RU92004314A - COMPLEX SALTS OF HEMATOPORPHIRIN AND ITS DERIVATIVES, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL AGENT - Google Patents

COMPLEX SALTS OF HEMATOPORPHIRIN AND ITS DERIVATIVES, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL AGENT

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Publication number
RU92004314A
RU92004314A RU92004314/04A RU92004314A RU92004314A RU 92004314 A RU92004314 A RU 92004314A RU 92004314/04 A RU92004314/04 A RU 92004314/04A RU 92004314 A RU92004314 A RU 92004314A RU 92004314 A RU92004314 A RU 92004314A
Authority
RU
Russia
Prior art keywords
carboxy
ethylamine
group
complex salts
propylamine
Prior art date
Application number
RU92004314/04A
Other languages
Russian (ru)
Other versions
RU2122003C1 (en
Inventor
Грачык Альфреда
Конарски Ежы
Original Assignee
Войсковая академия технична им.Ярослава Дабровского
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL91292220A external-priority patent/PL165249B1/en
Application filed by Войсковая академия технична им.Ярослава Дабровского filed Critical Войсковая академия технична им.Ярослава Дабровского
Publication of RU92004314A publication Critical patent/RU92004314A/en
Application granted granted Critical
Publication of RU2122003C1 publication Critical patent/RU2122003C1/en

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Claims (1)

Предложены комплексные соли гематопорфирина и его производных, имеющих общую формулу, в которой R1 и R2 одинаковые или разные и обозначают группу - CH - CH2, группу - CH/OH/-CH3, группу - CH/OR3/CH3, где R3 обозначает группу, образующую олигомер, содержащий связи эфирные и/или сложноэфирные, составленную из 1 до 5 таких же самых или разных единиц, происходящих от мономера, или R1 и R2 одинаковые и обозначают группу - CH/R4/-CH3, где R4 обозначает группу карбоксиметиламиновую, 1 - карбокси-этиламиновую, 1-карбокси-2-метилпропилоаминовую, 1-карбокси-3-метил-бутиламиновую, 1-карбокси-2-метил-бутиламиновую, 1-карбокси-пентиламиновую, 1-карбокси-2-гидрокси-этиламиновую, 1-карбокси-2-гидрокси-пропилоаминовую, 1-карбокси-2-меркапто-этиламиновую, 1-карбокси-3-метилотио-пропилоаминовую, 1,2-дикарбокси-этиламиновую, 1-карбокси-2-карбомоил-этиламиновую, 1,3-дикарбокси-пропилоаминовую, 1-карбокси-3-карбамоил-пропилоаминовую, 1-карбокси-2-фенил-этиламиновую, 1-карбокси-2-/ 4-гидроксифенил/ - этиламиновую, 1-карбокси-2-индолил-этиламиновую, 2-карбокси-пиролидиновую, 2-карбокси-4-гидроксипирилидиновую, 1-карбокси-5-аминопентиламиновую, 1-карбокси-4-гуанидил-бутиламиновую, 1-карбокси-4-гидрокси-5-аминопентиламиновую или группу 1-карбокси-2-/IH-имидазол/-этиламиновую; А обозначает основную аминокислоту; m равно 2-6; n равно 1-5. Способ изготовления новых комплексных солей по предлагаемой формуле основан на реакции гематопорфириновых производных с общей формулой 4, в которой R1 и R2 имеют выше поданное значение, с основной аминокислотой. Новые комплексные соли находят применение как средство для обнаруживания и лечения новообразований.The proposed complex salts of hematoporphyrin and its derivatives, having the general formula in which R 1 and R 2 are the same or different and denote the group - CH - CH 2 , the group - CH / OH / -CH 3 , the group - CH / OR 3 / CH 3 where R 3 denotes a group forming an oligomer containing ether and / or ester bonds, composed of 1 to 5 of the same or different units derived from the monomer, or R 1 and R 2 are the same and denote the group - CH / R 4 / -CH 3 , where R 4 denotes a carboxymethylamine group, 1 - carboxy-ethylamine, 1-carboxy-2-methylpropylamine, 1-carboxy-3-methyl-butyls new, 1-carboxy-2-methyl-butylamine, 1-carboxy-pentylamine, 1-carboxy-2-hydroxy-ethylamine, 1-carboxy-2-hydroxy-propylamine, 1-carboxy-2-mercapto-ethylamine, 1- carboxy-3-methylothio-propylamine, 1,2-dicarboxy-ethylamine, 1-carboxy-2-carbomoyl-ethylamine, 1,3-dicarboxy-propylamine, 1-carboxy-3-carbamoyl-propylamine, 1-carboxy-2- phenyl-ethylamine, 1-carboxy-2- (4-hydroxyphenyl) - ethylamine, 1-carboxy-2-indolyl-ethylamine, 2-carboxy-pyrolidine, 2-carboxy-4-hydroxypyrillidine, 1-carboxy-5-aminopentyl oic, 1-carboxy-4-guanidyl-butylamine, 1-carboxy-4-hydroxy-5-aminopentilaminovuyu group or 1-carboxy-2- / IH-imidazol / -etilaminovuyu; A indicates the basic amino acid; m is 2-6; n is 1-5. A method of manufacturing new complex salts according to the proposed formula is based on the reaction of hematoporphyrin derivatives with the general formula 4, in which R 1 and R 2 have the above filed value, with the basic amino acid. New complex salts are used as a tool for the detection and treatment of tumors.
RU92004314/04A 1991-10-29 1992-10-28 Complex salt of hematoporphyrine and derivatives thereof, mixture of complex salts of hematoporhyrine and derivatives thereof, method of preparing complex salts, method of preparing mixture of complex salts, and pharmaceutical composition RU2122003C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL91292220A PL165249B1 (en) 1991-10-29 1991-10-29 Method op obtaining complex salts of hematporphyrine and its derivatives
PLP-292220 1991-10-29

