RU2797846C1 - Method for treatment of skin papilloma - Google Patents

Abstract

FIELD: medicine; dermatology.

SUBSTANCE: invention can be used to treat skin papillomas. Skin papilloma is treated once with an aqueous solution of calcium hydroxide. An aqueous solution of calcium hydroxide is prepared in the ratio of 1 part of calcium hydroxide and 2 parts of water.

EFFECT: invention provides affordable, conservative treatment of human skin papilloma in the absence of this disease recurrence.

1 cl, 4 ex

Description

The invention relates to medicine, namely to oncology, because papilloma refers to benign tumors of epithelial origin. Human papilloma is caused by the human papillomavirus (HPV). 2 strains have the highest oncogenicity - 16 and 18. This means that when infected with them, there is a probability of 18-22% of the appearance of human skin cancer. Danger signs include:

1. Color change of papilloma;

2. The color of the papilloma becomes uneven.

3. Changing its shape;

4. Increase in the size of papilloma;

5. Lack of mobility of papilloma;

6. An increase in the size of regional lymph nodes.

More than 300 thousand people a year die from the transition to human papilloma skin cancer (J. Meyers, E. Ryndok, M.J. Conway et all. Susceptibilit at high - risk human papillomavirus type 16 to clinical disinfectants // J. of Antimikrobial Chemotherapy. - 2014 - 6. - V. 69, issue 6. - S. 1546-1550. ISSN 0305-7453).

Analog

A known method of destructive treatment of skin papilloma proposed by Yu.Yu. Stirschneider, V.A. Volnukhin in 2012. (Stirshnaider Yu.Yu., Volnukhin V.A. Comparative evaluation of the effectiveness of the treatment of patients with common warts by destructive methods. Bulletin of Dermatology and Venereology, 2012. - No. 5. - P. 65-70). These authors refer to destructive methods of treating papillomas: cryotherapy, coagulation and excision of a benign tumor, i.e. papillomas.

The destructive method of treatment has the following disadvantages. Expensive equipment is needed for a destructive method of treatment:

electroknife for papilloma coagulation; Dubois balloon, liquid nitrogen and special equipment for bringing liquid nitrogen to papilloma during cryotherapy; scalpel and clamps for papilloma excision.

After the use of destructive methods, a scar is observed on the patient's skin.

Prototype

A method for the treatment of human skin papilloma, which consists in the fact that Keravort cream (imichimod - 5% cream) is applied to the surface of the papilloma, is taken as a prototype. (Papillovirus infection: modern ideas about the pathogenesis and treatment. Clinical dermatology and venereology, 2018. - No. 1. - P. 94-103).

Keravort cream is applied to the papilloma every other day before going to bed for 6-10 hours, and the next morning, the area of application of the cream is cleaned with water and mild soap. Treatment is continued until the papilloma disappears. When using the drug, local reactions may occur. If necessary, you can take a break for a few days and continue treatment. 32-80% of patients are cured. There are recurrences of papilloma in patients who have been treated from 20-68%. After applying keravort, destruction and inflammation are observed.

Criticism of the prototype

Keravort cream treatment has the following disadvantages.

- It is necessary to treat papilloma with Keravort cream three times a week (every other day) until the papilloma disappears.

- Some patients have allergies.

- It is possible to cure 32-80% of patients. Relapses are possible in 20-68% of patients.

- Sometimes you have to take a break with poor tolerance, which increases the duration of treatment.

- The cost of this drug is high.

Treatment with Keravort cream has the following disadvantages: duration of treatment and insufficient clinical effect of treatment, in some cases, patients have an allergy.

The purpose of the proposed invention is to develop an affordable conservative method for the treatment of skin papilloma in an experiment using a calcium hydroxide solution.

The essence of the alleged invention.

Treatment with calcium hydroxide of skin papilloma is carried out according to the following scheme. In the experiment, 10 rabbits of the French Sheep breed were treated with an aqueous solution of calcium hydroxide for the treatment of skin papillomas. Calcium hydroxide has the chemical formula CA(OH)2. Treatment regimen: prepare a solution of 1 part of calcium hydroxide and 2 parts of water in a ratio of 1: 2, this solution is used to treat rabbit skin papilloma once. After applying an aqueous solution of calcium hydroxide, swelling of the skin and papilloma is observed for 1-2 days, and then on the 4th day the papilloma disappears, recovery occurs.

In the clinic, 15 patients applied the proposed method for the treatment of skin papilloma with a solution of calcium hydroxide.

