RU94045824A - Method for production of 3-carbonylandrostadiene-17-carboxamides - Google Patents

Method for production of 3-carbonylandrostadiene-17-carboxamides

Info

Publication number
RU94045824A
RU94045824A RU94045824/04A RU94045824A RU94045824A RU 94045824 A RU94045824 A RU 94045824A RU 94045824/04 A RU94045824/04 A RU 94045824/04A RU 94045824 A RU94045824 A RU 94045824A RU 94045824 A RU94045824 A RU 94045824A
Authority
RU
Russia
Prior art keywords
carbonylandrostadiene
carboxamides
production
diene
steroide
Prior art date
Application number
RU94045824/04A
Other languages
Russian (ru)
Inventor
Ховард Бейн Нейл
Us]
Фелл Оуингс Франклин
Original Assignee
Смитклайн Бичам Корпорейшн (US)
Смитклайн Бичам Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Корпорейшн (US), Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Корпорейшн (US)
Publication of RU94045824A publication Critical patent/RU94045824A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Abstract

FIELD: organic chemistry. SUBSTANCE: method involves conversion of substituted steroide 3-halogen-3,5-diene compounds into steroide 3,5-diene-3-carboxylic acids and novel intermediate products of synthesis. EFFECT: improves efficiency of the method.

Claims (1)

Изобретение относится к улучшенному способу превращения замещенных стероидных 3-галоген-3,5-диеновых соединений в размещенные стероидные 3,5-диен-З-карбоновые кислоты и новые полупродукты синтеза.The invention relates to an improved method for converting substituted steroidal 3-halogen-3,5-diene compounds into placed steroidal 3,5-diene-3-carboxylic acids and new synthesis intermediates.
RU94045824/04A 1992-02-07 1993-02-05 Method for production of 3-carbonylandrostadiene-17-carboxamides RU94045824A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83228092A 1992-02-07 1992-02-07
US071832.280 1992-02-07

Publications (1)

Publication Number Publication Date
RU94045824A true RU94045824A (en) 1996-07-10

Family

ID=25261209

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94045824/04A RU94045824A (en) 1992-02-07 1993-02-05 Method for production of 3-carbonylandrostadiene-17-carboxamides

Country Status (23)

Country Link
EP (1) EP0643724A4 (en)
JP (1) JPH07505140A (en)
KR (1) KR950700319A (en)
CN (1) CN1078475A (en)
AP (1) AP9600790A0 (en)
AU (1) AU666177B2 (en)
BG (1) BG98955A (en)
BR (1) BR9305837A (en)
CA (1) CA2129342A1 (en)
CZ (1) CZ188794A3 (en)
FI (1) FI943660A (en)
HU (1) HUT68303A (en)
IL (1) IL104602A (en)
MA (1) MA22788A1 (en)
MX (1) MX9300676A (en)
NO (1) NO942925L (en)
NZ (1) NZ249382A (en)
OA (1) OA10090A (en)
RU (1) RU94045824A (en)
SI (1) SI9300065A (en)
TW (1) TW327175B (en)
WO (1) WO1993016097A1 (en)
ZA (1) ZA93801B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9206413D0 (en) * 1992-03-24 1992-05-06 Smithkline Beecham Corp N-t-butyl-androst-3,5-diene-17b-carboxamide-3-carboxylic acid polymorph a
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA883034B (en) * 1987-04-29 1989-03-29 Smithkline Beckman Corp Steroid 5-alpha-reductase inhibitors
IL104601A0 (en) * 1992-02-07 1993-07-08 Smithkline Beecham Corp Process for the preparation of steroidal dienes

Also Published As

Publication number Publication date
TW327175B (en) 1998-02-21
SI9300065A (en) 1993-09-30
MA22788A1 (en) 1993-10-01
EP0643724A1 (en) 1995-03-22
EP0643724A4 (en) 1995-05-10
NO942925L (en) 1994-08-08
BR9305837A (en) 1997-02-18
AU3612693A (en) 1993-09-03
HU9402303D0 (en) 1994-10-28
OA10090A (en) 1996-12-18
CA2129342A1 (en) 1993-08-19
KR950700319A (en) 1995-01-16
IL104602A0 (en) 1993-07-08
CN1078475A (en) 1993-11-17
HUT68303A (en) 1995-06-28
FI943660A0 (en) 1994-08-05
CZ188794A3 (en) 1994-12-15
AP9600790A0 (en) 1996-04-30
IL104602A (en) 1997-07-13
FI943660A (en) 1994-08-05
BG98955A (en) 1995-06-30
NZ249382A (en) 1996-05-28
ZA93801B (en) 1993-11-05
AU666177B2 (en) 1996-02-01
JPH07505140A (en) 1995-06-08
MX9300676A (en) 1994-07-29
NO942925D0 (en) 1994-08-05
WO1993016097A1 (en) 1993-08-19

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