Publications (2)

Publication Number Publication Date
RU92004314A true RU92004314A (en) 1995-05-20
RU2122003C1 RU2122003C1 (en) 1998-11-20

Family

ID=20055985

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92004314/04A RU2122003C1 (en) 1991-10-29 1992-10-28 Complex salt of hematoporphyrine and derivatives thereof, mixture of complex salts of hematoporhyrine and derivatives thereof, method of preparing complex salts, method of preparing mixture of complex salts, and pharmaceutical composition

Country Status (18)

Country Link
US (1) US5451599A (en)
EP (1) EP0539960B1 (en)
JP (1) JP3020759B2 (en)
CN (1) CN1040328C (en)
BG (1) BG61648B1 (en)
CA (1) CA2081605C (en)
CZ (1) CZ281694B6 (en)
DE (1) DE69217819T2 (en)
DK (1) DK0539960T3 (en)
FI (1) FI100243B (en)
HR (1) HRP921337B1 (en)
LV (1) LV11952B (en)
NO (1) NO300499B1 (en)
PL (1) PL165249B1 (en)
RU (1) RU2122003C1 (en)
SI (1) SI9200286B (en)
UA (1) UA40568C2 (en)
YU (1) YU48961B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO180167C (en) * 1994-09-08 1997-02-26 Photocure As Photochemical method for introducing molecules into the cytosol of cells
US5948771A (en) * 1996-01-31 1999-09-07 The Trustees Of Columbia University In The City Of New York Method for treating heart failure using tetrapyrroles and metallotetrapyrroles
GB9606293D0 (en) * 1996-03-26 1996-05-29 William Harvey Research Limite Treatment of cancers and other tumours
AU2210402A (en) 2000-11-29 2002-06-11 Norwegian Radium Hospital Res Photochemical internalization for virus-mediated molecule delivery into the cyosol
KR20080080685A (en) 2000-11-29 2008-09-04 피씨아이 바이오테크 에이에스 Photochemical internalization for delivery of molecules into the cytosol
CN104130266A (en) * 2013-05-02 2014-11-05 中国医学科学院生物医学工程研究所 Novel protoporphyrin derivative and preparation method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912M (en) * 1963-07-24 1964-11-09 Rech S Pharma E R P H A R Soc Procaine hematoporphyrinate dihydrochloride.
EP0220686B1 (en) * 1985-10-23 1992-12-30 Nihon Medi-Physics Co., Ltd. Porphyrin derivatives, and their production and use
US4882234A (en) * 1986-11-12 1989-11-21 Healux, Inc. Storage-stable porphin compositions and a method for their manufacture
US4968715A (en) * 1988-07-06 1990-11-06 Health Research, Inc. Use of purified hematoporphyrin trimers in photodynamic therapy
US5190966A (en) * 1988-07-06 1993-03-02 Health Research, Inc. Purified hematoporphyrin dimers and trimers useful in photodynamic therapy
US4961920A (en) * 1988-12-08 1990-10-09 Luminis Pty, Ltd. Phototherapeutic monovinyl and divinyl ether-linked dimers
CN102565846B (en) * 2011-12-30 2014-05-14 清华大学 Honeycomb-type thermal neutron detector

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