RU94002335A - Derivatives of quinoline or quinazoline and method of their production - Google Patents
Derivatives of quinoline or quinazoline and method of their productionInfo
- Publication number
- RU94002335A RU94002335A RU94002335/04A RU94002335A RU94002335A RU 94002335 A RU94002335 A RU 94002335A RU 94002335/04 A RU94002335/04 A RU 94002335/04A RU 94002335 A RU94002335 A RU 94002335A RU 94002335 A RU94002335 A RU 94002335A
- Authority
- RU
- Russia
- Prior art keywords
- quinazoline
- quinoline
- derivatives
- production
- nitrogen
- Prior art date
Links
- JWVCLYRUEFBMGU-UHFFFAOYSA-N Quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 229940116904 ANTIINFLAMMATORY THERAPEUTIC RADIOPHARMACEUTICALS Drugs 0.000 claims 1
- 206010003246 Arthritis Diseases 0.000 claims 1
- 229940074726 OPHTHALMOLOGIC ANTIINFLAMMATORY AGENTS Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Claims (1)
где Y является атомом азота или фрагментом C - G (G обозначает карбоксильную группу, которая может быть этерифицирована); кольцо R является азотсодержащей ненасыщенной гетероциклической группой, которая может быть замещенной, каждое из колец A и B может иметь заместитель, n является целым числом 1 - 4; k = 0 или 1, или их соли, которые являются хорошими антивоспалительными агентами, особенно терапевтическими средствами для лечения артрита.Compounds represented by the general formula are described.
where Y is a nitrogen atom or a fragment of C - G (G denotes a carboxyl group that can be esterified); ring R is a nitrogen-containing unsaturated heterocyclic group which may be substituted, each of rings A and B may have a substituent, n is an integer from 1 to 4; k = 0 or 1, or their salts, which are good anti-inflammatory agents, especially therapeutic agents for the treatment of arthritis.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP012628/1993 | 1993-01-28 | ||
| JP1262893 | 1993-01-28 | ||
| JP20612893 | 1993-08-20 | ||
| JP206128/1993 | 1993-08-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94002335A true RU94002335A (en) | 1995-11-27 |
| RU2132330C1 RU2132330C1 (en) | 1999-06-27 |
Family
ID=26348258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94002335A RU2132330C1 (en) | 1993-01-28 | 1994-01-27 | Quinoline derivatives, method of their synthesis and anti-inflammatory agent |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US5436247A (en) |
| EP (1) | EP0608870B1 (en) |
| KR (1) | KR100224135B1 (en) |
| CN (1) | CN1041520C (en) |
| AT (1) | ATE205199T1 (en) |
| AU (1) | AU673213B2 (en) |
| CA (1) | CA2114300C (en) |
| DE (1) | DE69428142T2 (en) |
| FI (1) | FI940414A (en) |
| HU (1) | HU217907B (en) |
| NO (2) | NO306992B1 (en) |
| NZ (1) | NZ250761A (en) |
| RU (1) | RU2132330C1 (en) |
| SG (1) | SG50546A1 (en) |
| TW (1) | TW256832B (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW232013B (en) * | 1992-04-24 | 1994-10-11 | Takeda Pharm Industry Co Ltd | |
| KR100224135B1 (en) * | 1993-01-28 | 1999-10-15 | 다께다 구니오 | Quinoline or quinoline derivatives, their production and use |
| EP0634169B1 (en) * | 1993-06-29 | 2000-01-05 | Takeda Chemical Industries, Ltd. | Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis |
| CA2184392A1 (en) * | 1994-03-08 | 1995-09-14 | Takashi Sohda | Quinoline or quinazoline derivatives as anti-inflammatory agents, in particular for treating arthritis |
| US5641788A (en) * | 1994-06-07 | 1997-06-24 | Takeda Chemical Industries, Ltd. | Quinoline derivatives and pharmaceutical composition containing them |
| EP0766681A1 (en) * | 1994-06-24 | 1997-04-09 | Takeda Chemical Industries, Ltd. | Processes for production of quinoline or quinazoline derivatives and intermediates therefor |
| US5523312A (en) * | 1994-09-27 | 1996-06-04 | Sterling Winthrop Inc. | Antipicornaviral agents |
