RU2672391C1 - Method for diagnosis of drusen of the optic nerve disc using the method of optical coherence tomography - angiography - Google Patents

Method for diagnosis of drusen of the optic nerve disc using the method of optical coherence tomography - angiography Download PDF

Info

Publication number
RU2672391C1
RU2672391C1 RU2018104819A RU2018104819A RU2672391C1 RU 2672391 C1 RU2672391 C1 RU 2672391C1 RU 2018104819 A RU2018104819 A RU 2018104819A RU 2018104819 A RU2018104819 A RU 2018104819A RU 2672391 C1 RU2672391 C1 RU 2672391C1
Authority
RU
Russia
Prior art keywords
mm
angiography
method
diagnosis
optic nerve
Prior art date
Application number
RU2018104819A
Other languages
Russian (ru)
Inventor
Елена Эдуардовна Иойлева
Евгения Анатольевна Кабанова
Мария Алексеевна Бондаренко
Original Assignee
Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации filed Critical Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации
Priority to RU2018104819A priority Critical patent/RU2672391C1/en
Application granted granted Critical
Publication of RU2672391C1 publication Critical patent/RU2672391C1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/10Eye inspection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13Tomography
    • A61B8/14Echo-tomography

Abstract

FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely to ophthalmology, and can be used for the diagnosis of drusen of the optic nerve head (OPN). Measure the vascular density of the optic disc by optical coherent tomography-angiography using the Angiography Analysis protocol: Angiography 6×6 mm in three topographic areas of the optic disc: central – with a diameter of 3 mm, internal – 6 mm, external – 9 mm. If the density of vessels in the central zone is more than 3.2 mm-1, in the inner zone more than 17.3 mm-1, and in the outer more than 17.6 mm-1, then diagnose druses of the optic disc.
EFFECT: method provides an increase in the accuracy of diagnosis of optic disc drusen due to the assessment of the density of blood vessels in the zone of the optic disc and the peripapillary zone using optical coherence tomography angiography using the Angiography Analysis protocol.
1 cl, 2 ex

Description

The invention relates to medicine, in particular to ophthalmology, and can be used to diagnose friends of the optic nerve disc (optic nerve disc). The frequency of detected congenital pathology of the organ of vision is 2-4%. Of these, anomalies of the optic nerve head 15%, accompanied by a decrease in visual function - 7%. Druze DZN occur from 0.3% to 2.4% in the population. In most cases, Druze DZNs flow unnoticed for patients, but can cause a decrease in visual function.

Diagnosis of friends of the optic disc is complicated. There are various modern methods for the diagnosis of DZN friends: fundus ophthalmoscopy, fluorescence angiography, eyeball ultrasound, computed tomography of the orbits, optical coherence tomography.

The closest analogue is a method for diagnosing drusen of the optic nerve disc (Ioyleva E.E., Kabanova E.A., Krivosheeva M.S., RF patent No. 2576810), which is carried out using the method of optical coherence tomography. This method allows you to determine the area of the optic nerve disk (Disk Aria), as well as the thickness of the retinal nerve fiber layer in four quadrants (RNFL Thickness) on a Cirrus HD-OCT spectral optical coherent tomograph using the Optic Disc Cube 200x200 protocol.

The method is not accurate enough, since it did not evaluate the density of blood vessels in the area of the optic nerve head, which is an important diagnostic criterion, since changes in the vessels of the optic nerve occur with optic druse.

With the advent of the method of optical coherence tomography-angiography, it is possible to differentiate blood vessels from surrounding tissues at the entire scanning depth without the use of a contrast medium. It is possible to evaluate perfusion of the optic nerve disc, obtain layered information on the structure of the vasculature of the optic nerve disc from the superficial to deep vessels, and determine the density of blood vessels in the region of the optic nerve disk.

The objective of the invention is the creation of a method for the diagnosis of Druze disabilities, which are characterized by an abnormal distribution of blood vessels in the optic nerve, using the modern method - optical coherence tomography with angiography function.

The technical result of the invention is to increase the accuracy of the method due to the possibility of estimating the density of blood vessels in the optic nerve disc zone and the peripapillary zone.

The technical result is achieved by the fact that in the method for diagnosing friends of the optic nerve disc (optic nerve disc), according to the invention, the density of the vascular discs is measured by optical coherence tomography angiography protocol Angiography Analysis: Angiography 6X6 mm in three topographic areas of the optic disc: 3 mm in diameter, inner - 6 mm, outer - 9 mm, and if the density of blood vessels in the central zone is more than 3.2 mm -1 , in the inner zone more than 17.3 mm -1 , and in the outer zone more than 17.6 mm -1 , then disk druses are diagnosed optic nerve.

Density of vessels (Vessel) DZN is calculated as a percentage of the area of vessels and microvascular network in the study area in mm -1 in three topographic zones: central (Central), internal (Inner), and external (Outer).

