RU2725608C1 - Method of producing nanocapsules of goldenrod (solidago canadensis) dry extract - Google Patents

Abstract

FIELD: nanotechnologies.SUBSTANCE: invention relates to nanotechnology, medicine and food industry, specifically to a method for producing nanocapsules of goldenrod extract. Method for production of nanocapsules of dry extract of goldenrod, in which nanocapsules are represented by kappa-carrageenan, and as core – dry extract of goldenrod, wherein dry extract of goldenrod is added to a suspension of kappa-carrageenan in methanol in presence of 0.01 g of E472 s as a surfactant while stirring at 600 rpm, then adding 7 ml of methylene chloride, obtained suspension of nanocapsules is filtered and dried at room temperature, wherein weight ratio of core : shell is 1:1, 1:2 or 1:3.EFFECT: method described above simplifies and speeds up the process of producing nanocapsules and increases mass output.1 cl, 3 ex

Description

The invention relates to the field of nanotechnology, medicine, pharmacology, cosmetics and the food industry.

Previously known methods for producing microcapsules.

In US Pat. 2173140 IPC A61K 009/50, A61K 009/127 Russian Federation published September 10, 2001. A method for producing silicon organolipid microcapsules using a rotary-cavitation unit with high shear forces and powerful sonar acoustic and ultrasonic dispersion ranges is proposed.

The disadvantage of this method is the use of special equipment - rotary cavitation unit, which has an ultrasonic effect, which affects the formation of microcapsules and can cause adverse reactions due to the fact that ultrasound destructively affects polymers of a protein nature, therefore, the proposed method is applicable when work with polymers of synthetic origin

In US Pat. 2359662 IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published on 06/27/2009 The Russian Federation proposed a method for producing microcapsules of sodium chloride using spray cooling in a Niro spray cooling tower under the following conditions: inlet air temperature 10 ° C, outlet air temperature 28 ° C, the rotation speed of the spray drum 10,000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, rotation speed of the spray drum 10,000 rpm).

The closest method is the method proposed in US Pat. 2134967 IPC A01N 53/00, A01N 25/28 published on 08.27.1999 Russian Federation (1999). A solution of a mixture of natural lipids and a pyrethroid insecticide in a weight ratio of 2-4: 1 in an organic solvent is dispersed in water, which simplifies the microencapsulation method.

The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for producing microcapsules of water-soluble preparations in water-soluble polymers.

The technical task is to simplify and accelerate the process of obtaining nanocapsules, reducing losses in obtaining nanocapsules (increase in yield by mass).

The solution to the technical problem is achieved by the method of producing nanocapsules, characterized in that kappa-carrageenan is used as the shell of the nanocapsules, and a dry goldenrod extract is used as the core when nanocapsules are prepared by the non-solvent precipitation method using methylene chloride as a precipitant.

A distinctive feature of the proposed method is the preparation of nanocapsules by non-solvent precipitation using methylene chloride as a precipitant, as well as the use of kappa-carrageenan as a particle shell and dry goldenrod extract as a core.

The result of the proposed method are obtaining nanocapsules of dry goldenrod extract.

EXAMPLE 1 Obtaining nanocapsules of dry goldenrod extract, core: shell ratio 1: 3

1.5 g of dry goldenrod extract is added to a suspension of 4.5 g of kappa-carrageenan in methanol in the presence of 0.01 g of the preparation E472 s (glycerol ester with one or two molecules of food fatty acids and one or two molecules of citric acid, with citric the acid, as tribasic, can be esterified with other glycerides and as the acid with other fatty acids. Free acid groups can be neutralized with sodium) as a surfactant with stirring at 600 rpm. Then poured 7 ml of methylene chloride. The resulting suspension is filtered and dried at room temperature.

Received 6 g of nanocapsule powder. The yield was 100%.

EXAMPLE 2 Preparation of nanocapsules of dry goldenrod extract, core: shell ratio 1: 1

2 g of dry goldenrod extract is added to a suspension of 2 g of kappa-carrageenan in methanol in the presence of 0.01 g of the preparation E472 as a surfactant with stirring at 600 rpm. Then poured 7 ml of methylene chloride. The resulting suspension is filtered and dried at room temperature.

Received 4 g of nanocapsule powder. The yield was 100%.

Example 3 Obtaining nanocapsules of dry goldenrod extract, core: shell ratio 1: 2

2 g of dry goldenrod extract is added to a suspension of 4 g of kappa-carrageenan in methanol in the presence of 0.01 g of the preparation E472 c as a surfactant with stirring at 600 rpm. Then poured 7 ml of methylene chloride. The resulting suspension is filtered and dried at room temperature.

Received 4 g of nanocapsule powder. The yield was 100%.

Claims (1)

A method of producing nanocapsules of dry goldenrod extract, characterized in that kappa-carrageenan is used as the shell of the nanocapsules, and dry goldenrod extract is used as the core, while dry goldenrod extract is added to the suspension of kappa-carrageenan in methanol in the presence of 0.01 g E472 s as a surfactant with stirring at 600 rpm, then 7 ml of methylene chloride are poured, the resulting suspension of nanocapsules is filtered and dried at room temperature, while the mass ratio of the core: shell is 1: 1, 1: 2 or 1: 3.