EP1109887A4 - Production and use of dopaminergic cells to treat dopaminergic deficiencies - Google Patents

Production and use of dopaminergic cells to treat dopaminergic deficiencies

Info

Publication number
EP1109887A4
EP1109887A4 EP98959412A EP98959412A EP1109887A4 EP 1109887 A4 EP1109887 A4 EP 1109887A4 EP 98959412 A EP98959412 A EP 98959412A EP 98959412 A EP98959412 A EP 98959412A EP 1109887 A4 EP1109887 A4 EP 1109887A4
Authority
EP
European Patent Office
Prior art keywords
dopaminergic
production
treat
deficiencies
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98959412A
Other languages
German (de)
French (fr)
Other versions
EP1109887A1 (en
Inventor
Michael P Mcgrogan
Gary L Snable
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Layton Bioscience Inc
Original Assignee
Layton Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Layton Bioscience Inc filed Critical Layton Bioscience Inc
Publication of EP1109887A1 publication Critical patent/EP1109887A1/en
Publication of EP1109887A4 publication Critical patent/EP1109887A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/24—Genital tract cells, non-germinal cells from gonads
    • C12N2502/246—Cells of the male genital tract, non-germinal testis cells
EP98959412A 1998-07-29 1998-11-10 Production and use of dopaminergic cells to treat dopaminergic deficiencies Withdrawn EP1109887A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9451598P 1998-07-29 1998-07-29
US94515P 1998-07-29
PCT/US1998/023977 WO2000006700A1 (en) 1998-07-29 1998-11-10 Production and use of dopaminergic cells to treat dopaminergic deficiencies

Publications (2)

Publication Number Publication Date
EP1109887A1 EP1109887A1 (en) 2001-06-27
EP1109887A4 true EP1109887A4 (en) 2003-05-21

Family

ID=22245637

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98959412A Withdrawn EP1109887A4 (en) 1998-07-29 1998-11-10 Production and use of dopaminergic cells to treat dopaminergic deficiencies

Country Status (2)

Country Link
EP (1) EP1109887A4 (en)
WO (1) WO2000006700A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4573332B2 (en) 2003-01-24 2010-11-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 Lrp4 / Corin dopaminergic neuron proliferative progenitor cell marker
EP1666590B1 (en) 2004-07-22 2015-11-04 Eisai R&D Management Co., Ltd. Lrp4/corin dopamine-producing neuron precursor cell marker
JP4926965B2 (en) 2005-08-18 2012-05-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 Dopaminergic neuron proliferative progenitor cell marker Nato3
EP2089512B1 (en) * 2006-11-01 2014-11-26 Rutgers, The State University of New Jersey Lithium stimulation of cord blood stem cell proliferation and growth factor production
EP2737057B1 (en) 2011-07-27 2018-10-24 Kyoto University Novel markers for dopaminergic neuron progenitor cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006757A1 (en) * 1988-12-15 1990-06-28 The Regents Of The University Of California Grafting genetically modified cells to treat diseases of the central nervous system
WO1994010292A1 (en) * 1992-10-28 1994-05-11 Neurospheres Ltd. Biological factors and neural stem cells
WO1996015224A1 (en) * 1994-11-14 1996-05-23 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
WO1997033470A1 (en) * 1996-03-12 1997-09-18 University Of South Florida Method and media for enhancing viability, maturation, and cryopreservation of cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175103A (en) * 1991-10-21 1992-12-29 Trustees Of University Of Pennsylvania Preparation of pure cultures of post-mitotic human neurons

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006757A1 (en) * 1988-12-15 1990-06-28 The Regents Of The University Of California Grafting genetically modified cells to treat diseases of the central nervous system
WO1994010292A1 (en) * 1992-10-28 1994-05-11 Neurospheres Ltd. Biological factors and neural stem cells
WO1996015224A1 (en) * 1994-11-14 1996-05-23 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
WO1997033470A1 (en) * 1996-03-12 1997-09-18 University Of South Florida Method and media for enhancing viability, maturation, and cryopreservation of cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LAYTONBIO: "Press releases number: 24, 26, 27, 28, 29, 30, 31(a) to (k)", HTTP://WWW.LAYTONBIO.COM/WHATSNEW.HTM, 9 March 1999 (1999-03-09), XP002199748 *
MENA MARIA ANGELES ET AL: "Effects of dibutyryl cyclic AMP and retinoic acid on the differentiation of dopamine neurons: Prevention of cell death by dibutyryl cyclic AMP.", JOURNAL OF NEUROCHEMISTRY, vol. 65, no. 6, 1995, pages 2612 - 2620, XP009001318, ISSN: 0022-3042 *
PLEASURE S J ET AL: "PURE, POSTMITOTIC, POLARIZED HUMAN NEURONS DERIVED FROM NTERA 2 CELLS PROVIDE A SYSTEM FOR EXPRESSING EXOGENOUS PROTEINS IN TERMINALLY DIFFERENTIATED NEURONS", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 12, no. 5, May 1992 (1992-05-01), pages 1802 - 1815, XP002915302, ISSN: 0270-6474 *
See also references of WO0006700A1 *
TERAO T ET AL: "LITHIUM CHLORIDE STIMULATES CATECHOLAMINE SYNTHESIS AND SECRETION IN CULTURED BOVINE ADRENAL MEDULLARY CELLS", BIOLOGICAL PSYCHIATRY, vol. 31, no. 10, 1992, pages 1038 - 1049, XP009001664, ISSN: 0006-3223 *

Also Published As

Publication number Publication date
EP1109887A1 (en) 2001-06-27
WO2000006700A1 (en) 2000-02-10

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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