RU95106651A - Analogs of des-tyr-dinorphine and method of treatment of patient with tolerant states - Google Patents

Analogs of des-tyr-dinorphine and method of treatment of patient with tolerant states

Info

Publication number
RU95106651A
RU95106651A RU95106651/14A RU95106651A RU95106651A RU 95106651 A RU95106651 A RU 95106651A RU 95106651/14 A RU95106651/14 A RU 95106651/14A RU 95106651 A RU95106651 A RU 95106651A RU 95106651 A RU95106651 A RU 95106651A
Authority
RU
Russia
Prior art keywords
tyr
des
dinorphine
analogs
patient
Prior art date
Application number
RU95106651/14A
Other languages
Russian (ru)
Inventor
М.Ли Нэнси
Us]
Х.Лох Хорак
Е.Такемори Акира
Original Assignee
Де-Тюр Дайнорфин Партнершип (US)
Де-Тюр Дайнорфин Партнершип
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Де-Тюр Дайнорфин Партнершип (US), Де-Тюр Дайнорфин Партнершип filed Critical Де-Тюр Дайнорфин Партнершип (US)
Publication of RU95106651A publication Critical patent/RU95106651A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

FIELD: medicine, peptides. SUBSTANCE: new peptides are analogs of dinorphine and show activity that is similar with that of endogenous dinorphine though they are des-Tyr- or des-Tyr-Gly-analogs of endogenous dinorphine. New peptides can be administrated to host exhibiting tolerance to narcotic analgetic to enhance narcotic analgetic action and/or block abstinence symptoms. EFFECT: enhanced effectiveness of method.

Claims (1)

Новые пептиды изобретения являются аналогами динорфина и характеризуются активностью, аналогичной активности эндогенного динорфина, хотя и являются дез-Тyr - или дез-Тyr -Gly- аналогами эндогенного динорфина. Новые пептиды находят применение в медицине, например, введением хозяину с толерантностью к наркотическому анальгетику с целью усиления действия наркотического анальгетика и/или блокирования симптомов абстиненции.The new peptides of the invention are analogs of dinorphin and are characterized by activity similar to the activity of endogenous dinorphin, although they are des-Tyr - or des-Tyr -Gly - analogues of endogenous dinorphin. New peptides are used in medicine, for example, by administering to a host with a tolerance to narcotic analgesics in order to enhance the effects of narcotic analgesics and / or block withdrawal symptoms.
RU95106651/14A 1992-06-12 1993-06-01 Analogs of des-tyr-dinorphine and method of treatment of patient with tolerant states RU95106651A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89792092A 1992-06-12 1992-06-12
US07/897,920 1992-06-12

Publications (1)

Publication Number Publication Date
RU95106651A true RU95106651A (en) 1996-12-27

Family

ID=25408662

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95106651/14A RU95106651A (en) 1992-06-12 1993-06-01 Analogs of des-tyr-dinorphine and method of treatment of patient with tolerant states

Country Status (11)

Country Link
EP (1) EP0652765A4 (en)
JP (1) JPH08501075A (en)
KR (1) KR950701818A (en)
AU (1) AU4399093A (en)
CA (1) CA2137916A1 (en)
CZ (1) CZ281630B6 (en)
FI (1) FI945811A (en)
HU (1) HUT70160A (en)
NO (1) NO944778L (en)
RU (1) RU95106651A (en)
WO (1) WO1993025217A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482930A (en) * 1993-06-09 1996-01-09 The Regents Of The University Of California Anti-inflammatory composition and method with des-Tyr dynorphin and analogues
ATE510542T1 (en) 1997-09-04 2011-06-15 Novoneuron Inc NORIBOGAIN USED TO TREAT PAIN AND DRUG DEPENDENCE
US7220737B1 (en) 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
US6437092B1 (en) 1998-11-06 2002-08-20 Conjuchem, Inc. Conjugates of opioids and endogenous carriers
US6887470B1 (en) 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
CA2623458A1 (en) 1999-05-17 2000-11-23 Conjuchem Biotechnologies Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
US6849714B1 (en) 1999-05-17 2005-02-01 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6706892B1 (en) 1999-09-07 2004-03-16 Conjuchem, Inc. Pulmonary delivery for bioconjugation
BR0206919A (en) 2001-02-02 2004-07-06 Conjuchem Inc Long-Term Growth Hormone Release Factor Derivatives
AU2002233089B2 (en) 2001-02-16 2005-12-22 Conjuchem Biotechnologies Inc. Long lasting glucagon-like peptide 2 (GLP-2) for the treatment of gastrointestinal diseases and disorders
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
RU2586296C2 (en) 2010-07-23 2016-06-10 Демеркс, Инк. Noribogaine compositions
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
EP2788003A4 (en) 2011-12-09 2015-05-27 Demerx Inc Phosphate esters of noribogaine
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
EP2807168A4 (en) 2012-01-25 2015-10-14 Demerx Inc Synthetic voacangine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
CA2896133A1 (en) 2012-12-20 2014-06-26 Demerx, Inc. Substituted noribogaine
US10428115B2 (en) 2013-05-24 2019-10-01 Arizona Board Of Regents On Behalf Of The University Of Arizona Dynorphin A analogs with bradykinin receptors specificity for modulation of neuropathic pain
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ52397A3 (en) * 1994-08-26 1997-07-16 Nancy M Lee Analgesic method by dynorphin analogs being modified at n-end

Also Published As

Publication number Publication date
JPH08501075A (en) 1996-02-06
FI945811A0 (en) 1994-12-09
CZ313194A3 (en) 1995-08-16
CA2137916A1 (en) 1993-12-23
HUT70160A (en) 1995-09-28
EP0652765A4 (en) 1997-04-09
AU4399093A (en) 1994-01-04
HU9403563D0 (en) 1995-02-28
NO944778D0 (en) 1994-12-09
EP0652765A1 (en) 1995-05-17
KR950701818A (en) 1995-05-17
NO944778L (en) 1995-02-10
CZ281630B6 (en) 1996-11-13
WO1993025217A1 (en) 1993-12-23
FI945811A (en) 1995-02-06

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