RU92016234A - DERIVATIVES 3 (2H) -PYRIDAZINONE, METHOD FOR THEIR PRODUCTION, USE, PHARMACEUTICAL COMPOSITION, METHOD - Google Patents

DERIVATIVES 3 (2H) -PYRIDAZINONE, METHOD FOR THEIR PRODUCTION, USE, PHARMACEUTICAL COMPOSITION, METHOD

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Publication number
RU92016234A
RU92016234A RU92016234/04A RU92016234A RU92016234A RU 92016234 A RU92016234 A RU 92016234A RU 92016234/04 A RU92016234/04 A RU 92016234/04A RU 92016234 A RU92016234 A RU 92016234A RU 92016234 A RU92016234 A RU 92016234A
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RU
Russia
Prior art keywords
group
optionally
alkyl
substituent
hydrogen
Prior art date
Application number
RU92016234/04A
Other languages
Russian (ru)
Other versions
RU2130019C1 (en
Inventor
Матюш Петер
Цако Клара
Варга Ильдико
Йеднакович Андреа
Папп Агнеш
Боди Илона
Раблоцкий Дьердь
Варро Андраш
Яслиц Ласло
Миклош Анико
Левай Луца
Шмидт Дьердь
Фекете Мартон
Керти Мария
Семерейди Каталин
Зара Эржебет
Original Assignee
Эгиш Дьедьсердьяр
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from HU914057A external-priority patent/HU214320B/en
Application filed by Эгиш Дьедьсердьяр filed Critical Эгиш Дьедьсердьяр
Publication of RU92016234A publication Critical patent/RU92016234A/en
Application granted granted Critical
Publication of RU2130019C1 publication Critical patent/RU2130019C1/en

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Claims (1)

Предполагаемое изобретение относится к рацемическим или оптически активным новым производным 3(2H)-пиридазинона, к способу получения их, к фармацевтическим композициям, включающим эти соединения, к использованию указанных производных 3(2H)-пиридазинона для лечения заболеваний и для приготовления фармацевтических композиций, пригодных для лечения болезней. Новые производные 3(2H) - пиридазинона настоящего изобретения соответствуют общей формуле (I)
Figure 00000001

где R1 представляет водород, фенил, метил, необязательно имеющий бензилокси-заместитель, C1-C4-алкил, необязательно имеющий заместитель формулы R8R9N-, в которой R8 и R9 являются независимо C1-C4-алкилом, или R8 и R9 образуют вместе с примыкающим атомом азота 6-членную гетероциклическую группу, необязательно содержащую атом кислорода, или группу формулы R1 0N-, где R1 0 обозначает C1-C4-алкил, необязательно имеющий фенокси-заместитель, или C3-C5- алкенил, имеющий фенильный заместитель, кроме того, указанный C1-C4-алкил, необязательно замещается фенилом, имеющим метокси- или метансульфониламино-заместитель, или C3-C5-алкенил, необязательно имеющий галоген или галогенфенильный заместители. А и В обозначают водород, галоген или группу общей формулы (II),
Figure 00000002

где R2 и R3 независимо являются водородом или C1-C4-алкилом, или вместе с примыкающей -N-(CH2)n - группой образуют пиперазиновое или гомопиперазиновое кольцо, R4 представляет водород, C1-C4-алкил или фенил, R5, R6 и R7 каждый обозначает водород, C1-C4-алкокси -или аминогруппу, необязательно имеющую метансульфонильный заместитель, X является простой валентной связью, атомом кислорода или группой формулы -CH=CH-, m является 0 или 1, n является 2 или 3, при условии, что А и В являются всегда различными, и, если один из А и В является водородом или галогеном, другой обозначает группу формулы (II) и их аддитивные соли кислоты, обладают ценным антиаритмическим действием.The alleged invention relates to racemic or optically active novel 3 (2H) -pyridazinone derivatives, to a method for preparing them, to pharmaceutical compositions comprising these compounds, to using said 3 (2H) -pyridazinone derivatives for treating diseases and for preparing pharmaceutical compositions suitable for the treatment of diseases. New derivatives of 3 (2H) - pyridazinone of the present invention correspond to the General formula (I)
Figure 00000001

