RU2750358C1 - Method for correcting age changes in lower third face skin - Google Patents

Abstract

FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to dermatology and cosmetology, and can be used in the correction of age-related changes associated with aging processes of the skin, in particular the skin of the face. The method includes radio wave exposure to a given area using a 21G cannula electrode of the Innofill apparatus, followed by the introduction of autologous platelet-rich plasma into this area. The radio wave exposure is carried out first in the defibrosis mode with the set parameters of the Innofill apparatus: power level level 5 and frequency 1 MHz, at which the cannula electrode is inserted into the hypodermis through the access point located behind the lower pre-chin packet, and its reciprocating movements are carried out in the lower layers dermis and hypodermis in different directions from the access point. Then they act in the lifting mode with the set parameters of the Innofill apparatus: power levels level 6, level 7 or level 8 and a frequency of 2 MHz, at which circular movements of the cannula electrode are carried out retrograde in the lower layers of the dermis and hypodermis in different directions from the access point. Autologous platelet-rich plasma is first injected in a volume of 0.5 ml in a linear retrograde technique through a 21G cannula electrode, which was exposed to radio waves, then the cannula electrode is removed and plasma is injected in a volume of 1-1.5 ml through a 32G needle into the papular infiltrative technique, by injecting the needle to the depth of the needle cut with an interval of 0.7-1.0 cm and the volume of injected plasma 0.05-0.1 ml for each injection. The procedure is performed once a month in a course of 2-3 procedures.EFFECT: invention provides retraction of a skin flap (skin lifting) of the lower third of the face in 2-3 procedures with a reduction in the rehabilitation period (up to 2-7 days).15 cl, 2 dwg, 1 ex

Description

Technology area

The invention relates to medicine, namely to dermatology and cosmetology, and can be used to correct age-related changes associated with aging processes of the skin, in particular the skin of the face.

State of the art

Involutionary changes in the skin of the face are one of the leading problems of our time. Age-related changes in the lower third of the face are more pronounced than in other areas of the face. There are many different methods of therapy, however, low efficiency, trauma, long course, a large number of procedures, high cost require new approaches in the treatment of involutional changes in the skin of the lower third of the face.

From the prior art, there is a method for the treatment of atrophic skin (RF Patent No. 2372872), during which intradermal implantation of metal needle electrodes along the skin tension lines and exposure to an electric current of the radio frequency range with an energy of 5-7 J per centimeter of its length by means of a thread is performed. 3-10 seconds. After exposure during natural healing, an elastic threadlike scar is formed. The scar formation zone leads to a tight connection of the tissues and provides them with long-lasting support in the new positioning position.

The disadvantage of this method is the use of electrode-needles, active along the entire length, which can injure the surrounding tissues during their implantation. In addition, after exposure to the needle electrode, scar tissue remains, in contrast to minimally invasive radio wave lifting using a cannula, in which protein denaturation does not occur.

It is also known to use autologous platelet-rich plasma in the correction of involutional skin changes both in monotherapy and in combination with polychromatic red light with a wavelength of 618-633 nm [Karagadyan A.D. Autologous platelet-rich plasma in the correction of involutional skin changes. Abstract of the dissertation for the degree of candidate of medical sciences 2018, 3-24]. Treatment includes 5 plasma therapy procedures with an interval of 7-10 days and 30 procedures of polychromatic red light with a wavelength of 618-633 nm for 2.5-3 months.

The disadvantage of this method is a large number of procedures for 3.5 months and low efficiency in the treatment of age-related changes in the lower third of the face, which is very time-consuming for the patient.

Closest to the proposed method is a method of aesthetic correction of involutional changes in the skin of the face (RF patent No. 2603618), which consists in the simultaneous exposure to infrared low-intensity laser radiation and platelet-rich blood plasma, which is carried out in two stages. At the first stage, the patient's venous blood is taken with a volume of 20-40 ml and its centrifugation at 4000 rpm for 5 minutes to obtain a plasma fraction enriched with platelets. At the second stage, the plasma is applied to the skin of the face and, without a time interval, the effect is carried out with low-intensity laser radiation of the infrared range with a wavelength of 0.89 μm. The course is 10 procedures, carried out 2 times a week.

