RU2785541C2 - Aerosolised composition - Google Patents

Abstract

FIELD: smoking devices.

SUBSTANCE: group of inventions relates to an aerosolised composition for inhalation by the user of an aerosol providing apparatus, a method for generation thereof, an electronic aerosol providing system, and a method for improving the delivery of a flavouring substance into the aerosolised composition. Aerosolised composition for inhalation by the user of an aerosol supply apparatus contains: (i) water in the amount of at least 50 wt.% relative to the mass of the aerosolised composition and (ii) at least one flavouring substance, wherein the aerosolised composition contains at least one flavouring substance in the amount of at least 70 wt.% in relation to the mass of said flavouring substance present in the aerosolising composition used to produced the aerosolised composition.

EFFECT: creation of a composition with improved organoleptic properties, with protection of the flavouring substance from heat-induced decomposition, reduction of harm caused by electronic cigarette devices.

29 cl, 1 dwg, 2 ex

Description

The technical field to which the invention belongs

The present disclosure relates to an aerosolized composition, a method for its formation, a device for its formation, as well as methods and uses of such a composition.

State of the art

Electronic aerosol delivery systems, such as electronic cigarettes, typically contain a reservoir of liquid to be vaporized, typically containing a flavor or active agent such as nicotine. When a user inhales through such a device, the heater is activated so as to vaporize a small amount of liquid which is subsequently inhaled by the user.

The use of e-cigarettes in the UK is growing rapidly and it is estimated that over a million people are currently using them in the UK.

One of the problems encountered in designing such systems is to provide an inhalable aerosol from the aerosol supply device that provides an acceptable user experience. Some consumers may prefer e-cigarettes that produce an aerosol that very closely "simulates" the smoke inhaled from a tobacco product such as a cigarette. Aerosols from electronic cigarettes and smoke from tobacco products such as cigarettes provide the user with a complex chain of taste sensations in the mouth and, if nicotine is present, absorption of nicotine in the mouth and throat followed by absorption of nicotine in the lungs. These various aspects are described by users in terms of flavor sensation, intensity/quality, impact, irritation/softness, and nicotine satisfaction. The flavoring agent influences a number of these factors and is closely related to the flavor in the mouth and providing the desired taste and smell, whether mimicking the taste and smell of a tobacco product or providing alternative flavors. Reliable provision of a specific taste and smell is difficult due to the volatility and thermal sensitivity of some flavoring substances. Heating flavors in electronic cigarettes may cause some flavors to degrade. This has a number of disadvantages. Flavors present in the liquid may be lost, resulting in poor user experience or the need to include excess flavor in the liquid, which adds to the cost. Also, if e-liquid contains multiple flavors and only some of them are degraded, the balance of taste and smell may be adversely affected. In addition, decomposed flavors may have an undesirable or "off-taste". Each of these factors and their balance can greatly contribute to consumer acceptance of an e-cigarette. Therefore, it is desirable for manufacturers of electronic cigarettes to offer means to optimize the overall perception of smoking an electronic cigarette.

Another problem such systems face is the constant demand for harm reduction. Harm from cigarettes and e-cigarette devices is primarily associated with toxic substances. Therefore, there is a desire to reduce the potential for the formation of toxic substances.

Disclosure of invention

In one aspect, an aerosolized composition is provided comprising:

(i) water in an amount of at least 50 wt. % based on the weight of the aerosolized composition; and

(ii) at least one flavoring agent;

wherein the aerosolized composition contains said at least one flavoring agent in an amount of at least 70 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared.

In one aspect, a method is provided for generating an aerosol, the method comprising aerosolizing an aerosol-formable composition comprising

(i) water in an amount of at least 50 wt. % based on the weight of the aerosolized composition; and

(ii) at least one flavoring agent;

to obtain an aerosol containing the specified at least one flavoring substance in an amount of at least 70 wt. % based on the weight of said flavor present in the aerosolizable composition.

In one aspect, an electronic aerosol delivery system is provided, comprising:

(a) an aerosol generator for aerosolizing a composition to be inhaled by a user of the electronic aerosol delivery system;

(b) a power supply containing a galvanic cell or battery, designed to supply the aerosol generator with energy

(c) an aerosolizable composition comprising:

(i) water in an amount of at least 50 wt. % based on the weight of the aerosolized composition; and

(ii) at least one flavoring agent;

in which the aerosol generator provides an aerosol containing the specified at least one flavoring substance in an amount of at least 70 wt. % based on the weight of said flavor present in the aerosolizable composition.

In one aspect, a method is provided for improving flavor delivery to an aerosolized composition, the method comprising the steps of:

(a) providing capable of forming an aerosol material containing (i) water in an amount of at least 50 wt. %, based on the weight of the aerosolizable material; and (ii) at least one flavoring agent;

(b) transfer to the aerosol state of the specified capable of forming an aerosol material to obtain an aerosol containing the specified at least one flavoring substance in an amount of at least 70 wt. % based on the weight of said flavor present in the aerosolizable composition.

Implementation of the invention

As discussed herein, in one aspect, an aerosolized composition is provided, comprising:

(i) water in an amount of at least 50 wt. % based on the weight of the aerosolized composition; and

(ii) at least one flavoring agent;

wherein the aerosolized composition contains said at least one flavoring agent in an amount of at least 70 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared.

The inventors have found that an advantageous system can be provided in which an aerosolized composition having a high water content and containing a flavoring agent is derived from an aerosolizable composition. The use of a system containing at least 50 wt. % water, "protects" the flavoring substance from decomposition under the influence of heat and, in particular, allows the formation of an aerosolized composition at low temperature. This is in contrast to "traditional" e-cigarettes, which use a heater commonly used with glycerin and propylene glycol based liquids to form an aerosolized composition.

For ease of reference, these and other aspects of the present invention are now discussed under their respective section headings. However, the ideas in each section are not necessarily limited to each particular section.

Water

As indicated in the present description, the aerosolized composition contains water in an amount of at least 50 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of at least 55 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of at least 60 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of at least 65 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of at least 70 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of at least 75 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of at least 80 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of at least 85 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of at least 90 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of at least 95 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of at least 99 wt. % by weight of the aerosolized composition.

