RU94021658A - MONO AND BIS-ALKYLAMINE-ANTHRACYCLINES, METHOD OF OBTAINING, PHARMACEUTICAL COMPOSITION - Google Patents

MONO AND BIS-ALKYLAMINE-ANTHRACYCLINES, METHOD OF OBTAINING, PHARMACEUTICAL COMPOSITION

Info

Publication number
RU94021658A
RU94021658A RU94021658/04A RU94021658A RU94021658A RU 94021658 A RU94021658 A RU 94021658A RU 94021658/04 A RU94021658/04 A RU 94021658/04A RU 94021658 A RU94021658 A RU 94021658A RU 94021658 A RU94021658 A RU 94021658A
Authority
RU
Russia
Prior art keywords
group
hydrogen
formula
pharmaceutical composition
anthracyclines
Prior art date
Application number
RU94021658/04A
Other languages
Russian (ru)
Other versions
RU2118328C1 (en
Inventor
Барджотти Альберто
Карузо Микеле
Файарди Даниэла
Суарато Антонино
Монджелли Никола
Original Assignee
Фармиталиа Карло Эрба С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919114549A external-priority patent/GB9114549D0/en
Application filed by Фармиталиа Карло Эрба С.Р.Л. filed Critical Фармиталиа Карло Эрба С.Р.Л.
Publication of RU94021658A publication Critical patent/RU94021658A/en
Application granted granted Critical
Publication of RU2118328C1 publication Critical patent/RU2118328C1/en

Links

Claims (1)

Антрациклиновый гликозид общей формулы (I), в которой R1 водород или метоксигруппа, R2 - водород или гидроксигруппа, А и В представляют собой водород или один из А или В - водород, а другой является гидроксигруппой или группой формулы OSO2R5, в которой R5 - С1 - С4 алкил или арил, произвольно замещенный С1 - С4 алкилом, нитро, амино, метокси или галоидом; R3 - атом водорода или группа формулы (2); R4 - группа формулы (2): - (СН2) n - X, где n равно 2 или 3, X является гидроксигруппой, галоидом или группой формулы - OSO2R5, в которой R5 такой, как определено выше, и при условии, что если R2, X и А являются гидроксигруппой и R3 = H, то n должно быть 3; или его фармацевтически пригодная соль. Соединения проявляют противоопухолевую активность. Раскрываются способы их получения и фармацевтическая композиция, содержащая их.An anthracycline glycoside of general formula (I), in which R 1 is hydrogen or methoxy, R 2 is hydrogen or hydroxy, A and B are hydrogen or one of A or B is hydrogen and the other is hydroxy group or group of the formula OSO 2 R 5 , in which R 5 - C 1 - C 4 alkyl or aryl, optionally substituted with C 1 - C 4 alkyl, nitro, amino, methoxy or halogen; R 3 is a hydrogen atom or a group of the formula (2); R 4 is a group of formula (2): - (CH 2 ) n - X, where n is 2 or 3, X is a hydroxy group, halogen or group of the formula - OSO 2 R 5 , in which R 5 is as defined above, and provided that if R 2 , X and A are a hydroxy group and R 3 = H, then n must be 3; or a pharmaceutically acceptable salt thereof. Compounds exhibit antitumor activity. Disclosed are methods for their preparation and a pharmaceutical composition containing them.
RU94021658A 1991-07-05 1992-07-03 Anthracycline glycoside, method of its synthesis, pharmaceutical composition RU2118328C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB91145490 1991-07-05
GB9114549.0 1991-07-05
GB919114549A GB9114549D0 (en) 1991-07-05 1991-07-05 Mono and bis alkylamino-anthracyclines

Publications (2)

Publication Number Publication Date
RU94021658A true RU94021658A (en) 1995-09-10
RU2118328C1 RU2118328C1 (en) 1998-08-27

Family

ID=10697877

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94021658A RU2118328C1 (en) 1991-07-05 1992-07-03 Anthracycline glycoside, method of its synthesis, pharmaceutical composition

Country Status (24)

