RU93056846A - Pyridopyrimidine derivatives, their production, pharmaceutical composition, method of treatment - Google Patents

Pyridopyrimidine derivatives, their production, pharmaceutical composition, method of treatment

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Publication number
RU93056846A
RU93056846A RU93056846/04A RU93056846A RU93056846A RU 93056846 A RU93056846 A RU 93056846A RU 93056846/04 A RU93056846/04 A RU 93056846/04A RU 93056846 A RU93056846 A RU 93056846A RU 93056846 A RU93056846 A RU 93056846A
Authority
RU
Russia
Prior art keywords
treatment
integer
production
pharmaceutical composition
pyridopyrimidine derivatives
Prior art date
Application number
RU93056846/04A
Other languages
Russian (ru)
Other versions
RU2127734C1 (en
Inventor
Фуруйя Суити
Охтаки Тетсуйя
Original Assignee
Такеда Кемикал Индастриз, Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Такеда Кемикал Индастриз, Лтд. filed Critical Такеда Кемикал Индастриз, Лтд.
Publication of RU93056846A publication Critical patent/RU93056846A/en
Application granted granted Critical
Publication of RU2127734C1 publication Critical patent/RU2127734C1/en

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Claims (1)

Описано новое производное пиридопиримидина общей формулы
Figure 00000001

где n - целое число от 0 до 3; Q - -(CH2)m - целое число от 0 до 2, -O-, -S(O)p; p - целое число от 0 до 2 или -N-; R1 - R5 - заместители, или его соль. Показано их получение и использование как антагонистического агента в отношении эндотелинового рецептора. Антагонист эндотелинового рецептора является эффективным в качестве композиции для лечения острой почечной недостаточности, инфаркта миокарда, гипертензии, церебрального инфаркта, грудной ангины, артериосклероза, гепатопатии, легочной гипертензии, бронхиальной астмы, органогипофункции, вызванной операцией или трансплантацией органов.A new pyridopyrimidine derivative of the general formula is described.
Figure 00000001

where n is an integer from 0 to 3; Q - - (CH 2 ) m is an integer from 0 to 2, -O-, -S (O) p ; p is an integer from 0 to 2 or -N-; R 1 - R 5 - substituents, or its salt. Their preparation and use as an antagonistic agent for the endothelin receptor has been shown. An endothelin receptor antagonist is effective as a composition for the treatment of acute renal failure, myocardial infarction, hypertension, cerebral infarction, chest sore throat, arteriosclerosis, hepatopathy, pulmonary hypertension, bronchial asthma, organohypofunction caused by surgery or organ transplantation.
RU93056846A 1992-12-29 1993-12-28 Derivatives of pyridopyrimidine, their synthesis, a pharmaceutical composition, a method of treatment RU2127734C1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP360384/92 1992-12-29
JP36038492 1992-12-29
JP277136/93 1993-11-05
JP27713693 1993-11-05

Publications (2)

Publication Number Publication Date
RU93056846A true RU93056846A (en) 1997-04-20
RU2127734C1 RU2127734C1 (en) 1999-03-20

Family

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Family Applications (1)

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RU93056846A RU2127734C1 (en) 1992-12-29 1993-12-28 Derivatives of pyridopyrimidine, their synthesis, a pharmaceutical composition, a method of treatment

Country Status (12)

Country Link
US (1) US5654309A (en)
EP (1) EP0608565B1 (en)
KR (1) KR940014398A (en)
CN (1) CN1041090C (en)
AT (1) ATE214391T1 (en)
CA (1) CA2112425A1 (en)
DE (1) DE69331688T2 (en)
FI (1) FI935897A (en)
HU (1) HU218782B (en)
NO (1) NO301762B1 (en)
RU (1) RU2127734C1 (en)
TW (1) TW299333B (en)

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NZ322197A (en) * 1995-11-21 1999-02-25 Yamanouchi Pharma Co Ltd Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
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KR100377788B1 (en) * 2000-12-29 2003-03-26 씨제이 주식회사 Novel pyridopyrimidine derivatives, preparing process thereof and pharmaceutical composition containing the same
DE10110747A1 (en) 2001-03-07 2002-09-12 Bayer Ag Substituted 2,6-diamino-3,5-dicyano-4-aryl-pyridines and their use
US6825180B2 (en) 2001-05-18 2004-11-30 Cell Therapeutics, Inc. Pyridopyrimidine compounds and their uses
WO2006019965A2 (en) * 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
DE102004042607A1 (en) 2004-09-03 2006-03-09 Bayer Healthcare Ag Substituted phenylaminothiazoles and their use
MX2008013034A (en) * 2006-04-13 2008-10-17 Actelion Pharmaceuticals Ltd Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis.
DE102006042143A1 (en) 2006-09-08 2008-03-27 Bayer Healthcare Aktiengesellschaft Novel substituted bipyridine derivatives and their use
DE102006056739A1 (en) 2006-12-01 2008-06-05 Bayer Healthcare Ag Substituted 4-amino-3,5-dicyano-2-thiopyridines and their use
DE102006056740A1 (en) 2006-12-01 2008-06-05 Bayer Healthcare Ag Cyclic substituted 3,5-dicyano-2-thiopyridines and their use
SA08280783B1 (en) * 2007-01-11 2011-04-24 استرازينيكا ايه بي Pyridopyrimidine Derivatives as PDE4 Inhibitors
DE102007035367A1 (en) 2007-07-27 2009-01-29 Bayer Healthcare Ag Substituted aryloxazoles and their use
DE102007036076A1 (en) 2007-08-01 2009-02-05 Bayer Healthcare Aktiengesellschaft Dipeptoid Produgs and their use
DE102007061763A1 (en) 2007-12-20 2009-06-25 Bayer Healthcare Ag Substituted azabicyclic compounds and their use
DE102007061764A1 (en) 2007-12-20 2009-06-25 Bayer Healthcare Ag Anellated cyanopyridines and their use
DE102008013587A1 (en) 2008-03-11 2009-09-17 Bayer Schering Pharma Aktiengesellschaft Heteroaryl-substituted dicyanopyridines and their use
JP2011520997A (en) 2008-05-29 2011-07-21 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト 2-alkoxy-substituted dicyanopyridines and their use
DE102008062567A1 (en) 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Dipeptoid prodrugs and their use
DE102009006602A1 (en) 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituted dicyanopyridines and their amino acid ester prodrugs
EP2266984A1 (en) * 2009-06-26 2010-12-29 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis
DE102010030688A1 (en) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituted dicyanopyridines and their use
US20120058983A1 (en) 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
CN107245074B (en) * 2017-06-20 2019-04-09 牡丹江医学院附属红旗医院 Compound and preparation method thereof for treating cerebral infarction

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JPS5758347B2 (en) * 1974-04-03 1982-12-09 Hisamitsu Pharmaceutical Co
DE3601731A1 (en) * 1986-01-22 1987-07-23 Merck Patent Gmbh Pyrimidine derivatives
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TW270116B (en) * 1991-04-25 1996-02-11 Hoffmann La Roche

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