RU94018524A - DERIVATIVES OF TETRAHYDROPYRANE, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS - Google Patents
DERIVATIVES OF TETRAHYDROPYRANE, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION ON THEIR BASISInfo
- Publication number
- RU94018524A RU94018524A RU94018524/04A RU94018524A RU94018524A RU 94018524 A RU94018524 A RU 94018524A RU 94018524/04 A RU94018524/04 A RU 94018524/04A RU 94018524 A RU94018524 A RU 94018524A RU 94018524 A RU94018524 A RU 94018524A
- Authority
- RU
- Russia
- Prior art keywords
- tetrahydropyrane
- derivatives
- basis
- production
- pharmaceutical composition
- Prior art date
Links
- DHXVGJBLRPWPCS-UHFFFAOYSA-N THP Chemical class C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940116904 ANTIINFLAMMATORY THERAPEUTIC RADIOPHARMACEUTICALS Drugs 0.000 claims 2
- 229940074726 OPHTHALMOLOGIC ANTIINFLAMMATORY AGENTS Drugs 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 238000005917 acylation reaction Methods 0.000 claims 1
- 230000001028 anti-proliferant Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 238000005658 halogenation reaction Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 238000006722 reduction reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Claims (1)
в которой заместители имеют различные значения, в свободной форме или, когда такие форму существуют, в форме солей. Они могут быть получены различными способами, например путем облучения, окислением, элиминированием, восстановлением, преобразованием, например посредством галогенирования или ацилирования, отщеплением защитных групп от защищенных гидроксигрупп, введением защитных групп для защиты свободных гидроксигрупп и разделением смесей стереоизомеров на отдельные изомеры. Эти соединения показаны в качестве фармацевтических препаратов, особенно в качестве противовоспалительных средств и в качестве антипролиферативных и противовоспалительных средств.The invention relates to new compounds of the formula
in which the substituents have different meanings, in free form or, when such forms exist, in the form of salts. They can be obtained in various ways, for example by irradiation, oxidation, elimination, reduction, conversion, for example by halogenation or acylation, cleavage of protecting groups from protected hydroxy groups, introduction of protecting groups to protect free hydroxy groups and separation of stereoisomer mixtures into individual isomers. These compounds are indicated as pharmaceuticals, especially as anti-inflammatory agents and as anti-proliferative and anti-inflammatory agents.
Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9310969.2 | 1993-05-27 | ||
| GB9310975.9 | 1993-05-27 | ||
| GB939310969A GB9310969D0 (en) | 1993-05-27 | 1993-05-27 | Organic compounds |
| GB939310975A GB9310975D0 (en) | 1993-05-27 | 1993-05-27 | Organic compounds |
| GB939312590A GB9312590D0 (en) | 1993-06-18 | 1993-06-18 | Organic compounds |
| GB9312590.4 | 1993-06-18 | ||
| GB9313553.1 | 1993-07-01 | ||
| GB939313553A GB9313553D0 (en) | 1993-07-01 | 1993-07-01 | Organic compounds |
| GB9319617.8 | 1993-09-23 | ||
| GB939319618A GB9319618D0 (en) | 1993-09-23 | 1993-09-23 | Organic compounds |
| GB939319617A GB9319617D0 (en) | 1993-09-23 | 1993-09-23 | Organic compounds |
| GB9319618.6 | 1993-09-23 | ||
| GB9326045.3 | 1993-12-21 | ||
| GB939326045A GB9326045D0 (en) | 1993-12-21 | 1993-12-21 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94018524A true RU94018524A (en) | 1996-01-10 |
| RU2130460C1 RU2130460C1 (en) | 1999-05-20 |
Family
ID=27562893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94018524A RU2130460C1 (en) | 1993-05-27 | 1994-05-26 | Derivatives of tetrahydropyrane and pharmaceutical composition |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5493019A (en) |
| EP (1) | EP0626385B1 (en) |
| JP (1) | JP3076724B2 (en) |
| CN (1) | CN1048495C (en) |
| AT (1) | ATE252105T1 (en) |
| AU (1) | AU682499B2 (en) |
| CA (1) | CA2124260C (en) |
| CY (1) | CY2523B1 (en) |
| CZ (1) | CZ286157B6 (en) |
| DE (1) | DE69433234T2 (en) |
| DK (1) | DK0626385T3 (en) |
| ES (1) | ES2208651T3 (en) |
| FI (1) | FI107159B (en) |
| HK (1) | HK1011684A1 (en) |
| HU (1) | HU218919B (en) |
| IL (1) | IL109775A (en) |
| MY (1) | MY110603A (en) |
| NO (1) | NO308302B1 (en) |
| NZ (1) | NZ260596A (en) |
| PH (1) | PH30420A (en) |
| PT (1) | PT626385E (en) |
| RU (1) | RU2130460C1 (en) |
| SI (1) | SI0626385T1 (en) |
| SK (1) | SK281541B6 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0786986B1 (en) | 1994-10-26 | 2002-03-20 | Novartis AG | Use of an unsaturated fatty alcohol |
| AU748334B2 (en) | 1997-10-16 | 2002-05-30 | Board Of Regents, The University Of Texas System | Models and treatments for cardiac hypertrophy in relation with NF-AT3 function |