In one aspect, water is present in an amount of 50 to 99 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount ranging from 55 to 99 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of 60 to 99 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount ranging from 65 to 99 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of 70 to 99 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of 75 to 99 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of 80 to 99 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of 85 to 99 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of 90 to 99 wt. % by weight of the aerosolized composition. In one aspect, water is present in an amount of 95 to 99 wt. % by weight of the aerosolized composition.

As indicated in the present description, capable of forming an aerosol composition contains water in an amount of at least 50 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of at least 55 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of at least 60 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of at least 65 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of at least 70 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of at least 75 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of at least 80 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of at least 85 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of at least 90 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of at least 95 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of at least 99 wt. % by weight of the aerosolizable composition.

In one aspect, water is present in an amount of 50 to 99 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount ranging from 55 to 99 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of 60 to 99 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount ranging from 65 to 99 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of 70 to 99 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of 75 to 99 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of 80 to 99 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of 85 to 99 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of 90 to 99 wt. % by weight of the aerosolizable composition. In one aspect, water is present in an amount of 95 to 99 wt. % by weight of the aerosolizable composition.

As discussed herein, the use of water makes it possible to replace some or all of the glycerol, propylene glycol, 1,3-propanediol, and mixtures thereof commonly used in electronic cigarettes. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, 1,3-propanediol, and mixtures thereof in a total amount of not more than 10 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, 1,3-propanediol, and mixtures thereof in a total amount of not more than 8 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, 1,3-propanediol, and mixtures thereof in a total amount of not more than 5 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, 1,3-propanediol, and mixtures thereof in a total amount of not more than 2 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, 1,3-propanediol, and mixtures thereof in a total amount of not more than 1 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, 1,3-propanediol, and mixtures thereof in a total amount of not more than 0.5 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, 1,3-propanediol, and mixtures thereof in a total amount of not more than 0.2 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, 1,3-propanediol, and mixtures thereof in a total amount of not more than 0.1 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, 1,3-propanediol, and mixtures thereof in a total amount of not more than 0.01 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition is free of glycerin, propylene glycol, 1,3-propanediol, and mixtures thereof.

In one aspect, the aerosolizable composition contains glycerin, propylene glycol, and mixtures thereof in a total amount of not more than 10 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, and mixtures thereof in a total amount of not more than 8 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, and mixtures thereof in a total amount of not more than 5 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, and mixtures thereof in a total amount of not more than 2 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, and mixtures thereof in a total amount of not more than 1 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, and mixtures thereof in a total amount of not more than 0.5 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, and mixtures thereof in a total amount of not more than 0.2 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, and mixtures thereof in a total amount of not more than 0.1 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerin, propylene glycol, and mixtures thereof in a total amount of not more than 0.01 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition is free of glycerin, propylene glycol, and mixtures thereof.

In one aspect, the aerosolizable composition contains glycerol in an amount of not more than 10 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerol in an amount of not more than 8 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerol in an amount of not more than 5 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerol in an amount of not more than 2 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerol in an amount of not more than 1 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerol in an amount of not more than 0.5 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerol in an amount of not more than 0.2 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerol in an amount of not more than 0.1 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains glycerol in an amount of not more than 0.01 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition does not contain glycerin.

In one aspect, the aerosolizable composition contains propylene glycol in an amount of not more than 10 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains propylene glycol in an amount of not more than 8 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains propylene glycol in an amount of not more than 5 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains propylene glycol in an amount of not more than 2 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains propylene glycol in an amount of not more than 1 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains propylene glycol in an amount of not more than 0.5 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains propylene glycol in an amount of not more than 0.2 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains propylene glycol in an amount of not more than 0.1 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition contains propylene glycol in an amount of not more than 0.01 wt. % by weight of the aerosolizable composition or by weight of the aerosolized composition. In one aspect, the aerosolizable composition does not contain propylene glycol.

Flavoring substance

As discussed here, the aerosolized composition contains at least one flavoring substance in an amount of at least 70 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, the aerosolized composition contains at least one flavoring substance in an amount of at least 75 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, the aerosolized composition contains at least one flavoring substance in an amount of at least 80 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, the aerosolized composition contains at least one flavoring substance in an amount of at least 85 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, the aerosolized composition contains at least one flavoring substance in an amount of at least 90 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, the aerosolized composition contains at least one flavoring substance in an amount of at least 95 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, the aerosolized composition contains at least one flavoring substance in an amount of at least 98 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, the aerosolized composition contains at least one flavoring substance in an amount of at least 99 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared.

In one aspect, the aerosolized composition contains more than one flavoring agent. In one aspect, when the aerosolized composition contains a plurality of flavors, the aerosolized composition contains each of said plurality of flavors in an amount of at least 70 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, when the aerosolized composition contains a plurality of flavors, the aerosolized composition contains each of said plurality of flavors in an amount of at least 75 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, when the aerosolized composition contains a plurality of flavors, the aerosolized composition contains each of said plurality of flavors in an amount of at least 80 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, when the aerosolized composition contains a plurality of flavors, the aerosolized composition contains each of said plurality of flavors in an amount of at least 85 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, when the aerosolized composition contains a plurality of flavors, the aerosolized composition contains each of said plurality of flavors in an amount of at least 90 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, when the aerosolized composition contains a plurality of flavors, the aerosolized composition contains each of said plurality of flavors in an amount of at least 95 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, when the aerosolized composition contains a plurality of flavors, the aerosolized composition contains each of said plurality of flavors in an amount of at least 98 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared. In one aspect, when the aerosolized composition contains a plurality of flavors, the aerosolized composition contains each of said plurality of flavors in an amount of at least 99 wt. % based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was prepared.

