RU93056846A - Pyridopyrimidine derivatives, their production, pharmaceutical composition, method of treatment - Google Patents
Pyridopyrimidine derivatives, their production, pharmaceutical composition, method of treatmentInfo
- Publication number
- RU93056846A RU93056846A RU93056846/04A RU93056846A RU93056846A RU 93056846 A RU93056846 A RU 93056846A RU 93056846/04 A RU93056846/04 A RU 93056846/04A RU 93056846 A RU93056846 A RU 93056846A RU 93056846 A RU93056846 A RU 93056846A
- Authority
- RU
- Russia
- Prior art keywords
- treatment
- integer
- production
- pharmaceutical composition
- pyridopyrimidine derivatives
- Prior art date
Links
- 150000008518 pyridopyrimidines Chemical class 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 208000006673 Asthma Diseases 0.000 claims 1
- 206010008118 Cerebral infarction Diseases 0.000 claims 1
- 102000010180 Endothelin Receptors Human genes 0.000 claims 1
- 108050001739 Endothelin Receptors Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000010125 Myocardial Infarction Diseases 0.000 claims 1
- 206010068319 Oropharyngeal pain Diseases 0.000 claims 1
- 208000002815 Pulmonary Hypertension Diseases 0.000 claims 1
- 206010038436 Renal failure acute Diseases 0.000 claims 1
- 230000003042 antagnostic Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000000038 chest Anatomy 0.000 claims 1
- 239000002308 endothelin receptor antagonist Substances 0.000 claims 1
- 201000009673 liver disease Diseases 0.000 claims 1
- 210000000056 organs Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Claims (1)
где n - целое число от 0 до 3; Q - -(CH2)m - целое число от 0 до 2, -O-, -S(O)p; p - целое число от 0 до 2 или -N-; R1 - R5 - заместители, или его соль. Показано их получение и использование как антагонистического агента в отношении эндотелинового рецептора. Антагонист эндотелинового рецептора является эффективным в качестве композиции для лечения острой почечной недостаточности, инфаркта миокарда, гипертензии, церебрального инфаркта, грудной ангины, артериосклероза, гепатопатии, легочной гипертензии, бронхиальной астмы, органогипофункции, вызванной операцией или трансплантацией органов.A new pyridopyrimidine derivative of the general formula is described.
where n is an integer from 0 to 3; Q - - (CH 2 ) m is an integer from 0 to 2, -O-, -S (O) p ; p is an integer from 0 to 2 or -N-; R 1 - R 5 - substituents, or its salt. Their preparation and use as an antagonistic agent for the endothelin receptor has been shown. An endothelin receptor antagonist is effective as a composition for the treatment of acute renal failure, myocardial infarction, hypertension, cerebral infarction, chest sore throat, arteriosclerosis, hepatopathy, pulmonary hypertension, bronchial asthma, organohypofunction caused by surgery or organ transplantation.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP36038492 | 1992-12-29 | ||
JP360384/92 | 1992-12-29 | ||
JP27713693 | 1993-11-05 | ||
JP277136/93 | 1993-11-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93056846A true RU93056846A (en) | 1997-04-20 |
RU2127734C1 RU2127734C1 (en) | 1999-03-20 |
Family
ID=26552272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93056846A RU2127734C1 (en) | 1992-12-29 | 1993-12-28 | Derivatives of pyridopyrimidine, their synthesis, a pharmaceutical composition, a method of treatment |
Country Status (12)
Country | Link |
---|---|
US (1) | US5654309A (en) |
EP (1) | EP0608565B1 (en) |
KR (1) | KR940014398A (en) |
CN (1) | CN1041090C (en) |
AT (1) | ATE214391T1 (en) |
CA (1) | CA2112425A1 (en) |
DE (1) | DE69331688T2 (en) |
FI (1) | FI935897A (en) |
HU (1) | HU218782B (en) |
NO (1) | NO301762B1 (en) |
RU (1) | RU2127734C1 (en) |
TW (1) | TW299333B (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0626174A3 (en) * | 1993-04-21 | 1996-01-03 | Takeda Chemical Industries Ltd | Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction. |
NZ322197A (en) * | 1995-11-21 | 1999-02-25 | Yamanouchi Pharma Co Ltd | Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof |
KR100377788B1 (en) * | 2000-12-29 | 2003-03-26 | 씨제이 주식회사 | Novel pyridopyrimidine derivatives, preparing process thereof and pharmaceutical composition containing the same |