The disadvantages of this method are low efficiency in involutional changes in the lower third of the face, the need for a large number of procedures.

The technical problem to be solved by the invention is to increase the effectiveness of therapy for age-related changes in the skin of the lower third of the face, to obtain a pronounced cosmetic effect while reducing the duration of treatment.

Disclosure of the essence of the invention

The technical result of the invention is to provide retraction of the skin flap (skin lifting) of the lower third of the face for 2-3 procedures while reducing the rehabilitation period (up to 2-7 days). Due to the retraction of the skin flap, the clarity of the contour of the lower jaw, the angle of the lower jaw is achieved, as well as the improvement of the quality of the skin, increasing its tone and elasticity, reducing the severity of wrinkles in the area of nasolabial folds, "marionette wrinkles", parotid wrinkles. The proposed method allows you to achieve a good clinical result in the early stages due to the use of complex treatment of involutional changes in the lower third of the face with a minimally invasive radio wave method using the Innofill apparatus and autologous platelet-rich plasma (BTA).

The technical result is achieved through the use of a method including a radio wave exposure to a given area using a cannula electrode 21G of the Innofill apparatus, followed by the introduction of autologous platelet-rich plasma into this area, while the radio wave exposure is carried out first in the defibrosis mode with the set parameters of the Innofill level 5 apparatus, 1 MHz, in which the cannula electrode is inserted into the hypodermis through the access point located behind the lower premental package, and its reciprocating movements are carried out in the lower layers of the dermis and hypodermis in different directions from the access point, with the provision of defibrosis of the tissues of the dermis and hypodermis of the treated area , then - in the lifting mode with the set parameters of the Innofill device level 6-8, 2 MHz, in which circular movements of the cannula electrode are carried out retrograde within the lower layers of the dermis and hypodermis in different directions from the access point, autologous rich thrombocyte tami plasma is first injected in a volume of 0.5 ml in a linear retrograde technique through a 21G cannula electrode, which was exposed to radio waves, then the cannula electrode is removed and plasma is injected in a volume of 1-1.5 ml through a 32G needle in a papular infiltrative technique by injecting the needle to the depth of the needle cut with an interval of 0.7-1.0 cm and a volume of injected plasma of 0.05-0.1 ml for each injection, while for the preparation of autologous platelet-rich plasma, the patient's blood is taken with a volume of 9, 0 ml into 2 empty tubes and centrifuging them at a speed of 3000 rpm for 10 minutes with the formation of plasma in the upper part of the tubes, after which the obtained plasma from each tube in a volume of 4.0-4.5 ml is poured into an empty tube and again centrifuged at a speed of 3000 rpm for 10 minutes to obtain platelet-rich plasma in the lower part of the test tube in a volume of 3.0-4.0 ml; the procedure is performed once a month in a course of 2-3 procedures.

Before the cannula electrode is inserted into the hypodermis, an 18 G needle is punctured at the access point to the hypodermis to facilitate subsequent insertion of the cannula electrode.

The cannula electrode is selected with a length of 45 mm and a diameter of 0.8 mm, a needle - 4 mm long and 0.23 mm in diameter.

Radio wave defibrosis is carried out for the entire specified area, followed by radio wave lifting of this area, or segment-by-segment processing of the specified area with radio wave exposure to each segment is carried out sequentially, first in the defibrating mode, then in the lifting mode.

The movement of the cannula electrode in the hypodermis layer is carried out mainly in such a way that the distal end of the cannula describes a circle within the zone of the lower third of the face.

The radio wave effect on a given area is carried out mainly for 30-60 minutes.

When autologous platelet-rich plasma is administered via a cannula electrode, it is preferably positioned along the mandible.

After the introduction of autologous platelet-rich plasma, the access point can be treated with an antibacterial ointment, which can be used as Levomekol ointment.