The aerosolizable composition contains one or more flavoring agents or flavoring components. As used herein, the terms "flavour" and "flavor" refer to materials that, where local laws permit, may be added to a composition to create a desired flavor or aroma in an adult product. These may include extracts (eg, licorice, hydrangea, Japanese white magnolia leaves, chamomile, fenugreek, cloves, menthol, Japanese mint, aniseed, cinnamon, herbs, wintergreen, cherries, berries, peach, apple, Drambuie, bourbon, scotch , whiskey, spearmint, peppermint, lavender, cardamom, celery, cascarole, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, cassia, cumin, cognac, jasmine, ylang -ylang, sage, fennel, cloves, ginger, anise, coriander, coffee, or peppermint oil from any plant of the genus Mentha), flavor enhancers, bitterness receptor site blockers, sensory receptor site activators or stimulants, sugars and/or sugar substitutes (eg sucralose, acesulfame potassium, aspartame, saccharin, cyclamates, lactose, sucrose, glucose, fructose, sorbitol, or mannitol) and other additives such as charcoal, chlorophyll l, minerals, vegetable raw materials or breath fresheners. They may be artificial, synthetic or natural ingredients, or mixtures thereof. They may be in any suitable form, such as an oil, liquid or powder. One or more flavoring agents may be selected from the group consisting of 4-(p-methoxyphenyl)-2-butanone, vanillin, γ-undecalactone, menthone, 5-propenylguaethol, menthol, p-mentha-8-thiol-3-one and their mixtures. In one aspect, the flavoring agent is at least menthol.

One or more flavors may be present in any amount, if present. In one aspect, one or more flavoring substances are present in a total amount of not more than 10 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 7 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 5 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 4 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 3 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 2 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 1 wt. % based on the weight of the aerosolizable composition.

In one aspect, one or more flavoring substances are present in a total amount of from 0.01 to 5 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in a total amount of from 0.01 to 4 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in an amount of from 0.01 to 3 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in a total amount of from 0.01 to 2 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in an amount of from 0.01 to 1 wt. % based on the weight of the aerosolizable composition. In one aspect, one or more flavoring substances are present in an amount of from 0.01 to 0.5 wt. % based on the weight of the aerosolizable composition.

In one aspect, one or more flavoring substances are present in a total amount of not more than 10 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 7 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 5 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 4 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 3 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 2 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in a total amount of not more than 1 wt. % based on the weight of the aerosolized composition.

In one aspect, one or more flavoring substances are present in a total amount of from 0.01 to 5 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in a total amount of from 0.01 to 4 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in an amount of from 0.01 to 3 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in a total amount of from 0.01 to 2 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in an amount of from 0.01 to 1 wt. % based on the weight of the aerosolized composition. In one aspect, one or more flavoring substances are present in an amount of from 0.01 to 0.5 wt. % based on the weight of the aerosolized composition.

active agent

The aerosolizable composition and the aerosolizable composition of the present invention may contain one or more additional components. These components may be selected depending on the nature of the composition. In one aspect, the aerosolizable composition and the aerosolized composition further comprise an active agent. By "active agent" is meant an agent that exerts a biological effect on a subject upon inhalation of the aerosol. The active agent, for example, can be selected from nutraceuticals, nootropics, psychoactive substances. The active substance can be of natural origin or obtained synthetically. The active agent may include, for example, nicotine, caffeine, taurine, theine, vitamins such as B6 or B12 or C, melatonin, cannabinoids, or their constituents, derivatives, or combinations thereof. The active agent may include one or more components, derivatives or extracts of tobacco, cannabis or another plant. In some embodiments, the active agent contains caffeine, melatonin, or vitamin B12. One or more active agents may be selected from nicotine, plant materials and mixtures thereof. One or more active agents may be of synthetic or natural origin. The active substance may be an extract of a plant, such as a plant from the tobacco family. An example of an active agent is nicotine.

As noted herein, the active agent may contain one or more components, derivatives or extracts of cannabis, such as one or more cannabinoids or terpenes. Cannabinoids are a class of natural or synthetic chemical compounds that act on cannabinoid receptors (i.e. CB1 and CB2) on cells that inhibit the release of neurotransmitters in the brain. Cannabinoids can be natural (phytocannabinoids) from plants such as cannabis, animals (endocannabinoids) or artificially produced (synthetic cannabinoids). Cannabis species are expressed by at least 85 different phytocannabinoids and are divided into subclasses including cannabigerols, cannabichromenes, cannabidiols, tetrahydrocannabinols, cannabinols and cannabinodiols, as well as other cannabinoids. Cannabinoids found in hemp include, without limitation: cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabinodiol (CBDL), cannabicyclol (CBL), cannabivarin (CBV) , tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabinerolic acid, cannabidiolic acid (CBDA), cannabinol propyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabinolic acid (THCA) and tetrahydrocannabivarinic acid (THCV A).

In some embodiments, the active agent includes one or more components, derivatives or extracts of cannabis.

As noted in this document, the active agent may contain or be derived from one or more plant materials or their components, derivatives or extracts. As used herein, the term "botanical" includes any material derived from plants, including, but not limited to, extracts, leaves, bark, fibers, stems, roots, seeds, flowers, fruits, pollen, husks, shells, and the like. Alternatively, the material may contain an active compound naturally present in plants, obtained synthetically. The material may be in the form of liquid, gas, solid, powder, dust, particulate matter, granules, pellets, chips, strips, sheets, and the like. Examples of plants are tobacco, eucalyptus, star anise, hemp, cocoa, cannabis, fennel, lemongrass, peppermint, spearmint, rooibos, chamomile, flax, ginger, ginkgo biloba, hazel, hibiscus, laurel herb, liquorice (licorice), matcha , mate, orange peel, papaya, rose, sage, tea such as green tea or black tea, thyme, cloves, cinnamon, coffee, common anise (anise), basil, bay leaf, cardamom, coriander, cumin, nutmeg, oregano, paprika, rosemary, saffron, lavender, lemon peel, mint, juniper, elderberry, vanilla, wintergreen, perilla perennial, turmeric, turmeric, sandalwood, cilantro, bergamot, orange blossom, myrtle, cassia, valerian, cloves , nutmeg, damien, marjoram, olive, lemon balm, lemon basil, garlic, cumin, verbena, wormwood tarragon, geranium, mulberry, ginseng, theanine, theacrine, maca, ashwagandha, turner (damiana), guarana, chlorophyll , baobab or any combination of them. Mint can be selected from the following mint varieties: Mentha arventis, Mentha cv, Mentha niliaca, Mentha piperita, Mentha piperita citrata cv, Mentha piperita cv, Mentha spicata crispa, Mentha cardifolia, Memtha longifolia, Mentha suaveolens variegata, Mentha pulegium, Mentha spicata cv and Mentha suaveolens.

In some embodiments, the active agent comprises or is derived from one or more plant materials or components, derivatives, or extracts thereof, and the plant material is tobacco.

