RU94017674A - METHOD OF OBTAINING COMPOUNDS, VECTOR, CELL - Google Patents

METHOD OF OBTAINING COMPOUNDS, VECTOR, CELL

Info

Publication number
RU94017674A
RU94017674A RU94017674/13A RU94017674A RU94017674A RU 94017674 A RU94017674 A RU 94017674A RU 94017674/13 A RU94017674/13 A RU 94017674/13A RU 94017674 A RU94017674 A RU 94017674A RU 94017674 A RU94017674 A RU 94017674A
Authority
RU
Russia
Prior art keywords
adipoyl
adca
apa
vector
cell
Prior art date
Application number
RU94017674/13A
Other languages
Russian (ru)
Other versions
RU2178808C2 (en
Inventor
Дж. КОНДЕР Майкл
КРОФОРД Лорили
К. МакЭЙДА Филлис
А. РЭМБОУСЕК Джон
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/933,469 external-priority patent/US5318896A/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of RU94017674A publication Critical patent/RU94017674A/en
Application granted granted Critical
Publication of RU2178808C2 publication Critical patent/RU2178808C2/en

Links

Claims (1)

Предлагается промежуточное соединение для получения цефалоспориновых антибиотиков, 7-аминодезацетоксицэфалоспориновую кислоту (7-ADCA), получают с помощью нового биопроцесса, в котором выращивают штамм трансформированного Penicillium chrysogenum в присутствии адипинатного питания, и получают адипоил-6-АРА (6-аминопенициллиновую кислоту), и insitu вектор экспрессии гена экспандазы, например, из streptomyces clavuligerus, с которым трансформирован Р. chrysogпenum, превращает адипоил-6-АРА, путем расширения кольца, в адипоил-7-ADCA. Конечный продукт - 7-ADCA - получают затем путем отщепления адипоильной боковой цепи, используя адипоилацилазу. Соответственно, используя биопроцесс, осуществляют полный синтез, являющийся эффективным и экономичным.Proposed intermediate for the preparation of cephalosporin antibiotics, 7-aminodezatsetoksitsefalosporinovuyu acid (7-ADCA), is prepared using the novel bioprocess in which the grown strain was transformed Penicillium chrysogenum in the presence adipate power to give adipoyl-6-APA (6-aminopenitsillinovuyu acid) and in situ the expression vector of the expandase gene, for example, from streptomyces clavuligerus, with which P. chrysogpenum is transformed, converts adipoyl-6-APA, by expanding the ring, into adipoyl-7-ADCA. The final product, 7-ADCA, is then obtained by cleaving the adipoyl side chain using adipoyl acylase. Accordingly, using a bioprocess, complete synthesis is performed, which is efficient and economical.
RU94017674/13A 1991-09-11 1992-09-11 Method of 7-aminodesacetoxycephalosporanic acid (7-adca) producing RU2178808C2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75787991A 1991-09-11 1991-09-11
US757,879 1991-09-11
US933,469 1992-08-28
US07/933,469 US5318896A (en) 1991-09-11 1992-08-28 Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)

Publications (2)

Publication Number Publication Date
RU94017674A true RU94017674A (en) 1996-03-10
RU2178808C2 RU2178808C2 (en) 2002-01-27

Family

ID=27116462

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94017674/13A RU2178808C2 (en) 1991-09-11 1992-09-11 Method of 7-aminodesacetoxycephalosporanic acid (7-adca) producing

Country Status (25)

Country Link
US (1) US5318896A (en)
EP (2) EP0843013A3 (en)
JP (2) JP3027847B2 (en)
KR (2) KR0132440B1 (en)
CN (2) CN1066488C (en)
AT (1) ATE173017T1 (en)
AU (1) AU657787B2 (en)
BG (1) BG62177B1 (en)
CA (1) CA2077921C (en)
CZ (1) CZ287357B6 (en)
DE (1) DE69227494T2 (en)
DK (1) DK0532341T3 (en)
ES (1) ES2126588T3 (en)
FI (1) FI108148B (en)
HU (1) HU217171B (en)
IL (1) IL103076A (en)
MX (1) MX9205175A (en)
NO (1) NO316742B1 (en)
NZ (1) NZ244236A (en)
RO (1) RO115886B1 (en)
RU (1) RU2178808C2 (en)
SK (1) SK282387B6 (en)
TW (1) TW270149B (en)
UA (1) UA41292C2 (en)
WO (1) WO1993005158A1 (en)

Families Citing this family (34)

