RU92016488A - METHOD OF OBTAINING WATER SUSPENSION - Google Patents

METHOD OF OBTAINING WATER SUSPENSION

Info

Publication number
RU92016488A
RU92016488A RU92016488/14A RU92016488A RU92016488A RU 92016488 A RU92016488 A RU 92016488A RU 92016488/14 A RU92016488/14 A RU 92016488/14A RU 92016488 A RU92016488 A RU 92016488A RU 92016488 A RU92016488 A RU 92016488A
Authority
RU
Russia
Prior art keywords
water suspension
obtaining water
pentyloxyphenyl
thiazolidin
ethoxy
Prior art date
Application number
RU92016488/14A
Other languages
Russian (ru)
Other versions
RU2098094C1 (en
Inventor
Накаяма Хисаюки
Усио Казуцити
Инада Катеухиро
Original Assignee
Сендзю Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сендзю Фармасьютикал Ко., Лтд. filed Critical Сендзю Фармасьютикал Ко., Лтд.
Priority claimed from PCT/JP1991/000932 external-priority patent/WO1992017174A1/en
Publication of RU92016488A publication Critical patent/RU92016488A/en
Application granted granted Critical
Publication of RU2098094C1 publication Critical patent/RU2098094C1/en

Links

Claims (1)

Способ получения водной суспензии. Стабильная водная суспензия, используемая для приготовления глазных капель при лечении кератопатии и других заболеваний, содержащая 5-(3-этокси-4-н-пентилоксифенил) тиазолидин-2,4-дион, может быть приготовлена добавлением кислоты к водному раствору, содержащему одно или более соединений, выбранных из группы, состоящей из поливинилового спирта, поливинилпирролидона, оксипропилметилцеллюлозы, метилцеллюлозы и оксиэтилцеллюлозы, и 5(3-этокси-4-н-пентилоксифенил)тиазолидин-2,4-диод, и имеющему значение рН не ниже 8 для регулирования водного раствора до значения рН не выше 7.A method of obtaining an aqueous suspension. A stable aqueous suspension used to prepare eye drops in the treatment of keratopathy and other diseases containing 5- (3-ethoxy-4-n-pentyloxyphenyl) thiazolidin-2,4-dione can be prepared by adding acid to an aqueous solution containing one or more compounds selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, hydroxypropylmethylcellulose, methylcellulose, and hydroxyethylcellulose, and 5 (3-ethoxy-4-n-pentyloxyphenyl) thiazolidin-2,4-diode, and having a pH value not lower than 8 for regulation water growth ora to a pH not higher than 7.
RU9292016488A 1991-03-27 1991-07-11 Method of preparing an aqueous suspension and an aqueous ophthalmic preparation RU2098094C1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP062909/1991 1991-03-27
JP6290991 1991-03-27
JP062909/91 1991-03-27
PCT/JP1991/000932 WO1992017174A1 (en) 1991-03-27 1991-07-11 Process for preparing aqueous suspension

Publications (2)

Publication Number Publication Date
RU92016488A true RU92016488A (en) 1995-04-20
RU2098094C1 RU2098094C1 (en) 1997-12-10

Family

ID=13213855

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9292016488A RU2098094C1 (en) 1991-03-27 1991-07-11 Method of preparing an aqueous suspension and an aqueous ophthalmic preparation

Country Status (14)

Country Link
US (1) US5366985A (en)
EP (1) EP0531529B1 (en)
KR (1) KR0181973B1 (en)
AT (1) ATE145328T1 (en)
AU (2) AU650889B2 (en)
CA (1) CA2083842A1 (en)
DE (1) DE69123248T2 (en)
DK (1) DK0531529T3 (en)
ES (1) ES2094227T3 (en)
FI (1) FI100694B (en)
NO (1) NO301215B1 (en)
RU (1) RU2098094C1 (en)
TW (1) TW207500B (en)
WO (1) WO1992017174A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1284030B1 (en) * 1996-06-18 1998-05-08 Solchem Italiana Spa METHOD FOR THE PRODUCTION OF STABLE AQUEOUS SUSPENSIONS, USEFUL IN PHARMACEUTICAL COMPOSITIONS
US6274634B1 (en) 1997-05-14 2001-08-14 Senju Pharmaceutical Co., Ltd. Aqueous suspension preparations with excellent redispersibility
US6858230B1 (en) * 1999-04-12 2005-02-22 Shionogi & Co., Ltd. Process for producing medicinal composition of basic hydrophobic medicinal compound
US7947295B2 (en) * 2003-06-13 2011-05-24 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
KR101147046B1 (en) * 2003-06-13 2012-05-22 알콘, 인코퍼레이티드 Ophthalmic compositions containing a synergistic combination of two polymers
TWI363626B (en) * 2004-11-15 2012-05-11 Otsuka Pharma Co Ltd Aqueous ophthalmic suspension of crystalline rebamipide
US20070110812A1 (en) * 2005-11-14 2007-05-17 Bausch & Lomb Incorporated Ophthalmic composition for dry eye therapy
TW200808375A (en) * 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof
TWI415629B (en) * 2006-10-26 2013-11-21 Otsuka Pharma Co Ltd Aqueous pharmaceutical suspensions containing rebamipide and manufacturing process thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6610081A (en) * 1980-01-24 1981-07-30 Senju Pharmaceutical Co., Ltd. Thiazolidine derivatives
JPS6143114A (en) * 1984-08-03 1986-03-01 Takeda Chem Ind Ltd Eye drop for remedy of iridal and ciliary disease
US5192535A (en) * 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions

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