RU94037136A - Imidazole-containing inhibitors of cathepsin-g-induced platelet aggregation
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Imidazole-containing inhibitors of cathepsin-g-induced platelet aggregation
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RU94037136A
RU94037136ARU94037136/14ARU94037136ARU94037136ARU 94037136 ARU94037136 ARU 94037136ARU 94037136/14 ARU94037136/14 ARU 94037136/14ARU 94037136 ARU94037136 ARU 94037136ARU 94037136 ARU94037136 ARU 94037136A
Московская государственная академия тонкой химической технологии им.М.В.Ломоносова
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FIELD: organic chemistry. SUBSTANCE: invention relates to blood biochemistry, in part, to low-molecular synthetic inhibitors of thrombosis. Product: imidazole-containing compounds of the general formula- histidine methyl ester dihydrochloride and lauroylhistamine as inhibitors of cathepsin-G-induced platelet aggregation. Proposed inhibitors can be used as reagents for hemostasis control and as pharmacological agents for thrombosis prevention, especially, at infectious and inflammatory diseases. EFFECT: enhanced effectiveness of inhibitors proposed.
Claims (1)
Изобретение относится к области биохимии крови, а именно к низкомолекулярным синтетическим ингибиторам тромбообразования. Сущность изобретения: имидазолсодержащие соединения общей формулы, приведенной в описании, а именно метиловый эфир гистидина дихлоргидрат и лауроилгистамин как ингибиторы катепсин-G-индуцированной агрегации тромбоцитов. Предлагаемые ингибиторы могут найти применение в качестве реагентов для контроля гемостаза, а также фармакологических средств для предотвращения тромбообразования, особенно при инфекционных и воспалительных заболеваниях.The invention relates to the field of blood biochemistry, namely to low molecular weight synthetic thrombus inhibitors. The inventive imidazole-containing compounds of the General formula given in the description, namely the methyl ester of histidine dichlorohydrate and lauroylhistamine as inhibitors of cathepsin-G-induced platelet aggregation. The proposed inhibitors can be used as reagents for controlling hemostasis, as well as pharmacological agents for preventing thrombosis, especially in infectious and inflammatory diseases.
RU94037136/14A1994-09-301994-09-30Imidazole-containing inhibitors of cathepsin g-induced platelet aggregation
RU2097033C1
(en)