RU92016360A - VISUALIZING AGENT, COMPOSITION, METHOD OF DETECTING MATERIAL, PLASMIDES, CELL, METHODS OF OBTAINING POLYPEPTIDE, POLYPEPTIDE, METHOD OF RECOVERY POLYPEPTIDE CONFORMATION - Google Patents

VISUALIZING AGENT, COMPOSITION, METHOD OF DETECTING MATERIAL, PLASMIDES, CELL, METHODS OF OBTAINING POLYPEPTIDE, POLYPEPTIDE, METHOD OF RECOVERY POLYPEPTIDE CONFORMATION

Info

Publication number
RU92016360A
RU92016360A RU92016360/13A RU92016360A RU92016360A RU 92016360 A RU92016360 A RU 92016360A RU 92016360/13 A RU92016360/13 A RU 92016360/13A RU 92016360 A RU92016360 A RU 92016360A RU 92016360 A RU92016360 A RU 92016360A
Authority
RU
Russia
Prior art keywords
polypeptide
fibrin
methods
binding
polypeptides
Prior art date
Application number
RU92016360/13A
Other languages
Russian (ru)
Other versions
RU2109750C1 (en
Inventor
Вогель Тиква
Леванон Авигдор
Вербер Моуш
Гай Рэчел
Пэнет Амос
Хартман Джекоб
Шейкт Хадасса
Original Assignee
Био-Текнолоджи Дженерал Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/526,397 external-priority patent/US5270030A/en
Application filed by Био-Текнолоджи Дженерал Корп. filed Critical Био-Текнолоджи Дженерал Корп.
Publication of RU92016360A publication Critical patent/RU92016360A/en
Application granted granted Critical
Publication of RU2109750C1 publication Critical patent/RU2109750C1/en

Links

Claims (1)

Предлагаемый визуализирующий агент содержит полипептид, меченный визуализируемым маркером, таким, как полипептид, включающий аминокислотную последовательность, по существу содержащуюся в связывающем фибрин человеческом фибронектине, и способный связываться с фибрином. Кроме того, в соответствии с настоящим изобретением предлагается способ использования визуализирующего агента для визуализации содержащего фибрина материала, в частности тромба или атеросклеротической бляшки. Кроме того, предлагаются плазмиды для экспрессии полипептидов, включающие аминокислотную последовательность, по существу содержащуюся в связывающем фибрин человеческом фибронектине и способную связываться с фибрином, а также хозяева, содержащие плазмиды, способы получения полипептидов, способы лечения, использующие полипептиды, и способы извлечения, размножения и повторного окисления полипептидов. В соответствии с настоящим изобретением предлагаются очищенные полипептиды, по существу не содержащие других материалов человеческой природы, с аминокислотной последовательностью, которая находится в связывающем фибрин человеческом фибронектине и способна связываться с фибрином.The proposed imaging agent contains a polypeptide labeled with a visualizable marker, such as a polypeptide, comprising an amino acid sequence essentially contained in human fibronectin fibrin-binding fibrin, and capable of binding to fibrin. In addition, in accordance with the present invention, a method is proposed for using an imaging agent to visualize a material containing fibrin, in particular a thrombus or an atherosclerotic plaque. In addition, plasmids are proposed for the expression of polypeptides, including the amino acid sequence essentially contained in human fibronectin fibrin binding and capable of binding to fibrin, as well as hosts containing plasmids, methods for producing polypeptides, methods of treatment using polypeptides, and methods for extracting, reproducing and re-oxidation of polypeptides. In accordance with the present invention, purified polypeptides are proposed that are substantially free of other materials of human nature, with an amino acid sequence that is found in human fibronectin fibrin binding and is capable of binding to fibrin.
RU92016360/13A 1990-05-21 1991-05-21 Visualizing agent and a method of detection of fibrin-containing material RU2109750C1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/526,397 US5270030A (en) 1988-12-29 1990-05-21 Fibrin binding domain polypeptide and method of producing
US526.397 1990-05-21
US526397 1990-05-21
PCT/US1991/003584 WO1991017765A1 (en) 1990-05-21 1991-05-21 Fibrin binding domain polypeptides and uses and methods of producing same

Publications (2)

Publication Number Publication Date
RU92016360A true RU92016360A (en) 1996-04-20
RU2109750C1 RU2109750C1 (en) 1998-04-27

Family

ID=24097174

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92016360/13A RU2109750C1 (en) 1990-05-21 1991-05-21 Visualizing agent and a method of detection of fibrin-containing material

Country Status (18)

