RU93058363A - ANTIBIOTIC COMPOUNDS, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT, INTERMEDIATE PRODUCTS AND METHOD OF THEIR PRODUCTION - Google Patents
ANTIBIOTIC COMPOUNDS, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT, INTERMEDIATE PRODUCTS AND METHOD OF THEIR PRODUCTIONInfo
- Publication number
- RU93058363A RU93058363A RU93058363/04A RU93058363A RU93058363A RU 93058363 A RU93058363 A RU 93058363A RU 93058363/04 A RU93058363/04 A RU 93058363/04A RU 93058363 A RU93058363 A RU 93058363A RU 93058363 A RU93058363 A RU 93058363A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- production
- intermediate products
- treatment
- pharmaceutical composition
- Prior art date
Links
- -1 METHOD OF TREATMENT Substances 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 title claims 3
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 230000003115 biocidal Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims 1
- 125000004776 1-fluoroethyl group Chemical group [H]C([H])([H])C([H])(F)* 0.000 claims 1
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 claims 1
- 229940041011 Carbapenems Drugs 0.000 claims 1
- 125000005236 alkanoylamino group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N sulfonic acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Claims (1)
где R1 является 1-гидроксиэтилом, 1-фторэтилом или гидроксиметилом; R2 является водородом или C1 - 4 алкилом; R3 является водородом или C1-C4 алкилом; а тиенильное кольцо далее произвольно замещено одним или двумя заместителями, выбранными из групп гало, циано, C1 - 4 алкил, нитро, гидрокси, карбокси, C1 - 4 алкокси, трифторметил, C1 - 4 алкоксикарбонил, амино, C1 - 4 алкиламино, ди-C1 - 4 алкиламино, сульфокислоты, C1-- 4 алкил S(O)n-, где n составляет 0 - 2, C1 - 4 алканоиламино, C1 - 4 алканоил (N-C1 - 4 алкил), амино, карбамоил, C1 - 4 алкилкарбамоил, ди-C1 - 4 алкилкарбамоил и N -C1 - 4 алкансульфонамидо; или тетраметиленовой группой, присоединенной к соседним атомам углерода тиенильного кольца; или фармецевтически приемлемые соли, или гидролизуемые in vivo эфиры этих соединений. Также описаны процессы их получении, промежуточные продукты при их получении, их использование в качестве терапевтических агентов и содержащие их фармацевтические составы.The present invention relates to carbapenems and represents compounds with the formula:
where R 1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R 2 is hydrogen or C 1 - 4 alkyl; R 3 is hydrogen or C 1 -C 4 alkyl; and the thienyl ring further substituted by one or two substituents selected from halo groups, cyano, C 1 - 4 alkyl, nitro, hydroxy, carboxy, C 1 - 4 alkoxy, trifluoromethyl, C 1 - 4 alkoxycarbonyl, amino, C 1 - 4 alkylamino, di-C 1 - 4 alkylamino, sulfonic acid, C 1 - - 4 alkyl, S (O) n -, where n is 0 - 2, C 1 - 4 alkanoylamino, C 1 - 4 alkanoyl (NC 1 - 4 alkyl) , amino, carbamoyl, C 1 - 4 alkylcarbamoyl, di-C 1 - 4 alkylcarbamoyl and N -C 1 - 4 alkanesulphonamido; or a tetramethylene group attached to adjacent carbon atoms of the thienyl ring; or pharmaceutical acceptable salts, or in vivo hydrolysable esters of these compounds. Also described are processes for their preparation, intermediate products for their preparation, their use as therapeutic agents, and pharmaceutical compositions containing them.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92400836.0 | 1992-03-26 | ||
| FR92402763.4 | 1992-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU93058363A true RU93058363A (en) | 1996-04-27 |
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