where R 1 is hydrogen, phenyl, methyl, optionally having a benzyloxy substituent, C 1 -C 4 alkyl, optionally having a substituent of the formula R 8 R 9 N-, in which R 8 and R 9 are independently C 1 -C 4 - alkyl, or R 8 and R 9 form together with the adjacent nitrogen atom a 6-membered heterocyclic group, optionally containing an oxygen atom, or a group of the formula R 1 0 N-, where R 1 0 means C 1 -C 4 alkyl, optionally having phenoxy substituent, or C 3 -C 5 - alkenyl group having a phenyl substituent, in addition, said C 1 -C 4 alkyl optionally substituted with Fe yl having methoxy or methanesulfonylamino substituent, or C 3 -C 5 -alkenyl, optionally having a halogen or halophenyl substituents. A and B represent hydrogen, halogen or a group of the general formula (II),
Figure 00000002

where R 2 and R 3 are independently hydrogen or C 1 -C 4 -alkyl, or together with the adjacent -N- (CH 2 ) n - group form a piperazine or homopiperazine ring, R 4 is hydrogen, C 1 -C 4 -alkyl or phenyl, R 5 , R 6 and R 7 each denotes hydrogen, a C 1 -C 4 alkoxy-or amino group, optionally having a methanesulfonyl substituent, X is a simple valence bond, an oxygen atom or a group of the formula -CH = CH-, m is 0 or 1, n is 2 or 3, provided that A and B are always different, and if one of A and B is hydrogen or halogen, the other Second is a group of formula (II) and their acid addition salts possess valuable antiarrhythmic effect.
RU92016234A 1991-12-20 1992-12-18 Derivatives of 3(2)-pyridazinone, a pharmaceutical composition, a method of treatment RU2130019C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU4057/91 1991-12-20
HU914057A HU214320B (en) 1991-12-20 1991-12-20 Process for producing novel 3(2h)-pyridazinon derivatives and pharmaceutical compositions producing them

Publications (2)

Publication Number Publication Date
RU92016234A true RU92016234A (en) 1995-03-27
RU2130019C1 RU2130019C1 (en) 1999-05-10

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US (1) US5395934A (en)
JP (1) JP3165935B2 (en)
KR (1) KR100234596B1 (en)
CN (1) CN1088578A (en)
AT (1) AT403282B (en)
BE (1) BE1006223A4 (en)
CA (1) CA2085796C (en)
CH (1) CH684754A5 (en)
CZ (1) CZ286039B6 (en)
DE (1) DE4243381B4 (en)
DK (1) DK152892A (en)
ES (1) ES2108595B1 (en)
FI (1) FI106374B (en)
FR (1) FR2685329B1 (en)
GB (1) GB2262526B (en)
GR (1) GR1002281B (en)
HU (1) HU214320B (en)
NL (1) NL194966C (en)
PL (1) PL172933B1 (en)
RU (1) RU2130019C1 (en)
YU (1) YU48973B (en)
ZA (1) ZA929903B (en)

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US7173063B1 (en) 2000-11-10 2007-02-06 Fred Hutchinson Cancer Research Center Topoisomerase poisons for the treatment of proliferative disorders
HUP0103064A3 (en) * 2001-07-26 2005-06-28 Egis Gyogyszergyar Nyilvanosan Polymorphic form of 5-chloro-4-(3-{[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino]-propylamino)-3-(2h)-piridazinone fumarate, its use, process for its preparation and pharmaceutical compositions containing it
HU227237B1 (en) * 2001-09-27 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
BR0306988A (en) * 2002-01-18 2004-11-23 Pharmacia Corp Pyridazinones substituted as p38 inhibitors
HU227181B1 (en) * 2002-09-11 2010-09-28 Egis Gyogyszergyar Nyilvanosan Use of 5-chloro-4-[3-[n-[2-(3,4-dimethoxyphenyl)ethyl)]-n-methylamino]-propylamino]-3-(2h)-pyridazinone for producing pharmaceutical compositions having metabolic modulator effect
ES2549502T3 (en) 2009-11-20 2015-10-28 Sk Chemicals Co., Ltd. Gonadoliberin receptor antagonists, method of manufacture thereof, and pharmaceutical composition containing them
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FR2969606B1 (en) * 2010-12-22 2013-01-11 Pf Medicament DERIVATIVES OF DIARYLPYRIDAZINONES, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPEUTICS
RU2455004C1 (en) * 2011-04-01 2012-07-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" (ФГБОУ ВПО "ЯГТУ") Method for producing sulphochlorides of 6-arylpyridazine-3(2h)-ones

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