RU2811744C2 - Appliance for injection device, in particular for removing needle cap, and injection system and injection device containing the same - Google Patents

Abstract

FIELD: medical equipment.

SUBSTANCE: invention relates to appliances for injection devices. The appliance contains a needle cap, a main part containing a recess configured to receive an injection device, and a cover connected to the main part. The lid is rotatable between an open position, in which the recess is open to receive the injection device, and a closed position, in which the lid at least partially covers the recess, retaining the injection device in the main part. The device further comprises a decapping device with a gripper, wherein the decapping device has an expanded configuration in which the needle cap can pass between the gripper, and a contracted configuration in which the gripper holds the needle cap to at least partially remove the needle cap from the injection device. The decapping device is moved from the reduced configuration so that at least one movable element changes direction to move from the needle cap in an outward direction opposite to the inward direction.

EFFECT: obtaining an appliance for an injection device.

14 cl, 15 dwg

Description

Technical field

[001] The present description relates to an apparatus for an injection device.

Prerequisites for creating the invention

[002] When performing injections, needle guards are typically used in combination with syringes to reduce the risk of accidental needle sticks, which can lead to the transmission of blood-borne pathogens. These needle guards are often necessary to protect healthcare workers, particularly nurses, who frequently use syringes to administer injections to a patient. Needle guards can generally be classified into one of two types: (1) passive devices that automatically cover the needle after injection without requiring the user to perform any additional action to activate the device; and (2) devices that require the user to perform additional actions to activate the needle guard.

[003] Passive needle safety devices are generally considered superior in their ability to protect the user from accidental needlesticks, since for various reasons users may not take the additional steps required to activate non-passive devices. Health authorities and health care systems often require the use of needle guards when healthcare workers administer injections. Moreover, needle guards are desirable when administering injections independently or with the assistance of a caregiver to reduce the risk of injury, infection, and transmission of blood-borne pathogens to patients, family members, caregivers, and any individuals who may come into contact with the patient. with injection devices during the injection process and disposal of used syringes.

[004] The most common example of needle safety devices is the UltraSafe(TM) series of devices from Becton Dickinson. UltraSafe(TM) consists of two plastic components and a spring that are attached to the syringe along with a special plunger rod. Once the injection is complete, the plunger rod engages the latches on the UltraSafe(TM) housing components, activating the device and causing a spring to push one of the housing components over the needle and lock it in place in a locked position. An example of an UltraSafe(TM) device is shown in FIG. 1A and 1B.

[005] In FIG. 1A shows the device in a ready state prior to injection or in a pre-injection position. In FIG. 1B shows the device in a safe state after completion of injection or in a locked position.

[006] In FIG. 2A, 2B, 2C and 2D provide typical instructions for use of the UltraSafe(TM) device. As can be seen, the steps for using UltraSafe(TM) are essentially the same as when performing an injection using a syringe without a safety device. Tightening the skin and inserting at a 45-degree angle is necessary to limit the depth of injection and ensure that the injection is performed subcutaneously and not into the muscle (too deep) or intradermally (into the skin). Administration that is too superficial or too deep may affect the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs intended for subcutaneous administration.

[007] As shown in FIG. 2A-2D, the steps to properly use a syringe to perform a subcutaneous injection are complex, and variations in their performance by different individuals may result in differences in the depth of injection, which may affect the effectiveness of the drug. Health care professionals, such as nurses, are familiar and experienced in performing injection procedures using syringes. However, different nurses use the technique differently, which may influence FC and PD. Moreover, the injection technique requires the use of two hands—one for tightening the skin and one for insertion—making it difficult for nurses to administer injections to complex patients such as children who may move during the injection. Moreover, even if the nurse is comfortable using the syringe, patients are often afraid of the syringe and needle and experience discomfort during the injection.

[008] Syringes, including those equipped with the UltraSafe(TM) device, are particularly difficult for patients and caregivers to use, not only because of the complexity of the device's application steps, but also because syringes with exposed needles typically cause anxiety in the patient. Thus, there is a need to develop a device that makes it easier to apply a needle safety device, such as UltraSafe(TM).

Summary of the invention

[009] In one aspect of the invention, there is provided a fixture for an injection device comprising a needle cap, the fixture including: a body with a recess configured to receive an injection device; a cover coupled to the main body, the cover being rotatable from an open position in which the recess is open to receive the injection device, to a closed position in which the cover at least partially covers the recess for holding the injection device in the main body; and a decapping device comprising a gripper, comprising a gripper, wherein the decapping device has an expanded configuration in which the needle cap can be passed between the gripper, and a contracted configuration in which the gripper holds the needle cap to at least partially remove the needle cap from the injection device. devices; wherein the cap and the decapping device are operatively coupled to each other such that when the cap is moved from an open position to a closed position, the decapping device i) moves from an expanded configuration to a reduced configuration, and ii) moves from a reduced configuration so that at least At least one movable element changes direction to move from the needle cap in an outward direction opposite to the inward direction to release the needle cap.

[010] In this way, the injection device can be loaded into the device without the grip coming into contact with the needle cap. Then, when the lid is closed, the gripper compresses on the needle cap to automatically remove the needle cap. Additionally, once the cap is removed, the grip opens again, releasing the cap so that it can be separated from the fixture.

[011] A fixture for an injection device is also described, comprising a needle cap, the fixture comprising: a main body with a recess configured to receive an injection device; a cover connected to the main body, the cover being rotatable from an open position in which the recess is open to receive the injection device, to a closed position in which the cover at least partially covers the recess for holding the injection device in the main part; and a decapping device comprising a gripper configured to hold a needle cap, the decapping device being movable relative to the main portion, the cap including: a proximal end movable by a user to move the cap from an open position to the closed position; and a distal end configured to move the gripper toward the end of the device when moving the cap from an open position to a closed position to at least partially remove the needle cap from the injection device.

[012] In this way, the needle cap can be automatically removed when the cover is closed. This is achieved by the cap acting as a lever to move the decapping device, resulting in the removal of the needle cap. This provides a simple and reliable mechanism for removing the needle cap in a manner that is easy for users with limited mobility. In addition, the cap provides a mechanical advantage for moving the decapping device, thereby reducing the required force exerted by the user.

[013] A device for an injection device is also described, comprising a protective cover and at least one flange configured to provide a user with a grip of the injection device and a syringe sheath configured to move relative to the at least one flange from a pre-injection position to a locked position, with this device contains: a main part containing a recess configured to accommodate a protective cover of the injection device, and a groove configured to accommodate at least one flange of the injection device; and a cover connected to the main part, wherein the cover is rotatable from an open position in which the recess and groove are open to receive a protective partition and a flange of the injection device, respectively, and a closed position in which the cover at least partially covers the recess and groove for holding the injection device in the main part; wherein the groove is shaped to prevent the at least one flange from moving distally and proximally relative to the body and to allow the syringe sheath to move proximally relative to the body from a pre-injection position to a locked position.

[014] In this way, the cover can be opened to facilitate access to the recess and groove. Subsequently, when the cap is closed, the groove holds the flange in place but allows the syringe shell to move, thus not interfering with the function of the injection device.

[015] A fixture for an injection device is also described, comprising a needle cap, the fixture comprising: a main body with a recess configured to receive an injection device; a cover connected to the main body, the cover being rotatable from an open position in which the recess is open to receive the injection device, to a closed position in which the cover at least partially covers the recess for holding the injection device in the main part; and a decapping device comprising a gripper configured to hold a needle cap, the decapping device being movable in an axial direction relative to the main body from a rest position to an extended position for removing the needle cap from the injection device, the main part comprises a guide within which the decap removal device is configured to be axially movable relative to the main part, and wherein the guide is configured to accommodate the injection device in the main part while the decap removal device is held against the guide by the injection device.

[016] Thus, the injection device holds the needle cap removal device inside the guide. This eliminates the need for additional components, simplifying design and production.

[017] The needle cover (equivalently often referred to as a “needle shield” or “needle shield”) may be a rigid needle cover or a non-rigid needle cover. The rigid needle cap may be formed from at least two components, for example, it may comprise a rigid outer shell and an internal portion that surrounds the syringe needle in the inserted position. The inner part can be plastic, elastic or flexible. This inner part may be made of rubber. Alternatively, a non-rigid needle cover may be used, in which case the needle cover may be a single plastic, resilient or flexible body, such as a rubberized needle cover.

Brief description of graphic materials

[018] Embodiments of the invention are described by way of example with reference to the accompanying drawings, in which:

[019] in FIG. 1A-B are perspective views of the injection device in the pre-injection ready position (FIG. 1A) and in the secure, locked position (FIG. 1B);

[020] in FIG. 2A-D show illustrative side views of the injection device shown in FIG. 1, during use;

[021] in FIG. 3 is a perspective view of the injection device fixture with the fixture in the closed position.

[022] in FIG. 4 is a perspective view of the device in the open position;

[023] in FIG. 5 is a perspective view of the fixture in an open position with the injection device inside the fixture;

[024] in FIG. 6 is a perspective view of the fixture in a closed position with the injection device inside the fixture;

[025] in FIG. 7 is a view from the inside of the device without the injection device and cover;

[026] in FIG. 8 is an enlarged perspective view of the device for removing the cap and cover of the device in the open position, the main part not being shown;

[027] in FIG. 9 is an enlarged perspective view of the decap and cap removal device, with the main part not shown.

[028] in FIG. 10 is an additional perspective view of the fixture in the open position with the injection device within the fixture;

[029] in FIG. 11 is a perspective view of the cap and lid removal device in a closed position, the main part not being shown.

[030] in FIG. 12 is a perspective view of the base of the fixture.

[031] in FIG. 13 is a view from the inside of the main part of the device;

[032] in FIG. 14 is a horizontal plan view of the device for removing the cap of the device; And

[033] in FIG. 15 is an additional perspective view of the main part.

Detailed description

[034] In FIG. 1A-B show a hand-held injection device 100 that is suitable for use with the device of the present invention. The injection device 100 includes a syringe 110 that extends from a proximal end containing a needle 130 to an open distal end. The open distal end of the syringe is closed by a stopper 140. A removable needle cap 190 is provided to cover the needle 130.

[035] The syringe 110 is secured within the syringe shell 120 by a syringe locking member 125. The syringe locking element 125 may comprise diametrically opposed adjacent surfaces, between which the flange of a standard syringe is located. The presence of the flanges between the adjacent surfaces prevents movement of the syringe 110 relative to the syringe shell 120.

[036] The syringe sheath 120 includes an open distal end into which the syringe 110 can be inserted and an open proximal end from which a needle 130 extends when the syringe 110 is secured within the sheath 120. The protective sheath 150 is movably mounted relative to the syringe sheath 120. The protective sheath 150 is movable between a retracted position (shown in FIG. 1A), in which the needle 130 extends beyond the proximal end of the protective sheath, and an extended position (shown in FIG. 1B), in which the protective sheath extends beyond the proximal end. needle 130. In the second position shown in FIG. 1B, the needle 130 is covered by a protective cover 150, thereby protecting the user from the needle and preventing accidental needlestick injuries.

[037] To allow the user to grip the injection device 100 with a standard dart grip (as shown in FIG. 2), the protective sheath 150 includes flanges 155 at or toward its distal end. The flanges 155 shown in FIG. 1, extend from the protective cover 150.

[038] The protective sheath 150 is biased into its extended position relative to the syringe sheath 120 (shown in FIG. 1B) by the biasing member 160. The biasing member 160, shown in FIG. 1A-B, takes the form of a coil spring located between the syringe sheath 120 and the protective sheath 150 such that the sheath 150 is displaced proximally relative to the syringe sheath 120 into its extended position.

[039] A release locking mechanism 180 holds the protective cover 150 in its retracted position relative to the syringe sheath 120. The locking mechanism 180 is movable between a locked position, in which the locking mechanism 180 prevents movement of the protective sheath 150 relative to the syringe sheath 120 (FIG. 1A), and an unlocked position, in which the locking mechanism 180 no longer prevents the movement of the protective sheath 150 relative to the sheath 120. syringe. After moving the locking mechanism to its unlocked position, the protective cover 150 is moved to its extended position under the influence of the coil spring 160 (Fig. 1B).

[040] In the device shown in FIG. 1A-B, the locking mechanism 180 between the protective sheath 150 and the syringe sheath 120 takes the form of a pair of flexible locking arms 181 provided on the sheath 150 that engage opposing locking surfaces 183 on the syringe sheath 120. The flexible locking arms 181 are moved to a first position in which they engage their respective locking surfaces 183, thereby preventing proximal movement of the protective sheath 150 relative to the syringe sheath 120. As the flexible locking arms 181 move toward this offset, the locking arms 181 move away from their respective locking surfaces 183, thereby allowing the protective sheath 150 to move proximally relative to the syringe sheath 120.

[041] The locking arms 181 are movable from a first position to a second position by means of a plunger rod 170. The plunger rod 170 includes an elongate member configured at its proximal end to engage the plug 140 and move the plug 140 in a proximal direction along the longitudinal the axis of the main body of the syringe for administering a dose of medicament through the needle 130. At or toward its distal end, the plunger 170 is provided with an actuation surface 175 on which a user can place a thumb or other finger to push the plunger 170 in a proximal direction to administer an injection. As the plunger rod 170 approaches or reaches the end of its stroke within the body of the syringe, the actuation surface 175 of the plunger rod 170 deflects the flexible locking arms 181 outward to a position in which they no longer interact with the locking surfaces 183 on the syringe shell 120. Thus, the locking mechanism is released at the end of the injection and the protective cover 150 is moved to its extended position.

[042] Although not apparent from the accompanying drawings, the manual injection device shown in FIG. 1A-B may further include a security locking element for locking the protective cover 150 in its extended position after completion of the injection.

[043] As shown in FIG. 3, there is an attachment 200 for use with an injection device 100, such as an UltraSafe(TM) device. The device 200 is described herein using the UltraSafe(TM) as a specific example of the injection device 100. However, the device 200 can be used with injection devices other than the UltraSafe(TM) device. For example, the specified device can be used with the UltraSafe Plus (TM) device. The design of the device 200 can be modified to fit the form factor of any suitable injection device.

[044] Device 200 includes a body 202 and a cap 204. Device 200 has a distal end 206 for positioning toward or on the injection site when performing an injection and a proximal end 208 opposite the distal end 206. Device 200 includes a window 210 in the cover 204 In addition, the main body 202 is provided with another window on the opposite side of the fixture 200.

[045] As shown in FIG. 4, the cover 204 is connected to the main body 202. Specifically, the cover 204 is pivotally coupled to the body 202 by a pair of hinges 216. Each of the hinges 216 is provided on a corresponding side of the fixture 200. Each hinge 216 includes an opening 218 in the main body 202 , through which a projection 203 extends in the cover 204. Alternatively, the projection 203 may be located on the body 202 with holes 218 in the cover 204. The projection 203 is shown in more detail in FIG. 8 and 9. The protrusion 203 is rotatable within the opening 218, which allows the cover 204 to rotate relative to the main body 202. Thus, the cover 204 is movable between the open position, which is represented in FIG. 4, and the closed position, which is shown in FIG. 3.

[046] An opening 218 of each hinge 216 is provided on a resilient fastener 217 coupled to the body 202. In this example, the resilient fastener 217 is integral with the body 202. The resilient fastener 217 is flexible relative to the body 202 so that so that the cover 204 can be inserted between the hinges 216. This simplifies the assembly process. In addition, each projection 203 on the cover 204 has a longitudinal surface and a lateral surface. The lateral surface is inclined relative to the longitudinal surface. In other words, the lateral surface is not perpendicular to the longitudinal surface. Thus, the projections help bend the resilient fasteners 217 when the cover 204 is installed on the body 202.

[047] The main body 202 includes a recess 220 for receiving the injection device 100. In FIG. 5 shows the injection device 100 located within the recess 220, with the length of the protective cover 150 located longitudinally within the recess 220. As shown in FIG. 4, the main body 202 also includes a slot 222. The length of the slot 222 is perpendicular to the longitudinal axis of the fixture 200. The slot 222 is configured to receive flanges 155 of the injection device 100, as illustrated in FIG. 5.

[048] When the cover 204 is in the open position, the recess 220 and slot 222 are open to receive the injection device 100. Specifically, the recess 220 receives the protective cover 150, and the slot 222 receives flanges 155. After positioning the injection device 100 in the recess 220 and slot 222, cover 204 moves from an open position to a closed position, as illustrated in FIG. 6. After this, the injection device 100 and the device 200 are ready to administer the injection. The user can place the device 200 containing the injection device on the injection site, such as the skin, and operate the activation surface 175 with one hand to administer the injection in a safe, simple and reliable manner.

[049] When the lid 204 is in the closed position, the lid 204 covers the recess 220 and the groove 222, holding the injection device 100 in the main body 202. When the injection device 100 is held within the device 200 by the lid 204 and the main body 202, the injection device 100 is visible through each window 210 provided on each side of the means 200. This allows the user to check the contents of the syringe before administering the injection.

[050] As shown in FIG. 4 and 5, the slot 222 is shaped to prevent the flanges 155 from moving toward the distal end 206 of the fixture 200, or in other words, the slot 222 is shaped to stop the flanges 155 from moving distally. The groove 222 is also shaped to prevent the flanges 155 from moving toward the proximal end 208 of the fixture 200, or in other words, the groove 222 is shaped to prevent the flanges 155 from moving proximally. However, the groove 222 is shaped to allow the syringe shell 120 of the injection device 100 to move proximally relative to the body 202. This allows the injection device 100 to move from a pre-injection position to a locked position, as described above. In this particular example, a cavity is formed in the body 202 and the cap 204 through which the syringe sheath can move. However, the width of this cavity is such that the flanges 155 cannot move through the cavity, and thus the flanges 155 are retained in the slot 222 when the lid 204 is in the closed position.

[051] As shown in FIG. 3, the main body 202 and the cover 204 are connected together to form a pair of opposite sides. The right side 212 is shown in FIG. 3, the opposite left side is not shown but is a mirror image of the right side 212. The fixture 200 includes a pair of opposing surfaces. Front surface 214 is shown in FIG. 3; the opposite dorsal surface is not shown. Each of the opposite surfaces has the same area, and each of them has a larger area than each of the opposite sides. The cover 204 forms part of the front surface 214, and the main part 202 forms the rear surface. The surfaces and sides connect the distal end 206 of the device 200 to the proximal end 208 of the device 200.

[052] The injection device 100 is positioned in the recess 220 by lowering the injection device 100 into the recess 220 at an angle. The direction in which the injection device 100 is moved toward the fixture 200 to position the injection device 100 in the recess 220 has a component in a direction perpendicular to the longitudinal axis of the fixture 200 and a component in a direction parallel to the longitudinal axis of the fixture 200. This direction extends toward the rear surface of the main body. 202. In particular, the groove 222 and recess 220 have an open end parallel to the ends of the fixture 200 into which the injection device 100 is lowered. Because the surfaces of the fixture 200 have a larger surface area than the sides, this provides a wider area required for the user to position the injection device. device 100 in fixture 200. This allows the user to position the injection device 100 with greater ease, especially for users with limited mobility.

[053] As shown in FIG. 4, the slot 222 includes a pair of distal support portions 224 on each side of the body 202. The distal support portions 224 are attached to the body 202, and each of the distal support portions 224 prevents distal movement of one of the flanges 155. Each of the distal support portions 224 is configured to integral with the main part 202, which provides a reliable connection that is easy to manufacture. However, the body 202 may be a modular portion in which the distal support portions 224 are removable from the body 202. Each distal support portion 224 has a flat top surface that extends into a curved bottom surface. This reflects the shape of the outer surface of the bottom of the flange, which helps securely secure the injection device 100 to the body 202.

[054] The groove 222 also includes a pair of proximal support portions 226. The proximal support portions 226 are attached to the body 202, and each of the proximal support portions 226 prevents proximal movement of one of the respective flanges 155. Each of the proximal support portions 226 is integral with main part 202, which provides a reliable connection that is easy to manufacture. However, the main body 202 may be a modular part in which the proximal support portions 226 are configured to be removable from the main body 202. Each proximal support portion 226 has a flat bottom surface for engagement with the top surface of one of the corresponding flanges 155. The proximal support portions 226 are located spaced apart to form a cavity through which the syringe sheath 120 can move.

[055] As shown in FIG. 4, the cover 204 has a slot 228. The cover slot 228 is configured to retain the edges 155 when the cover 204 is moved from the open position shown in FIG. 4 to the closed position shown in FIG. 6. The lid groove 228 is shaped to prevent the flanges 155 from moving toward the distal end 206 of the fixture 200 when the lid 204 is in the closed position, or in other words, the lid groove 228 is shaped to stop the flanges 155 from moving distally. The cover slot 228 is also shaped to prevent the flanges 155 from moving toward the proximal end 208 of the fixture 200, or in other words, the cover slot 228 is shaped to prevent the flanges 155 from moving proximally. However, the cap groove 228 is shaped to allow the syringe shell 120 of the injection device 100 to move proximally relative to the body 202. This allows the injection device 100 to move from a pre-injection position to a locked position, as described above. In this particular example, the cap slot 228 cooperates with the slot 222 in the body 202 to form a cavity through which the syringe shell 120 can move. However, the width of the cavity is such that the flanges 155 cannot move through the cavity, and thus the flanges 155 are retained in the lid slot 228 when the lid 204 is in the closed position.

[056] The cover groove 228 also includes a pair of distal support portions 230 on each side of the cover 204. The distal support portions 230 are attached to the cover 204, and each of the distal support portions 230 prevents distal movement of one of the respective flanges 155. Each of the distal support portions 230 is integrally formed with the cover 204, which provides a reliable connection that is easy to manufacture. However, the cover 204 may be a modular portion in which the distal support portions 230 are removable from the cover 204. As shown in FIG. 4, each distal support portion 230 includes a rib extending the entire length of the cover 204, thereby providing structural support for the cover 204.

[057] The cover groove 228 also includes a pair of proximal support portions 232. The proximal support portions 232 are attached to the cover 204, and each of the proximal support portions 232 prevents proximal movement of one of the respective flanges 155. Each of the proximal support portions 232 is integral with cover 204, which provides a reliable connection that is easy to manufacture. However, the cover 204 may be a modular portion in which the proximal support portions 232 are removable from the cover 204.

[058] As shown in FIG. 7 and 8, fixture 200 includes a decapping device 234 for removing the cap of the needle 190 from the injection device 100. The decapping device 234 includes a gripper, which in this example includes a pair of movable members 236, each of which has a gripping end for engaging the cap. 190 needles. Each of the gripping ends is shaped to match the outer surface of the needle cap 190. Each gripping end has a concave end for mating with the cylindrical outer shape of the needle cap 190. In this example, the movable elements 236 are integral with the cap removal device 234. However, the movable element 236 may be provided as separate components that flex or rotate relative to the cap removal device 234. For example, each movable member 236 may be mounted on the cap removal device 234 using a hinge. The needle cover 190 may be a rigid needle cover or a non-rigid needle cover. The rigid needle cap may be formed from at least two components, for example, it may comprise a rigid outer shell and an internal portion that surrounds the needle 130 of the syringe 110 in the applied position. The inner part can be plastic, elastic or flexible. This inner part may be made of rubber. Alternatively, a non-rigid needle cover may be used, in which case the needle cover may be a single plastic, resilient or flexible body, such as a rubberized needle cover. In the case of a non-rigid needle cap, the cap removal device 234 is configured to elastically grip the non-rigid needle cap during removal of the cap, for example, between a pair of movable members 236. Because the cap is not rigid, it is deformed within the cap removal device 234, in particular within the gripper , so that the grip is tight and close, and thus secure removal of the cap is ensured.

[059] In this example, the cap removal device 234 has an expanded configuration (as shown in FIG. 8) and a contracted configuration (not shown). In an extended configuration, the cap removal device 234 does not interact with the needle cap 190. In particular, the needle cap 190 may pass through or behind the movable member 236 when the decapping device 234 is in an expanded configuration, such as when the injection device 100 is inserted into the recess 220. In a narrowed configuration, the decapping device 234 holds the needle cap 190 so that that the decapping device 234 can remove the needle cap 190 from the injection device 100. Specifically, the movable members 236 move toward each other so that the decapping device 234 adopts a tapered configuration for gripping the needle cap 190 by the gripping ends. When the cap 204 is in the open position, the cap removal device 234 is in the extended position. Closing the cap 204 causes the cap removal device 234 to assume a contracted configuration as it slides forward to remove the needle cap 190. However, when the cap 204 is completely closed (as shown in FIG. 6), the cap removal device 234 again assumes an extended configuration for releasing the needle cap 190.

[060] In this particular example, the gripper has two configurations: an extended configuration and a narrowed configuration. However, in another example, the default capture may take a narrowed configuration. In this case, the gripper holds the needle cap 190 while placing the injection device 100 in the device 200 without having to move it from the expanded configuration to the contracted configuration. Such an alternative embodiment may be simpler to manufacture. However, the extended grip configuration allows the injection device 100 to be inserted into the fixture 200 without resisting the grip. In another embodiment, the gripper may include only one movable element that pushes the needle cap towards the stationary element.

[061] The decapping device 234 includes a pair of guides 240, each of which is located within a guide in the main body 202. The decapping device 234 is configured to slide along the guides in the main body 202.

[062] As shown in FIG. 9 and 10, the decapper 234 includes a pair of decap slots 242, each of which is provided on one side of the decapper 234. The cover 204 includes a proximal end 244 that can be moved by the user to move the cover 204 from an open position to a closed position. The cap 204 also includes a distal end 246 operatively coupled to the decapping device 234 for moving the decapping device 234 and the gripper including the movable members 236 distally.

[063] In this example, there is a pair of distal ends 246 of the cap 204, each of which includes a cap cam 243 located within one of the slots 242 of the cap removal device. Thus, each distal end 246 interacts with a corresponding one of the decap slots 242 to progressively move the decap device 234 distally as the cap 204 is rotated from an open position to a closed position. In FIG. 11 shows cap 204 in a closed position with cap removal device 234 distally moved.

[064] As shown in FIG. 9, cover 204 includes a pair of distal extensions, each of which extends distally from each hinge 216. A distal end 246 and a cover cam 243 are provided on the distal extension. There are a pair of proximal extensions, each corresponding to one of the distal extensions. Each proximal extension extends proximally from each hinge 216 to thereby form two sides of the proximal end 244 of the cap 204.

[065] Each proximal extension is longer than each distal extension. This helps provide mechanical advantage to the hinge 216 so that the lid 204 can be closed with less force. This is especially important because this movement also moves the decapping device 234 distally to remove the needle cap 190.

[066] As shown in FIG. 8 and 14, each of the movable grip members 236 is made of a flexible, resilient material. This allows the gripper to move from an expanded configuration, in which the needle cap 190 can pass between or past the gripper, to a contracted configuration, in which the gripper holds the needle cap 190 to remove the needle cap 190 from the injection device 100. On the outer surface of each of the movable elements 236 there is a cap removal device cam 248. Each decapper cam 248 mates with a curved decapper surface 250 on the body 202 as the decapper 234 is moved distally by the action of the cap 204. The decapper cam surfaces 250 are shown in FIG. 12 and 13. The cap removal device 234 also includes a pair of receiving slots, each of which is configured to receive at least a portion of the cap 204 when the cap 204 is in a closed position.

[067] The decapper cams 248 are inserted into the decapper curved surfaces 250 as the decapper 234 is advanced distally. This pushes the movable members 236 toward each other to move the gripper from an expanded configuration to a contracted configuration. Thus, when the injection device 100 is within the recess 200, the movable members 236 grasp the needle cap 190 and at the same time move the cap removal device 234 distally, thereby pulling the needle cap 190 distal from the injection device 100. This removes the needle cap 190 from injection device 100.

[068] As shown in FIG. 12 and 13, each of the curved surfaces 250 of the decapper is shaped such that the gripper moves from an expanded configuration to a contracted configuration and back to an expanded configuration as the cap 204 moves from an open position to a fully closed position. In this example, each of the curved surfaces 250 of the decapper has a proximal end 252 and a distal end 254 that do not interact with a corresponding one of the cams 248 of the decapper, and an intermediate section 256 that is positioned to interact with a corresponding one of the cams. 248 of the cap removal device, moving the movable element 236 as the removal device 234 moves distally.

[069] In FIG. 8 shows cap 204 in a fully open position with cap removal device 234 in an expanded configuration. In FIG. 12 shows the cap 204 in a fully closed position in which the decapper has returned to the expanded position from the contracted position when the cap 204 is moved from the fully open to the fully closed position.

[070] As shown in FIG. 15, the main body 202 includes a pair of guides 258 that receive a corresponding guide 240 of the cap removal device 234. Each guide 258 is configured to prevent the decapping device 234 from moving from the guide when the injection device 100 is positioned in the body 202. This is illustrated in FIG. 10. Specifically, the injection device 100 retains a cap removal device 234 in each guide 258 while the injection device 100 is located in the recess 220.

[071] Each guide 258 is configured such that when the injection device 100 is not located in the main body 202, the decapping device 234 can be moved in a direction having a component perpendicular to the axial direction (i.e., in a longitudinal direction that extends from the proximal end 208 to the distal end 206 of the device 200). However, when the injection device 100 is positioned in the main body 202, the decapping device 234 is held along each rail 258 by the injection device 100 such that the decapping device 234 can only slide in an axial direction relative to the main body 202.

[072] As shown in FIG. 7, each guide opens at least a portion of the decapping device 234 such that the injection device 100 at least partially retains the decapping device 234 within the guides 258 when the injection device 100 is positioned in the recess 220. As shown in FIG. 10, guides 258 open cap removal device 234 such that each guide 258 does not include means for contacting the top surface of cap removal device 234. That is, the body 202 does not have a collar or other such holding means for holding the decapper 234 in the body 202. Instead, the injection device 100 holds the decapper 234 in the guides 258. In particular, the decapper 234 directly contacts the injection device 100 when the injection device 100 is located within the recess 220. This simplifies the design of the device 200.

[073] As shown in FIG. 15, each guide 258 has a base 260 and a pair of side walls 264, 266 for guiding respective side surfaces of the decap removal device 234. In this example, a pair of side walls 264, 266 are integral with the main part 202. However, in another example, one or both of the side walls 264, 266 are separate components of the main body 202. The first of the side walls 266 of each rail 258 forms the wall of the window 268 through which the injection device 100 is visible when the injection device 100 is located within the device 200. The second the side wall 264 of each passage 258 forms the outer side wall of the fixture 200. The base 260 and/or side walls 264, 266 of each guide 248 are integral with the main body 202.

[074] The design features of the tool 200 described above allow the tool 200 to be inexpensive, simple and uncomplicated to use. In addition, the device 200 can be operated with one hand to administer an injection using the injection device 100.

[075] When used, the injection device as described above can be used to contain and deliver substances such as: antibodies (such as monoclonal antibodies, ustekinumab, golimumab, infliximab, guselkumab, sirukumab, adalimumab, rituximab, tocilizumab, certolizumab, certolizumab pegol, sarilumab, secukinumab, ixekizumab or its biosimilars), etanercept, abatacept, anakinira, epoetin alfa, darbepoetin alfa, epoetin beta-methoxypolyethylene glycol, peginesatide, hormones, antitoxins, analgesics, agents to control thrombosis, agents to control or eliminate infection , peptides, proteins, human insulin or human insulin analogue or derivative, polysaccharide, DNA, RNA, enzymes, oligonucleotides, antiallergic agents, antihistamines, anti-inflammatory drugs, corticosteroids, disease-modifying antirheumatic drugs, erythropoietin or vaccines for use in the treatment or prevention of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, hormone deficiency, poisoning, pain, thrombosis, infection, diabetes mellitus, diabetic retinopathy, acute coronary syndrome, angina pectoris, myocardial infarction, atherosclerosis, cancer, macular degeneration, allergies, hay fever, inflammation, anemia or myelodysplasia, or when protective immunity is activated. In addition to these substances, any drug contained within the injection device may also include other substances, such as inactive ingredients, as will be appreciated by one skilled in the art. One skilled in the art will undoubtedly know specific substances that are effective for use in the treatment or prevention of certain conditions. For example, antiallergic agents are known to be effective for use in the treatment or prevention of allergies; antihistamines are effective for use in the treatment or prevention of hay fever; anti-inflammatory drugs are effective for use in the treatment or prevention of inflammation; and so on. Accordingly, free selection is provided for one or more substances listed herein or in the claims for use in the treatment or prevention of one or more conditions for which the substance(s) are known to be effective. However, in a specific example, golimumab is known to be effective for use in the treatment or prevention of one or more types of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis or ulcerative colitis, or any combination of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and ulcerative colitis, or all types rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and ulcerative colitis.

[076] Golimumab can optionally be used in combination with one or more inactive components, such as any or all of L-histidine, L-histidine monohydrate monohydrochloride, sorbitol, polysorbate 80 and water. Golimumab may be present in a formulation where golimumab is the only active ingredient. For example, golimumab can be administered as SIMPONI®.

[077] The term "including" covers both "including" and "consisting of", for example, the composition "including" X may consist solely of X or may include something additional, for example X+ Y. Unless otherwise indicated, each of the embodiments described herein can be combined with another embodiment described herein. In the specific examples described above, pairs of specific components are provided to achieve certain functions. However, these functions can be performed using at least one of these components.

[078] It should be understood that the intended benefits and advantages described above may apply to one or more embodiments of the invention. Embodiments of the invention are not limited to those that solve any or all of the above problems or to those with any or all of the stated benefits and advantages. Single element references refer to one or more of these elements.

[079] It should be understood that the above description of a preferred embodiment of the invention is given by way of example only and that various modifications may be made by those skilled in the art. Although various embodiments of the invention have been described above in some detail or with reference to one or more individual embodiments, those skilled in the art will be able to make many changes to the described embodiments without departing from the scope of the present invention.

List of enumerated embodiments

1. A device for an injection device comprising a needle cap, the device comprising:

a main part containing a recess configured to receive an injection device;

a cover coupled to the main body, the cover being rotatable between an open position in which the recess is open to receive the injection device, and a closed position in which the cover at least partially covers the recess to retain the injection device in the main body; And

a decapping device comprising a gripper, wherein the decapping device has an expanded configuration in which the needle cap can be passed between the gripper, and a contracted configuration in which the gripper holds the needle cap to at least partially remove the needle cap from the injection device;

wherein the cap and the decapping device are operatively coupled to each other such that when the cap is moved from an open position to a closed position, the decapping device moves from an expanded configuration to a contracted configuration.

2. The device of embodiment 1, wherein the cap removal device is configured to return to an expanded configuration when the cap reaches a closed position to release the needle cap.

3. The device of Embodiment 1 or Embodiment 2, wherein the gripper comprises at least one movable element configured to hold the needle cap when the decapping device is in a reduced configuration, and offset from the needle cap when The cap removal device is in an advanced configuration.

4. The device according to embodiment 3, characterized in that the at least one movable element is made of a flexible elastic material that allows the at least one movable element to move between a position in which the gripper holds the needle cap and a position in which the needle cap can pass between grips.

5. The device according to embodiment 4, characterized in that the at least one movable element is flexible between a position in which the gripper holds the needle cap and a position in which the needle cap can pass between the gripper.

6. The apparatus of any one of the preceding embodiments, further comprising at least one decapper cam configured to engage at least one curved surface of the decapper so as to move the decapper from an expanded configuration to a reduced configuration configuration

7. The device according to embodiment 3, embodiment 6 and optionally embodiment 4, and/or embodiment 5, characterized in that at least one cam of the cap removal device is connected to or provided on the at least one movable element.

8. The device according to embodiment 6 or embodiment 7, characterized in that the curved surface of the cap removal device is connected to or provided on the main part.

9. The tool as in any one of embodiments 6 to 8, wherein at least one curved surface of the decapper is configured to interact with a cam of the decapper to move the decapper from an expanded configuration to a contracted configuration, and back to an expanded configuration where the decapper is moved over and past the curved surface of the decapper.

10. The device as in any one of embodiments 6 to 9, wherein at least one cam of the decapping device and at least one curved surface of the decapping device are offset relative to each other when the cap is in the open position.

11. The device as in any one of embodiments 6 to 10, wherein movement of the cap from the open position to the closed position causes the cap removal device cam to move into engagement with the curved surface of the decap device so that the decap device moves out of expanded configuration into a narrowed configuration.

12. A device according to any of the preceding embodiments, characterized in that the gripper includes at least one gripping end having a shape corresponding to the outer surface of the needle cap.

13. A device as in any of the preceding embodiments, wherein the gripper comprises a pair of movable members configured to retain a needle cap when the decapping device is in a reduced configuration and to move away from the needle cap when the decapping device is in a reduced configuration. advanced configuration.

14. The apparatus of embodiment 13, wherein each of the pair of movable members is formed from a flexible resilient material allowing each movable member to move between a position in which the gripper holds the needle cap and a position in which the needle cap can pass between the gripper.

15. The device of Embodiment 13 or Embodiment 14, wherein each of the pair of movable members is flexible between a position in which the gripper holds the needle cap and a position in which the needle cap can pass between the gripper.

16. The apparatus of any one of the preceding embodiments, further comprising a pair of decapper cams, each of which is positioned to engage one of a pair of corresponding curved surfaces of the decapper so as to move the decapper from an expanded configuration to a reduced configuration configuration

17. The device according to embodiment 13, embodiment 16 and optionally embodiment 14, and/or embodiment 15, characterized in that each cam of the cap removal device is connected to or provided on one of the corresponding movable elements.

18. The device according to embodiment 16 or embodiment 17, characterized in that each curved surface of the cap removal device is connected to or provided on the main part.

19. The fixture as in any one of embodiments 16 through 18, wherein the curved surfaces of the decapping device are arranged to move the decapping device from an expanded configuration to a narrowed configuration and back to the expanded configuration as the cams of the decapping device The cap removers move over and past each respective curved surface of the cap remover.

20. The device as in any one of embodiments 16 to 19, wherein each decapping cam and a corresponding curved surface of the decapping device are offset from each other when the cap is in the open position, so that the decapping cam and cap removal devices do not interact with each other.

21. The device as in any one of embodiments 16 to 20, wherein movement of the cap from an open position to a closed position causes each respective cam of the decapping device to move into engagement with a corresponding curved surface of the decapping device such that the decapping device The cap moves from an expanded configuration to a contracted configuration.

22. The device according to any of the preceding embodiments, characterized in that the gripper includes a pair of gripping ends, each of which is shaped to correspond to the outer surface of the needle cap.

23. The device as in any one of the preceding embodiments, wherein the cap includes a proximal end movable by a user to move the cap from an open position to a closed position.

24. The device as in any one of the preceding embodiments, wherein the cap includes a distal end configured to move the grip toward the end of the device when the cap is moved from an open position to a closed position to at least partially remove the needle cap from the injection device.

25. A device according to any of the previous embodiments, characterized in that the cover is connected to the main part by means of at least one hinge.

26. The device according to embodiment 25, characterized in that at least one hinge contains:

at least one hole in the main part; And

at least one protrusion in the cover, wherein at least one protrusion is rotatable within the opening.

27. The device of embodiment 25 or embodiment 26, wherein the cap includes at least one distal extension extending distally from the at least one hinge, the distal end of the cap being provided at the end of the distal extension.

28. The device as in any one of embodiments 25 to 27, wherein the cap includes a proximal extension that extends proximally from the at least one hinge.

29. The device according to embodiment 27 and embodiment 28, characterized in that the distal extension is shorter than the proximal extension.

30. The fixture of embodiment 24, and optionally of any of the preceding embodiments, wherein the distal end of the cap includes a cap cam located within a cap removal device groove in the cap removal device.

31. The tool of embodiment 30, wherein rotation of the cap cam about the axis of rotation causes the cap cam to act on a groove of the cap removal device so as to progressively move the cap removal device within the fixture.

32. The fixture of Embodiment 30 or Embodiment 31, wherein the cap is rotatably positioned from an open position to a closed position causing the cap cam to act on a decapper slot so as to move the decapper toward the distal end of the fixture. .

33. The device of embodiment 32, wherein the gripper is positioned to hold the needle cap and the decapping device slot is moved toward the distal end of the device to at least partially remove the needle cap from the injection device.

34. The device as in any one of embodiments 30 to 33, wherein the cap is rotatable from a closed position to an open position causing the cap cam to act on the cap removal device slot so as to move the cap removal device proximally. the end of the device.

35. A device according to any of the previous embodiments, characterized in that the cover is connected to the main part by means of a pair of hinges.

36. The apparatus of embodiment 35, wherein each of the pair of hinges includes an opening in the main portion and a protrusion in the cover, the protrusion being rotatable within the opening.

37. The apparatus of embodiment 35 or embodiment 36, wherein the cap comprises a pair of distal extensions, each of which extends distally from a corresponding hinge of the pair of hinges.

38. The device as in any one of embodiments 35 to 37, wherein the cap includes a pair of proximal extension ends, each of which extends proximally from a corresponding hinge of the pair of hinges.

39. The device of embodiment 36 and embodiment 37, wherein each distal extension is shorter than the corresponding proximal extension.

40. The device of embodiment 37 and optionally embodiment 38 and/or embodiment 39, further comprising a pair of distal cap ends, each provided at the end of each of the distal extensions, each of the distal ends being operatively coupled to a cap removal device so as to move the gripper toward the end of the device while moving the cap from an open position to a closed position to at least partially remove the needle cap from the injection device.

41. The apparatus of embodiment 40, wherein each distal end of the cap includes a cap cam positioned within a corresponding cap removal device slot in the cap removal device.

42. The fixture of embodiment 41, wherein the rotation of each cap cam about the axis of rotation causes each corresponding cap cam to act on a corresponding slot of the cap remover so as to progressively move the cap remover within the fixture.

43. The apparatus of Embodiment 41 or Embodiment 42, wherein the lid is rotatably positioned from an open position to a closed position causing each cam of the lid to act on a corresponding slot of the decapping device so as to move the decapping device to the distal end of the device.

44. The device as in embodiment 43, wherein the gripper is positioned to hold the needle cap and the decapping device slot is moved to the distal end of the device for removing the needle cap from the injection device.

45. The fixture as in any one of embodiments 41 to 44, wherein the lid is rotatable from a closed position to an open position causing each cam of the lid to act on a corresponding slot of the decapper so as to move the decapper toward proximal end of the device.

46. A device according to any of the preceding embodiments, characterized in that the device is intended for an injection device containing a protective cover and at least one flange configured to provide a user with a grip of the injection device and a syringe sheath configured to move relative to at least one flange from the pre-injection position to the locked position, and the main part further includes a groove configured to receive at least one flange of the injection device.

47. The device of embodiment 46, wherein the recess and groove are open to receive the protective cover and at least one flange, respectively, when the cover is in the open position.

48. The device of embodiment 46 or embodiment 47, wherein the lid at least partially covers the recess and groove for holding the injection device in the device when the lid is in the closed position.

49. The device as in any one of embodiments 46 to 48, wherein the groove is shaped to prevent the at least one flange from moving distally and proximally relative to the body and to allow the syringe sheath to move proximally relative to the body from a pre-injection position to a locked position.

50. The device according to any of embodiments 46 to 49, further comprising:

a distal end of the device configured to be located in the direction of the injection site, and an opposite proximal end of the device;

a pair of opposing surfaces and a pair of opposing sides connecting the distal end of the proximal end of the device.

51. The apparatus of embodiment 50, wherein each of the opposing surfaces has a larger area than each of the opposing sides.

52. The device according to embodiment 50 or embodiment 51, characterized in that one of the opposing surfaces contains a cover.

53. The fixture as in any one of embodiments 50 to 52, wherein the groove and recess have an open surface parallel to the surfaces of the fixture.

54. The device according to any one of embodiments 46 to 53, characterized in that the recess and groove are located to receive the injection device when it moves in a direction perpendicular to the longitudinal axis of the device.

55. The fixture as in any one of embodiments 46 to 54, wherein the groove includes at least one distal support portion configured to prevent movement of the at least one flange distally relative to the fixture.

56. The device according to embodiment 55, characterized in that at least one distal support portion of the groove is integral with the main part.

57. The fixture of embodiment 55 or embodiment 56, wherein the shape of the at least one distal support portion at least partially matches the shape of the underside of the at least one flange.

58. The fixture as in any one of embodiments 46 to 57, wherein the groove includes at least one proximal support portion configured to prevent movement of the at least one flange proximally relative to the fixture.

59. The device according to embodiment 58, characterized in that at least one proximal groove support portion is integral with the main part.

60. The device as in any one of embodiments 46 to 59, wherein the cap includes a cap groove shaped to prevent movement of the at least one flange distally and proximally relative to the device, but allowing the syringe sheath to move proximally relative to the device from a pre-injection position. to the locked position.

61. The device according to embodiment 60, characterized in that the lid groove is formed inside the lid.

62. The fixture of embodiment 61, wherein the cover groove includes at least one distal support portion configured to prevent movement of the at least one flange distally relative to the fixture.