A theoretical prerequisite for the development of the proposed method was the examination of patients aged 24-50 years with a diagnosis of Druze DZN.

The method is as follows. Optical coherence tomography with angiography function is performed on a Cirrus HD-OCT spectral optical coherence tomography (Carl Zeiss Meditec Inc) angiography function. The examination is carried out according to the standard method: the patient sits in front of the device, rests his head on the chin support, fixes his gaze on the point fixation (the patient sees a green fixation point on a black background in the form of a star). Then the subject is asked to blink and keep his eyes wide open, at this time the system of optical coherence tomography - angiography is built scans of images of the optic nerve disc and the peripapillary zone of high resolution. Measurement of the density of the vascular discs is carried out according to the Angiography Analysis protocol: Angiography 6X6 mm (recognized as the best for the diagnosis of DZN friends) with the subsequent analysis of three zones: central (Central) - with a diameter of 3.0 mm, inner (Inner ) - 6.0 mm, external (Outer) - 9.0 mm In addition, the technique of frequency filtering of B-scans based on their intensity is used to create images with a detailed vascular network.

The method is illustrated by clinical examples:

Example 1. Patient M., 19 years old, was examined at the ISTC MG. Visual acuity of the left eye of 0.8. Computed perimetry revealed multiple relative scotomas in the nasal segment. The threshold of electrical sensitivity of the left eye was 40 μA, the electrical lability of 35 imp / sec. The fundus of the eye: the optic disc is monotonous, the scalloped borders, with a prominence in the vitreous. When conducting OCT with angiography function according to the proposed method, it was determined: vascular density: V. Central - 18.4 mm -1 , V. Inner 19.3 mm -1 V. Outer 19.4 mm -1 . Given that all indicators are in the declared range, the diagnosis was made of drusen disabilities.

To confirm the diagnosis, an additional computed tomography of the orbits was performed, in which calcifications were found in the projection of the optic nerves. The diagnosis of Druze DZN is confirmed.

Subsequently, the patient was under dynamic observation in the MNTK MG. Visual functions, optic ophthalmoscopy of the optic nerve disc, the vascular network in the area of the optic nerve disc in dynamics were examined.

Example 2. Patient A., 25 years old. Visual acuity with correction of the right eye - 0.7. With computer perimetry, peripheral narrowing of the visual field in the lower temporal segment by 10 °. The threshold of electrical sensitivity is 50 μA, the electrical lability is -20 imp / s. Fundus: optic nerve disc monotonous, borders fused, proinence in the vitreous. When conducting OCT with angiography function according to the proposed method, it was determined: vascular density: V. Central - 1.1 mm -1 , V. Inner 15.4 mm -1 V. Outer 17.9 mm -1 . Considering that two indicators are not included in the declared range, the diagnosis of DTEs was not made.

Additionally, the patient underwent magnetic resonance imaging of the brain. Signs of increased intracranial pressure were identified. The presumptive diagnosis of Druze disabilities has not been confirmed. Subsequently, the patient was observed by a neurologist.

Claims (1)

  1. Method for the diagnosis of optic nerve disk friends (DZN), characterized in that the density of the vascular DZN is measured by the method of optical coherent tomography-angiography according to the Angiography Analysis: Angiography protocol 6 × 6 mm in three topographic zones of the DZN: central - with a diameter of 3 mm, internal - 6 mm , outer - 9 mm, and if the density of blood vessels in the central zone is more than 3.2 mm -1 , in the inner zone more than 17.3 mm -1 , and in the outer zone more than 17.6 mm -1 , then the druses of the optic nerve disc are diagnosed.
RU2018104819A 2018-02-08 2018-02-08 Method for diagnosis of drusen of the optic nerve disc using the method of optical coherence tomography - angiography RU2672391C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2018104819A RU2672391C1 (en) 2018-02-08 2018-02-08 Method for diagnosis of drusen of the optic nerve disc using the method of optical coherence tomography - angiography

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2018104819A RU2672391C1 (en) 2018-02-08 2018-02-08 Method for diagnosis of drusen of the optic nerve disc using the method of optical coherence tomography - angiography

Publications (1)

Publication Number Publication Date
RU2672391C1 true RU2672391C1 (en) 2018-11-14

Family

ID=64328038

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018104819A RU2672391C1 (en) 2018-02-08 2018-02-08 Method for diagnosis of drusen of the optic nerve disc using the method of optical coherence tomography - angiography

Country Status (1)