In some embodiments, the active agent comprises or is derived from one or more plant materials or components, derivatives, or extracts thereof, and the plant material is selected from eucalyptus, star anise, cocoa, and hemp.

In some embodiments, the active agent comprises or is derived from one or more plant materials or components, derivatives, or extracts thereof, and the plant component is selected from rooibos and fennel.

In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) of not more than 6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.01 to 6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.02 to 6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.05 to 6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.08 to 6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.01 to 5 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.02 to 5 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.05 to 5 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.08 to 5 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) of not more than 4 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) in an amount of from 0.01 to 4 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.02 to 4 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.05 to 4 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.08 to 4 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) of not more than 3 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.01 to 3 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.02 to 3 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.05 to 3 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.08 to 3 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) of not more than 2 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.01 to 2 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.02 to 2 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.05 to 2 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.08 to 2 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) of not more than 1 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.01 to 1 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.02 to 1 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.05 to 1 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.08 to 1 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.1 to 1 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) of not more than 0.6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.01 to 0.6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.02 to 0.6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.05 to 0.6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.08 to 0.6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.1 to 0.6 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) of not more than 0.5 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.01 to 0.5 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.02 to 0.5 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.05 to 0.5 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.08 to 0.5 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) of not more than 0.2 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.01 to 0.2 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.02 to 0.2 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.05 to 0.2 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.08 to 0.2 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) of not more than 0.1 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.01 to 0.1 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.02 to 0.1 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. In one aspect, one or more active agents are present in a total amount (for example, nicotine is present in an amount) from 0.05 to 0.1 wt. % based on the total weight of the aerosolizable composition or the aerosolized composition. % based on the total weight of the aerosolizable composition or the aerosolized composition.

Acid

As discussed above, the aerosolizable composition and the aerosolizable composition of the present invention may contain one or more additional components. These components may be selected depending on the nature of the composition. In one aspect, the aerosolizable composition and the aerosolized composition further comprise an acid.

In one aspect, the acid is an organic acid. In one aspect, the acid is a carboxylic acid. In one aspect, the acid is an organic carboxylic acid.

In one aspect, the acid is selected from the group consisting of acetic acid, lactic acid, formic acid, citric acid, benzoic acid, pyruvic acid, levulinic acid, succinic acid, tartaric acid, sorbic acid, propionic acid, phenylacetic acid, and mixtures thereof. In one aspect, the acid is selected from the group consisting of citric acid, benzoic acid, levulinic acid, lactic acid, sorbic acid, and mixtures thereof. In one aspect, the acid is selected from the group consisting of citric acid, benzoic acid, levulinic acid, and mixtures thereof. In one aspect, the acid is at least citric acid. In one aspect, the acid is citric acid.

In one aspect, the acid is selected from acids having a pka of 2 to 5. In one aspect, the acid is a weak acid. In one aspect, the acid is a weak organic acid.

In one aspect, the acid has a water solubility of at least 5 g/l at 20°C. In one aspect, the acid has a water solubility of at least 10 g/l at 20°C. In one aspect, the acid has a water solubility of at least 20 g/l at 20°C. In one aspect, the acid has a water solubility of at least 50 g/l at 20°C. In one aspect, the acid has a water solubility of at least 100 g/l at 20°C. In one aspect, the acid has a water solubility of at least 200 g/l at 20°C. In one aspect, the acid has a water solubility of at least 300 g/l at 20°C. In one aspect, the acid has a water solubility of at least 400 g/l at 20°C. In one aspect, the acid has a water solubility of at least 500 g/l at 20°C. In one aspect, the acid has a water solubility of at least 600 g/l at 20°C. In one aspect, the acid has a water solubility of at least 700 g/l at 20°C. In one aspect, the acid has a water solubility of at least 800 g/l at 20°C. In one aspect, the acid has a water solubility of at least 900 g/l at 20°C. In one aspect, the acid has a water solubility of at least 1000 g/l at 20°C. In one aspect, the acid has a water solubility of at least 1100 g/l at 20°C.

The molar ratio of acid to active agent (such as nicotine) may be chosen as desired. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 5:1 to 1:5. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 4:1 to 1:4. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 3:1 to 1:3. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 2:1 to 1:2. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 1.5:1 to 1:1.5. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 1.2:1 to 1:1.2. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 5:1 to 1:1. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 4:1 to 1:1. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 3:1 to 1:1. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 2:1 to 1:1. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 1.5:1 to 1:1. In one aspect, the molar ratio of acid to active agent (such as nicotine) is from 1.2:1 to 1:1.

In one aspect, the total acid content present in the composition is not more than 5 molar equivalents, based on the active agent (such as nicotine). In one aspect, the total acid content present in the composition is not more than 4 molar equivalents, based on the active agent (such as nicotine). In one aspect, the total acid content present in the composition is no more than 3 molar equivalents, based on the active agent (such as nicotine). In one aspect, the total acid content present in the composition is not more than 2 molar equivalents, based on the active agent (such as nicotine). In one aspect, the total acid content present in the composition does not exceed 1 mol equivalent based on the active agent (such as nicotine).

In one aspect, the total content of acid present in the composition is not less than 0.01 mole equivalents, based on the active agent (such as nicotine). In one aspect, the total content of acid present in the composition is not less than 0.05 mole equivalents based on the active agent (such as nicotine). In one aspect, the total content of acid present in the composition is not less than 0.1 mole equivalents based on the active agent (such as nicotine). In one aspect, the total content of acid present in the composition is not less than 0.2 mole equivalents, based on the active agent (such as nicotine). In one aspect, the total acid content present in the composition is not less than 0.3 mole equivalents, based on the active agent (such as nicotine). In one aspect, the total content of acid present in the composition is not less than 0.4 mole equivalents, based on the active agent (such as nicotine). In one aspect, the total content of acid present in the composition is not less than 0.5 mole equivalents based on the active agent (such as nicotine). In one aspect, the total content of acid present in the composition is not less than 0.7 molar equivalents, based on the active agent (such as nicotine).