| HUP9801628A2 (en) * | 1995-04-28 | 1999-01-28 | Takeda Chemical Industries, Ltd. | Therapeutic composition for arthritis |
| DE19610882A1 (en) * | 1996-03-20 | 1997-09-25 | Dresden Arzneimittel | New 1,3,5-trisubstituted indazole derivatives with antiasthmatic, antiallergic, anti-inflammatory and immunomodulating effects, processes for their preparation and their use as medicines |
| IL133007A (en) * | 1997-05-28 | 2005-06-19 | Aventis Pharma Inc | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| EP1354603A1 (en) * | 2000-12-26 | 2003-10-22 | Takeda Chemical Industries, Ltd. | Concomitant drugs |
| ATE394398T1 (en) * | 2002-07-15 | 2008-05-15 | Scinopharm Taiwan Ltd | METHOD FOR PRODUCING IMIDAZO(1,2-A)PYRIDINE-3-ACETAMIDE |
| EP1568693A4 (en) * | 2002-11-06 | 2007-09-05 | Nissan Chemical Ind Ltd | Process for producing quinolinecarbaldehyde |
| JP2006525357A (en) * | 2003-04-30 | 2006-11-09 | ジ インスチチュート フォー ファーマシューティカル ディスカバリー、エルエルシー | Substituted heteroaryls as protein tyrosine phosphatase inhibitors |
| US7937406B2 (en) * | 2003-09-11 | 2011-05-03 | Oracle America, Inc. | Mechanism for automatically establishing a resource grid |
| DE102004055633A1 (en) * | 2004-11-12 | 2006-05-18 | Schering Ag | New 5-substituted quinoline and isoquinoline derivatives are glucocorticoid receptor binders useful for treating inflammatory diseases e.g. alveolitis, Sjogren's syndrome, atopic dermatitis, acute lymphatic leukemia, rhinitis and emesis |
| US20070225632A1 (en) * | 2006-03-21 | 2007-09-27 | David Rauser | Hydratable polymeric ester matrix for drug electrotransport |
| AU2010265974B2 (en) | 2009-06-25 | 2014-09-11 | Amgen Inc. | Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases |
| US8765768B2 (en) | 2010-11-17 | 2014-07-01 | Amgen Inc. | Heterocyclic compounds and their uses |
| MX2015001099A (en) * | 2012-08-24 | 2015-04-08 | Hoffmann La Roche | New bicyclicpyridine derivatives. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| CA2002864C (en) * | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
| GB8827822D0 (en) * | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
| TW232013B (en) * | 1992-04-24 | 1994-10-11 | Takeda Pharm Industry Co Ltd | |
| KR100224135B1 (en) * | 1993-01-28 | 1999-10-15 | 다께다 구니오 | Quinoline or quinoline derivatives, their production and use |
| EP0766681A1 (en) * | 1994-06-24 | 1997-04-09 | Takeda Chemical Industries, Ltd. | Processes for production of quinoline or quinazoline derivatives and intermediates therefor |
-
1994
- 1994-01-24 KR KR1019940001217A patent/KR100224135B1/en not_active IP Right Cessation
- 1994-01-24 NO NO940245A patent/NO306992B1/en unknown
- 1994-01-24 NO NO940245D patent/NO940245D0/en unknown
- 1994-01-25 TW TW083100595A patent/TW256832B/zh active
- 1994-01-26 US US08/186,638 patent/US5436247A/en not_active Expired - Fee Related
- 1994-01-26 NZ NZ250761A patent/NZ250761A/en unknown
- 1994-01-26 CA CA002114300A patent/CA2114300C/en not_active Expired - Fee Related
- 1994-01-27 FI FI940414A patent/FI940414A/en unknown
- 1994-01-27 AT AT94101144T patent/ATE205199T1/en not_active IP Right Cessation
- 1994-01-27 EP EP94101144A patent/EP0608870B1/en not_active Expired - Lifetime
- 1994-01-27 AU AU54742/94A patent/AU673213B2/en not_active Ceased
- 1994-01-27 DE DE69428142T patent/DE69428142T2/en not_active Expired - Fee Related
- 1994-01-27 SG SG1996004643A patent/SG50546A1/en unknown
- 1994-01-27 RU RU94002335A patent/RU2132330C1/en active
- 1994-01-28 HU HU9400250A patent/HU217907B/en not_active IP Right Cessation
- 1994-01-28 CN CN94101137A patent/CN1041520C/en not_active Expired - Fee Related
-
1995
- 1995-05-08 US US08/436,629 patent/US5770602A/en not_active Expired - Fee Related
-
1997
- 1997-10-21 US US08/954,854 patent/US5932592A/en not_active Expired - Fee Related
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