RU94016161A - METHOD OF OBTAINING DERIVATIVES III OR 10-DEZACETHILBACACATINE III AND THEIR APPLICATION - Google Patents

METHOD OF OBTAINING DERIVATIVES III OR 10-DEZACETHILBACACATINE III AND THEIR APPLICATION

Info

Publication number
RU94016161A
RU94016161A RU94016161/04A RU94016161A RU94016161A RU 94016161 A RU94016161 A RU 94016161A RU 94016161/04 A RU94016161/04 A RU 94016161/04A RU 94016161 A RU94016161 A RU 94016161A RU 94016161 A RU94016161 A RU 94016161A
Authority
RU
Russia
Prior art keywords
iii
dezacethilbacacatine
application
obtaining derivatives
general formula
Prior art date
Application number
RU94016161/04A
Other languages
Russian (ru)
Other versions
RU2088578C1 (en
Inventor
Иттенжер Огюстен
Original Assignee
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9108673A external-priority patent/FR2678930B1/en
Application filed by Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А.
Publication of RU94016161A publication Critical patent/RU94016161A/en
Application granted granted Critical
Publication of RU2088578C1 publication Critical patent/RU2088578C1/en

Links

Claims (1)

Изобретение относится к способу получения производного таксана общей формулы (I) и к применению полученного продукта для получения производных таксана общей формулы (II). В общей формуле (I) R1 является ацетилом или защищающей группировкой, G1 является защищающей группировкой и R является трет.-бутоксирадикалом или фенилом. В общей формуле (П) R является трет.-бутокси-радикалом или фенилом и R'1 является атомом водорода или ацетилом.The invention relates to a method for producing a taxane derivative of general formula (I) and to the use of the obtained product for the preparation of taxane derivatives of general formula (II). In the general formula (I), R 1 is acetyl or a protecting group, G 1 is a protecting group, and R is a tert-butoxy radical or phenyl. In the general formula (P), R is a tert-butoxy radical or phenyl and R ′ 1 is a hydrogen atom or acetyl.
RU9294016161A 1991-07-10 1992-07-08 Method of synthesis of derivatives of baccatin-iii or 10-desacetyl-baccatin-iii and a method of taxane derivatives synthesis RU2088578C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9108673 1991-07-10
FR9108673A FR2678930B1 (en) 1991-07-10 1991-07-10 PROCESS FOR THE PREPARATION OF DERIVATIVES OF BACCATIN III AND DESACETYL-10 BACCATIN III.
PCT/FR1992/000649 WO1993001179A1 (en) 1991-07-10 1992-07-08 Process for the preparation of baccatin iii and 10-deacetyl baccatin iii derivatives

Publications (2)

Publication Number Publication Date
RU94016161A true RU94016161A (en) 1995-09-10
RU2088578C1 RU2088578C1 (en) 1997-08-27

Family

ID=9414931

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9294016161A RU2088578C1 (en) 1991-07-10 1992-07-08 Method of synthesis of derivatives of baccatin-iii or 10-desacetyl-baccatin-iii and a method of taxane derivatives synthesis

Country Status (25)