Prior to the procedure, the patient can be prescribed Rehydron intake and a 30% increase in water consumption for 3 days.

Before the introduction of the cannula electrode, the treated area is anesthetized, for example, with lidocaine with saline, taken in a 1: 1 ratio.

After the administration of autologous platelet-rich plasma, Traumeel S ointment can be applied to the treated area.

After the procedure, the patient may be prescribed the application of Recowell cream gel or Traumeel C ointment to the treated area 2 times a day for 2-5 days.

During the entire course, the patient can be prescribed the intake of Collagen with Vitamin C in powder 5 g on an empty stomach 1 time per day and the use of water in the amount of 1500-2000 ml per day.

A repeat of the procedure is prescribed no earlier than 28 days after the previous procedure.

The combined use of radio wave exposure to the skin of the lower third of the face using the Innofill apparatus in the stated modes and the introduction of autologous platelet-rich plasma allows obtaining a qualitatively new, synergistic effect of rejuvenating the skin of the lower third of the face and significantly slowing down involutional changes in the skin due to the activation of heat shock proteins HSP47, which stimulate procollagen and normalize the structuring of collagen types I and III, and the action of platelet-rich autologous plasma, which has not only a regenerating property, but also additionally enhances the lifting effect after radio wave therapy by normalizing metabolic processes in tissues. In addition, due to the fact that the work is carried out in the hypodermis (and the lower layers of the dermis), damage to important anatomical structures - neurovascular bundles, salivary gland, etc. is excluded, which also affects the reduction of the patient's rehabilitation period. With the declared levels of defibrosis and tissue lifting in combination with the use of platelet-rich autologous plasma, there is a quick result (immediately after the procedure) and visual retraction of the skin flap. The introduction of autoplasma prepared by the claimed method after radio wave exposure helps to maximize its therapeutic efficacy and achieve more pronounced clinical results.

Brief Description of Drawings

The invention is illustrated by illustrations, where Fig. 1 shows a photo of a 36-year-old patient M. with age-related changes in the lower third of the face before complex treatment, which shows the marking of the vectors of passage of the cannula electrode, diverging in the form of rays from the access point. FIG. 2 shows a photo of a 36-year-old patient M. with age-related changes in the lower third of the face after complex treatment according to the proposed method.

Implementation of the invention

The doctor collects in detail the anamnesis, allergic anamnesis, concomitant diseases of the patient, assesses the condition of his skin, the thickness of the subcutaneous fat and skin of the lower third of the face, the mobility of soft tissues. The patient signs an informed consent to carry out procedures for the correction of involutional changes in the skin of the lower third of the face. Then a photo is taken. At the first stage, using the Innofill apparatus (Innofill, DOSIS M&M Co., Ltd, South Korea), radio wave defibrosis and lifting (tunneling) of the skin area of the lower third of the face are performed. Previously, the patient is shown a sterile 21G cannula electrode (diameter 0.8 mm, length 45 mm) in a sterile package, after which the package is opened and the cannula electrode is connected to the Innofill apparatus, a passive (indifferent) electrode is connected under the right scapula. Then, the area behind the lower pre-chin pack is anesthetized with Lidocaine diluted with saline (0.9% sodium chloride solution) in a 1: 1 ratio, after which a puncture is performed with an 18 G needle (diameter 1.2 mm, length 40 mm) to the depth of cut needles (up to the hypodermis) at the access point behind the lower pre-chin package, which ensures the subsequent easier insertion of the cannula electrode. In this case, the doctor chooses an access point behind the lower pre-chin package, based on tissue ptosis and the convenience of working with a given area, for example, stepping back 1-2 cm from the edge of the lower jaw (Fig. 1). Then, through this access point, an electrode-cannula 21 G (hereinafter referred to as a cannula) is inserted into the hypodermis and the specified area is treated in the radio wave defibrosis mode with the set parameters of the Innofill apparatus: level 5 (power level), frequency 1 MHz. In the process of treatment, the cannula is reciprocated (without effort) in the lower layers of the dermis and hypodermis in different directions from the access point to the entire length of the cannula for 5-30 minutes, until the movement of the cannula is impeded, with the provision of defibrosis of the tissues of the lower layers of the dermis and hypodermis. Next, the operating parameters of the Innofill apparatus are set at level 6, level 7 or level 8 (power levels), and a frequency of 2 MHz is the radio wave lifting mode, and the specified area is processed in this mode for 5-30 minutes, performing circular movements of the cannula retrograde (t during its return movement) in the lower layers of the dermis and hypodermis in different directions from the access point (tunneling technique, see for example, Hyuk Kim, Kui Young Park1, Sun Young Choi1 et al. The efficacy, longevity, and safety of combined radiofrequency treatment and hyaluronic acid filler for skin rejuvenation.Ann Dermatol Vol. 26, No. 4, 2014, 447-456). At the same time, the power of the device corresponding to level 6, 7 or 8 is selected individually, depending on the patient's subjective sensations, tissue reactivity (redness, swelling, bleeding). If the patient does not notice subjective discomfort (soreness, burning), tissue edema, hyperemia is not observed, there is no capillary bleeding, then the level is increased to 8, if subjective discomfort is noted, the level is set within 6, 7.

