RU95115822A - Biological factors and neuronal stem cells - Google Patents

Biological factors and neuronal stem cells

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Publication number
RU95115822A
RU95115822A RU95115822/13A RU95115822A RU95115822A RU 95115822 A RU95115822 A RU 95115822A RU 95115822/13 A RU95115822/13 A RU 95115822/13A RU 95115822 A RU95115822 A RU 95115822A RU 95115822 A RU95115822 A RU 95115822A
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RU
Russia
Prior art keywords
stem cells
neuronal stem
growth factor
oligodendrocytes
astrocytes
Prior art date
Application number
RU95115822/13A
Other languages
Russian (ru)
Inventor
Вайсс Самюэль
Ca]
А.Рейнолдс Брент
П.Хэмменг Джозеф
Бейтдж Е.Эдвард
Us]
Original Assignee
Нейросферес Лтд. (CA)
Нейросферес Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25513066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU95115822(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Нейросферес Лтд. (CA), Нейросферес Лтд. filed Critical Нейросферес Лтд. (CA)
Publication of RU95115822A publication Critical patent/RU95115822A/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01011—Phosphopyruvate hydratase (4.2.1.11), i.e. enolase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/46—Amines, e.g. putrescine
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/148—Transforming growth factor alpha [TGF-a]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

FIELD: cellular biology. SUBSTANCE: invention describes methods for increase of neuronal stem cells amount that differentiate to astrocytes, oligodendrocytes or neurons. Methods involve proliferation of the isolated neuronal stem cells in cultural medium containing the growth factor for cell-precursors producing. Cell-precursors were differentiated then to astrocytes, oligodendrocytes or neurons in the second cultural medium no containing the first growth factor but containing the second growth factor or combination of the growth factors. EFFECT: improved methods of cell amount increase.

Claims (1)

Сущность изобретения: способы повышения числа нейрональных стволовых клеток, которые дифференцируются в астроциты, олигодендроциты или нейроны, включают пролиферацию изолированных нейрональных стволовых клеток в культуральной среде, содержащей первый фактор роста для продуцирования клеток-предшественников. Клетки-предшественники затем дифференцируют в астроциты, олигодендроциты или нейроны во второй культуральной среде, не содержащей первый фактор роста, а содержащей второй фактор роста или сочетание факторов роста.The inventive methods for increasing the number of neuronal stem cells that differentiate into astrocytes, oligodendrocytes or neurons include the proliferation of isolated neuronal stem cells in a culture medium containing a first growth factor for the production of progenitor cells. Precursor cells then differentiate into astrocytes, oligodendrocytes or neurons in a second culture medium that does not contain the first growth factor but contains a second growth factor or a combination of growth factors.
RU95115822/13A 1992-10-28 1995-05-26 Biological factors and neuronal stem cells RU95115822A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96762292A 1992-10-28 1992-10-28
US07/967.622 1992-10-28

Publications (1)

Publication Number Publication Date
RU95115822A true RU95115822A (en) 1997-03-20

Family

ID=25513066

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95115822/13A RU95115822A (en) 1992-10-28 1995-05-26 Biological factors and neuronal stem cells

Country Status (14)

Country Link
EP (2) EP1298202B1 (en)
JP (2) JPH08502652A (en)
KR (1) KR950704476A (en)
AT (2) ATE234353T1 (en)
AU (2) AU5367694A (en)
CA (1) CA2148138C (en)
DE (2) DE69332759T3 (en)
DK (1) DK0669973T4 (en)
ES (1) ES2194016T5 (en)
FI (1) FI952022A (en)
NO (1) NO324412B1 (en)
PT (1) PT669973E (en)
RU (1) RU95115822A (en)
WO (1) WO1994010292A1 (en)

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EP1298202B1 (en) 2010-10-06
PT669973E (en) 2003-06-30
WO1994010292A1 (en) 1994-05-11
FI952022A0 (en) 1995-04-27
EP0669973B1 (en) 2003-03-12
ATE234353T1 (en) 2003-03-15
DE69332759T2 (en) 2003-10-16
EP1298202A3 (en) 2003-12-03
DK0669973T4 (en) 2007-08-27
JPH08502652A (en) 1996-03-26
EP0669973A1 (en) 1995-09-06
KR950704476A (en) 1995-11-20
AU4924197A (en) 1998-03-12
CA2148138C (en) 2002-01-08
FI952022A (en) 1995-04-27
AU703729B2 (en) 1999-04-01
DE69332759T3 (en) 2008-01-24
DE69332759D1 (en) 2003-04-17
NO324412B1 (en) 2007-10-08
ES2194016T5 (en) 2007-11-16
CA2148138A1 (en) 1994-05-11
NO951617L (en) 1995-04-27
DE69334344D1 (en) 2010-11-18
AU5367694A (en) 1994-05-24
ATE483795T1 (en) 2010-10-15
DK0669973T3 (en) 2003-07-14
JP2007014352A (en) 2007-01-25
EP0669973B9 (en) 2007-10-10
EP1298202A2 (en) 2003-04-02
NO951617D0 (en) 1995-04-27
EP0669973B2 (en) 2007-04-18
ES2194016T3 (en) 2003-11-16

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