Country Link
US (4) US5270030A (en)
EP (1) EP0651799B1 (en)
JP (1) JP3419772B2 (en)
AT (1) ATE183545T1 (en)
AU (1) AU660618B2 (en)
CA (1) CA2083271C (en)
DE (1) DE69131539T2 (en)
DK (1) DK0651799T3 (en)
ES (1) ES2137928T3 (en)
FI (1) FI108298B (en)
GR (1) GR3031708T3 (en)
HK (1) HK1013255A1 (en)
HU (1) HU216302B (en)
IL (1) IL98197A0 (en)
NO (1) NO310559B1 (en)
NZ (1) NZ238208A (en)
RU (1) RU2109750C1 (en)
WO (1) WO1991017765A1 (en)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972890A (en) * 1988-05-02 1999-10-26 New England Deaconess Hospital Corporation Synthetic peptides for arterial imaging
US7087722B1 (en) * 1988-12-29 2006-08-08 Savient Pharmaceuticals, Inc. Fibrin binding domain polypeptides and uses and methods of producing same
US5679320A (en) * 1988-12-29 1997-10-21 Bio-Technology General Corp. Fibrin binding domain polypeptides and uses and methods of producing same
US5270030A (en) * 1988-12-29 1993-12-14 Bio-Technology General Corp. Fibrin binding domain polypeptide and method of producing
US6034233A (en) * 1990-05-04 2000-03-07 Isis Pharmaceuticals Inc. 2'-O-alkylated oligoribonucleotides and phosphorothioate analogs complementary to portions of the HIV genome
US5792742A (en) * 1991-06-14 1998-08-11 New York University Fibrin-binding peptide fragments of fibronectin
US5668104A (en) * 1992-03-31 1997-09-16 Toray Industries, Inc. Hematopoietic stem cell growth-promoting compositions containing a fibroblast-derived fragment of fibronectin and a growth factor, and methods employing them in vitro or in vivo
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
DK145092D0 (en) * 1992-12-03 1992-12-03 Novo Nordisk As
US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US6218529B1 (en) * 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
AU3126097A (en) * 1996-05-16 1997-12-05 The Texas A & M University System Collagen binding protein compositions and methods of use
US20030176663A1 (en) * 1998-05-11 2003-09-18 Eidgenossische Technische Hochscule Specific binding molecules for scintigraphy
US7049289B1 (en) * 1998-05-15 2006-05-23 Amersham Plc Labelled glutamine and lysine analogues
IN190822B (en) 1998-12-24 2003-08-23 Council Scient Ind Res
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6685914B1 (en) * 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
AU2001242432B2 (en) * 2000-02-24 2007-11-08 Eidgenossische Technische Hochschule Zurich Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis
US20020197700A1 (en) * 2000-09-07 2002-12-26 Schering Ag Receptor of the EDb-fibronectin domains
US6714808B2 (en) * 2000-10-03 2004-03-30 University Of Arkansas Method for detecting and excising nonpalpable lesions
US20040121314A1 (en) * 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in containers
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
WO2002074324A1 (en) * 2001-03-15 2002-09-26 The Texas A & M University System Collagen-binding adhesin from staphylococcus epidermidis and method of use
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US20030224476A1 (en) * 2002-03-01 2003-12-04 Szu-Yi Chou Method of producing transglutaminase reactive compound
JP2006516193A (en) 2002-12-06 2006-06-29 アイシス・ファーマシューティカルス・インコーポレーテッド Rapid identification of pathogens in humans and animals
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7319149B2 (en) * 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20120122099A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
EP2330111A3 (en) 2004-01-30 2011-08-17 Quark Pharmaceuticals, Inc. Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
ES2641832T3 (en) 2004-05-24 2017-11-14 Ibis Biosciences, Inc. Mass spectrometry with selective ion filtration by setting digital thresholds
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
AP2007003921A0 (en) 2004-08-16 2007-02-28 Atugen Ag Therapeutic uses of inhibitors of rtp801
DK1799269T3 (en) 2004-09-28 2016-10-03 Quark Pharmaceuticals Inc Oligoribonucleotides and methods of use thereof for treating alopecia, acute renal failure, and other diseases
US8182992B2 (en) 2005-03-03 2012-05-22 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
ATE483825T1 (en) * 2005-04-13 2010-10-15 Ibis Biosciences Inc COMPOSITIONS FOR IDENTIFYING ADENOVIRUSES
US7414254B2 (en) * 2005-06-28 2008-08-19 United Pharmacy Partners, Inc. Tungsten pig for radio-pharmaceuticals
JP2009502137A (en) 2005-07-21 2009-01-29 アイシス ファーマシューティカルズ インコーポレイティッド Method for rapid identification and quantification of nucleic acid variants
DOP2007000015A (en) 2006-01-20 2007-08-31 Quark Biotech Inc THERAPEUTIC USES OF RTP801 INHIBITORS
EP2064332B1 (en) 2006-09-14 2012-07-18 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
JP2010507387A (en) 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド Novel siRNA and method of using the same
EP2126132B1 (en) 2007-02-23 2013-03-20 Ibis Biosciences, Inc. Methods for rapid foresnsic dna analysis
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
CN103898110A (en) 2007-10-03 2014-07-02 夸克制药公司 Novel sirna structures
US8253725B2 (en) * 2007-12-28 2012-08-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Method and system for generating surface models of geometric structures
EP2293800B1 (en) 2008-06-06 2016-10-05 Quark Pharmaceuticals, Inc. Compositions and methods for treatment of ear disorders
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
WO2010033625A1 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
WO2010033599A2 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
WO2010080452A2 (en) 2008-12-18 2010-07-15 Quark Pharmaceuticals, Inc. siRNA COMPOUNDS AND METHODS OF USE THEREOF
US8158936B2 (en) 2009-02-12 2012-04-17 Ibis Biosciences, Inc. Ionization probe assemblies
GB0905328D0 (en) * 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives
WO2011008971A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Lift and mount apparatus
WO2011008972A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systems for bioagent identification
EP3225695A1 (en) 2009-10-15 2017-10-04 Ibis Biosciences, Inc. Multiple displacement amplification
TW201124160A (en) 2009-11-26 2011-07-16 Quark Pharmaceuticals Inc SiRNA compounds comprising terminal substitutions
US8778904B2 (en) 2009-12-09 2014-07-15 Quark Pharmaceuticals, Inc. Methods and compositions for treating diseases, disorders or injury of the CNS
WO2011084193A1 (en) 2010-01-07 2011-07-14 Quark Pharmaceuticals, Inc. Oligonucleotide compounds comprising non-nucleotide overhangs
NZ604094A (en) 2010-06-24 2014-11-28 Quark Pharmaceuticals Inc Double stranded rna compounds to rhoa and use thereof
SG190412A1 (en) 2010-12-06 2013-06-28 Quark Pharmaceuticals Inc Double stranded oligonucleotide compounds comprising threose modifications
SG193280A1 (en) 2011-03-03 2013-10-30 Quark Pharmaceuticals Inc Oligonucleotide modulators of the toll-like receptor pathway
US9796979B2 (en) 2011-03-03 2017-10-24 Quark Pharmaceuticals Inc. Oligonucleotide modulators of the toll-like receptor pathway
US9422560B2 (en) 2011-11-03 2016-08-23 Quark Pharmaceuticals, Inc. Methods and compositions for neuroprotection
EP2776565A1 (en) 2011-11-08 2014-09-17 Quark Pharmaceuticals, Inc. Methods and compositions for treating diseases, disorders or injury of the nervous system
KR20140111673A (en) 2012-01-12 2014-09-19 쿠아크 파마수티칼스 인코퍼레이티드 Combination therapy for treating hearing and balance disorders
EP2895608B1 (en) 2012-09-12 2018-12-05 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide molecules to p53 and methods of use thereof
US9611473B2 (en) 2012-09-12 2017-04-04 Quark Pharmaceuticals, Inc. Double-stranded nucleic acid compounds
US9932578B2 (en) 2012-09-12 2018-04-03 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide molecules to P53 and methods of use thereof
EP3027223A1 (en) 2013-07-31 2016-06-08 QBI Enterprises Ltd. Methods of use of sphingolipid polyalkylamine oligonucleotide compounds
WO2015015496A1 (en) 2013-07-31 2015-02-05 Qbi Enterprises Ltd. Sphingolipid-polyalkylamine-oligonucleotide compounds
WO2016054079A1 (en) 2014-09-29 2016-04-07 Zyomed Corp. Systems and methods for blood glucose and other analyte detection and measurement using collision computing
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
EP3671511B1 (en) 2018-12-19 2022-07-06 Rohde & Schwarz GmbH & Co. KG Communication system and method
EP3922720A1 (en) 2020-06-09 2021-12-15 Universidad de Murcia Therapy to prevent adverse cardiac remodeling following an acute myocardial infarction
ES2894201B2 (en) * 2020-08-05 2022-09-29 Fundacion Para La Investig Biomedica Del Hospital Gregorio Maranon RADIOACTIVE COMPOUNDS BASED ON SELECTIVE BACTERIA PROTEINS FOR THE NON-INVASIVE DETECTION OF INFECTIOUS FOCUSES

