RU2718921C2 - Лечение жировой болезни печени с применением антагонистов глюкокортикоидных и минералокортикоидных рецепторов - Google Patents

Лечение жировой болезни печени с применением антагонистов глюкокортикоидных и минералокортикоидных рецепторов Download PDF

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RU2718921C2
RU2718921C2 RU2017114596A RU2017114596A RU2718921C2 RU 2718921 C2 RU2718921 C2 RU 2718921C2 RU 2017114596 A RU2017114596 A RU 2017114596A RU 2017114596 A RU2017114596 A RU 2017114596A RU 2718921 C2 RU2718921 C2 RU 2718921C2
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liver disease
fatty liver
liver
receptor
alcoholic
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RU2017114596A
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Russian (ru)
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RU2017114596A3 (https=
RU2017114596A (ru
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Джозеф К. БЕЛАНОФФ
Хэйзел ХАНТ
Онно К. МЕЙЕР
ДЕН ХЁВЕЛ Хосе ВАН
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Корсепт Терапьютикс, Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2017114596A 2014-10-15 2015-10-14 Лечение жировой болезни печени с применением антагонистов глюкокортикоидных и минералокортикоидных рецепторов RU2718921C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462064358P 2014-10-15 2014-10-15
US62/064,358 2014-10-15
US201462092041P 2014-12-15 2014-12-15
US62/092,041 2014-12-15
PCT/US2015/055487 WO2016061195A1 (en) 2014-10-15 2015-10-14 Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists

Publications (3)

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RU2017114596A RU2017114596A (ru) 2018-11-15
RU2017114596A3 RU2017114596A3 (https=) 2019-05-08
RU2718921C2 true RU2718921C2 (ru) 2020-04-15

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CN (2) CN111557942B (https=)
AU (1) AU2015333645B2 (https=)
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RU2849641C1 (ru) * 2020-08-19 2025-10-28 ЕА Фарма Ко., Лтд. Терапевтическое средство против жировой болезни печени

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JP7196201B2 (ja) 2018-06-04 2022-12-26 コーセプト セラピューティクス, インコーポレイテッド ピリミジンシクロヘキセニル糖質コルチコイドレセプター調節因子
EP4653047A3 (en) 2019-03-18 2026-02-18 Nieman, Lynnette K. Mifepristone for use in improving insulin sensitivity
KR102911885B1 (ko) * 2020-05-06 2026-01-12 코어셉트 쎄라퓨틱스 인코포레이티드 피리미딘 사이클로헥실 글루코코르티코이드 수용체 조절제의 다형체
JP7474869B2 (ja) * 2020-05-06 2024-04-25 コーセプト セラピューティクス, インコーポレイテッド ピリミジンシクロヘキシルグルココルチコイド受容体モジュレーターの製剤
KR102481705B1 (ko) * 2020-08-04 2022-12-27 연세대학교 산학협력단 트리아졸 유도체를 유효성분으로 포함하는 간 섬유증의 예방 또는 치료용 조성물
AU2021409656B2 (en) * 2020-12-21 2025-04-10 Corcept Therapeutics Incorporated Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators
CA3217413A1 (en) * 2021-05-05 2022-11-10 Ada Lee Methods for reducing liver fat and for treating fatty liver disorders
WO2025174745A1 (en) * 2024-02-12 2025-08-21 Corcept Therapeutics Incorporated MIRICORILANT TREATMENT FOR FATTY LIVER DISEASES and its EFFECTS on LIVER FAT CONTENT, FATTY ACIDS, ACYLGLYCEROLS, and SECONDARY BILE ACIDS
WO2025255357A1 (en) * 2024-06-06 2025-12-11 Corcept Therapeutics Incorporated Methods for preparing and maintaining livers and portions thereof for liver transplantation

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EP4353310A3 (en) 2024-06-19
FI3206692T3 (fi) 2024-05-06
IL251729A0 (en) 2017-06-29
IL251729B (en) 2020-03-31
ZA201702813B (en) 2019-05-29
CN111557942A (zh) 2020-08-21
PL3206692T3 (pl) 2024-07-22
KR102435956B1 (ko) 2022-08-23
EP3206692A1 (en) 2017-08-23
UA123537C2 (uk) 2021-04-21
PT3206692T (pt) 2024-04-30
ES2978871T3 (es) 2024-09-23
CN107106562A (zh) 2017-08-29
US20190151318A1 (en) 2019-05-23
BR112017007860B1 (pt) 2023-03-07
EP3206692B1 (en) 2024-04-03
US11590135B2 (en) 2023-02-28
MX2017004943A (es) 2017-07-19
BR112017007860A2 (pt) 2018-01-16
US20230218621A1 (en) 2023-07-13
JP6761410B2 (ja) 2020-09-23
DK3206692T3 (da) 2024-04-29
AU2015333645A1 (en) 2017-05-04
JP2017531013A (ja) 2017-10-19
US20160106749A1 (en) 2016-04-21
AU2015333645B2 (en) 2020-01-30
RU2017114596A3 (https=) 2019-05-08
CN107106562B (zh) 2020-08-18
US10238659B2 (en) 2019-03-26
KR20170066646A (ko) 2017-06-14
US10881660B2 (en) 2021-01-05
US20250221995A1 (en) 2025-07-10
RU2017114596A (ru) 2018-11-15
EP3206692A4 (en) 2018-05-30
EP4353310A2 (en) 2024-04-17
CN111557942B (zh) 2023-10-03
CA2964625A1 (en) 2016-04-21
PH12017500710B1 (en) 2024-01-17
SG11201703024VA (en) 2017-05-30
WO2016061195A1 (en) 2016-04-21
US20210085682A1 (en) 2021-03-25
US12226417B2 (en) 2025-02-18
CA2964625C (en) 2023-03-07
NZ731060A (en) 2023-07-28
PH12017500710A1 (en) 2017-10-09

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