RU92014439A - METHOD OF OBTAINING INFUSAMINE - Google Patents

METHOD OF OBTAINING INFUSAMINE

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Publication number
RU92014439A
RU92014439A RU92014439/14A RU92014439A RU92014439A RU 92014439 A RU92014439 A RU 92014439A RU 92014439/14 A RU92014439/14 A RU 92014439/14A RU 92014439 A RU92014439 A RU 92014439A RU 92014439 A RU92014439 A RU 92014439A
Authority
RU
Russia
Prior art keywords
hydrolyzate
neutralized
activated carbon
addition
cold
Prior art date
Application number
RU92014439/14A
Other languages
Russian (ru)
Inventor
В.С. Муратов
А.А. Мялкин
А.С. Пригода
И.В. Мазенко
В.И. Курилкин
Н.В. Горбунова
Н.В. Чекотина
Ю.С. Нижечик
Н.А. Ламберова
Original Assignee
Научно-производственная фирма "Метафар"
Filing date
Publication date
Application filed by Научно-производственная фирма "Метафар" filed Critical Научно-производственная фирма "Метафар"
Publication of RU92014439A publication Critical patent/RU92014439A/en

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Claims (1)

Изобретение относится к медицинской промышленности и касается получения лекарственного препарата инфузамин, предназначенного для парэнтерального питания, позволяет сократить длительности процесса, повысить выход и качество целевого продукта. Для этого гидролиз исходного белкового материала проводят серной кислотой, гидролизат двухступенчато нейтрализуют натриевой щелочью, твердую фазу отделяют и одновременно очищают гидролизат посредством ультрафильтрации частично нейтрализованного исходного белкового материала и завершают очистку осаждением на холоду сульфата натрия из осветленного активированным углем и полностью нейтрализованного гидролизата при добавлении спирта.The invention relates to the medical industry and relates to the production of the drug infusamin intended for parenteral nutrition, reduces the duration of the process, improve the yield and quality of the target product. For this, hydrolysis of the original protein material is carried out with sulfuric acid, the hydrolyzate is neutralized in two steps with sodium alkali, the solid phase is separated and at the same time the hydrolyzate is purified by ultrafiltration of the partially neutralized starting protein material and complete purification by cold precipitation of sodium sulfate from clarified with activated carbon and completely neutralized hydrolyzate with the addition of sodium sulfate in the cold with activated carbon and fully neutralized hydrolyzate added with the addition of sodium sulfate in the cold when added with activated carbon and completely neutralized hydrolyzate with the addition of sodium carbonate added.
RU92014439/14A 1992-12-23 METHOD OF OBTAINING INFUSAMINE RU92014439A (en)

Publications (1)

Publication Number Publication Date
RU92014439A true RU92014439A (en) 1995-09-27

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