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4315906A (en) * 1979-05-21 1982-02-16 New England Nuclear Corporation Cold insoluble globulin, its purification and use
US4455290A (en) * 1981-04-02 1984-06-19 Research Corporation Inhibition of fibrin polymerization by a peptide isolated from fibrin Fragment D1
US4663146A (en) * 1983-07-29 1987-05-05 Codon Genetic Engineering Laboratories Methods and compositions for the diagnosis of bloodclots using plasminogen activator
US4587122A (en) * 1985-04-23 1986-05-06 The Green Cross Corporation Fibronectin-dextran-drug complex and method of preparation thereof
GB8516421D0 (en) * 1985-06-28 1985-07-31 Biotechnology Interface Ltd Fibronectins
US4734362A (en) * 1986-02-03 1988-03-29 Cambridge Bioscience Corporation Process for purifying recombinant proteins, and products thereof
WO1989000051A1 (en) * 1987-07-07 1989-01-12 Cytrx Biopool Ltd. Fibrin-binding compound and method
US4839464A (en) * 1987-08-25 1989-06-13 Regents Of The University Of Minnesota Polypeptides with fibronectin activity
JP2561122B2 (en) * 1988-04-13 1996-12-04 寳酒造株式会社 Functional polypeptide
JP2561131B2 (en) * 1988-06-30 1996-12-04 寳酒造株式会社 Cell adhesion activity polypeptide
US5270030A (en) * 1988-12-29 1993-12-14 Bio-Technology General Corp. Fibrin binding domain polypeptide and method of producing
KR910700339A (en) * 1988-12-29 1991-03-14 보겔, 티그바 Cloning and Preparation of Polypeptide Analogues of Human Fibronectin and Methods of Using the Polypeptide Analogs
US5026537A (en) * 1989-04-06 1991-06-25 Centocor, Inc. Methods for imaging atherosclerotic plaque