Scheme of treatment: prepare a solution of calcium hydroxide in the ratio of 1 part of calcium hydroxide and 2 parts of water: 1:2. This solution treats the patient's skin papilloma once. After applying an aqueous solution of calcium hydroxide for 1-2 days, irritation is observed in the form of swelling of the skin and papilloma, and then on the 4th day the papilloma disappears, recovery occurs. The procedure is carried out 1 time.

Examples of specific implementation of the method.

Example #1.

We give example No. 1 from the experimental journal.

A papilloma of 0.7 by 0.8 cm in size was diagnosed in the rabbit "French Sheep" on the skin of the right hind leg. An aqueous solution of calcium hydroxide was prepared in a ratio of 1: 2 (1 part of calcium hydroxide and 2 parts of water) and the papilloma of the skin of the right was treated once hind leg. In the first 2 days, signs of skin irritation and swelling were found. On the 4th day there was a recovery. On the skin of the fore paw on the right, the papillomas disappeared; recovery has come. The goal set by the invention has been achieved. The procedure is carried out 1 time.

Example #2.

We give example No. 2 from the experimental magazine.

The rabbit "French Sheep" on the skin of the hind legs was diagnosed with papillomatosis-3 papillomas on the skin of the left leg measuring 0.9 by 1.0 cm and on the skin of the right leg 4 papillomas located next to each other. An aqueous solution of calcium hydroxide was prepared in a ratio of 1:2 (1 part of calcium hydroxide and 2 parts of water) and the papillomas of the skin of the hind legs were treated once. In the first 2 days, signs of skin irritation and swelling were found. On the 4th day there was a recovery. On the skin of the hind legs, the papillomas disappeared; recovery has come. The goal set by the invention has been achieved. The procedure is carried out 1 time.

Example #3

We give an example No. 3 from an outpatient card.

Patient R., aged 19, came to the appointment with complaints about the presence of papilloma 0.9 by 1 cm in size on the skin of the back surface of the 1st finger of the left hand. After the examination, the diagnosis was made: papilloma of the skin of the dorsum of the 1st finger of the left hand. An aqueous solution of calcium hydroxide was prepared in a ratio of 1:2 (1 part of calcium hydroxide and 2 parts of water) and the skin papilloma of the dorsum of the left hand was treated with this solution once. In the first 2 days, signs of skin irritation were found. After 4 days there was a recovery. The procedure is carried out 1 time.

Example #4

We give an example No. 4 from an outpatient card.

Patient O., 56 years old, came to the appointment complaining of the presence of 3 papillomas measuring 1 by 1.5 cm and measuring 1 by 1 cm on the skin of the back. After the examination, the diagnosis was made: papillomatosis of the skin of the back. An aqueous solution of calcium hydroxide was prepared in a ratio of 1:2 (1 part of calcium hydroxide and 2 parts of water) and the back skin papilloma was treated with this solution once. In the first 2 days, signs of skin irritation were found. After 4 days there was a recovery. The procedure is carried out 1 time.

Signs that are different from the prototype.

According to the proposed method, it is sufficient to treat the surface of the skin papilloma once with a solution of calcium hydroxide. According to the prototype method, it is necessary to treat papilloma with Keravort cream three times a week (every other day) until the papilloma disappears.

The positive effect of the application of the invention.

1. According to the proposed method, an aqueous solution of calcium hydroxide is proposed for treating the surface of skin papilloma in a ratio of 1:2.

2. Skin papilloma is treated with calcium hydroxide solution once.

The method for the treatment of skin papilloma was performed in the experiment on 10 rabbits and in the clinic in 15 patients. In all cases, skin papilloma disappeared on the 2-4th day. No relapse was observed.

Information sources

1. Klyuchareva SV. et al. Papillomavirus infection: modern concepts of pathogenesis and treatment. Clinical dermatology and venereology, 2018. - No. 1. - S. 94-103). - prototype

2. Stirshnaider Yu.Yu., Volnukhin V.A. Comparative evaluation of the effectiveness of the treatment of patients with common warts by destructive methods. Bulletin of dermatology and venereology, 2012. - No. 5. - S. 65-70.

3. John Rumble (June 18, 2018) CRC Hanbook of Chemistry and Physics (99 ed.). C.R.C. Press. - C.5-188. ISBN 978 - 1138561632.

4. Meyers J., Ryndok E., Conway M.J. et all. Susceptibility of high - risk human papillomavirus type 16 to clinical disinfectants // J. of Antimikrobial Chemotherapy. - 2014 - 6. - T. 69, no. 6. - S. 1546-1550. ISSN 0305-7453).

Claims (1)

A method for treating skin papilloma, characterized in that the skin papilloma is treated once with an aqueous solution of calcium hydroxide, prepared in a ratio of 1 part of calcium hydroxide and 2 parts of water.