RU94030750A - Method of preparing mixed medicinal form of penicillin order antibiotics - Google Patents

Method of preparing mixed medicinal form of penicillin order antibiotics

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Publication number
RU94030750A
RU94030750A RU94030750/14A RU94030750A RU94030750A RU 94030750 A RU94030750 A RU 94030750A RU 94030750/14 A RU94030750/14 A RU 94030750/14A RU 94030750 A RU94030750 A RU 94030750A RU 94030750 A RU94030750 A RU 94030750A
Authority
RU
Russia
Prior art keywords
solution
temperature
antibiotics
sodium salt
hours
Prior art date
Application number
RU94030750/14A
Other languages
Russian (ru)
Other versions
RU2082401C1 (en
Inventor
В.Я. Шарков
А.Е. Полстянов
Т.И. Скоблик
Т.И. Юдина
Т.И. Павлова
Д.Ф. Филорикьян
Л.К. Граковская
И.А. Павлова
Original Assignee
Фармацевтическое акционерное общество "Ферейн"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармацевтическое акционерное общество "Ферейн" filed Critical Фармацевтическое акционерное общество "Ферейн"
Priority to RU94030750/14A priority Critical patent/RU2082401C1/en
Publication of RU94030750A publication Critical patent/RU94030750A/en
Application granted granted Critical
Publication of RU2082401C1 publication Critical patent/RU2082401C1/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

FIELD: chemical-pharmaceutical industry. SUBSTANCE: method involves preparing ampicillin sodium salt solution by interaction of ampicillin trihydrate with alkaline component, dissolving sulbactam sodium salt in it at ratio 2:1 followed by sterilizing filtration and sublimation drying preparation solution in bottles. It is necessary the quick freezing solution to (-50)-(-40) C for 0.5-3.0 hr, keeping at this temperature for at least 2 hr. Sublimation drying frozen solution is carried out for 1 hr without heating, then plates were heated to product temperature 25-30 C and keeping at this temperature for 2-6 hr. EFFECT: enhanced quality of preparation, good solubility.

Claims (1)

Изобретение относится к химико-фармацевтической промышленности, а именно к способу получения комбинированной лекарственной формы антибиотиков пенициллинового ряда. Способ заключается в получении раствора ампициллина натриевой соли путем взаимодействия ампициллина тригидрата с щелочным агентом, растворением в нем сульбактама натриевой соли в соотношении 2:1 и последующим проведением стерилизующей фильтрации и сублимационной сушки раствора препарата во флаконах. С целью исключения расслаивания, вспенивания продукта и образования пленки на поверхности "таблетки" установлена необходимость быстрого замораживания раствора до температуры (-50) - (-40)°С в течение 0,5-3,0 ч, выдержки при этой температуре не менее 2 ч, проведения сублимационной сушки замороженного раствора изначально не менее 1 ч без подогрева, проведения нагрева плит до достижения температуры продукта 25-30oС, выдержки его при этой температуре в течение 2-6 ч. Предложенный способ получения комбинированной лекарственной формы антибиотиков пенициллинового ряда и разработанный режим сушки обеспечивают получение препарата без сплава, с хорошей растворимостью, отвечающего всем требованиям нормативно-технической документации.The invention relates to the pharmaceutical industry, and in particular to a method for producing a combined dosage form of penicillin antibiotics. The method consists in obtaining a solution of ampicillin sodium salt by reacting ampicillin trihydrate with an alkaline agent, dissolving sulbactam sodium salt in it in a ratio of 2: 1 and then sterilizing filtration and freeze-drying the solution of the drug in vials. In order to prevent delamination, foaming of the product and the formation of a film on the surface of the "tablet", the need for quick freezing of the solution to a temperature of (-50) - (-40) ° C for 0.5-3.0 hours, holding at this temperature for at least 2 hours of freeze drying the frozen solution is initially at least 1 h without heating, the heating of the plates to achieve 25-30 o C. product temperature, soaking it at this temperature for 2-6 hours. The proposed method of preparing a combined dosage form of antibiotics penits llinovogo series and developed provide a drying mode without the alloy preparation, with good solubility, would meet all regulatory requirements and technical documentation.
RU94030750/14A 1994-08-18 1994-08-18 Method of preparing the combined preparation medicinal form RU2082401C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU94030750/14A RU2082401C1 (en) 1994-08-18 1994-08-18 Method of preparing the combined preparation medicinal form

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU94030750/14A RU2082401C1 (en) 1994-08-18 1994-08-18 Method of preparing the combined preparation medicinal form

Publications (2)

Publication Number Publication Date
RU94030750A true RU94030750A (en) 1996-09-27
RU2082401C1 RU2082401C1 (en) 1997-06-27

Family

ID=20159835

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94030750/14A RU2082401C1 (en) 1994-08-18 1994-08-18 Method of preparing the combined preparation medicinal form

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RU (1) RU2082401C1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4836797B2 (en) 2003-10-23 2011-12-14 大塚製薬株式会社 Controlled release sterile injection aripiprazole formulations and methods
AR067747A1 (en) 2007-07-31 2009-10-21 Otsuka Pharma Co Ltd METHODS TO PRODUCE SUSPENSION OF ARIPIPRAZOL AND LIOFILIZED FORMULATION

Also Published As

Publication number Publication date
RU2082401C1 (en) 1997-06-27

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Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20040819