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EP0233715B1 (en) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolation and expression of genes involved in the biosynthesis of beta-lactams
HU219370B (en) * 1991-10-15 2001-03-28 Gist Brocades Bv Novel bioprocesses for preparing 7-aca and 7-adac
PL180799B1 (en) * 1993-07-30 2001-04-30 Gist Brocades Bv Method of efficient production of 7-adca via 2-(carboxyl ethyl tio) acetyl-7-adca and 3-(carboxyl methyl tio) - propionyl -7- adca
JP3574453B2 (en) * 1993-07-30 2004-10-06 ギスト ブロカデス ベスローテン フェンノートシャップ Effective method for producing 7-ADCA via 3- (carboxyethylthio) propionyl-7-ADCA
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
AU1097297A (en) * 1995-11-27 1997-06-19 Gist-Brocades B.V. Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin
AU2508897A (en) * 1996-04-04 1997-10-29 Gist-Brocades B.V. An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
EP0924180A4 (en) 1996-07-02 2005-04-20 Toray Finechemicals Co Ltd Processes for the preparation of optically active ketones
WO1998002567A2 (en) 1996-07-16 1998-01-22 Gist-Brocades B.V. PROCESS FOR THE PREPARATION OF CEPHALOSPORINS USING $i(ACREMONIUM CHRYSOGENUM)
EP1690945A3 (en) * 1997-02-20 2009-06-03 DSM IP Assets B.V. Fermentative production of valuable compounds on an industrial scale using chemically defined media
ZA983396B (en) * 1997-04-22 1998-10-27 Gist Brocades Bv A method for controlling the solubility of a beta-lactam nucleus
ZA983394B (en) * 1997-04-22 1998-10-30 Gist Brocades Bv Process for the fermentative production of deacylated cephalosporins
DE69828940T2 (en) 1997-04-22 2005-12-29 Dsm Ip Assets B.V. IMPROVED METHOD FOR THE FERMENTATIVE MANUFACTURE OF CEPHALOSPORIN
EP0918879A1 (en) * 1997-04-22 1999-06-02 Gist-Brocades B.V. A METHOD FOR PREPARING A $g(b)-LACTAM ANTIBIOTIC
KR20000022109A (en) * 1997-04-22 2000-04-25 한스 발터 라벤 Process for the fermentative production of deacylated cephalosporins
PL341396A1 (en) * 1997-12-24 2001-04-09 Isis Innovation Modified syntheses of diacetoxycephalosporin c (daocs) and its roentgenographic structure
ES2186347T3 (en) 1998-03-27 2003-05-01 Dsm Nv NEW PRODUCTION PROCEDURE FOR FERMENTATION OF CEPHALOSPORINE.
US6383773B2 (en) * 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
EP1078069B1 (en) 1998-05-19 2008-02-13 DSM IP Assets B.V. Improved in vivo production of cephalosporins
ES2165276B1 (en) * 1999-06-18 2003-03-01 Antibioticos Sau BIOTECHNOLOGICAL PROCEDURE FOR THE PRODUCTION OF OSPORANIC 7-AMINOCEPHAL ACID (7-ADCA) AND PARTICULARLY INTERMEDIATE SYNTHESIS COMPOUNDS PENICILLIN N AND DEACETOXYCHEFALOSPORINE C (DAOC)
ES2225524T5 (en) 2000-05-13 2009-03-01 Smithkline Beecham Plc PROCEDURE FOR PURIFICATION OF A CLAVULANIC ACID SALT.
BRPI0621278A2 (en) 2005-12-28 2011-12-06 Dsm Ip Assests Bv mutant acylases
CN101389635B (en) * 2006-02-23 2013-03-06 中化帝斯曼制药有限公司荷兰公司 Improved cephalosporin production
EP2123772A1 (en) 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-lactam antibiotic producing strains
EP2310487A2 (en) 2008-08-05 2011-04-20 DSM IP Assets B.V. Adipoyl-7-adca producing strains
CN102131917A (en) * 2008-08-05 2011-07-20 帝斯曼知识产权资产管理有限公司 Adipoyl-7-adca producing strains
WO2010015624A1 (en) * 2008-08-05 2010-02-11 Dsm Ip Assets B.V. Adipoyl-7-adca producing strains
EP2414530A1 (en) 2009-04-03 2012-02-08 DSM Sinochem Pharmaceuticals Netherlands B.V. Fermentation process
EP2585608B1 (en) 2010-06-22 2017-07-26 DSM Sinochem Pharmaceuticals Netherlands B.V. Air bubble fermentation process
WO2012032040A1 (en) 2010-09-07 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the production of cephalosporins
EA023822B1 (en) 2011-03-03 2016-07-29 Дсм Синокем Фармасьютикалз Нидерландз Б.В. Degradation of penicillin compounds
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
CN113699209B (en) * 2021-08-30 2023-05-02 浙江昂利康制药股份有限公司 7-ADCA recovery method

Family Cites Families (9)

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FR1270852A (en) * 1960-09-20 1961-09-01 Bayer Ag 6-Aminopenicillanic acid enzymatic acylation process
EP0233715B1 (en) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolation and expression of genes involved in the biosynthesis of beta-lactams
IL81555A0 (en) * 1986-11-17 1987-09-16 Baldwin Jack Edward Enzymatic process for 3-substituted cephalosporins
DE3881531D1 (en) * 1987-01-17 1993-07-15 Hoechst Ag USE OF GAMMA GLUTAMYL TRANSPEPTIDASE.
US5070020A (en) * 1988-05-09 1991-12-03 Eli Lilly And Company Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
US5108918A (en) * 1988-08-11 1992-04-28 Gist-Brocades Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites
IL95766A (en) * 1989-09-27 1996-12-05 Lilly Co Eli Recombinant DNA expression vectors and DNA compounds that encode acyltransferase activity of aspergillus
KR0171897B1 (en) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 Process for producing 7-aminocephem compound or salts thereof
HU219370B (en) * 1991-10-15 2001-03-28 Gist Brocades Bv Novel bioprocesses for preparing 7-aca and 7-adac

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