In one aspect, the acid is present in an amount of not more than 6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of from 0.01 to 6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of from 0.02 to 6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of from 0.05 to 6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.08 to 6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of from 0.01 to 5 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.02 to 5 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.05 to 5 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.08 to 5 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of not more than 4 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of from 0.01 to 4 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.02 to 4 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.05 to 4 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.08 to 4 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of not more than 3 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of from 0.01 to 3 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of from 0.02 to 3 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.05 to 3 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.08 to 3 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of not more than 2 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.01 to 2 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.02 to 2 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.05 to 2 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.08 to 2 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of not more than 1 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of from 0.01 to 1 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.02 to 1 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.05 to 1 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.08 to 1 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of from 0.1 to 1 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of not more than 0.6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.01 to 0.6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.02 to 0.6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.05 to 0.6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.08 to 0.6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.1 to 0.6 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of not more than 0.5 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.01 to 0.5 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.02 to 0.5 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.05 to 0.5 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.08 to 0.5 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of not more than 0.2 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.01 to 0.2 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.02 to 0.2 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.05 to 0.2 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.08 to 0.2 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of not more than 0.1 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of from 0.01 to 0.1 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.02 to 0.1 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.05 to 0.1 wt. % by weight of the aerosolizable composition or the aerosolized composition. In one aspect, the acid is present in an amount of 0.08 to 0.1 wt. % by weight of the aerosolizable composition or the aerosolized composition.

The amount of acid and the solubility of the acid can be chosen such that a given amount of acid is soluble in water. In one aspect, at 20° C., at least 20% of the acid dissolves in water. In one aspect, at 25° C., at least 20% of the acid is dissolved in water. In one aspect, at 30° C., at least 20% of the acid is dissolved in water. In one aspect, at 20° C., at least 35% of the acid is dissolved in water. In one aspect, at 20° C., at least 40% of the acid is dissolved in water. In one aspect, at 20° C., at least 45% of the acid dissolves in water. In one aspect, at 20° C., at least 50% of the acid is dissolved in water. In one aspect, at 20° C., at least 55% of the acid dissolves in water.

As one of skill in the art will understand, nicotine can exist in a non-protonated form, a monoprotonated form, or a diprotonated form. The structure of each of these forms is presented below.

Unprotonated nicotine Monoprotonated nicotine Diprotonated nicotine

Reference in the specification to the protonated form means both monoprotonated nicotine and diprotonated nicotine. Reference in the specification to amounts in protonated form means the combined amount of monoprotonated nicotine and diprotonated nicotine. Furthermore, when reference is made to a fully protonated formulation, it should be understood that very small amounts of unprotonated nicotine may be present at any given time, such as less than 1% unprotonated nicotine.

The composition may contain nicotine in protonated form. The composition may contain nicotine in a non-protonated form. In one aspect, the composition contains nicotine in a non-protonated form and nicotine in a monoprotonated form. In one aspect, the composition contains nicotine in a non-protonated form and nicotine in a diprotonated form. In one aspect, the composition comprises nicotine in unprotonated form, nicotine in monoprotonated form, and nicotine in diprotonated form.

In one aspect, at least 5 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 10 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 15 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 20 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 25 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 30 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 35 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 40 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 45 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 50 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 55 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 60 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 65 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 70 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 75 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 80 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 85 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 90 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 95 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 99 wt. % of nicotine present in the composition is in protonated form.

In one aspect, at least 99.9 wt. % of nicotine present in the composition is in protonated form.

In one aspect, from 50 to 95 wt. % of nicotine present in the composition is in protonated form. In one aspect, from 55 to 95 wt. % of nicotine present in the composition is in protonated form. In one aspect, from 60 to 95 wt. % of nicotine present in the composition is in protonated form. In one aspect, from 65 to 95 wt. % of nicotine present in the composition is in protonated form. In one aspect, from 70 to 95 wt. % of nicotine present in the composition is in protonated form. In one aspect, from 75 to 95 wt. % of nicotine present in the composition is in protonated form. In one aspect, from 80 to 95 wt. % of nicotine present in the composition is in protonated form. In one aspect, from 85 to 95 wt. % of nicotine present in the composition is in protonated form. In one aspect, from 90 to 95 wt. % of nicotine present in the composition is in protonated form.

Suitable amounts of nicotine present in the composition in protonated form are provided herein. These quantities can be easily calculated by those skilled in the art. Nicotine, which is 3-(1-methylpyrrolidin-2-yl)pyridine, is a dibasic base characterized by pKa values of 3.12 for the pyridine ring and 8.02 for the pyrrolidine ring. It can exist in pH-dependent protonated (mono- and di-) and non-protonated (free base) forms, which are characterized by different bioavailability.

The distribution of protonated and non-protonated nicotine will vary with different pH elevations.

The proportion of non-protonated nicotine will predominate at high pH values, while a decrease in pH will lead to an increase in the proportion of protonated nicotine (mono- or di- depending on the pH value). If the relative proportion of protonated nicotine and the total amount of nicotine in the sample are known, the absolute amount of protonated nicotine can be calculated.

The relative proportion of protonated nicotine in a composition can be calculated using the Henderson-Hasselbach equation, which describes the pH value as a derivative of the acid dissociation constant equation, and which is widely used in chemical and biological systems. The following equilibrium is considered:

The Henderson-Hasselbach equation for this equilibrium is:

where [B] is the amount of unprotonated nicotine (i.e., free base), [BH+] is the amount of protonated nicotine (i.e., conjugate acid), and pKa is the pKa reference value for the nitrogen atom of the pyrrolidine ring of nicotine (pKa = 8 .02). The relative proportion of protonated nicotine can be derived from the alpha value for non-protonated nicotine calculated from the Henderson-Hasselbach equation as:

Determination of pKa values for nicotine solutions can be done using the basic approach described in "Spectroscopic investigations into the acid-base properties of nicotine at different temperatures", Peter M. Clayton, Carl A. Vas, Tam T. T. Bui, Alex F. Drake and Kevin McAdam, Anal. Methods, 2013, 5, 81-88.

Compositions

One or more cyclodextrins may or may not be present in any suitable amount in the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 12 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 10 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 9 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 8 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 7 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 6 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 5 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 4 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 3 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 2 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 1 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in an amount of not more than 0.5 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in an amount of not more than 0.1 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in an amount of not more than 0.01 wt. % by weight of the aerosolizable composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 0.001 wt. % by weight of the aerosolizable composition.