The treatment is completed when the distal end of the cannula describes a circumference (within the zone of the lower third of the face) and the contraction of the skin flap is visually noted. In this case, it is possible to perform radio wave defibrosis as the entire specified area, followed by switching the device to the radio wave lifting mode and processing the entire area in this mode, as well as performing segment-by-segment processing of a specified area when a small part of a specified area is worked out (for example, a circular sector with a distance of 2- 4 cm between the most distal cannula points), first in the radio wave defibrosis mode, and then the same part in the radio wave lifting mode, gradually passing the entire specified area. The second option is the most preferable, since after the development of the site, a slight edema of the tissues is possible, which will further restrict the movement of the cannula, and the segmental treatment allows tunneling to be performed before the edema occurs.

The total time of radio wave treatment of a given area can range from 30 minutes to 1 hour, depending on the individual characteristics of the patient and the reaction of the tissues. If the patient has post-acne scars or a history of cosmetic procedures (reinforcing and lifting threads, reinforcement with fillers based on hyaluronic acid or calcium hydroxyapatite, SMAS-lifting), then the movement of the cannula may be limited due to the presence of fibrosis in the tissues, in this In this case, the defibrosis stage can be time-consuming (up to 25-30 minutes). In most cases, the total defibrosis time for the entire given area is 10-20 minutes, the lifting time is also 10-20 minutes.

If the patient experiences discomfort during the treatment of the area, the doctor will administer pain relievers through the hollow cannula (for example, lidocaine with saline in the above ratio).

At the second stage, without removing the cannula from the tissues, autologous platelet-rich plasma is injected in a volume of 0.5 ml on each side in the region of the lower third of the face into the hypodermis in a linear-retrograde technique (at the time the cannula is removed from the tissues), then the cannula is removed and massaged distribute the injected plasma over the treated area with movements. Then autologous platelet-rich plasma is injected through a 32 G needle (diameter 0.23 mm, length 4 mm) in a volume of 1.0-1.5 ml on each side in the region of the lower third of the face in a papular-infiltrative technique to the depth of the needle cut (4 mm) with an interval of 0.7-1.0 cm (distance between injection sites) in an amount of 0.05-0.1 ml per injection. In this case, the needle is inserted into the skin at an angle of 30-45 °. The puncture site is treated with an antibacterial ointment, the procedure is completed with the application of Traumeel C ointment. When plasma is injected in quantities exceeding the declared values, severe tissue edema and an increase in the rehabilitation period up to a week can be observed, with smaller quantities the desired therapeutic effect will not be achieved. In this case, platelet-rich autologous plasma is prepared as follows. Venous blood is taken in 9.0 ml in 2 empty tubes (total 18 ml) and centrifuged at 3000 rpm for 10 minutes with the formation of plasma in the upper part of the tubes, after which the plasma from each tube in a volume of 4.0-4 , 5 ml is poured into an empty 9.0 ml tube and centrifuged again at 3000 rpm for 10 minutes. The lower part of the prepared plasma in the amount of 3.0-4.0 ml is rich in platelets.

