RU92014927A - METHOD OF MANUFACTURING BIVALENT VACCINE AGAINST MIXOMATOSIS AND VIRAL HEMORRHAGIC RABBIT DISEASE - Google Patents

METHOD OF MANUFACTURING BIVALENT VACCINE AGAINST MIXOMATOSIS AND VIRAL HEMORRHAGIC RABBIT DISEASE

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Publication number
RU92014927A
RU92014927A RU92014927/13A RU92014927A RU92014927A RU 92014927 A RU92014927 A RU 92014927A RU 92014927/13 A RU92014927/13 A RU 92014927/13A RU 92014927 A RU92014927 A RU 92014927A RU 92014927 A RU92014927 A RU 92014927A
Authority
RU
Russia
Prior art keywords
vaccine against
manufacturing
bivalent
myxomatosis
viral hemorrhagic
Prior art date
Application number
RU92014927/13A
Other languages
Russian (ru)
Other versions
RU2064304C1 (en
Inventor
А.А. Шевченко
В.П. Князев
А.И. Неверовский
Л.В. Шевченко
Н.В. Малоголовкина
В.В. Зиновьев
М.А. Лавров
Л.В. Бузун
Original Assignee
Всероссийский научно-исследовательский институт ветеринарной вирусологии и микробиологии
Filing date
Publication date
Application filed by Всероссийский научно-исследовательский институт ветеринарной вирусологии и микробиологии filed Critical Всероссийский научно-исследовательский институт ветеринарной вирусологии и микробиологии
Priority to RU92014927A priority Critical patent/RU2064304C1/en
Priority claimed from RU92014927A external-priority patent/RU2064304C1/en
Publication of RU92014927A publication Critical patent/RU92014927A/en
Application granted granted Critical
Publication of RU2064304C1 publication Critical patent/RU2064304C1/en

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Claims (1)

Изобретение относится к области биотехнологии, в частности к способу изготовления бивалентной лиофилизированной вакцины против миксоматоза и вирусной геморрагической болезни кроликов (ВГБК), и может быть использовано в научных и производственных лабораториях, занимающихся конструированием биопрепаратов, а также на предприятиях биологической промышленности. Задача - изготовление ареактогенной бивалентной лиофилизированной вакцины против миксоматоза и ВГБК, обладающей стабильными свойствами при хранении. Сущность предлагаемого способа заключается в том, что используют два основных компонента: живой вакцинный вирус миксоматоза кроликов, выращенный в первично-трипсинизированной культуре клеток куриных фибробластов с активностью не ниже 104 , 0 ИД 50/см3, и инактивированную суспензию печени, полученную после заражения вирулентным вирусом геморрагической болезни кроликов. Компоненты смешивают в равных частях, стабилизируют защитной средой в соотношении 10:1 и лиофилизируют. Предложенный способ прост в исполнении, доступен и является промышленно применимым.The invention relates to the field of biotechnology, in particular to a method of manufacturing a bivalent freeze-dried vaccine against myxomatosis and viral hemorrhagic disease of rabbits (UGBC), and can be used in scientific and industrial laboratories involved in the design of biological products, as well as in biological industry. The task is to manufacture an areactogenic bivalent freeze-dried vaccine against myxomatosis and UHDB, which has stable storage properties. The essence of the proposed method lies in the fact that they use two main components: live rabbit myxomatosis vaccine virus grown in primary trypsinized cell culture of chicken fibroblasts with activity not lower than 10 4 , 0 EID 50 / cm 3 , and inactivated suspension of the liver, obtained after infection virulent rabbit haemorrhagic disease virus. The components are mixed in equal parts, stabilized with a protective medium in a ratio of 10: 1 and lyophilized. The proposed method is simple, affordable and is industrially applicable.
RU92014927A 1992-12-28 1992-12-28 Method of preparing bipartial vaccine against myxomatosis and viral hemorrhagic disease in rabbit RU2064304C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU92014927A RU2064304C1 (en) 1992-12-28 1992-12-28 Method of preparing bipartial vaccine against myxomatosis and viral hemorrhagic disease in rabbit

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU92014927A RU2064304C1 (en) 1992-12-28 1992-12-28 Method of preparing bipartial vaccine against myxomatosis and viral hemorrhagic disease in rabbit

Publications (2)

Publication Number Publication Date
RU92014927A true RU92014927A (en) 1995-10-27
RU2064304C1 RU2064304C1 (en) 1996-07-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU92014927A RU2064304C1 (en) 1992-12-28 1992-12-28 Method of preparing bipartial vaccine against myxomatosis and viral hemorrhagic disease in rabbit

Country Status (1)

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RU (1) RU2064304C1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2443774C1 (en) * 2010-06-29 2012-02-27 Федеральное государственное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" Method for producing associated colibacillosis, streptococcosis and rabbit viral hemorrhagic disease vaccine
RU2553557C2 (en) * 2013-07-08 2015-06-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" Method of manufacturing vaccine, associated against pseudomonosis and viral rabbit haemorrhagic disease
RU2741643C1 (en) * 2020-06-15 2021-01-28 Федеральное государственное бюджетное учреждение "Федеральный центр охраны здоровья животных" (ФГБУ "ВНИИЗЖ") Associated vaccine against myxomatosis, pasteurellosis and viral haemorrhagic disease 1 and type 2 of rabbits

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