One or more cyclodextrins may or may not be present in any suitable amount in the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 12 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 10 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 9 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 8 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 7 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 6 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 5 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 4 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 3 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 2 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 1 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in an amount of not more than 0.5 wt. % by weight of the capable aerosolized composition. In one aspect, one or more cyclodextrins are present in an amount of not more than 0.1 wt. % by weight of the capable aerosolized composition. In one aspect, one or more cyclodextrins are present in an amount of not more than 0.01 wt. % by weight of the aerosolized composition. In one aspect, one or more cyclodextrins are present in a total amount of not more than 0.001 wt. % by weight of the aerosolized composition.

One or more cyclodextrins may be selected from the group consisting of unsubstituted cyclodextrins, substituted cyclodextrins, and mixtures thereof. In one aspect, at least one cyclodextrin is an unsubstituted cyclodextrin. In one aspect, one or more cyclodextrins are selected from the group consisting of unsubstituted cyclodextrins. In one aspect, at least one cyclodextrin is a substituted cyclodextrin. In one aspect, one or more cyclodextrins are selected from the group consisting of substituted cyclodextrins.

In one aspect, one or more cyclodextrins are selected from the group consisting of unsubstituted (α)-cyclodextrin, substituted (α)-cyclodextrin, unsubstituted (β)-cyclodextrin, substituted (β)-cyclodextrin, unsubstituted (γ)-cyclodextrin, substituted ( γ)-cyclodextrin and mixtures thereof. In one aspect, one or more cyclodextrins are selected from the group consisting of unsubstituted (β)-cyclodextrin, substituted (β)-cyclodextrin, and mixtures thereof.

In one aspect, one or more cyclodextrins are selected from the group consisting of unsubstituted (α)-cyclodextrin, unsubstituted (β)-cyclodextrin, unsubstituted (γ)-cyclodextrin, and mixtures thereof. In one aspect, one or more cyclodextrins are selected from unsubstituted (β)-cyclodextrin.

In one aspect, one or more cyclodextrins are selected from the group consisting of substituted (α)-cyclodextrin, substituted (β)-cyclodextrin, substituted (γ)-cyclodextrin, and mixtures thereof. In one aspect, one or more cyclodextrins are selected from substituted (β)-cyclodextrins. Chemical substitutions are contemplated at the 2-, 3-, and 6-hydroxyl positions, with more preferred substitutions at the 2-position.

In one aspect, one or more cyclodextrins are selected from the group consisting of 2-hydroxypropyl-α-cyclodextrin, 2-hydroxypropyl-β-cyclodextrin, 2-hydroxypropyl-γ-cyclodextrin, and mixtures thereof. In one aspect, one or more cyclodextrins are at least 2-hydroxypropyl-α-cyclodextrin. In one aspect, one or more cyclodextrins are at least 2-hydroxypropyl-β-cyclodextrin. In one aspect, one or more cyclodextrins are at least 2-hydroxypropyl-γ-cyclodextrin.

2-Hydroxypropyl derivatives of cyclodextrins such as 2-hydroxypropyl-β-cyclodextrin have increased water solubility compared to basic cyclodextrins such as β-cyclodextrin.

In one aspect, if the aerosolizable composition contains one or more cyclodextrins, then the aerosolizable composition does not contain flavors that can be encapsulated by the one or more cyclodextrins.

Way

As described herein, in one aspect, a method for generating an aerosol is provided, the method comprising aerosolizing an aerosol-formable composition comprising

(i) water in an amount of at least 50 wt. % based on the weight of the aerosolized composition; and

(ii) at least one flavoring agent;

to obtain an aerosol containing the specified at least one flavoring substance in an amount of at least 70 wt. % based on the weight of said flavor present in said aerosolizable composition.

In the method, the aerosol may be formed by a process carried out at a temperature below 60°C. In the method, the aerosol may be formed by a process carried out at a temperature below 50°C. In the method, the aerosol may be formed by a process carried out at a temperature below 40°C. In the method, the aerosol may be formed by a process carried out at a temperature below 30°C. In the method, the aerosol may be formed by a process carried out at a temperature below 25°C. In the method, the aerosol may be formed by a process that does not include heating.

In the method, an aerosol can be formed by applying ultrasonic energy to an aerosol-formable composition.

In one aspect, the aerosol of the aerosolized composition has a D50 of 2 to 6 microns. References in this specification to particle size distributions, D50, D10 or D90 refer to values measured according to British and European Pharmacopoeias, 2.9.31 Particle size analysis by laser light diffraction (see BRITISH PHARMACOPOEIA COMMISSION. (2014), British Pharmacopoeia, London, England: Stationery Office and COUNCIL OF EUROPE (2013), European Pharmacopoeia, Strasbourg, France: Council of Europe. The terms D50, Dv50 and Dx50 are interchangeable. The terms D10, Dv10 and Dx10 are interchangeable. The terms D90, Dv90 and Dx90 are interchangeable.

In one aspect, the aerosol has a D50 of 2.5 to 6 microns. In one aspect, the aerosol has a D50 of 3 to 6 microns. In one aspect, the aerosol has a D50 of 3.5 to 6 microns. In one aspect, the aerosol has a D50 of 4 to 6 microns. In one aspect, the aerosol has a D50 of 4.5 to 6 microns. In one aspect, the aerosol has a D50 of 5 to 6 microns. In one aspect, the aerosol has a D50 of 2.5 to 5.5 microns. In one aspect, the aerosol has a D50 of 3 to 5.5 microns. In one aspect, the aerosol has a D50 of 3.5 to 5.5 microns. In one aspect, the aerosol has a D50 of 4 to 5.5 microns. In one aspect, the aerosol has a D50 of 4.5 to 5.5 microns. In one aspect, the aerosol has a D50 of 5 to 5.5 microns.

In one aspect, the aerosol has a D10 of at least 0.5 microns. In one aspect, the aerosol has a D10 of at least 1 micron. In one aspect, the aerosol has a D10 of at least 2 microns.

In one aspect, the aerosol has a D90 of no more than 15 microns. In one aspect, the aerosol has a D90 of no more than 12 microns. In one aspect, the aerosol has a D90 of no more than 10 microns.

In one aspect, D50 is measured after excluding particles having a size of less than 1 micron. In one aspect, D10 is measured after excluding particles having a size of less than 1 micron. In one aspect, D90 is measured after excluding particles having a size of less than 1 micron.