Country Link
US (1) US5496808A (en)
EP (1) EP0521458B1 (en)
JP (1) JP3153552B2 (en)
KR (1) KR100235365B1 (en)
CN (1) CN1031878C (en)
AT (1) ATE134376T1 (en)
AU (1) AU661012B2 (en)
CA (1) CA2112818C (en)
CZ (1) CZ2494A3 (en)
DE (1) DE69208400T2 (en)
FI (1) FI106204B (en)
GB (1) GB9114549D0 (en)
GR (1) GR3019429T3 (en)
HK (1) HK1006460A1 (en)
HU (1) HU218913B (en)
IE (1) IE76921B1 (en)
IL (1) IL102409A (en)
MX (1) MX9203928A (en)
NO (1) NO300099B1 (en)
NZ (1) NZ243450A (en)
RU (1) RU2118328C1 (en)
TW (1) TW201753B (en)
WO (1) WO1993001201A1 (en)
ZA (1) ZA924971B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9325420D0 (en) * 1993-12-13 1994-02-16 Erba Carlo Spa 4'-o-sulfonyl-anthracycline derivatives
EP0781140A4 (en) * 1994-09-12 1999-11-03 Univ Pennsylvania Corticotropin release inhibiting factor and methods of using same
DE69601451T2 (en) * 1995-10-16 1999-06-10 Kyowa Hakko Kogyo Kk UCK14 connections
DE19548474A1 (en) * 1995-12-22 1997-06-26 Wacker Chemie Gmbh Organopolysiloxanes containing aliphatic unsaturated radicals, their preparation and their use in crosslinkable compositions
GB9613433D0 (en) * 1996-06-26 1996-08-28 Pharmacia Spa Fluoro labelled anthracyclinone and anthracycline derivatives
AU6150498A (en) * 1997-02-07 1998-08-26 Wistar Institute, The Methods and compositions for the inhibition of interleukin-12 production
GB9806324D0 (en) * 1998-03-24 1998-05-20 Pharmacia & Upjohn Spa Antitumour synergetic composition
GB9904387D0 (en) * 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
GB9904386D0 (en) * 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU570439B2 (en) * 1983-03-28 1988-03-17 Compression Labs, Inc. A combined intraframe and interframe transform coding system
US4591637A (en) * 1985-01-17 1986-05-27 Sri International Open chain-morpholino adriamycins
FR2591599B1 (en) * 1985-12-17 1988-08-05 Hoechst Lab NEW ANTHRACYCLINES AND MEDICINES CONTAINING THEM
DE3842836A1 (en) * 1988-12-20 1990-06-21 Behringwerke Ag RHODOMYCINE WITH A MODIFIED CARBOHYDRATE UNIT

Similar Documents

Publication Publication Date Title
DK165004C (en) SULPHAMATE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE
RU94036004A (en) Intermediate compounds for preparing aromatic aminoalcoholic derivatives
CA2090967A1 (en) Water soluble camptothecin analogues, processes and methods
RU93043106A (en) METHOD FOR OBTAINING TAXAN DERIVATIVES, TAXAN DERIVATIVES, PHARMACEUTICAL COMPOSITION ON THEIR BASIS, TREATMENT METHOD, OXASOLIDINE DERIVATIVES AND METHOD OF OBTAINING OXIALIDINE DERIVATIVES
DE3564566D1 (en) Quinone derivatives, method and use of preparing same, and pharmaceutical composition
RU94016161A (en) METHOD OF OBTAINING DERIVATIVES III OR 10-DEZACETHILBACACATINE III AND THEIR APPLICATION
RU94021658A (en) MONO AND BIS-ALKYLAMINE-ANTHRACYCLINES, METHOD OF OBTAINING, PHARMACEUTICAL COMPOSITION
ES8802014A1 (en) Aminohydroxyalkylbenzene anti-obesity and/or anti-hyperglycaemic agents.
ATE10368T1 (en) URACIL DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM.
UA27108A1 (en) Anthracycline glycosides and their pharmaceutically acceptable acid-additive salts, method of their synthesis, diiodointermediate compound and method of its synthesis
ES8706139A1 (en) Coumarin derivatives, pharmaceutical compositions containing the same, and the use thereof in the treatment of cancer.
RU94013440A (en) DERIVATIVES 3-DEZOXYOLYSACCHARIDES, METHODS OF THEIR RECEIVING AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS
ATE41772T1 (en) POLYMETHOXYBENZYL PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES.
AU611113B2 (en) Basically substituted phenylacetonitriles, their preparation and drugs containing these compounds
CA2112818A1 (en) Mono and bis alkylamino-anthracyclines
RU94011565A (en) THIOXANTENONE COMPOUNDS, THEIR USE, ANTI-SMALL COMPOSITION
CA2028465A1 (en) Novel anthracycline glycoside derivatives and preparing method thereof
ATE63921T1 (en) 6-AMINO-ANTHRACYCLINES, PROCESSES FOR THEIR PREPARATION AND USE.
DE3064485D1 (en) Anthracycline glycosides, process for their preparation and therapeutical composition containing them
ES2098338T3 (en) HETEROARILMETILBENCENOS.
FR2358408A1 (en) NEW CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
RU92016209A (en) Benzofuranylimidazole derivatives, method for their production and therapeutic compositions containing derivatives
RU93005329A (en) DERIVATIVES 5,6,7,9-TETRAHYDRO-1,2,3-TRIMETOXY-9-OXOBENZO [α] HEPTALENE, METHODS OF THEIR RECEIVING, PHARMOCOMPOSITION, DRUG TREATMENT, METHOD OF TREATMENT
ES546646A0 (en) A PROCEDURE FOR PREPARING AN ARFAMENIN RELATED COMPOUND
RU93004977A (en) ANTHRACYCLINGGLYCOSIDES, METHOD FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITION