RU2764666C2 - Соединения, ингибирующие металлоферменты - Google Patents
Соединения, ингибирующие металлоферменты Download PDFInfo
- Publication number
- RU2764666C2 RU2764666C2 RU2019123854A RU2019123854A RU2764666C2 RU 2764666 C2 RU2764666 C2 RU 2764666C2 RU 2019123854 A RU2019123854 A RU 2019123854A RU 2019123854 A RU2019123854 A RU 2019123854A RU 2764666 C2 RU2764666 C2 RU 2764666C2
- Authority
- RU
- Russia
- Prior art keywords
- cyclopropyl
- mmol
- disease
- benzo
- present
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662440181P | 2016-12-29 | 2016-12-29 | |
| US62/440,181 | 2016-12-29 | ||
| PCT/US2017/068190 WO2018125800A2 (en) | 2016-12-29 | 2017-12-22 | Metalloenzyme inhibitor compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019123854A RU2019123854A (ru) | 2021-02-01 |
| RU2019123854A3 RU2019123854A3 (enExample) | 2021-05-12 |
| RU2764666C2 true RU2764666C2 (ru) | 2022-01-19 |
Family
ID=62709109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019123854A RU2764666C2 (ru) | 2016-12-29 | 2017-12-22 | Соединения, ингибирующие металлоферменты |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10085984B2 (enExample) |
| EP (2) | EP4311577A3 (enExample) |
| JP (2) | JP7227157B2 (enExample) |
| KR (1) | KR102690885B1 (enExample) |
| CN (2) | CN110691598A (enExample) |
| AU (2) | AU2017387033B2 (enExample) |
| CA (1) | CA3055292A1 (enExample) |
| DK (1) | DK3562487T3 (enExample) |
| ES (1) | ES2967119T3 (enExample) |
| FI (1) | FI3562487T3 (enExample) |
| MX (2) | MX2019007892A (enExample) |
| RU (1) | RU2764666C2 (enExample) |
| TW (1) | TWI786078B (enExample) |
| WO (1) | WO2018125800A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104136427B (zh) * | 2012-01-20 | 2017-03-01 | 威尔金制药有限公司 | 金属酶抑制剂化合物 |
| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| RU2764666C2 (ru) | 2016-12-29 | 2022-01-19 | Селенити Терапьютикс (Бермуда), Лтд. | Соединения, ингибирующие металлоферменты |
| AU2020207051B2 (en) * | 2019-01-08 | 2025-07-24 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| GB201901757D0 (en) | 2019-02-08 | 2019-03-27 | Syngenta Crop Protection Ag | Herbicidal compounds |
| WO2021233861A1 (en) | 2020-05-19 | 2021-11-25 | Bayer Aktiengesellschaft | Azabicyclic(thio)amides as fungicidal compounds |
| EP4165038A1 (en) | 2020-06-10 | 2023-04-19 | Bayer Aktiengesellschaft | Azabicyclyl-substituted heterocycles as fungicides |
| AT524288B1 (de) * | 2020-09-16 | 2024-05-15 | Gatan Inc | Computergestütztes Verfahren zur Bestimmung eines Elementanteiles eines Bestimmungselementes kleiner Ordnungszahl, insbesondere eines Li-Anteiles, und Vorrichtung zur Datenverarbeitung hierzu |
| WO2025157275A1 (zh) * | 2024-01-26 | 2025-07-31 | 箕星药业香港有限公司 | 金属酶抑制剂化合物的固体形式 |
| CN120463643B (zh) * | 2025-05-27 | 2025-11-28 | 咸阳职业技术学院 | 一种2-环丙基胺基-3-硝基-6-氯吡啶的合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080255085A1 (en) * | 2005-10-03 | 2008-10-16 | Astrazeneca Ab | Novel Imidazo [4,5-b] Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase 3 for Use in the Treatment of Dementia and Neurodegenerative Disorders |
| RU2380368C2 (ru) * | 2002-01-07 | 2010-01-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Деазапурины и их применение |
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| DE2939916A1 (de) | 1979-10-02 | 1981-04-23 | Hoechst Ag, 6000 Frankfurt | Quaternierte, verbrueckte benzimidazolyl-benzimidazole, verfahren zu deren herstellung und deren verwendung |
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| RU2764666C2 (ru) | 2016-12-29 | 2022-01-19 | Селенити Терапьютикс (Бермуда), Лтд. | Соединения, ингибирующие металлоферменты |
| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| AU2020207051B2 (en) | 2019-01-08 | 2025-07-24 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
-
2017
- 2017-12-22 RU RU2019123854A patent/RU2764666C2/ru active
- 2017-12-22 CN CN201780087610.1A patent/CN110691598A/zh active Pending
- 2017-12-22 MX MX2019007892A patent/MX2019007892A/es unknown
- 2017-12-22 EP EP23212447.9A patent/EP4311577A3/en active Pending
- 2017-12-22 CA CA3055292A patent/CA3055292A1/en active Pending
- 2017-12-22 CN CN202511035515.XA patent/CN120987917A/zh active Pending
- 2017-12-22 AU AU2017387033A patent/AU2017387033B2/en active Active
- 2017-12-22 EP EP17887556.3A patent/EP3562487B1/en active Active
- 2017-12-22 JP JP2019556790A patent/JP7227157B2/ja active Active
- 2017-12-22 DK DK17887556.3T patent/DK3562487T3/da active
- 2017-12-22 FI FIEP17887556.3T patent/FI3562487T3/fi active
- 2017-12-22 WO PCT/US2017/068190 patent/WO2018125800A2/en not_active Ceased
- 2017-12-22 KR KR1020197022285A patent/KR102690885B1/ko active Active
- 2017-12-22 ES ES17887556T patent/ES2967119T3/es active Active
- 2017-12-29 TW TW106146533A patent/TWI786078B/zh active
- 2017-12-29 US US15/857,950 patent/US10085984B2/en active Active
-
2018
- 2018-09-07 US US16/124,846 patent/US11040034B2/en active Active
-
2019
- 2019-06-28 MX MX2022012386A patent/MX2022012386A/es unknown
-
2021
- 2021-06-17 US US17/350,726 patent/US12458642B2/en active Active
-
2023
- 2023-02-09 JP JP2023018482A patent/JP7611278B2/ja active Active
-
2024
- 2024-05-01 AU AU2024202860A patent/AU2024202860A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2380368C2 (ru) * | 2002-01-07 | 2010-01-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Деазапурины и их применение |
| US20080255085A1 (en) * | 2005-10-03 | 2008-10-16 | Astrazeneca Ab | Novel Imidazo [4,5-b] Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase 3 for Use in the Treatment of Dementia and Neurodegenerative Disorders |
Non-Patent Citations (2)
| Title |
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