| ATE464900T1 (en) | 1998-03-26 | 2010-05-15 | Astellas Pharma Inc | SUSTAINED-RELEASE PREPARATION WITH MACROLIDS SUCH AS TACROLIMUS |
| US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
| US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
| GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| US6121257A (en) * | 1999-03-31 | 2000-09-19 | Abbott Laboratories | Sulfamate containing macrocyclic immunomodulators |
| US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
| WO2004009056A1 (en) | 2002-07-23 | 2004-01-29 | Novartis Ag | Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent |
| CA2552305A1 (en) * | 2003-12-30 | 2005-07-14 | Astellas Pharma Inc. | Use of macrolides for treating or preventing airflow obstruction |
| GT200500282A (en) | 2004-10-12 | 2006-05-04 | HETEROATOMOS CONTAINING TRICYCLE COMPOUNDS. | |
| EP1688161A1 (en) * | 2004-11-02 | 2006-08-09 | Switch Biotech Aktiengesellschaft | Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis |
| US9062074B2 (en) * | 2009-07-15 | 2015-06-23 | Cti Biopharma Corp. | (9E)-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2.5).1(14,18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22-nonaene citrate salt |
| EP3246036B1 (en) | 2014-10-28 | 2021-10-13 | Koushi Yamaguchi | Medicine for improving pregnancy-induced hypertension syndrome |
| AU2019318035A1 (en) | 2018-08-10 | 2021-03-04 | Koushi Yamaguchi | Therapeutic agent for humoral immunity-related diseases in materno-fetal relationship |
| EP3900729A4 (en) | 2018-12-18 | 2022-09-07 | Koushi Yamaguchi | Agent for improving infertility, recurrent miscarriage, and state of pregnancy |
| EP3914599A4 (en) * | 2019-01-23 | 2022-10-19 | The Johns Hopkins University | Non-immunosuppressive fk506 analogs and use thereof |
| WO2022139524A1 (en) * | 2020-12-24 | 2022-06-30 | 서울대학교산학협력단 | Novel fk506 derivative and composition comprising same for promoting hair growth |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0078235A3 (en) * | 1981-10-23 | 1983-06-29 | Ciba-Geigy Ag | Dihalogenated steroids |
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| CH677448A5 (en) * | 1987-11-09 | 1991-05-31 | Sandoz Ag | |
| EP0385936A1 (en) * | 1989-02-27 | 1990-09-05 | Ciba-Geigy Ag | Peptide lactone and derivatives thereof, process for their production and means for carrying out the process |
| IE910847A1 (en) * | 1990-03-13 | 1991-09-25 | Fisons Plc | Immunosuppressive macrocyclic compounds |
| CA2051872A1 (en) * | 1990-09-24 | 1992-03-25 | Kevin M. Byrne | Directed biosynthesis process for prolyl-immunomycin |
| GB2249787A (en) * | 1990-11-19 | 1992-05-20 | Fujisawa Pharmaceutical Co | Lactone compounds |
| WO1992013862A1 (en) * | 1991-02-05 | 1992-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Lactone compounds |
| JP3036923B2 (en) * | 1991-10-28 | 2000-04-24 | 理化学研究所 | Depsipeptides A and B, production method thereof, antiviral agent and antibacterial agent |
| HUT66531A (en) * | 1992-05-07 | 1994-12-28 | Sandoz Ag | Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them |
-
1994
- 1994-05-23 MY MYPI94001314A patent/MY110603A/en unknown
- 1994-05-24 SI SI9430457T patent/SI0626385T1/en unknown
- 1994-05-24 EP EP94810297A patent/EP0626385B1/en not_active Expired - Lifetime
- 1994-05-24 PT PT94810297T patent/PT626385E/en unknown
- 1994-05-24 AT AT94810297T patent/ATE252105T1/en not_active IP Right Cessation
- 1994-05-24 DE DE69433234T patent/DE69433234T2/en not_active Expired - Lifetime
- 1994-05-24 PH PH48331A patent/PH30420A/en unknown
- 1994-05-24 ES ES94810297T patent/ES2208651T3/en not_active Expired - Lifetime
- 1994-05-24 DK DK94810297T patent/DK0626385T3/en active
- 1994-05-25 CA CA002124260A patent/CA2124260C/en not_active Expired - Fee Related
- 1994-05-25 FI FI942444A patent/FI107159B/en not_active IP Right Cessation
- 1994-05-25 IL IL10977594A patent/IL109775A/en not_active IP Right Cessation
- 1994-05-25 HU HU9401582A patent/HU218919B/en not_active IP Right Cessation
- 1994-05-25 NO NO941936A patent/NO308302B1/en not_active IP Right Cessation
- 1994-05-25 AU AU63317/94A patent/AU682499B2/en not_active Ceased
- 1994-05-25 NZ NZ260596A patent/NZ260596A/en not_active IP Right Cessation
- 1994-05-25 SK SK611-94A patent/SK281541B6/en not_active IP Right Cessation
- 1994-05-26 CZ CZ19941295A patent/CZ286157B6/en not_active IP Right Cessation
- 1994-05-26 JP JP06112552A patent/JP3076724B2/en not_active Expired - Fee Related
- 1994-05-26 CN CN94105935A patent/CN1048495C/en not_active Expired - Fee Related
- 1994-05-26 RU RU94018524A patent/RU2130460C1/en not_active IP Right Cessation
- 1994-05-26 US US08/249,911 patent/US5493019A/en not_active Expired - Lifetime
-
1998
- 1998-12-04 HK HK98112853A patent/HK1011684A1/en not_active IP Right Cessation
-
2005
- 2005-04-14 CY CY0500023A patent/CY2523B1/en unknown
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