The composition may be placed in a container or delivered by any means. In one aspect, the present invention relates to a containerized aerosolizable composition comprising (a) one or more containers; and (b) an aerosolizable composition as defined herein. The container may be any suitable container, for example for storage or delivery of the composition. In one aspect, the container is configured to interact with an electronic aerosol delivery system. The container may be configured to be in fluid communication with the electronic aerosol delivery system so that the composition can be delivered to the electronic aerosol delivery system. As described above, the present invention relates to a container that can be used in an electronic aerosol delivery system such as an electronic cigarette. In the following description, the term "electronic cigarette" is used; however, the term may be used as a synonym for an electronic aerosol delivery system.

As discussed herein, the container of the present invention is typically designed to deliver an aerosolizable composition to or within an electronic cigarette. The aerosolizable composition may be stored within an electronic cigarette or may be sold as a separate container for later use with or in an electronic cigarette. As one skilled in the art will appreciate, electronic cigarettes may comprise a unit known as a plug-in cartomizer, which typically includes a reservoir of aerosolizable composition, an aerosol generator, such as a wick material, and a heating element to vaporize the aerosolizable composition. In some electronic cigarettes, the cartomizer is part of the whole device and is not removable. In one aspect, the container is a cartomizer or part of a cartomizer. In one aspect, the container is not a cartomizer or part of a cartomizer, but is a container, such as a reservoir, that can be used to deliver a nicotine composition to or within an electronic cigarette.

In one aspect, the container is part of an electronic cigarette. Therefore, in a further aspect, the present invention provides an electronic aerosol delivery system comprising: an aerosolizable composition as defined herein; an aerosol generator for aerosolizing a composition to be inhaled by a user of the electronic aerosol supply system; a power source containing a galvanic cell or battery, designed to supply the aerosol generator with energy.

In addition to the aerosolizable composition of the present invention and systems such as containers and electronic aerosol delivery systems containing it, the present invention provides a method for improving the organoleptic properties of aerosolized nicotine. In a further aspect of the present invention, there is provided a method for improving the storage stability of an aerosolized nicotine composition.

Reference to improving the organoleptic properties of the vaporized nicotine solution may include improving the softness of the vaporized nicotine solution as perceived by the user.

The method of the present invention may include additional steps either before the listed steps, or after the listed steps, or between one or more of the listed steps.

Brief description of the drawings

The present invention will now be described in more detail by way of example only with reference to the accompanying figure, in which:

The figure 1 shows a graph illustrating the change in p _s K _a2 depending on the concentration of nicotine.

The invention will now be described with reference to the following non-limiting example.

Examples

Example 1

A number of tests were carried out using a composition containing 90.0% (w/w) water, 9.0% 2-hydroxypropyl-β-cyclodextrin, 0.9% l-menthol and 0.1% nicotine.

In this embodiment, measurements of menthol and nicotine are performed using gas chromatography and a suitable detection mechanism such as flame ionization detection (CG-FID).

After aerosolization, the mechanism of complex formation between l-menthol and 2-hydroxypropyl-β-cyclodextrin becomes dynamic due to the transfer of kinetic energy from the device to the composition. Thus, menthol can migrate back to the 2-hydroxypropyl-β-cyclodextrin host material as a guest molecule if the aerosol transit time is long enough.

The experiment was designed to trap the condensed formulation on surfaces colder than ambient to provide equivalent measurements of menthol and nicotine after aerosolization. Since l-menthol is expected to be released from the 2-hydroxypropyl-β-cyclodextrin host material upon energy transfer, any differences between before and after aerosolization can be attributed to its vapor release due to the hydrophobic behavior of l-menthol.

It should be noted that the behavior of nicotine is omitted in this example because it is water soluble and is expected to be trapped in water droplets in the particulate phase.

In practice, since the mechanism of complex formation is dynamic, we expect little difference between the composition before and after aerosolization. This is an observable effect when using GC-FID as a measurement system. In this case, a tolerance of ± 10% is appropriate.

Example 2

A number of compositions were prepared by the inventors in accordance with the described methodology and tested for flavor compounds in an analytical laboratory.

Songs containing

83.1% (w/w) water, 15.0% (w/w) 2-hydroxypropyl-β-cyclodextrin, 0.9% (w/w) 1-menthol and 1% ( w/w) nicotine; as well as

98.8% (w/w) water, 0.6% (w/w) vanillin and 0.6% (w/w) nicotine.

In both examples, the compositions were aerosolized using a commercially available nebulizer and the resulting aerosol collected on 44 mm Cambridge filter pads (CFP) followed by 2 impingers connected in series containing isopropyl alcohol and internal standards for quantitation. This was done to ensure that both gas and droplet phases are captured for analysis. Aerosol preparation and sample analysis for both formulations were performed in triplicate. Analytical testing was performed using gas chromatography (gas chromatograph Agilent 7890A or equivalent) combined with mass spectroscopy (Markes Bench Time of Flight or equivalent). For each parallel analysis, 20 puffs were collected using a single port smoking machine such as the Borgwaldt LX or similar. CFP weight was recorded before and after aerosol capture. The CFP was then extracted using the combined solutions from both impingers and analyzed for the presence of target compounds. Prior to analysis, a 5-point calibration curve was generated using high purity standards for quantification. The compositions were analyzed prior to aerosolization to demonstrate the amount of flavor before and after the process.

Liquid analysis of the composition containing 1-menthol showed 0.8% (w/w) (8 mg/g) 1-menthol and 1.0% (w/w) (10 mg/g) nicotine. Aerosol analysis of the same composition showed 0.7-0.8% (w/w) (7 to 8 mg/g) 1-menthol and 1-1.1% (w/w) (from 10 up to 11 mg/g) of nicotine.

Liquid analysis of the composition containing vanillin showed 0.5% (w/w) (5 mg/g) vanillin and 0.6% (w/w) (6 mg/g) nicotine. Aerosol analysis of the same formulation showed 0.5-0.6% (w/w) (5 to 6 mg/g) vanillin and 0.6% (w/w) (6 mg/g) nicotine .

The results showed 100% flavor and nicotine recovery and showed no degradation of the active ingredients during the aerosolization process.