63. The device according to embodiment 62, characterized in that at least one distal support portion of the cover groove is integral with the cover.

64. The fixture as in any one of embodiments 60 through 63, wherein the cover groove includes at least one proximal support portion configured to prevent movement of the at least one flange proximally relative to the fixture.

65. The device according to embodiment 64, characterized in that at least one proximal support portion of the cover groove is integral with the cover.

66. The apparatus of any one of embodiments 46 to 65, which is configured for an injection device having a pair of flanges configured to allow a user to grip the injection device.

67. The fixture of embodiment 66, wherein the groove comprises a pair of distal support portions, each of which is configured to prevent movement of a corresponding flange of the pair of flanges distally relative to the fixture.

68. The device according to embodiment 67, characterized in that the pair of distal support sections is integral with the main part.

69. The apparatus of Embodiment 67 or Embodiment 68, wherein the shape of each of the pair of distal support portions at least partially matches the shape of the underside of the corresponding flange of the pair of flanges.

70. The device as in any one of embodiments 66 to 69, wherein the groove includes a pair of proximal support portions, each of which is configured to inhibit proximal movement of a corresponding flange of the pair of flanges relative to the main body.

71. The device according to embodiment 70, characterized in that the pair of proximal support sections is integral with the main part.

72. The device as in any one of embodiments 60 to 71, wherein the cover groove includes a pair of distal support portions configured to prevent movement of the pair of flanges distally relative to the body.

73. The device according to embodiment 72, characterized in that the pair of distal support portions of the cover groove are integral with the cover.

74. The device as in any one of embodiments 60 to 73, wherein the cover groove includes a pair of proximal support portions configured to prevent movement of the pair of flanges proximally relative to the body.

75. The device according to embodiment 74, characterized in that the pair of proximal support portions of the cover groove are integral with the cover.

76. A device according to any of the previous embodiments, characterized in that the main part contains a guide, inside of which there is a device for removing the cap with the possibility of translational movement; And

wherein the guide opens at least a portion of the decapping device such that the injection device at least partially retains the decapping device within the guide when the injection device is positioned in the recess.

77. The device according to embodiment 76, characterized in that the guide is designed in such a way that the decapping device directly contacts the injection device when the injection device is positioned in the recess.

78. The device of embodiment 76 or embodiment 77, wherein the guide does not include means configured to contact the top surface of the cap removal device.

79. The device according to any one of embodiments 76 to 78, characterized in that the guide includes a base and at least one side wall.

80. The device according to any of embodiments 76 to 79, characterized in that the guide contains:

a base configured to guide a lower surface of the cap removal device; And

at least one side wall configured to guide a side surface of the cap removal device.

81. The device according to embodiment 80, characterized in that at least one side wall forms a window wall through which the injection device is visible when the injection device is located inside the device.

82. The fixture of embodiment 80, wherein the at least one side wall defines an outer side wall of the fixture.

83. The device according to any of embodiments 80 to 82, characterized in that the base and/or at least one side wall is integral with the main part.

84. The device as in any one of embodiments 80 to 83, wherein the guide comprises a pair of side walls configured to guide corresponding side surfaces of the decap removal device.

85. The device according to any of embodiments 80 to 84, characterized in that the pair of side walls is integral with the main part.

86. The device according to any of the embodiments from 76 to 85, characterized in that the main part contains a pair of guides, inside of which there is a device for removing the cap with the possibility of translational movement; And

wherein each guide exposes at least a portion of the decap device such that the injection device at least partially retains the decap device within each guide when the injection device is positioned in the recess.

87. The apparatus of embodiment 86, wherein each guide is configured such that the decapping device is in direct contact with the injection device when the injection device is positioned within the recess.

88. The device of embodiment 86 or embodiment 87, wherein each guide does not include means configured to contact the top surface of the cap removal device.

89. The device according to any one of embodiments 86 to 88, characterized in that each guide includes a base and at least one side wall.

90. The device according to any of embodiments 86 to 89, characterized in that each guide contains:

a base configured to guide a lower surface of the cap removal device; And

at least one side wall configured to guide a side surface of the cap removal device.

91. The device according to embodiment 90, characterized in that at least one side wall of each guide forms the wall of a window through which the injection device is visible when the injection device is in the device.

92. The fixture of embodiment 90, wherein at least one side wall of each rail defines an outer side wall of the fixture.

93. The device according to any of embodiments 90 to 92, characterized in that the base and/or at least one side wall of each guide is integral with the main part.

94. The device as in any one of embodiments 90 to 93, wherein each guide includes a pair of side walls configured to guide corresponding side surfaces of the decap removal device.

95. The device according to any of embodiments 90 to 94, characterized in that a pair of side walls of each guide is integral with the main part.

96. The device according to any one of embodiments 76 to 95, characterized in that the device for removing the cap includes a guide configured to be placed inside the guide.

97. The device according to any of the preceding embodiments, characterized in that the cap removal device includes at least one receiving slot configured to receive at least a portion of the cap when the cap is in a closed position.

98. The device as in any one of the preceding embodiments, wherein the cap removal device comprises a pair of receiving slots, each of which is configured to receive at least a portion of the cap when the cap is in a closed position.

99. A device according to any of the preceding embodiments, characterized in that the main part contains at least one elastic fastening element configured to connect the cover to the main part.

100. The device according to any of the preceding embodiments, characterized in that the main part contains a guide, within which the device for removing the cap is placed with the possibility of axial movement relative to the main part, and wherein the guide is designed so that when the injection device is positioned in the main part part of the cap removal device is held close to the guide by an injection device.

101. The device according to embodiment 100, characterized in that the guide is configured such that when the injection device is placed in the main part, the decapping device cannot move from the guide.

102. The apparatus of Embodiment 100 or Embodiment 101, wherein the guide is configured such that, in the absence of an injection device in the main body, the cap removal device can be moved in a direction having a component perpendicular to the axial direction.

103. The device according to any one of embodiments 100 to 102, characterized in that the guide is configured such that when the injection device is placed in the main part, the decapping device is held close to the guide by the injection device so that the decapping device can only move in axial direction relative to the main part.

104. The device according to any of the preceding embodiments, characterized in that the main part includes a guide within which the cap removal device slides.

105. The fixture of Embodiment 1 and Embodiment 6, and optionally any of the other preceding embodiments, wherein at least one cam of the cap removal device is slidable within a groove on the body portion comprising a curved surface of the cap removal device. cap.

106. A system for administering an injection, comprising: an injection device containing a needle cap; and the device according to any of the previous embodiments.

107. The system of embodiment 106,

characterized in that the injection device contains a substance that is selected from the group consisting of the following:

antibodies (such as monoclonal antibodies, ustekinumab, golimumab, infliximab, guselkumab, sirukumab, adalimumab, rituximab, tocilizumab, certolizumab, certolizumab pegol, sarilumab, secukinumab, ixekizumab or their biosimilar variants), etanercept, abatacept, anakinra, epoetin alfa, darbepoetin alfa , epoetin beta-methoxypolyethylene glycol, peginesatide, hormones, antitoxins, analgesics, thrombosis control agents, infection control or elimination agents, peptides, proteins, human insulin or human insulin analog or derivative, polysaccharide, DNA, RNA, enzymes, oligonucleotides, antiallergic drugs, antihistamines, anti-inflammatory drugs, corticosteroids, disease-modifying antirheumatic drugs, erythropoietin or vaccines for use in the treatment or prevention of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, hormone deficiency, pain, thrombosis, infection, diabetes mellitus , diabetic retinopathy, acute coronary syndrome, angina pectoris, myocardial infarction, atherosclerosis, cancer, macular degeneration, allergies, hay fever, inflammation, anemia or myelodysplasia, or when protective immunity is activated.