KR100377787B1 (en) * | 2000-12-29 | 2003-03-26 | 씨제이 주식회사 | Novel pyridopyrimidine derivatives, preparing process thereof and pharmaceutical composition containing the same |
DE10110747A1 (en) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituted 2,6-diamino-3,5-dicyano-4-aryl-pyridines and their use |
US6825180B2 (en) * | 2001-05-18 | 2004-11-30 | Cell Therapeutics, Inc. | Pyridopyrimidine compounds and their uses |
WO2006019965A2 (en) * | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
DE102004042607A1 (en) | 2004-09-03 | 2006-03-09 | Bayer Healthcare Ag | Substituted phenylaminothiazoles and their use |
US20100022568A1 (en) * | 2006-04-13 | 2010-01-28 | Actelion Pharmaceeuticals Ltd. | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
DE102006042143A1 (en) | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Novel substituted bipyridine derivatives and their use |
DE102006056739A1 (en) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Substituted 4-amino-3,5-dicyano-2-thiopyridines and their use |
DE102006056740A1 (en) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Cyclic substituted 3,5-dicyano-2-thiopyridines and their use |
SA08280783B1 (en) * | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | Pyridopyrimidine Derivatives as PDE4 Inhibitors |
DE102007035367A1 (en) | 2007-07-27 | 2009-01-29 | Bayer Healthcare Ag | Substituted aryloxazoles and their use |
DE102007036076A1 (en) | 2007-08-01 | 2009-02-05 | Bayer Healthcare Aktiengesellschaft | Dipeptoid Produgs and their use |
DE102007061763A1 (en) | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Substituted azabicyclic compounds and their use |
DE102007061764A1 (en) | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellated cyanopyridines and their use |
DE102008013587A1 (en) | 2008-03-11 | 2009-09-17 | Bayer Schering Pharma Aktiengesellschaft | Heteroaryl-substituted dicyanopyridines and their use |
ES2428818T3 (en) | 2008-05-29 | 2013-11-11 | Bayer Intellectual Property Gmbh | Dicianopyridines substituted with 2-alkoxy and their use |
DE102008062567A1 (en) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid prodrugs and their use |
DE102009006602A1 (en) | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituted dicyanopyridines and their amino acid ester prodrugs |
EP2266984A1 (en) * | 2009-06-26 | 2010-12-29 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis |
DE102010030688A1 (en) | 2010-06-30 | 2012-01-05 | Bayer Schering Pharma Aktiengesellschaft | Substituted dicyanopyridines and their use |
US20120058983A1 (en) | 2010-09-02 | 2012-03-08 | Bayer Pharma Aktiengesellschaft | Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension |
CN107245074B (en) * | 2017-06-20 | 2019-04-09 | 牡丹江医学院附属红旗医院 | Compound and preparation method thereof for treating cerebral infarction |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5649917B2 (en) * | 1973-12-18 | 1981-11-25 | ||
JPS5758347B2 (en) * | 1974-04-03 | 1982-12-09 | Hisamitsu Pharmaceutical Co | |
DE3601731A1 (en) * | 1986-01-22 | 1987-07-23 | Merck Patent Gmbh | Pyrimidine derivatives |
WO1992012979A1 (en) * | 1991-01-17 | 1992-08-06 | Pfizer Inc. | 2,4-DIOXO-PYRIDO [2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF |
TW270116B (en) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche |
-
1993
- 1993-12-22 TW TW082110871A patent/TW299333B/zh not_active IP Right Cessation
- 1993-12-24 CA CA002112425A patent/CA2112425A1/en not_active Abandoned
- 1993-12-28 HU HU9303774A patent/HU218782B/en not_active IP Right Cessation
- 1993-12-28 EP EP93121004A patent/EP0608565B1/en not_active Expired - Lifetime
- 1993-12-28 NO NO934866A patent/NO301762B1/en not_active IP Right Cessation
- 1993-12-28 DE DE69331688T patent/DE69331688T2/en not_active Expired - Fee Related
- 1993-12-28 RU RU93056846A patent/RU2127734C1/en active
- 1993-12-28 FI FI935897A patent/FI935897A/en unknown
- 1993-12-28 AT AT93121004T patent/ATE214391T1/en active
- 1993-12-29 CN CN93121506A patent/CN1041090C/en not_active Expired - Fee Related
- 1993-12-29 KR KR1019930030921A patent/KR940014398A/en not_active Application Discontinuation
-
1995
- 1995-06-07 US US08/480,862 patent/US5654309A/en not_active Expired - Fee Related
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