RU94046014A - Clavulanic acid salt, process for preparation thereof, process for preparation of clavulanic acid, process for purification thereof, and pharmaceutical composition comprising said salt - Google Patents

Clavulanic acid salt, process for preparation thereof, process for preparation of clavulanic acid, process for purification thereof, and pharmaceutical composition comprising said salt

Info

Publication number
RU94046014A
RU94046014A RU94046014/04A RU94046014A RU94046014A RU 94046014 A RU94046014 A RU 94046014A RU 94046014/04 A RU94046014/04 A RU 94046014/04A RU 94046014 A RU94046014 A RU 94046014A RU 94046014 A RU94046014 A RU 94046014A
Authority
RU
Russia
Prior art keywords
clavulanic acid
preparation
salt
purification
pharmaceutical composition
Prior art date
Application number
RU94046014/04A
Other languages
Russian (ru)
Other versions
RU2135502C1 (en
Inventor
Гейсберт Вебер Питер
Nl]
Original Assignee
Гист-Брокейдс Н.В. (NL)
Гист-Брокейдс Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гист-Брокейдс Н.В. (NL), Гист-Брокейдс Н.В. filed Critical Гист-Брокейдс Н.В. (NL)
Priority claimed from PCT/EP1994/000919 external-priority patent/WO1994022873A1/en
Publication of RU94046014A publication Critical patent/RU94046014A/en
Application granted granted Critical
Publication of RU2135502C1 publication Critical patent/RU2135502C1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/10—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D503/12—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 unsubstituted in position 6
    • C07D503/14—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 unsubstituted in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, other than a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, attached in position 3
    • C07D503/16—Radicals substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical
    • C07D503/18—Radicals substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical by oxygen atoms

Abstract

FIELD: pharmaceutical composition. SUBSTANCE: claimed invention describes novel diamine salts pharmaceutical compositions comprising said salts and process for PREPARATION of clavulanic acid and salts and esters thereof by conversion of mono- or diamine salt of clavulanic acid. The claimed invention also describes process for purification of clavulanic acid. EFFECT: improved properties of the pharmaceutical composition and more efficient preparation and purification process.

Claims (1)

Предложены новые диаминовые соли, содержащие их фармацевтические композиции и способ получения клавулановой кислоты и ее солей и сложных эфиров путем соответствующего превращения моно- или диаминовой соли клавулановой кислоты. Предложен также способ очистки клавулановой кислоты.New diamine salts containing pharmaceutical compositions and a method for producing clavulanic acid and its salts and esters by the corresponding conversion of the mono- or diamine salt of clavulanic acid are proposed. A method for purifying clavulanic acid is also provided.
RU94046014A 1993-03-26 1994-03-22 Clavulanic acid diamine salts, method of their synthesis (variants), method of synthesis of clavulanic acid or its pharmaceutically acceptable salt, method of purification of clavulanic acid of its salt RU2135502C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP93200872 1993-03-26
EP93200872.5 1993-03-26
PCT/EP1994/000919 WO1994022873A1 (en) 1993-03-26 1994-03-22 Diamine salts of clavulanic acid

Publications (2)

Publication Number Publication Date
RU94046014A true RU94046014A (en) 1996-10-10
RU2135502C1 RU2135502C1 (en) 1999-08-27

Family

ID=8213723

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046014A RU2135502C1 (en) 1993-03-26 1994-03-22 Clavulanic acid diamine salts, method of their synthesis (variants), method of synthesis of clavulanic acid or its pharmaceutically acceptable salt, method of purification of clavulanic acid of its salt

Country Status (8)

Country Link
JP (1) JP2839955B2 (en)
KR (1) KR100187333B1 (en)
BG (1) BG61948B1 (en)
BR (1) BR9404743A (en)
GR (2) GR950300030T1 (en)
LV (1) LV11180B (en)
RU (1) RU2135502C1 (en)
SI (1) SI0647229T1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
AT399155B (en) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih NEW ALKYLENE DIAMMONIUM DICLAVULANATE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF

Also Published As

Publication number Publication date
BG61948B1 (en) 1998-10-30
BG99212A (en) 1995-12-29
LV11180B (en) 1996-08-20
KR950701635A (en) 1995-04-28
RU2135502C1 (en) 1999-08-27
KR100187333B1 (en) 1999-05-01
GR950300030T1 (en) 1995-06-30
BR9404743A (en) 1999-09-28
GR3021347T3 (en) 1997-01-31
LV11180A (en) 1996-04-20
JP2839955B2 (en) 1998-12-24
SI0647229T1 (en) 1997-10-31
JPH07507573A (en) 1995-08-24

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