Country Link
RU (1) RU2672391C1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2271249A1 (en) * 2008-03-27 2011-01-12 Doheny Eye Institute Optical coherence tomography device, method, and system
RU2576810C1 (en) * 2014-12-25 2016-03-10 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Method of diagnosing optic nerve disc druses
US20160278627A1 (en) * 2015-03-25 2016-09-29 Oregon Health & Science University Optical coherence tomography angiography methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2271249A1 (en) * 2008-03-27 2011-01-12 Doheny Eye Institute Optical coherence tomography device, method, and system
RU2576810C1 (en) * 2014-12-25 2016-03-10 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Method of diagnosing optic nerve disc druses
US20160278627A1 (en) * 2015-03-25 2016-09-29 Oregon Health & Science University Optical coherence tomography angiography methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Иойлева Е.Э. и др. Возможности современных методов визуализации в диагностике друз диска зрительного нерва (обзор литературы). // Бюллетень ВСНЦ СО РАМН. 2016. 1 (6 (112): 206-9. Flores-Reyes E. et al. Optic Nerve Head Drusen: Imaging Using Optical Coherence Tomography Angiography. // J Glaucoma. 2017 Sep; 26(9): 845-9. Gaier E.D. et al. Focal Capillary Dropout Associated With Optic Disc Drusen Using Optical Coherence Tomographic Angiography. // J Neuroophthalmol. 2017 Dec; 37 (4): 405-10. Cennamo G. et al. Optical Coherence Tomography Angiography in Optic Nerve Drusen. // Ophthalmic Res. 2018; 59(2): 76-80; Epub 2017 Nov 30. *
Ламброзо Б. и др. ОКТ сетчатки. Метод анализа и интерпретации/ Под ред. В.В. Нероева, О.В. Зайцевой. М.: Апрель, 2012. С.83. *
Ламброзо Б. и др. ОКТ сетчатки. Метод анализа и интерпретации/ Под ред. В.В. Нероева, О.В. Зайцевой. М.: Апрель, 2012. С.83. Иойлева Е.Э. и др. Возможности современных методов визуализации в диагностике друз диска зрительного нерва (обзор литературы). // Бюллетень ВСНЦ СО РАМН. 2016. 1 (6 (112): 206-9. Flores-Reyes E. et al. Optic Nerve Head Drusen: Imaging Using Optical Coherence Tomography Angiography. // J Glaucoma. 2017 Sep; 26(9): 845-9. Gaier E.D. et al. Focal Capillary Dropout Associated With Optic Disc Drusen Using Optical Coherence Tomographic Angiography. // J Neuroophthalmol. 2017 Dec; 37 (4): 405-10. Cennamo G. et al. Optical Coherence Tomography Angiography in Optic Nerve Drusen. // Ophthalmic Res. 2018; 59(2): 76-80; Epub 2017 Nov 30. *

Similar Documents

Publication Publication Date Title
Lederer et al. Analysis of macular volume in normal and glaucomatous eyes using optical coherence tomography
Trip et al. Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophy
Schlottmann et al. Relationship between visual field sensitivity and retinal nerve fiber layer thickness as measured by scanning laser polarimetry
Kang et al. Effect of myopia on the thickness of the retinal nerve fiber layer measured by Cirrus HD optical coherence tomography
Jia et al. Optical coherence tomography angiography of optic disc perfusion in glaucoma
Baumann et al. Reproducibility of retinal thickness measurements in normal eyes using optical coherence tomography
Lesk et al. Reversal of optic disc cupping after glaucoma surgery analyzed with a scanning laser tomograph
Rohrschneider et al. Use of fundus perimetry (microperimetry) to quantify macular sensitivity
Menke et al. Reproducibility of retinal thickness measurements in healthy subjects using spectralis optical coherence tomography
Marziani et al. Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography
Hrynchak et al. Optical coherence tomography: an introduction to the technique and its use
Hee et al. Optical coherence tomography of the human retina
Garas et al. Reproducibility of retinal nerve fiber layer and macular thickness measurement with the RTVue-100 optical coherence tomograph
Leung et al. Comparison of macular thickness measurements between time domain and spectral domain optical coherence tomography
Wang et al. Orbital cerebrospinal fluid space in glaucoma: the Beijing intracranial and intraocular pressure (iCOP) study
Chen Spectral domain optical coherence tomography in glaucoma: qualitative and quantitative analysis of the optic nerve head and retinal nerve fiber layer (an AOS thesis)
Hee et al. Optical coherence tomography of central serous chorioretinopathy
Chang et al. Myopia-related fundus changes in Singapore adults with high myopia
Chui et al. The use of forward scatter to improve retinal vascular imaging with an adaptive optics scanning laser ophthalmoscope
Jeoung et al. Macular ganglion cell imaging study: glaucoma diagnostic accuracy of spectral-domain optical coherence tomography
Wang et al. Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography
Medeiros et al. Axonal loss after traumatic optic neuropathy documented by optical coherence tomography
Archibald et al. Retinal thickness in Parkinson's disease
Ooto et al. High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy
González-García et al. Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements