RU93050068A - CYCLOPEPTIDES, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS AND METHOD OF THEIR PRODUCTION, METHOD OF TREATMENT - Google Patents

CYCLOPEPTIDES, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS AND METHOD OF THEIR PRODUCTION, METHOD OF TREATMENT

Info

Publication number
RU93050068A
RU93050068A RU93050068/04A RU93050068A RU93050068A RU 93050068 A RU93050068 A RU 93050068A RU 93050068/04 A RU93050068/04 A RU 93050068/04A RU 93050068 A RU93050068 A RU 93050068A RU 93050068 A RU93050068 A RU 93050068A
Authority
RU
Russia
Prior art keywords
production
treatment
cyclopeptides
asp
pharmaceutical compositions
Prior art date
Application number
RU93050068/04A
Other languages
Russian (ru)
Other versions
RU2129563C1 (en
Original Assignee
Альфред Йонзик
Гюнтер Хельцеманн
Брунхильде Фельдинг-Хаберманн
Фридрих Риппманн
Гвидо Мельцер
Беате Дифенбах
Хорст Кесслер
Роланд Хаубнер
Йлхен Вермут
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4237456A external-priority patent/DE4237456A1/en
Application filed by Альфред Йонзик, Гюнтер Хельцеманн, Брунхильде Фельдинг-Хаберманн, Фридрих Риппманн, Гвидо Мельцер, Беате Дифенбах, Хорст Кесслер, Роланд Хаубнер, Йлхен Вермут filed Critical Альфред Йонзик
Publication of RU93050068A publication Critical patent/RU93050068A/en
Application granted granted Critical
Publication of RU2129563C1 publication Critical patent/RU2129563C1/en

Links

Claims (1)

Изобретение относится к новым циклопептидам формулы: цикло-(А-В-С-Д-Arg), где А и В независимо друг от друга, обозначают AIa, Asn, Asp, Arg, Cys, GIn, GIu, GIy, His, IIe, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr или VaI; С обозначает Asp или Asp (О-С14-алкил), Д обозначает GIy или AIa, причем по меньшей мере два из указанных аминокислотных остатков находятся в Д-форме, а также их солям. Эти соединения действуют как ингибиторы интегрина и могут в особенности применяться для профилактики и лечения заболеваний круга кровообращения и терапии опухолей.The invention relates to cyclopeptides of the formula: cyclo- (A-B-C-D-Arg), where A and B are independently of each other, denote AIa, Asn, Asp, Arg, Cys, GIn, GIu, GIy, His, IIe , Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr or VaI; C is Asp or Asp (O-C 1 -C 4 -alkyl), D is GIy or AIa, and at least two of these amino acid residues are in the D-form, as well as their salts. These compounds act as integrin inhibitors and can be used in particular for the prevention and treatment of circulatory diseases and the treatment of tumors.
RU93050068A 1992-11-06 1993-11-04 Cyclopeptides of salts thereof, method of preparation thereof, pharmaceutical compositions, method of preparing thereof, and method of treatment RU2129563C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4237456A DE4237456A1 (en) 1992-11-06 1992-11-06 cyclopeptides
DEP4237456.1 1992-11-06

Publications (2)

Publication Number Publication Date
RU93050068A true RU93050068A (en) 1996-04-27
RU2129563C1 RU2129563C1 (en) 1999-04-27

Family

ID=6472232

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93050068A RU2129563C1 (en) 1992-11-06 1993-11-04 Cyclopeptides of salts thereof, method of preparation thereof, pharmaceutical compositions, method of preparing thereof, and method of treatment

Country Status (21)

Country Link
EP (1) EP0596350B1 (en)
JP (1) JP3681764B2 (en)
KR (1) KR100238894B1 (en)
CN (1) CN1038751C (en)
AT (1) ATE154037T1 (en)
AU (1) AU666586B2 (en)
CA (1) CA2102447C (en)
CZ (1) CZ286170B6 (en)
DE (2) DE4237456A1 (en)
DK (1) DK0596350T3 (en)
ES (1) ES2105041T3 (en)
GR (1) GR3024550T3 (en)
HU (1) HU215600B (en)
MX (1) MX9306885A (en)
NO (1) NO309864B1 (en)
PL (1) PL177772B1 (en)
RU (1) RU2129563C1 (en)
SK (1) SK280597B6 (en)
TW (1) TW340849B (en)
UA (1) UA43822C2 (en)
ZA (1) ZA938281B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111372586B (en) * 2017-11-20 2023-07-25 诺麦塔制药有限公司 Composition for preventing, improving or treating bone loss diseases comprising CHP

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816449A (en) * 1984-08-09 1989-03-28 Immunetech Pharmaceuticals Immunotherapeutic anti-inflammatory peptide agents

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