The procedure according to the described method is performed once a month, the course is 2-3 procedures. In this case, the procedure is repeated no earlier than 28 days later. Recovery and neocollagenesis of the skin takes place within a month.

Simultaneously with the treatment, the patient is given the following recommendations:

• during the day, the injured area of the scar should not be wetted;

• it is recommended to apply Traumeel C ointment or Recowell cream-gel 2 times a day for 2-5 days to the place within the treated area, while in case of severe swelling, apply the ointment or cream-gel under a film for 15 minutes;

• Apply Levomikol ointment to the inlet (access point) 2 times a day for 2 days;

• exclude sports for five days;

• exclude insolation, baths, saunas, solarium for thirty days;

• on the treated area, the patient is recommended to apply a product with SPF 30;

• to carry out a control examination in a month;

• during the entire course, take Collagen with Vitamin C 5 g on an empty stomach 1 time per day, while drinking 1500-2000 ml of water per day.

Correction of involutional changes in the skin of the lower third of the face was performed in accordance with the proposed method in 25 patients aged 32 to 70 years. The observation period was up to 8 months.

In patients who underwent correction of age-related changes in the lower third of the face in accordance with the proposed method with defibrosis mode level 5, 1 MHz and lifting modes level 6-8, 2 MHz, followed by the introduction of autologous platelet-rich plasma prepared by the above method through a cannula in volume 0.5 ml and intradermally using a 32 G needle in a volume of 1.0-1.5 ml (on each side), there was a positive trend in the form of a skin flap reduction (skin lifting) of the lower third of the face, a more distinct contour and angle of the lower jaw , improving the quality of the skin, smoothing the complexion, increasing the tone and elasticity of the skin, reducing the signs of tightness and dryness of the skin, the severity of wrinkles in the area of nasolabial folds, "puppet wrinkles", parotid wrinkles. In these patients, the period after the course of procedures proceeded without complications, no inflammatory or other side reactions in the area of exposure were noted. The rehabilitation period was 2-5 days, while the result was visible already after the first procedure (immediately after the procedure) and improved with each subsequent procedure (only 2-3 procedures).

In patients who underwent correction of age-related changes in the lower third of the face with defibrosis mode level 5, 1 MHz and lifting modes level 4, 2 MHz; level 5, 2 MHz, followed by the introduction of autologous platelet-rich plasma prepared in the above way, in a volume of 0.5 ml and intradermally using a 32 G needle in a volume of 1-1.5 ml (on each side), there was a slight positive dynamics in the form of improving the quality of the skin, the appearance of a more even, healthy complexion, a moderate increase in skin tone and elasticity, a slight decrease in the severity of wrinkles in the area of nasolabial folds and retraction of the skin flap, reduction of dryness and tightness. Strengthening the clarity of the line of the lower jaw was weak.

In patients who underwent correction of age-related changes in the lower third of the face with defibrosis mode level 5, 1 MHz and lifting mode level 9, 2 MHz, followed by the introduction of autologous platelet-rich plasma prepared by the above method through a cannula in a volume of 0.5 ml and intradermally with Using a 32G needle in a volume of 1.5 ml (on each side), there was a long rehabilitation period (up to 2 weeks), there was a pronounced swelling within 2 weeks and pain on palpation.

When correcting age-related changes in the skin of the lower third of the face by means of radio wave exposure using the Innofill apparatus in the stated modes, but without the subsequent administration of autologous platelet-rich plasma, less pronounced edema was observed on the first day, but an improvement in texture, skin color and a decrease in signs was not achieved. dryness and tightness of the skin.

Clinical example

Patient M. 36 years old came to the clinic with complaints of skin laxity in the lower third of the face, fuzzy contour of the lower jaw, a smoothed angle of the lower jaw (see Fig. 1).

