RU94008833A - Method of highly active aspirin preparing - Google Patents

Method of highly active aspirin preparing

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Publication number
RU94008833A
RU94008833A RU94008833/14A RU94008833A RU94008833A RU 94008833 A RU94008833 A RU 94008833A RU 94008833/14 A RU94008833/14 A RU 94008833/14A RU 94008833 A RU94008833 A RU 94008833A RU 94008833 A RU94008833 A RU 94008833A
Authority
RU
Russia
Prior art keywords
preparing
highly active
aspirin
purity
atmosphere
Prior art date
Application number
RU94008833/14A
Other languages
Russian (ru)
Other versions
RU2099059C1 (en
Inventor
В.И. Лапшин
Е.Л. Фокина
А.И. Анисимов
Э.Г. Грязнухин
А.А. Зайцев
Original Assignee
Санкт-Петербургский научно-исследовательский институт травматологии и ортопедии им.Р.Р.Вредена
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санкт-Петербургский научно-исследовательский институт травматологии и ортопедии им.Р.Р.Вредена filed Critical Санкт-Петербургский научно-исследовательский институт травматологии и ортопедии им.Р.Р.Вредена
Priority to RU94008833A priority Critical patent/RU2099059C1/en
Publication of RU94008833A publication Critical patent/RU94008833A/en
Application granted granted Critical
Publication of RU2099059C1 publication Critical patent/RU2099059C1/en

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Abstract

FIELD: chemical-pharmaceutical industry, pharmacy technology. SUBSTANCE: method involves the additional stage of mechanical treatment in mill-activators at energy intensity 1-5 kW/kg in atmosphere with relative humidity 70-100% up to attainment of specific surface (2.0-2.5 kw/g). EFFECT: increased rate of acetylsalicylic acid (aspirin) dissolving, enhanced therapeutic activity, retained purity and composition.

Claims (1)

Изобретение относится к химико-фармацевтической области, а именно, к технологии получения лекарственных форм. Цель изобретения - повышение скорости растворения ацетилсалициловой кислоты и увеличение ее терапевтической активности при сохранении степени чистоты и неизменности состава. При этом вводится дополнительная операция механической обработки в мельницах-активаторах с энергонапряженностью 1-5 кВт/кг в атмосфере с относительной влажностью 70-100% до достижения удельной поверхности (2,0 - 2,5 мг/г).The invention relates to the chemical-pharmaceutical field, namely, to a technology for producing dosage forms. The purpose of the invention is to increase the dissolution rate of acetylsalicylic acid and increase its therapeutic activity while maintaining the degree of purity and unchanged composition. At the same time, an additional machining operation is introduced in activator mills with an energy intensity of 1-5 kW / kg in an atmosphere with a relative humidity of 70-100% until a specific surface is reached (2.0 - 2.5 mg / g).
RU94008833A 1994-03-15 1994-03-15 Method for producing highly active acetylsalicylic acid (aspirin) RU2099059C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU94008833A RU2099059C1 (en) 1994-03-15 1994-03-15 Method for producing highly active acetylsalicylic acid (aspirin)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU94008833A RU2099059C1 (en) 1994-03-15 1994-03-15 Method for producing highly active acetylsalicylic acid (aspirin)

Publications (2)

Publication Number Publication Date
RU94008833A true RU94008833A (en) 1996-05-20
RU2099059C1 RU2099059C1 (en) 1997-12-20

Family

ID=20153497

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94008833A RU2099059C1 (en) 1994-03-15 1994-03-15 Method for producing highly active acetylsalicylic acid (aspirin)

Country Status (1)

Country Link
RU (1) RU2099059C1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA027333B1 (en) 2007-10-17 2017-07-31 Тодд Ф. Овокайтис Room temperature stable non-crystalline aspirin

Also Published As

Publication number Publication date
RU2099059C1 (en) 1997-12-20

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