RU93042473A - METHOD FOR Acylating A 7-Amino Group Of Cephalosporan Ring - Google Patents
METHOD FOR Acylating A 7-Amino Group Of Cephalosporan RingInfo
- Publication number
- RU93042473A RU93042473A RU93042473/04A RU93042473A RU93042473A RU 93042473 A RU93042473 A RU 93042473A RU 93042473/04 A RU93042473/04 A RU 93042473/04A RU 93042473 A RU93042473 A RU 93042473A RU 93042473 A RU93042473 A RU 93042473A
- Authority
- RU
- Russia
- Prior art keywords
- phenyl
- amino group
- azyl
- acylating
- azide
- Prior art date
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 3
- -1 phenylacetyl Chemical group 0.000 claims 3
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N Amino radical Chemical group [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims 2
- JBGVPTVXEXCTEG-UHFFFAOYSA-N 2-amino-2-(1,3-thiazol-2-yl)acetic acid Chemical compound OC(=O)C(N)C1=NC=CS1 JBGVPTVXEXCTEG-UHFFFAOYSA-N 0.000 claims 1
- CTRLRINCMYICJO-UHFFFAOYSA-N Phenyl azide Chemical compound [N-]=[N+]=NC1=CC=CC=C1 CTRLRINCMYICJO-UHFFFAOYSA-N 0.000 claims 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide Chemical compound [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 1
- UDLLFLQFQMACJB-UHFFFAOYSA-N azidomethylbenzene Chemical compound [N-]=[N+]=NCC1=CC=CC=C1 UDLLFLQFQMACJB-UHFFFAOYSA-N 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929216759A GB9216759D0 (en) | 1992-08-07 | 1992-08-07 | Process for the production of 7-amino thiazolyl cephalosporins |
GB9216759.2 | 1992-08-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93042473A true RU93042473A (en) | 1996-09-20 |
RU2109017C1 RU2109017C1 (en) | 1998-04-20 |
Family
ID=10719967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93042473A RU2109017C1 (en) | 1992-08-07 | 1993-08-06 | Method of acylation of 7-amino group of cephalosporane ring, n-phenylacetyl-3-substituted cephalosporine |
Country Status (24)
Country | Link |
---|---|
US (2) | US5441874A (en) |
EP (1) | EP0582102B1 (en) |
JP (1) | JPH06172364A (en) |
KR (1) | KR100268959B1 (en) |
CN (1) | CN1045297C (en) |
AT (1) | ATE161052T1 (en) |
AU (1) | AU658761B2 (en) |
BR (1) | BR9303272A (en) |
CA (1) | CA2103696A1 (en) |
DE (1) | DE69315634T2 (en) |
DK (1) | DK0582102T3 (en) |
ES (1) | ES2110032T3 (en) |
FI (1) | FI933486A (en) |
GB (1) | GB9216759D0 (en) |
GR (1) | GR3025807T3 (en) |
HU (1) | HUT64962A (en) |
IL (1) | IL106574A (en) |
IN (1) | IN176319B (en) |
MX (1) | MX9304790A (en) |
NZ (1) | NZ248307A (en) |
PL (1) | PL299946A1 (en) |
RU (1) | RU2109017C1 (en) |
TW (1) | TW242627B (en) |
ZA (1) | ZA935688B (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100345847B1 (en) * | 1994-08-13 | 2002-12-16 | 제일제당주식회사 | Process for preparing cefazolin by using immobilized enzyme |
IT1295935B1 (en) | 1997-10-30 | 1999-05-28 | Acs Dobfar Spa | AMINOTHIAZOLE DERIVATIVES USEFUL IN THE PREPARATION OF B-LACTAMICS ANTIBIOTICS |
KR19990045922A (en) * | 1999-02-13 | 1999-06-25 | 오판원 | Sponge shoe sloe manufacturing method for female shoes |
EP1704153A2 (en) * | 2004-01-16 | 2006-09-27 | Wockhardt Limited | Improved process for the production of cefotaxime sodium |
US20070111980A1 (en) * | 2004-07-16 | 2007-05-17 | Bandi Parthasaradhi Reddy | Process for preparing pure cephalosporine intermediates |
WO2007013043A2 (en) * | 2005-07-29 | 2007-02-01 | Ranbaxy Laboratories Limited | Processes for the preparation of 7-amino-3-vinyl cephalosporanic acid |
KR100760429B1 (en) * | 2006-03-03 | 2007-10-04 | 한미약품 주식회사 | Improved method for the preparation of 2-aminothiazole-4-yl acetylchloride hydrochloride |
CN101045733B (en) * | 2007-01-26 | 2011-11-16 | 浙江永宁药业股份有限公司 | Preparation method of cefotiam chloride |