108. A connection selected from the group consisting of:

antibodies (such as monoclonal antibodies, ustekinumab, golimumab, infliximab, guselkumab, sirukumab, adalimumab, rituximab, tocilizumab, certolizumab, certolizumab pegol, sarilumab, secukinumab, ixekizumab or their biosimilar variants), etanercept, abatacept, anakinra, epoetin alfa, darbepoetin alfa , epoetin beta-methoxypolyethylene glycol, peginesatide, hormones, antitoxins, analgesics, thrombosis control agents, infection control or elimination agents, peptides, proteins, human insulin or human insulin analog or derivative, polysaccharide, DNA, RNA, enzymes, oligonucleotides, antiallergic drugs, antihistamines, anti-inflammatory drugs, corticosteroids, disease-modifying antirheumatic drugs, erythropoietin or vaccines for use in the treatment or prevention of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, hormone deficiency, pain, thrombosis, infection, diabetes mellitus , diabetic retinopathy, acute coronary syndrome, angina pectoris, myocardial infarction, atherosclerosis, cancer, macular degeneration, allergy, hay fever, inflammation, anemia or myelodysplasia, or upon activation of protective immunity by delivery of said substance to a human subject using the system of an embodiment 106.

109. Injection device for use in the treatment or prevention of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, hormone deficiency, poisoning, pain, thrombosis, infection, diabetes mellitus, diabetic retinopathy, acute coronary syndrome, angina pectoris, myocardial infarction, atherosclerosis, cancer, macular degeneration, allergy, hay fever, inflammation, anemia or myelodysplasia, or activation of protective immunity by delivery of a substance that is selected from the group consisting of: antibodies (such as monoclonal antibodies, ustekinumab, golimumab, infliximab, guselkumab, sirukumab, adalimumab, rituximab, tocilizumab, certolizumab, certolizumab pegol, sarilumab, secukinumab, ixekizumab or their biosimilars), etanercept, abatacept, anakinra, epoetin alfa, darbepoetin alfa, epoetin beta-methoxypolyethylene glycol, peginesatide, hormones, antitoxins, pain relievers substances, substances for thrombosis inhibitors, substances to control or eliminate infection; peptides, proteins, human insulin or human insulin analog or derivative, polysaccharide, DNA, RNA, enzymes, oligonucleotides, antiallergic drugs, antihistamines, anti-inflammatory drugs, corticosteroids, disease-modifying antirheumatic drugs, erythropoietin or vaccines, to a human subject by systems according to embodiment 106.

Claims (19)

1. A device for an injection device comprising a needle cap, the device comprising: a main part containing a recess configured to receive an injection device; a cover coupled to the main body, the cover being rotatable between an open position in which the recess is open to receive the injection device, and a closed position in which the cover at least partially covers the recess to retain the injection device in the main body; And a decapping device comprising a gripper having at least one movable member, the decapping device having an expanded configuration in which the needle cap can pass between the gripper, and a contracted configuration in which the gripper holds the needle cap for at least partial removal needle cap from the injection device; wherein the cap and the decapping device are operatively coupled to each other such that when the cap is moved from an open position to a closed position, the decapping device i) moves from an expanded configuration to a contracted configuration such that at least one movable element moves in an inward direction to the needle cover, and ii) moves from the constricted configuration such that the at least one movable element changes direction to move from the needle cover in an outward direction opposite to the inward direction to release the needle cover. 2. The device according to claim 1, characterized in that the at least one movable element is made of a flexible elastic material that allows the at least one movable element to move between a position in which the gripper holds the needle cap and a position in which the needle cap can pass between grips. 3. The device according to claim 2, characterized in that at least one movable element is flexible between a position in which the gripper holds the needle cap and a position in which the needle cap can pass between the gripper. 4. The apparatus of claim 1, further comprising at least one decapper cam configured to engage at least one curved surface of the decapper so as to move the decapper from an expanded configuration to a reduced configuration . 5. A device according to claim 4, characterized in that at least one cam of the cap removal device is connected to or provided on at least one movable element. 6. The device according to claim 4, characterized in that the curved surface of the cap removal device is connected to or provided on the main part. 7. The device of claim 4, wherein at least one curved surface of the decapping device is configured to interact with a cam of the decapping device to move the decapping device from the expanded configuration to the narrowed configuration and back to the expanded configuration, when the decapping device moves over and past the curved surface of the decapping device. 8. The device according to claim 4, characterized in that at least one cam of the decapping device and at least one curved surface of the decapping device are offset relative to each other when the cap is in the open position. 9. The apparatus of claim 4, wherein movement of the cap from the open position to the closed position causes the cap removal device cam to move into engagement with a curved surface of the decap device such that the decap device moves from an expanded configuration to a contracted configuration . 10. The device according to claim 1, characterized in that the gripper contains at least one gripping end having a shape corresponding to the outer surface of the needle cap. 11. The device according to claim 1, characterized in that the gripper contains a pair of movable elements configured to hold the needle cap when the cap removal device is in a narrowed configuration, and offset from the needle cap when the cap removal device is in an expanded configuration. configurations. 12. A system for administering an injection, comprising: an injection device containing a needle cap; and the device according to claim 1. 13. The system according to claim 12, characterized in that the injection device contains a substance selected from the group consisting of: antibodies (such as monoclonal antibodies, ustekinumab, golimumab, infliximab, guselkumab, sirukumab, adalimumab, rituximab, tocilizumab, certolizumab, certolizumab pegol, sarilumab, secukinumab, ixekizumab or their biosimilar variants), etanercept, abatacept, anakinra, epoetin alfa, darbepoetin alfa , epoetin beta-methoxypolyethylene glycol, peginesatide, hormones, antitoxins, analgesics, thrombosis control agents, infection control or elimination agents, peptides, proteins, human insulin or human insulin analogue or derivative, polysaccharide, DNA, RNA, enzymes, oligonucleotides, antiallergic drugs, antihistamines, anti-inflammatory drugs, corticosteroids, disease-modifying antirheumatic drugs, erythropoietin or vaccines for use in the treatment or prevention of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, hormone deficiency, pain, thrombosis, infection, diabetes mellitus, diabetic retinopathy, acute coronary syndrome, angina pectoris, myocardial infarction, atherosclerosis, cancer, macular degeneration, allergies, hay fever, inflammation, anemia or myelodysplasia or when protective immunity is activated. 14. Injection device for use in the treatment or prevention of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, hormone deficiency, poisoning, pain, thrombosis, infection, diabetes mellitus, diabetic retinopathy, acute coronary syndrome, angina pectoris, myocardial infarction, atherosclerosis, cancer, macular degeneration, allergy, hay fever, inflammation, anemia or myelodysplasia, or activation of protective immunity by delivery of a substance selected from the group consisting of: antibodies (such as monoclonal antibodies, ustekinumab, golimumab, infliximab, guselkumab, sirukumab, adalimumab , rituximab, tocilizumab, certolizumab, certolizumab pegol, sarilumab, secukinumab, ixekizumab or their biosimilars), etanercept, abatacept, anakinra, epoetin alfa, darbepoetin alfa, epoetin beta-methoxypolyethylene glycol, peginesatide, hormones, antitoxins, analgesics, substances for containment thrombosis, substances to control or eliminate infection; peptides, proteins, human insulin, or human insulin analog or derivative, polysaccharide, DNA, RNA, enzymes, oligonucleotides, antiallergic agents, antihistamines, anti-inflammatory agents, corticosteroids, disease-modifying antirheumatic drugs, erythropoietin or vaccines, human subject using the system according to clause 12.