RU93015116A - METHOD OF TREATMENT OF GENERALIZED TUBERCULOSIS PROCESS - Google Patents

METHOD OF TREATMENT OF GENERALIZED TUBERCULOSIS PROCESS

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Publication number
RU93015116A
RU93015116A RU93015116/14A RU93015116A RU93015116A RU 93015116 A RU93015116 A RU 93015116A RU 93015116/14 A RU93015116/14 A RU 93015116/14A RU 93015116 A RU93015116 A RU 93015116A RU 93015116 A RU93015116 A RU 93015116A
Authority
RU
Russia
Prior art keywords
treatment
dihydrogen
tuberculosis process
generalized
generalized tuberculosis
Prior art date
Application number
RU93015116/14A
Other languages
Russian (ru)
Other versions
RU2087146C1 (en
Inventor
В.А. Шкурупий
Ю.Н. Курунов
Т.Г. Чернова
Original Assignee
Новосибирский медицинский институт
Filing date
Publication date
Application filed by Новосибирский медицинский институт filed Critical Новосибирский медицинский институт
Priority to RU93015116A priority Critical patent/RU2087146C1/en
Priority claimed from RU93015116A external-priority patent/RU2087146C1/en
Publication of RU93015116A publication Critical patent/RU93015116A/en
Application granted granted Critical
Publication of RU2087146C1 publication Critical patent/RU2087146C1/en

Links

Claims (1)

Способ лечения генерализованного туберкулезного процесса относится к экспериментальной медицине, а именно к лечению генерализованного туберкулезного процесса. Способ заключается в том, что подопытному животному вводят внутрибрюшинно в интермиттирующем режиме (с интервалом 3 суток) комплексное соединение изониазида и диальдегиддекстрана (изоникотиноилгидразон диальдегиддекстран) в дозе 14 мг на 1 кг массы тела, причем комплексное соединение изоникотиноилгидразон диальдегиддекстран получают путем перйодатного окисления декстрана перйодатом натрия до диальдегиддекстрана с остановкой реакции 100%-ным этиленгликолем и последующей стабилизацией оснований Шиффа в конечном продукте боргидратом натрия. Предлагаемый способ позволяет повысить эффективность лечения и снизить токсические поражения печени противотуберкулезными препаратами.The method of treatment of generalized tuberculosis process relates to experimental medicine, namely to the treatment of generalized tuberculosis process. The method consists in administering intraperitoneally to the experimental animal in the intermittent mode (with an interval of 3 days) a search pattern for the search beard and dialdehydederane (isonicotinoylhydrazone dialdehydedextran) in a dose of 14 mg per 1 kg of body weight, and the complex compound isonicotinohydrozone dialdehydehydrohydric dihydrogen dihydrogen dihydrogen-containing dehydrogen dihydride. to dialdehyde dextran with stopping the reaction with 100% ethylene glycol and subsequent stabilization of Schiff bases in the final product with borohydrate and Tria. The proposed method allows to increase the effectiveness of treatment and reduce toxic liver damage with anti-TB drugs.
RU93015116A 1993-03-23 1993-03-23 Method of treatment the general tuberculosis process in experiment RU2087146C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU93015116A RU2087146C1 (en) 1993-03-23 1993-03-23 Method of treatment the general tuberculosis process in experiment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU93015116A RU2087146C1 (en) 1993-03-23 1993-03-23 Method of treatment the general tuberculosis process in experiment

Publications (2)

Publication Number Publication Date
RU93015116A true RU93015116A (en) 1996-06-10
RU2087146C1 RU2087146C1 (en) 1997-08-20

Family

ID=20139097

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93015116A RU2087146C1 (en) 1993-03-23 1993-03-23 Method of treatment the general tuberculosis process in experiment

Country Status (1)

Country Link
RU (1) RU2087146C1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2496475C2 (en) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Pharmaceutical composition and kit for treating bacterial infections
RU2491935C1 (en) * 2012-03-16 2013-09-10 Закрытое акционерное общество "ФАРМАПЭК" Antituberculous composition of isoniaside, antituberculous composition, antituberculous remedy, antituberculous preparation, and methods for producing it
RU2496868C1 (en) * 2012-06-19 2013-10-27 Федеральное государственное бюджетное учреждение "Центральный научно-исследовательский институт туберкулеза" Российской академии медицинских наук METHOD TO TREAT EXPERIMENTAL TUBERCULOSIS IN MICE OF LINE C57BL/6(H-2b)
RU2592617C1 (en) * 2015-04-30 2016-07-27 Акционерное общество "Федеральный научно-производственный центр "Алтай" Method of oxidised dextran producing
RU2592618C1 (en) * 2015-04-30 2016-07-27 Акционерное общество "Федеральный научно-производственный центр "Алтай" Method of dextranal producing

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