CN103012432B (en) * | 2012-12-04 | 2015-06-03 | 山东鑫泉医药有限公司 | Method for preparing hydrochloride of high purity cefotiam midbody |
CN103601737B (en) * | 2013-12-04 | 2016-02-03 | 哈药集团制药总厂 | A kind of preparation method of cefotiam hydrochloride |
CN104356146B (en) * | 2014-11-14 | 2016-09-14 | 浙江浙邦制药有限公司 | A kind of preparation method of cefotiam chloride |
CN109336906B (en) * | 2018-11-21 | 2020-05-22 | 山东罗欣药业集团股份有限公司 | Drying process of cefotiam hydrochloride |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4948760B1 (en) * | 1970-12-25 | 1974-12-23 | ||
DE2355078A1 (en) * | 1973-11-03 | 1975-05-07 | Bayer Ag | PROCESS FOR THE PREPARATION OF 7-AMINO-DELTA HIGH 3-CEPHEM DERIVATIVES |
NZ176206A (en) * | 1973-12-25 | 1978-03-06 | Takeda Chemical Industries Ltd | Cephalosporins |
GB1476981A (en) * | 1974-06-05 | 1977-06-16 | Bristol Myers Co | Substituted penicillanic acids |
US4091245A (en) * | 1974-06-26 | 1978-05-23 | Toyota Jidosha Kogyo Kabushiki Kaisha | Distributor electrode assembly having outer resistive layer for suppressing noise |
US4500526A (en) * | 1982-06-28 | 1985-02-19 | Bristol-Myers Company | Cephalosporin derivatives |
US4507487A (en) * | 1982-09-23 | 1985-03-26 | Bristol-Myers Company | Chemical compounds |
ZA874696B (en) * | 1986-07-03 | 1988-01-04 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Acyl derivatives |
EP0612751A3 (en) * | 1988-03-16 | 1994-09-21 | Eisai Co Ltd | Compounds for the preparation of cephem derivatives. |
NO175152C (en) * | 1988-10-07 | 1994-09-07 | Sankyo Co | Analogous Process for Preparing Therapeutically Active 3-Aryloxymethyl Cephalosporin Derivatives |
AU649275B2 (en) * | 1990-11-06 | 1994-05-19 | Bristol-Myers Squibb Company | Prodrugs for beta-lactamase and uses thereof |
EP0508375A3 (en) * | 1991-04-12 | 1992-12-09 | Lucky Ltd. | Novel cephalosporin compounds and processes for preparation thereof |
-
1992
- 1992-08-07 GB GB929216759A patent/GB9216759D0/en active Pending
-
1993
- 1993-07-07 US US08/086,849 patent/US5441874A/en not_active Expired - Fee Related
- 1993-07-09 AT AT93111006T patent/ATE161052T1/en not_active IP Right Cessation
- 1993-07-09 ES ES93111006T patent/ES2110032T3/en not_active Expired - Lifetime
- 1993-07-09 DK DK93111006T patent/DK0582102T3/en active
- 1993-07-09 DE DE69315634T patent/DE69315634T2/en not_active Expired - Fee Related
- 1993-07-09 EP EP93111006A patent/EP0582102B1/en not_active Expired - Lifetime
- 1993-08-02 NZ NZ248307A patent/NZ248307A/en unknown
- 1993-08-02 BR BR9303272A patent/BR9303272A/en not_active Application Discontinuation
- 1993-08-02 IN IN431CA1993 patent/IN176319B/en unknown
- 1993-08-03 IL IL10657493A patent/IL106574A/en not_active IP Right Cessation
- 1993-08-04 AU AU44452/93A patent/AU658761B2/en not_active Ceased
- 1993-08-05 KR KR1019930015169A patent/KR100268959B1/en not_active IP Right Cessation
- 1993-08-05 ZA ZA935688A patent/ZA935688B/en unknown
- 1993-08-05 PL PL29994693A patent/PL299946A1/en unknown
- 1993-08-06 CA CA002103696A patent/CA2103696A1/en not_active Abandoned
- 1993-08-06 HU HU9302292A patent/HUT64962A/en unknown
- 1993-08-06 FI FI933486A patent/FI933486A/en unknown
- 1993-08-06 JP JP5196262A patent/JPH06172364A/en active Pending
- 1993-08-06 TW TW082106314A patent/TW242627B/zh active
- 1993-08-06 RU RU93042473A patent/RU2109017C1/en active
- 1993-08-06 CN CN93109357A patent/CN1045297C/en not_active Expired - Fee Related
- 1993-08-06 MX MX9304790A patent/MX9304790A/en unknown
-
1995
- 1995-05-01 US US08/432,072 patent/US5654425A/en not_active Expired - Fee Related
-
1997
- 1997-12-30 GR GR970403453T patent/GR3025807T3/en unknown
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