EA200000204A1 - Pyrrolopyrlonone derivatives as ELASTASIS INHIBITORS NEUTROPHILS - Google Patents

Pyrrolopyrlonone derivatives as ELASTASIS INHIBITORS NEUTROPHILS

Info

Publication number
EA200000204A1
EA200000204A1 EA200000204A EA200000204A EA200000204A1 EA 200000204 A1 EA200000204 A1 EA 200000204A1 EA 200000204 A EA200000204 A EA 200000204A EA 200000204 A EA200000204 A EA 200000204A EA 200000204 A1 EA200000204 A1 EA 200000204A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolopyrlonone
elastasis
neutrophils
inhibitors
derivatives
Prior art date
Application number
EA200000204A
Other languages
Russian (ru)
Inventor
Джеффри Дюк Эдуард Кларк
Майкл Деннис Даул
Гарри Финч
Ли Эндрю Харрисон
Грэм Джордж Адам Инглис
Мартин Редпат Джонсон
Саймон Джон Фосетт Макдоналд
Прайтом Ша
Робин Эндрю Смит
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en
Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en
Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en
Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200000204A1 publication Critical patent/EA200000204A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Согласно настоящему изобретению предложены соединения формулы (I), где R, Rи Rявляются такими, как определено в описании. Соединения формулы (I) полезны, в частности, при лечении воспалительных расстройств дыхательных путей.Отчет о международном поиске был опубликован 1999.05.27.According to the present invention, compounds of formula (I) are provided, wherein R, R and R are as defined in the description. The compounds of formula (I) are useful, in particular, in the treatment of inflammatory disorders of the respiratory tract. The international search report was published 1999.05.27.

EA200000204A 1997-09-09 1998-09-07 Pyrrolopyrlonone derivatives as ELASTASIS INHIBITORS NEUTROPHILS EA200000204A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9719189.4A GB9719189D0 (en) 1997-09-09 1997-09-09 New therapeutic method
GBGB9719183.7A GB9719183D0 (en) 1997-09-09 1997-09-09 Compounds
GBGB9719290.0A GB9719290D0 (en) 1997-09-10 1997-09-10 Compounds
GBGB9803611.4A GB9803611D0 (en) 1998-02-21 1998-02-21 Compounds
PCT/EP1998/005609 WO1999012933A2 (en) 1997-09-09 1998-09-07 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (1)

Publication Number Publication Date
EA200000204A1 true EA200000204A1 (en) 2000-10-30

Family

ID=27451698

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000204A EA200000204A1 (en) 1997-09-09 1998-09-07 Pyrrolopyrlonone derivatives as ELASTASIS INHIBITORS NEUTROPHILS

Country Status (24)

Country Link
EP (1) EP1003748A2 (en)
JP (1) JP2001515904A (en)
KR (1) KR20010023766A (en)
CN (1) CN1278820A (en)
AP (1) AP2000001761A0 (en)
AR (1) AR017072A1 (en)
AU (1) AU9741298A (en)
BR (1) BR9812062A (en)
CA (1) CA2303176A1 (en)
CO (1) CO4970719A1 (en)
EA (1) EA200000204A1 (en)
EE (1) EE200000138A (en)
HU (1) HUP0004644A3 (en)
ID (1) ID24452A (en)
IL (1) IL134791A0 (en)
IS (1) IS5391A (en)
MA (1) MA26543A1 (en)
NO (1) NO20001198L (en)
NZ (1) NZ503130A (en)
PE (1) PE107899A1 (en)
PL (1) PL339176A1 (en)
SK (1) SK3192000A3 (en)
TR (1) TR200000907T2 (en)
WO (1) WO1999012933A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
US7429659B2 (en) 2004-03-31 2008-09-30 Janssen Pharmaceutica N.V. Furan compounds as histamine H3 modulators
DE102004024772A1 (en) * 2004-05-17 2005-12-22 Grünenthal GmbH Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides
JP4853759B2 (en) * 2004-05-27 2012-01-11 日本農薬株式会社 Substituted pyrazinecarboxylic acid anilide derivatives or salts thereof, intermediates thereof, agricultural and horticultural agents, and methods of use thereof
TWI355380B (en) 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
ATE439347T1 (en) 2004-11-23 2009-08-15 Warner Lambert Co 7-(2H-PYRAZOLE-3-YL)-3,5-DIHYDROXY-HEPTANIC ACID DERIVATIVES AS HMG-CO-A-REDUCTASE INHIBITORS FOR THE TREATMENT OF LIPIDEMIA
US8198288B2 (en) 2006-05-04 2012-06-12 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use in therapy
WO2007129060A1 (en) 2006-05-04 2007-11-15 Argenta Discovery Limited Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
US7662967B2 (en) 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
GB2452696B (en) 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
WO2009060206A1 (en) * 2007-11-07 2009-05-14 Argenta Discovery Limited 3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) * 2010-02-26 2011-09-01 The University Of Hong Kong Compositions and methods for treating chronic respiratory inflammation
JP2023500182A (en) 2019-09-17 2023-01-05 メレオ バイオファーマ ４ リミテッド Alberestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome, and graft-versus-host disease
DK4106757T3 (en) 2020-04-16 2023-10-23 Mereo Biopharma 4 Ltd METHODS INVOLVING THE NEUTROPHIL ELASTASE INHIBITOR ALVELESTAT FOR THE TREATMENT OF AIRWAY DISEASE MEDIATED BY ALPHA-1-ANTITRYPSIN DEFICIENCY
CA3234399A1 (en) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
PL329153A1 (en) * 1996-03-28 1999-03-15 Glaxo Group Ltd Derivatives of pyrrolopyrolone as inhibitors of neutropil elastase

Also Published As

Publication number Publication date
WO1999012933A2 (en) 1999-03-18
KR20010023766A (en) 2001-03-26
AU9741298A (en) 1999-03-29
HUP0004644A3 (en) 2002-01-28
MA26543A1 (en) 2004-12-20
AP2000001761A0 (en) 2000-03-31
NO20001198D0 (en) 2000-03-08
BR9812062A (en) 2000-09-26
HUP0004644A2 (en) 2001-09-28
PE107899A1 (en) 1999-11-17
CO4970719A1 (en) 2000-11-07
ID24452A (en) 2000-07-20
AR017072A1 (en) 2001-08-22
JP2001515904A (en) 2001-09-25
CA2303176A1 (en) 1999-03-18
CN1278820A (en) 2001-01-03
NZ503130A (en) 2001-08-31
NO20001198L (en) 2000-05-08
SK3192000A3 (en) 2001-03-12
WO1999012933A3 (en) 1999-05-27
IL134791A0 (en) 2001-04-30
TR200000907T2 (en) 2000-11-21
PL339176A1 (en) 2000-12-04
EP1003748A2 (en) 2000-05-31
IS5391A (en) 2000-02-29
EE200000138A (en) 2001-02-15

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