It is known from the anamnesis that there have been no previous procedures in this area.

Allergic anamnesis is not burdened, concomitant diseases are absent.

Local status: the skin is normal, slightly dehydrated, there is a decrease in skin tone and elasticity in the middle and lower third of the face, the contour and angle of the lower jaw are indistinct.

Was performed 2 procedures according to the proposed method: Innofill (Innofill, DOSIS M&M Co., Ltd, South Korea) in conjunction with the introduction of autologous platelet-rich plasma.

The area of the lower third of the face, within which the impact was carried out, is limited by the line of the lower jaw, the angle of the lower jaw, the tragus of the auricle and a line passing through a point lying in the medial-sagittal plane below the nasal thorn (Subnasale point) and a point on the lower edge of the lower jaw in the place of its intersection by the medial-sagittal plane (point of Gnathion) (Fig. 1).

Before the procedure, the area of the lower and middle third of the face and the submental area was treated three times with an alcohol solution of chlorhexidine 0.5%, after which anesthesia was introduced with Lidocaine: saline in a ratio of 1: 1 in an amount of 0.2 ml behind the lower pre-chin bag, 1-2 cm from the edge of the lower jaw. Then, in the same place, a puncture was made with an 18 G needle (1.2 mm × 40 mm) to cut the needle to the level of the hypodermis, and a 21 G cannula (0.8 mm × 45 mm) was inserted. Defibrating mode - level 5, 1 MHz, then lifting mode - level 7, 2 MHz.

At the same time, a predetermined area was worked out from the access point along the entire length of the cannula (45 mm), effortlessly moving the cannula in linear directions in the radio wave defibrosis mode for 10 minutes, until the movement of the cannula was impeded (Fig. 1). Next, a 360-degree rotation of the cannula was performed retrograde (tunneling) in the radio wave lifting mode for 20 minutes.

No anesthesia was added during the procedure. The duration of the procedure was 30 minutes on each side (total duration 60 minutes).

At the next stage, autologous platelet-rich plasma was injected through the cannula in an amount of 0.5 ml on each side in the lower third of the face into the hypodermis with the cannula positioned along the lower jaw, then the cannula was removed and the plasma was massaged over the treated area, after which through a 32 G needle (0.23 x 4 mm) plasma was injected in the amount of 1.5 ml on each side in the area of the lower third of the face in the papular-infiltrative technique to a depth of 4 mm with an interval of 0.7-1.0 cm in the amount of 0.05-0 , 1 ml per injection. The puncture site was treated with antibacterial ointment, the procedure was completed with the application of Traumeel S.

A month later, the procedure was repeated. At the 2nd procedure, the radio wave exposure mode, access point, and the volume of autologous plasma injection were the same. The procedure was completed by applying Traumeel S ointment and treating the puncture site with Levomekol.

The patient was given recommendations for care during the rehabilitation period.

FIG. 2 shows a photo of a patient after complex treatment.

There was an improvement in the quality of the skin in the form of an increase in skin tone and elasticity, an improvement and leveling of complexion, a decrease in signs of dryness and tightness of the skin, a decrease in the severity of nasolabial wrinkles, an improvement in the contour and angle of the lower jaw. The rehabilitation period was 2 days.

Conducted clinical studies of the proposed method have shown its effectiveness for the stated ranges of parameter values.

Thus, the use of complex therapy of involutional changes in the skin of the lower third of the face according to the proposed method, allows you to obtain a pronounced cosmetic effect, reduce the treatment time in comparison with other methods.

It should be noted that the proposed method can also be used to work out other areas: the forehead, the orbital region, the temporal region, the middle third of the face, the neck, the dorsum of the hands, local fat deposits (for example, in the submental region or in the area of the seventh cervical vertebra), the inner surface thighs, buttocks.

