибитор по п. 6, который представляет собой профилактическое или лечебное средство для лечения рака простаты, гипертрофии простаты, вирилизма, гипертрихоза, рака молочной железы, мастопатии, миомы матки и эндометриоза. 7. The inhibitor according to claim 6, which is a prophylactic or therapeutic agent for the treatment of prostate cancer, prostate hypertrophy, virilism, hypertrichosis, breast cancer, mastopathy, uterine fibroids and endometriosis. 8. Ингибитор по п.6 или 7, включающий 1-[1-(9Н-флуорен-2-ил)-этил]-1Н-имидазол или его фармацевтически приемлемую соль в качестве активного компонента. 8. The inhibitor according to claim 6 or 7, comprising 1- [1- (9H-fluoren-2-yl) ethyl] -1H-imidazole or its pharmaceutically acceptable salt as an active ingredient.
RU96108914/04A 1993-09-30 1994-09-28 DERIVATIVE OF AZOL AND CONTAINING ITS PHARMACEUTICAL COMPOSITION RU96108914A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JPHEI-5-244944 1993-09-30

Publications (1)

Publication Number Publication Date
RU96108914A true RU96108914A (en) 1998-06-10

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