Similar Documents

Publication Publication Date Title
RU92016360A (en) VISUALIZING AGENT, COMPOSITION, METHOD OF DETECTING MATERIAL, PLASMIDES, CELL, METHODS OF OBTAINING POLYPEPTIDE, POLYPEPTIDE, METHOD OF RECOVERY POLYPEPTIDE CONFORMATION
FI925296A (en) POLYPEPTIDER AV EN FIBRINBINDANDE DOMAEN, ANVAENDNING OCH FOERFARANDEN FOER FRAMSTAELLNING AV DESAMMA
Sanger The terminal peptides of insulin
DK0500785T3 (en) Human T cell activity feline protein (TRFP) isolated from house dust as well as applications thereof
DE69021000T2 (en) Radiolabeled peptides with anticoagulant activity.
ATE87655T1 (en) MARKERS OF T-CELL ACTIVATION.
DK601786A (en) HIS UNKNOWN PROCOAGULATION PROTEINS
JPH08502480A (en) Thrombus detection using radiolabeled disintegrin
RU93045577A (en) MULTIPLE POLYPEPTIDES
Lerch et al. Canine hepatic lysosomal copper protein: identification as metallothionein
Tuross Albumin preservation in the Taima-taima mastodon skeleton
JPS6229597A (en) Peptide composition
US5589340A (en) Process and primers for identifying nucleic acids encoding A-lineage conotoxin peptides
Stauffer et al. Fractionation and characterization of the polypeptide chains of low molecular weight calf lens alpha-crystallin
KR860006484A (en) Method for preparing protein or glycoprotein
CA2070961C (en) Thiol-reactive maleimido-based radiolabeling reagents
CH645880A5 (en) SYNTHETIC ANTIGENT ACTIVE POLYPEPTIDE, METHOD FOR THE PRODUCTION THEREOF, AND ANTIGEN AGENT AND POLYPTIDE CONTAINING IT, AND MEDICINAL PRODUCT.
JPS6248700A (en) Transferrin and use thereof
Gregory et al. A review of recent progress in the chemistry of gastrin
Thompson et al. Studies on Monotreme Proteins. III. Amino Acid Sequence of the a-and ß-Globin Chains of the Minor Haemoglobin from the Echidna, Tachyglossus Aculeatus Aculeatus
US4055524A (en) Synthesis of peptides
Norment et al. Electrophoresis and electrofocusing of venom of Loxosceles reclusa Gertsch & Mulaik (Araneida: Scytodidae)
FR2555577B1 (en) NOVEL PEPTIDE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE AS BIOLOGICAL REAGENTS
LIAN CLONING AND CHARACTERIZATION OF GENES ENCODING SNAKE CARDIOTOXIN AND PHOSPHOLIPASE A2
TH39847A (en) Isolated mammalian tissue protein genes Related chemicals