Claims (16)

1. A method of treating age-related changes in the skin of the lower third of the face, including a radio wave effect on a given area using the cannula electrode 21G of the Innofill apparatus, followed by the introduction of autologous platelet-rich plasma into this area, while the radio wave effect is carried out first in the defibrosis mode with the established parameters of the Innofill apparatus : power level level 5 and frequency 1 MHz, at which the cannula electrode is inserted into the hypodermis through the access point located behind the lower pre-chin pack, and its reciprocating movements are carried out in the lower layers of the dermis and hypodermis in different directions from the access point, ensuring defibrosis of the tissues of the dermis and hypodermis of the treated area, then - in the lifting mode with the set parameters of the Innofill apparatus: power levels level 6, level 7 or level 8 and a frequency of 2 MHz, at which circular movements of the cannula electrode are carried out retrograde in the lower layers of the dermis and hypodermis in different directions from the access point, autologous platelet-rich plasma is first injected in a volume of 0.5 ml in a linear-retrograde technique through the cannula electrode 21G, which was exposed to radio waves, then the cannula electrode is removed and plasma is injected in a volume of 1-1.5 ml through 32G needle in papular-infiltrative technique, by injecting the needle to the depth of the needle cut with an interval of 0.7-1.0 cm and a volume of injected plasma 0.05-0.1 ml for each injection, while for the preparation of autologous platelet-rich plasma is produced taking the patient's blood with a volume of 9.0 ml into 2 empty tubes and centrifuging them at a speed of 3000 rpm for 10 minutes with the formation of plasma in the upper part of the tubes, after which the obtained plasma from each tube in a volume of 4.0 - 4.5 ml is poured into an empty tube and centrifuged again at 3000 rpm for 10 minutes to obtain platelet-rich plasma in the lower part of the tube in a volume of 3.0-4.0 ml; the procedure is performed once a month in a course of 2-3 procedures. 2. The method according to claim 1, characterized in that before the cannula electrode is inserted into the hypodermis, an 18 G needle is punctured at the access point to the hypodermis to facilitate subsequent insertion of the cannula electrode. 3. The method according to claim 1, characterized in that the cannula electrode is selected with a length of 45 mm and a diameter of 0.8 mm, a needle - 4 mm long and 0.23 mm in diameter. 4. The method according to claim 1, characterized in that the radio wave defibrosis is carried out over the entire specified area, followed by radio wave lifting of this area. 5. The method according to claim 1, characterized in that the segment-by-segment processing of a given area with a radio wave effect on each segment is carried out sequentially, first in the defibrating mode, then in the lifting mode. 6. The method according to claim 1, characterized in that the movement of the cannula electrode in the hypodermis layer is carried out in such a way that the distal end of the cannula circumscribes a circle within the zone of the lower third of the face. 7. The method according to claim 1, characterized in that the radio wave effect on a given area is carried out for 30-60 minutes. 8. The method according to claim 1, characterized in that when autologous platelet-rich plasma is administered through a cannula electrode, the cannula is positioned along the lower jaw. 9. The method according to claim 1, characterized in that after administration of autologous platelet-rich plasma, the access point is treated with an antibacterial ointment. 10. The method according to claim 9, characterized in that Levomekol ointment is used as an antibacterial ointment. 11. The method according to claim 1, characterized in that before the procedure is performed, the patient is prescribed Rehydron and a 30% increase in water consumption for 3 days. 12. The method according to claim 1, characterized in that before the introduction of the cannula electrode, the treated area is anesthetized with lidocaine with saline, taken in a 1: 1 ratio. 13. The method according to claim 1, characterized in that after the administration of autologous platelet-rich plasma, Traumeel S ointment is applied to the treated area. 14. The method according to claim 1, characterized in that after the procedure is completed, the patient is prescribed to apply Recowell cream-gel or Traumeel C ointment to the treated area 2 times a day for 2-5 days. 15. The method according to claim 1, characterized in that during the entire course, the patient is prescribed Collagen with Vitamin C in powder 5 g on an empty stomach 1 time per day and the use of water in the amount of 1500-2000 ml per day. 16. The method according to claim 1, characterized in that the procedure is repeated no earlier than 28 days after the previous procedure.

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