AU666586B2 - Cyclopeptides - Google Patents
CyclopeptidesInfo
- Publication number
- AU666586B2 AU666586B2 AU50399/93A AU5039993A AU666586B2 AU 666586 B2 AU666586 B2 AU 666586B2 AU 50399/93 A AU50399/93 A AU 50399/93A AU 5039993 A AU5039993 A AU 5039993A AU 666586 B2 AU666586 B2 AU 666586B2
- Authority
- AU
- Australia
- Prior art keywords
- asp
- arg
- ala
- gly
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
The invention relates to novel cyclopeptides of the formula I Cyclo-(A-B-C-D-Arg) I in which A and B in each case independently of one another denote Ala, Asn, Asp, Arg, Cys, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr or Val, C denotes Asp or Asp(O-C1-4-alkyl) and D denotes Gly or Ala, at least two of the amino acid radicals indicated being present in the D-form, and their salts. These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of circulation disorders and in tumour therapy.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4237456 | 1992-11-06 | ||
DE4237456A DE4237456A1 (en) | 1992-11-06 | 1992-11-06 | cyclopeptides |
Publications (2)
Publication Number | Publication Date |
---|---|
AU5039993A AU5039993A (en) | 1994-05-19 |
AU666586B2 true AU666586B2 (en) | 1996-02-15 |
Family
ID=6472232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU50399/93A Expired AU666586B2 (en) | 1992-11-06 | 1993-11-01 | Cyclopeptides |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0596350B1 (en) |
JP (1) | JP3681764B2 (en) |
KR (1) | KR100238894B1 (en) |
CN (1) | CN1038751C (en) |
AT (1) | ATE154037T1 (en) |
AU (1) | AU666586B2 (en) |
CA (1) | CA2102447C (en) |
CZ (1) | CZ286170B6 (en) |
DE (2) | DE4237456A1 (en) |
DK (1) | DK0596350T3 (en) |
ES (1) | ES2105041T3 (en) |
GR (1) | GR3024550T3 (en) |
HU (1) | HU215600B (en) |
MX (1) | MX9306885A (en) |
NO (1) | NO309864B1 (en) |
PL (1) | PL177772B1 (en) |
RU (1) | RU2129563C1 (en) |
SK (1) | SK280597B6 (en) |
TW (1) | TW340849B (en) |
UA (1) | UA43822C2 (en) |
ZA (1) | ZA938281B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111372586B (en) * | 2017-11-20 | 2023-07-25 | 诺麦塔制药有限公司 | Composition for preventing, improving or treating bone loss diseases comprising CHP |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816449A (en) * | 1984-08-09 | 1989-03-28 | Immunetech Pharmaceuticals | Immunotherapeutic anti-inflammatory peptide agents |
-
1992
- 1992-11-06 DE DE4237456A patent/DE4237456A1/en not_active Withdrawn
-
1993
- 1993-10-23 EP EP93117204A patent/EP0596350B1/en not_active Expired - Lifetime
- 1993-10-23 ES ES93117204T patent/ES2105041T3/en not_active Expired - Lifetime
- 1993-10-23 DE DE59306654T patent/DE59306654D1/en not_active Expired - Lifetime
- 1993-10-23 AT AT93117204T patent/ATE154037T1/en active
- 1993-10-23 DK DK93117204.3T patent/DK0596350T3/en active
- 1993-10-29 KR KR1019930022666A patent/KR100238894B1/en not_active IP Right Cessation
- 1993-10-29 UA UA93002450A patent/UA43822C2/en unknown
- 1993-11-01 AU AU50399/93A patent/AU666586B2/en not_active Expired
- 1993-11-02 SK SK1217-93A patent/SK280597B6/en not_active IP Right Cessation
- 1993-11-04 RU RU93050068A patent/RU2129563C1/en active
- 1993-11-04 CZ CZ19932352A patent/CZ286170B6/en not_active IP Right Cessation
- 1993-11-04 TW TW082109233A patent/TW340849B/en active
- 1993-11-04 CA CA002102447A patent/CA2102447C/en not_active Expired - Lifetime
- 1993-11-04 MX MX9306885A patent/MX9306885A/en unknown
- 1993-11-04 PL PL93300935A patent/PL177772B1/en unknown
- 1993-11-05 NO NO934003A patent/NO309864B1/en unknown
- 1993-11-05 ZA ZA938281A patent/ZA938281B/en unknown
- 1993-11-05 HU HU9303149A patent/HU215600B/en unknown
- 1993-11-05 JP JP30962593A patent/JP3681764B2/en not_active Expired - Lifetime
- 1993-11-05 CN CN93114224A patent/CN1038751C/en not_active Expired - Lifetime
-
1997
- 1997-08-27 GR GR970402189T patent/GR3024550T3/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816449A (en) * | 1984-08-09 | 1989-03-28 | Immunetech Pharmaceuticals | Immunotherapeutic anti-inflammatory peptide agents |
Also Published As
Publication number | Publication date |
---|---|
DK0596350T3 (en) | 1997-12-29 |
PL177772B1 (en) | 2000-01-31 |
NO934003L (en) | 1994-05-09 |
AU5039993A (en) | 1994-05-19 |
NO934003D0 (en) | 1993-11-05 |
DE59306654D1 (en) | 1997-07-10 |
UA43822C2 (en) | 2002-01-15 |
CN1093090A (en) | 1994-10-05 |
NO309864B1 (en) | 2001-04-09 |
EP0596350B1 (en) | 1997-06-04 |
ZA938281B (en) | 1994-06-07 |
DE4237456A1 (en) | 1994-05-11 |
RU2129563C1 (en) | 1999-04-27 |
PL300935A1 (en) | 1994-05-16 |
HUT68321A (en) | 1995-06-28 |
EP0596350A1 (en) | 1994-05-11 |
CN1038751C (en) | 1998-06-17 |
CA2102447C (en) | 2007-04-10 |
JP3681764B2 (en) | 2005-08-10 |
CA2102447A1 (en) | 1994-05-07 |
TW340849B (en) | 1998-09-21 |
KR940011479A (en) | 1994-06-21 |
MX9306885A (en) | 1995-01-31 |
JPH0892282A (en) | 1996-04-09 |
ES2105041T3 (en) | 1997-10-16 |
SK280597B6 (en) | 2000-04-10 |
SK121793A3 (en) | 1995-06-07 |
ATE154037T1 (en) | 1997-06-15 |
KR100238894B1 (en) | 2000-01-15 |
CZ286170B6 (en) | 2000-02-16 |
HU215600B (en) | 1999-01-28 |
GR3024550T3 (en) | 1997-12-31 |
CZ235293A3 (en) | 1994-07-13 |
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