RU93005244A

RU93005244A - DERIVATIVES OF QUINOLINE, PHARMACEUTICAL COMPOSITION

Info

Publication number: RU93005244A
Application number: RU93005244/04A
Authority: RU
Inventors: Джилмор Джереми; Тодд Алек
Original assignee: Лилли Индастриз Лимитед
Priority date: 1990-07-31
Filing date: 1993-06-07
Publication date: 1996-05-10

Claims

Compound of formula

wherein R ¹ - hydrogen, halo, C ₁ _- ₄ alkyl, C ₁ _- ₄ -alkoxy, nitrile, optionally protected carboxyl group, optionally protected tetrazolyl, trihalomethyl, hydroxy-C ₁ = 00- ₄ -alkyl aldegin - CH ₂ Z, —CH═CH — Z or —CH ₂ CH ₂ Z, where Z is optionally protected carboxyl group or optionally protected tetrazolyl; R ² - halo, nitrile, an optionally protected acid group or -CONR ⁷ R ⁸ where R ⁷ and R ⁸ - are each hydrogen or C ₁ _- ₄ alkyl, R ³ and R ⁴ - are each hydrogen, C ₁ _- ₄ alkyl optionally substituted phenyl, or C ₁ _- ₄ alkyl substituted by -CONR ⁷ R ⁸ or optionally protected acid group;

where W - -CH = CH-, CH = N-, -N = CH-, -O- or -S-, R ⁹ - H, halo, C ₁ _- ₄ alkyl, C ₁ _- ₄ -alkoxy or trihalomethyl and R ¹ ⁰ is hydrogen, C ₁ _- ₄ alkyl,
C ₂ _- ₆ -alkenyl, C ₃ _- ₆ -cycloalkyl or C ₁ _- ₄ alkyl, C ₃ _- ₆ -cycloalkyl; R ⁶ - hydrogen or C ₁ _- ₄ alkyl; X - -O- (CH ₂ ) _n CR ¹ ¹ CR ¹ ² or -CR ¹ ¹ -Cr ¹ ² , where R ¹ ¹ , R ¹ ² , R ¹ ³ and R ¹ ⁴ - each hydrogen or C ₁ _- ₄ -alkyl, and n - 0, 1 or 2; Y - -O-CR ¹ ⁵ R ¹ ⁶ -, CR ¹ ⁵ = CR ¹ ⁶ or Cr ¹ ⁵ R ¹ ⁶ • CR ¹ ⁷ R ¹ ⁸ -, where R ¹ ⁵ , R ¹ ⁶ , R ¹ ⁷ and R ¹ ⁸ - each hydrogen or C ₁ _- ₄ alkyl; or their salt. Unprotected compounds are active leukotrin receptor antagonists.