Various modifications and variations of the present invention will be understood by those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the claimed invention should not be unduly limited to such specific embodiments. Indeed, various modifications of the described embodiments of the invention that are obvious to those skilled in the art of chemistry or related fields are intended to be within the scope of the following claims.

Claims (43)

1. An aerosolized composition for inhalation by a user of an aerosol providing device, comprising: (i) water in an amount of at least 50% by weight, based on the weight of the aerosolized composition; and (ii) at least one flavoring agent; wherein the aerosolized composition contains said at least one flavor in an amount of at least 70% by weight based on the weight of said flavor present in the aerosolizable composition from which said aerosolized composition was derived. 2. An aerosolized composition according to claim 1, characterized in that water is present in an amount of at least 75% by weight based on the weight of the aerosolized composition. 3. An aerosolized composition according to claim 1 or 2, characterized in that water is present in an amount of at least 90% by weight, based on the weight of the aerosolized composition. 4. Aerosolized composition according to any one of claims 1 to 3, characterized in that at least one flavor is selected from the group consisting of (4-(para-)methoxyphenyl)-2-butanone, vanillin, γ-undecalactone , menthone, 5-propenylguaetol, menthol, para-mentha-8-thiol-3-one and mixtures thereof. 5. An aerosolized composition according to claim 4, characterized in that the flavoring agent is at least menthol. 6. An aerosolized composition according to any one of claims 1 to 5, characterized in that at least one flavor is present in a total amount of not more than 2% by weight, based on the weight of the aerosolized composition. 7. An aerosolizable composition according to any one of claims 1 to 6, characterized in that at least one flavor is present in a total amount of 0.01 to 1% by weight based on the weight of the aerosolized composition. 8. An aerosolized composition according to any one of claims 1 to 7, characterized in that the aerosolized composition contains said at least one flavor in an amount of at least 80% by weight relative to the weight of said flavor, present in the aerosolizable composition from which said aerosolized composition was prepared. 9. An aerosolized composition according to any one of claims 1 to 8, characterized in that the aerosolized composition contains said at least one flavor in an amount of at least 90% by weight relative to the weight of said flavor, present in the aerosolizable composition from which said aerosolized composition was prepared. 10. An aerosolized composition according to any one of claims 1 to 9, characterized in that the aerosolized composition contains more than one flavoring agent. 11. An aerosolized composition according to claim 10, characterized in that the aerosolized composition contains each of said more than one flavoring substances in an amount of at least 70 wt.% relative to the weight of said flavoring substance present in the capable form an aerosol of the composition from which said aerosolized composition was obtained. 12. An aerosolized composition according to any one of claims 1 to 11, characterized in that it additionally contains cyclodextrins, wherein the total content of cyclodextrins is not more than 8% by weight, based on the weight of the aerosolized composition. 13. An aerosolized composition according to claim 12, characterized in that the total content of cyclodextrins is not more than 0.5% by weight based on the weight of the aerosolized composition. 14. An aerosolized composition according to any one of claims 1 to 13, characterized in that the aerosolized composition further comprises at least one active agent. 15. An aerosolized composition according to claim 14, characterized in that the active agent is present in an amount of not more than 1% by weight, based on the weight of the aerosolized composition. 16. An aerosolized composition according to claim 15, characterized in that the active agent is present in an amount of 0.01 to 0.6% by weight based on the weight of the aerosolized composition. 17. An aerosolized composition according to any one of claims 14 to 16, characterized in that the active agent is nicotine. 18. An aerosolized composition according to any one of claims 1 to 17, characterized in that the aerosolized composition further comprises an acid. 19. Aerosolized composition according to claim 18, characterized in that the acid is selected from the group consisting of acetic acid, lactic acid, formic acid, citric acid, benzoic acid, pyruvic acid, levulinic acid, succinic acid, tartaric acid, sorbic acid, propionic acid, phenylacetic acid and mixtures thereof. 20. An aerosolizable composition according to claim 18 or 19, wherein the acid is selected from the group consisting of citric acid, benzoic acid, levulinic acid, sorbic acid, lactic acid, and mixtures thereof. 21. An aerosolized composition according to any one of claims 18 to 20, characterized in that the acid is at least citric acid. 22. An aerosolizable composition according to any one of claims 1 to 21, characterized in that if the aerosolizable composition contains one or more cyclodextrins, then the aerosolizable composition does not contain flavoring substances that can be encapsulated by one or more cyclodextrins. 23. A method for generating an aerosol for inhalation by a user of the aerosol providing device, wherein the method includes converting to an aerosol state an aerosol-formable composition comprising: (i) water in an amount of at least 50% by weight, based on the weight of the aerosolized composition; and (ii) at least one flavoring agent; to obtain an aerosol containing said at least one flavor in an amount of at least 70% by weight relative to the weight of said flavor present in the aerosolizable composition. 24. The method according to claim 23, wherein the aerosolizable composition is a composition as defined in any one of claims 2-22. 25. The method according to claim 23 or 24, characterized in that the aerosol is formed by a process carried out at a temperature below 50°C. 26. The method according to claim 23, 24 or 25, characterized in that the aerosol is formed by applying ultrasonic energy to the aerosol-formable composition. 27. An electronic aerosol supply system for generating an aerosol from an aerosol-formable composition, said aerosol-formable composition comprising: (i) water in an amount of at least 50% by weight, based on the weight of the aerosolized composition; and (ii) at least one flavoring agent; and said system contains: (a) an aerosol generator for converting said aerosolizable composition into an aerosol state for inhalation by a user of the electronic aerosol supply system; (b) a power supply containing a galvanic cell or battery for supplying the aerosol generator with energy; wherein the aerosol generator provides an aerosol containing said at least one flavor in an amount of at least 70% by weight based on the weight of said flavor present in the aerosolizable composition. 28. An electronic aerosol supply system according to claim 27, characterized in that the aerosolized composition is an aerosolized composition according to any one of paragraphs. 2-22. 29. A method for improving flavor delivery to an aerosolized composition for inhalation by a user of an aerosol providing device, the method comprising the steps of: (a) providing an aerosolizable material containing (i) water in an amount of at least 50% by weight based on the weight of the aerosolizable material; and (ii) at least one flavoring agent; (b) aerosolizing said aerosolizable material to produce an aerosol containing said at least one flavor in an amount of at least 70% by weight based on the weight of said flavor present in the aerosolizable composition.

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