RU93042473A - METHOD FOR Acylating A 7-Amino Group Of Cephalosporan Ring - Google Patents

METHOD FOR Acylating A 7-Amino Group Of Cephalosporan Ring

Info

Publication number
RU93042473A
RU93042473A RU93042473/04A RU93042473A RU93042473A RU 93042473 A RU93042473 A RU 93042473A RU 93042473/04 A RU93042473/04 A RU 93042473/04A RU 93042473 A RU93042473 A RU 93042473A RU 93042473 A RU93042473 A RU 93042473A
Authority
RU
Russia
Prior art keywords
phenyl
amino group
azyl
acylating
azide
Prior art date
Application number
RU93042473/04A
Other languages
Russian (ru)
Other versions
RU2109017C1 (en
Inventor
Зенони Маурицио
Фиганти Клаудио
Original Assignee
Финпаел С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929216759A external-priority patent/GB9216759D0/en
Application filed by Финпаел С.п.А. filed Critical Финпаел С.п.А.
Publication of RU93042473A publication Critical patent/RU93042473A/en
Application granted granted Critical
Publication of RU2109017C1 publication Critical patent/RU2109017C1/en

Links

Claims (1)

Способ ацилирования 7-аминогруппы цефалоспоранового кольца, в соответствии с которым получают 7-AGA аминотиазолилзащищенный аддукт ацилированием указанной аминогруппы аминотиазолилуксусной кислотой, у которой аминогруппа защищена фенилацетильной или феноксиацетильной группой, с последующим снятием защиты аминогруппы водным гидролизом в присутствии пенициллин G амидазы или соответственно пенициллин V амидазы.A method for acylating the 7-amino group of a cephalosporan ring, according to which a 7-AGA aminothiazolyl-protected adduct is obtained by acylating the indicated amino group with an aminothiazolyl acetic acid, in which the amino group is protected with a phenylacetyl or phenoxyacetyl group, followed by deprotection of the amino group with an aminyl azylinzylinyl phenyl azylinzyl phenyl azylinzyl phenyl azyl azylinzyl phenyl azide phenyl aminyl azide hydroxyzyl benzyl azide hydrolyzyl phenyl azide hydroxymethyl azyl hydroxymethylmethylmethylmethyl aromatic hydroxymethylmethylmethyl benzyl benzyl amine hydroxyzylaminoethyl azyl hydroxymethyl benzyl azyl aminobenzylate; .
RU93042473A 1992-08-07 1993-08-06 Method of acylation of 7-amino group of cephalosporane ring, n-phenylacetyl-3-substituted cephalosporine RU2109017C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929216759A GB9216759D0 (en) 1992-08-07 1992-08-07 Process for the production of 7-amino thiazolyl cephalosporins
GB9216759.2 1992-08-07

Publications (2)

Publication Number Publication Date
RU93042473A true RU93042473A (en) 1996-09-20
RU2109017C1 RU2109017C1 (en) 1998-04-20

Family

ID=10719967

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93042473A RU2109017C1 (en) 1992-08-07 1993-08-06 Method of acylation of 7-amino group of cephalosporane ring, n-phenylacetyl-3-substituted cephalosporine

Country Status (24)

Country Link
US (2) US5441874A (en)
EP (1) EP0582102B1 (en)
JP (1) JPH06172364A (en)
KR (1) KR100268959B1 (en)
CN (1) CN1045297C (en)
AT (1) ATE161052T1 (en)
AU (1) AU658761B2 (en)
BR (1) BR9303272A (en)
CA (1) CA2103696A1 (en)
DE (1) DE69315634T2 (en)
DK (1) DK0582102T3 (en)
ES (1) ES2110032T3 (en)
FI (1) FI933486A (en)
GB (1) GB9216759D0 (en)
GR (1) GR3025807T3 (en)
HU (1) HUT64962A (en)
IL (1) IL106574A (en)
IN (1) IN176319B (en)
MX (1) MX9304790A (en)
NZ (1) NZ248307A (en)
PL (1) PL299946A1 (en)
RU (1) RU2109017C1 (en)
TW (1) TW242627B (en)
ZA (1) ZA935688B (en)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
KR100345847B1 (en) * 1994-08-13 2002-12-16 제일제당주식회사 Process for preparing cefazolin by using immobilized enzyme
IT1295935B1 (en) 1997-10-30 1999-05-28 Acs Dobfar Spa AMINOTHIAZOLE DERIVATIVES USEFUL IN THE PREPARATION OF B-LACTAMICS ANTIBIOTICS
KR19990045922A (en) * 1999-02-13 1999-06-25 오판원 Sponge shoe sloe manufacturing method for female shoes
EP1704153A2 (en) * 2004-01-16 2006-09-27 Wockhardt Limited Improved process for the production of cefotaxime sodium
US20070111980A1 (en) * 2004-07-16 2007-05-17 Bandi Parthasaradhi Reddy Process for preparing pure cephalosporine intermediates
WO2007013043A2 (en) * 2005-07-29 2007-02-01 Ranbaxy Laboratories Limited Processes for the preparation of 7-amino-3-vinyl cephalosporanic acid
KR100760429B1 (en) * 2006-03-03 2007-10-04 한미약품 주식회사 Improved method for the preparation of 2-aminothiazole-4-yl acetylchloride hydrochloride
CN101045733B (en) * 2007-01-26 2011-11-16 浙江永宁药业股份有限公司 Preparation method of cefotiam chloride
CN103012432B (en) * 2012-12-04 2015-06-03 山东鑫泉医药有限公司 Method for preparing hydrochloride of high purity cefotiam midbody
CN103601737B (en) * 2013-12-04 2016-02-03 哈药集团制药总厂 A kind of preparation method of cefotiam hydrochloride
CN104356146B (en) * 2014-11-14 2016-09-14 浙江浙邦制药有限公司 A kind of preparation method of cefotiam chloride
CN109336906B (en) * 2018-11-21 2020-05-22 山东罗欣药业集团股份有限公司 Drying process of cefotiam hydrochloride

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4948760B1 (en) * 1970-12-25 1974-12-23
DE2355078A1 (en) * 1973-11-03 1975-05-07 Bayer Ag PROCESS FOR THE PREPARATION OF 7-AMINO-DELTA HIGH 3-CEPHEM DERIVATIVES
NZ176206A (en) * 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
GB1476981A (en) * 1974-06-05 1977-06-16 Bristol Myers Co Substituted penicillanic acids
US4091245A (en) * 1974-06-26 1978-05-23 Toyota Jidosha Kogyo Kabushiki Kaisha Distributor electrode assembly having outer resistive layer for suppressing noise
US4500526A (en) * 1982-06-28 1985-02-19 Bristol-Myers Company Cephalosporin derivatives
US4507487A (en) * 1982-09-23 1985-03-26 Bristol-Myers Company Chemical compounds
ZA874696B (en) * 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
EP0612751A3 (en) * 1988-03-16 1994-09-21 Eisai Co Ltd Compounds for the preparation of cephem derivatives.
NO175152C (en) * 1988-10-07 1994-09-07 Sankyo Co Analogous Process for Preparing Therapeutically Active 3-Aryloxymethyl Cephalosporin Derivatives
AU649275B2 (en) * 1990-11-06 1994-05-19 Bristol-Myers Squibb Company Prodrugs for beta-lactamase and uses thereof
EP0508375A3 (en) * 1991-04-12 1992-12-09 Lucky Ltd. Novel cephalosporin compounds and processes for preparation thereof

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