RU2686325C2 - Лечение злокачественной опухоли налтрексоном - Google Patents
Лечение злокачественной опухоли налтрексоном Download PDFInfo
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6288074B1 (en) * | 1998-11-17 | 2001-09-11 | Bernard Bihari | Method of treating lymphoproliferative syndrome |
| US6384044B1 (en) * | 1999-11-29 | 2002-05-07 | Bernard Bihari | Method of treating cancer of the prostate |
| US20110136845A1 (en) * | 2009-07-16 | 2011-06-09 | Mallinckrodt Inc. | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof |
Non-Patent Citations (3)
| Title |
|---|
| ИСАЕНКО Е.Ю. и др. "Адъюванты в современной вакцинологии". Annals of Mechnikov Institute, 2013, no. 4, с.5-21, см. Таблица на стр. 14, найдено 06.02.2018 из Интернет: http://www.imiamn.org.ua/jornal/4_2013/PDF/3.pdf. * |
| ИСАЕНКО Е.Ю. и др. "Адъюванты в современной вакцинологии". Annals of Mechnikov Institute, 2013, no. 4, с.5-21, см. Таблица на стр. 14, найдено 06.02.2018 из Интернет: http://www.imiamn.org.ua/jornal/4_2013/PDF/3.pdf. Н.В.Медуницын "Вакцинология", М., "Триада-Х", 2010, с.389-391. * |
| Н.В.Медуницын "Вакцинология", М., "Триада-Х", 2010, с.389-391. * |
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