Country Link
US (1) US5578739A (en)
EP (2) EP0593641B1 (en)
JP (1) JP3085710B2 (en)
KR (1) KR100206458B1 (en)
AT (1) ATE132145T1 (en)
AU (1) AU662346B2 (en)
CA (1) CA2111319C (en)
CZ (1) CZ281288B6 (en)
DE (1) DE69207194T2 (en)
DK (1) DK0593641T3 (en)
ES (1) ES2081120T3 (en)
FI (1) FI109792B (en)
FR (1) FR2678930B1 (en)
GR (1) GR3018543T3 (en)
HU (1) HU217115B (en)
IE (1) IE73637B1 (en)
MX (1) MX9204029A (en)
NO (2) NO934485D0 (en)
NZ (1) NZ243491A (en)
PL (1) PL169780B1 (en)
RU (1) RU2088578C1 (en)
SK (1) SK281560B6 (en)
WO (1) WO1993001179A1 (en)
YU (1) YU49175B (en)
ZA (1) ZA925098B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
CA2111527C (en) * 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
FR2703049B1 (en) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Method for the purification of taxoids.
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
FR2718135B1 (en) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Process for the preparation of hydroxy-7 taxanes.
US5580899A (en) 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives
US6051600A (en) * 1995-09-12 2000-04-18 Mayhew; Eric Liposomal hydrolysis-promoting hydrophobic taxane derivatives
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
FR2740451B1 (en) * 1995-10-27 1998-01-16 Seripharm NOVEL INTERMEDIATES FOR THE HEMISYNTHESIS OF TAXANES, THEIR PREPARATION METHODS AND THEIR USE IN THE GENERAL SYNTHESIS OF TAXANES
FR2742751B1 (en) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa NOVEL TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
DE69812395T2 (en) 1997-08-21 2004-02-05 Florida State University, Tallahassee METHOD FOR THE SYNTHESIS OF TAXANS
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
ATE219070T1 (en) * 1998-01-14 2002-06-15 Bristol Myers Squibb Co NEW CRYSTAL COMPLEXES OF BACCATIN III WITH IMIDAZOLE, 2-METHYLIMIDAZOLE OR ISOPROPANOL
EP1082316B1 (en) 1998-05-01 2004-06-23 Napro Biotherapeutics, Inc. Methods and useful intermediates for paclitaxel synthesis from c-7, c-10 di-cbz baccatin iii
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
IT1319168B1 (en) * 2000-03-17 2003-09-26 Indena Spa ANTI-CANCER CONDENSATION DERIVATIVES, THEIR METHOD OF PREPARATION AND FORMULATIONS CONTAINING THEM.
EP2389951A1 (en) 2006-03-23 2011-11-30 Novartis AG Anti-tumor cell antigen antibody therapeutics
DE102008013929B3 (en) * 2008-03-12 2009-04-09 Wieland-Werke Ag Metallic heat exchanger pipe i.e. integrally rolled ribbed type pipe, for e.g. air-conditioning and refrigeration application, has pair of material edges extending continuously along primary grooves, where distance is formed between edges
CN101531645B (en) * 2009-04-29 2012-08-22 深圳万乐药业有限公司 Synthesis method of Duoxitasai
JP6427097B2 (en) 2012-06-15 2018-11-21 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Compositions for treating cancer and methods for producing said compositions
WO2015153345A1 (en) 2014-04-03 2015-10-08 Invictus Oncology Pvt. Ltd. Supramolecular combinatorial therapeutics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (en) * 1986-07-17 1988-09-23 Rhone Poulenc Sante TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2629818B1 (en) * 1988-04-06 1990-11-16 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF TAXOL
FR2629819B1 (en) * 1988-04-06 1990-11-16 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF BACCATIN III AND DESACETYL-10 BACCATIN III DERIVATIVES

Similar Documents

Publication Publication Date Title
RU94016161A (en) METHOD OF OBTAINING DERIVATIVES III OR 10-DEZACETHILBACACATINE III AND THEIR APPLICATION
MX9204029A (en) PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF BACATINE III AND 10-DESACETILE BACATINE III
RU94036004A (en) Intermediate compounds for preparing aromatic aminoalcoholic derivatives
RU93043106A (en) METHOD FOR OBTAINING TAXAN DERIVATIVES, TAXAN DERIVATIVES, PHARMACEUTICAL COMPOSITION ON THEIR BASIS, TREATMENT METHOD, OXASOLIDINE DERIVATIVES AND METHOD OF OBTAINING OXIALIDINE DERIVATIVES
DE69332577D1 (en) Process for the preparation of 13-ether derivatives of milbemycins and intermediates
NO901300D0 (en) TREATMENT AND RELATIONSHIPS.
DK570689A (en) imidazole
ES2101513T3 (en) NEW TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
RU94045271A (en) Use of 2-phenyl-3-aroylbenzothiophenes for terner's syndrome inhibition
CA2078871A1 (en) Cyclopropyl squalene derivatives and their use as inhibitors of cholesterol synthesis
RU93053038A (en) ANALOGUES OF 15-DEOXYPERGUALINE, METHOD FOR PRODUCING THERE AND PHARMACEUTICAL COMPOSITION ON THE BASIS AND INTERMEDIATE SYNTHESIS COMPOUNDS
NO981970L (en) Process for Preparing Camptothecin Derivatives
UA41871C2 (en) Derivatives of erythromycin, a process for the preparation thereof and a pharmaceutical composition based thereon
EA199600007A3 (en) Tricyclic derivatives their preparation their use in the preparation of optically active or racemic colchicine thiocolchicine and analogues or derivatives and intermediates
DK74189D0 (en) Medicinal product for the treatment of gastric ulcer
SE9203824L (en) BENSOFURANYLIMIDAZOLE DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND THERAPEUTIC COMPOSITIONS CONTAINING THEM
RU94022265A (en) Fluorinoline-3-carboxylic acid derivatives, the method of their production, their use as intermediate synthesis compounds and intermediate synthesis compounds
ATE159517T1 (en) METHOD FOR PRODUCING N-CARBONYLARYLIMINE AS INTERMEDIATE PRODUCTS IN THE SYNTHESIS OF THERAPEUTICALLY ACTIVE TAXOL DERIVATIVES
FI955680A (en) Psoralen derivatives, their preparation and use
MY104048A (en) New allylaminoethylazoles.
NO962250L (en) Carbonyl containing compounds
DK0580624T3 (en) New Cytarabine Derivatives, Preparation and Use thereof