RU93050566A - THREE AND TETRACYCLIC COMPOUNDS - Google Patents
THREE AND TETRACYCLIC COMPOUNDSInfo
- Publication number
- RU93050566A RU93050566A RU93050566/04A RU93050566A RU93050566A RU 93050566 A RU93050566 A RU 93050566A RU 93050566/04 A RU93050566/04 A RU 93050566/04A RU 93050566 A RU93050566 A RU 93050566A RU 93050566 A RU93050566 A RU 93050566A
- Authority
- RU
- Russia
- Prior art keywords
- amino acid
- formula
- radical
- group
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
Claims (1)
где X обозначает группу формулы
Y обозначает кислород или серу; R1 - водород или низшую алкоксильную группу; R2 - защищенную аминогруппу, аминогруппу или радикал формулы -NH-R7(c); R3 - карбоксильную группу, функционально измененную карбоксильную группу или радикал формулы -CO-R8(d); R4 - низший алкил, арил, арил-низший алкил, водород или ацил; R5 и R6 каждый обозначают низший алкил, арил или арил-низший алкил; и R7 и R8 по отдельности или вместе обозначают радикал аминокислоты или цепь, содержащую до 20 радикалов аминокислоты, причем радикал аминокислоты, соответственно, радикалы аминокислоты может быть защищен, соответственно, могут быть защищен(ы), и причем молекула содержит самое большее 20 радикалов аминокислоты, а также их соли. Те соединения формулы 1 и те соли, где R2 обозначает радикал формулы (c), R3 обозначает радикал формулы (d) и R7 и R8 вместе обозначают радикал аминокислоты или цепь, содержащую до 20 радикалов аминокислоты, в частности такие, где радикал аминокислоты, соответственно, цепь радикалов аминокислоты не содержит защищенную(ые) группу(ы), являются ценными вспомогательными средствами ("научными инструментами") для определения биологически активной последовательности пептидов; они подходят также непосредственно в качестве лечебных средств. Остальные соединения формулы 1 и их соли являются ценными промежуточными продуктами.Compounds of the formula are described.
where X denotes a group of the formula
Y is oxygen or sulfur; R 1 is hydrogen or a lower alkoxy group; R 2 is a protected amino group, an amino group or a radical of the formula —NH — R 7 (c); R 3 is a carboxyl group, a functionally modified carboxyl group, or a radical of the formula —CO — R 8 (d); R 4 is lower alkyl, aryl, aryl-lower alkyl, hydrogen or acyl; R 5 and R 6 each represent lower alkyl, aryl or aryl-lower alkyl; and R 7 and R 8 individually or together denote an amino acid radical or a chain containing up to 20 amino acid radicals, the amino acid radical, respectively, amino acid radicals can be protected, respectively, can be protected (s), and the molecule contains at most 20 amino acid radicals, as well as their salts. Those compounds of formula 1 and those salts, where R 2 denotes a radical of formula (c), R 3 denotes a radical of formula (d) and R 7 and R 8 together denote an amino acid radical or a chain containing up to 20 amino acid radicals, in particular those where the amino acid radical, respectively, the chain of amino acid radicals does not contain protected group (s), are valuable auxiliary means ("scientific instruments") for determining the biologically active peptide sequence; they are also suitable directly as therapeutic agents. The remaining compounds of formula 1 and their salts are valuable intermediate products.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2725/92 | 1992-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU93050566A true RU93050566A (en) | 1996-05-20 |
Family
ID=
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