RU2576810C1 - Method of diagnosing optic nerve disc druses - Google Patents

Method of diagnosing optic nerve disc druses Download PDF

Info

Publication number
RU2576810C1
RU2576810C1 RU2014152569/14A RU2014152569A RU2576810C1 RU 2576810 C1 RU2576810 C1 RU 2576810C1 RU 2014152569/14 A RU2014152569/14 A RU 2014152569/14A RU 2014152569 A RU2014152569 A RU 2014152569A RU 2576810 C1 RU2576810 C1 RU 2576810C1
Authority
RU
Russia
Prior art keywords
optic
disk
area
thickness
optic nerve
Prior art date
Application number
RU2014152569/14A
Other languages
Russian (ru)
Inventor
Елена Эдуардовна Иойлева
Мария Сергеевна Кривошеева
Евгения Анатольевна Кабанова
Original Assignee
федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации filed Critical федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации
Priority to RU2014152569/14A priority Critical patent/RU2576810C1/en
Application granted granted Critical
Publication of RU2576810C1 publication Critical patent/RU2576810C1/en

Links

Abstract

FIELD: medicine.
SUBSTANCE: invention can be used for diagnosing druses of optic nerve. Measuring the area of disc rim (Rim Aria), volume of optic disk excavation. Diagnostics is performed by optical coherence tomography according to Optic Disc Cube 200×200 protocol. Additionally, the optic disk area (Disk Aria) is defined, as well as thickness of retinal nerve fibres in four quadrants (RNFL Thickness). If the volume of excavation is equal to zero, the optic disk area and area of disk rim are equal, thickness of retinal nerve fibres in at least two quadrants of OND is less than 80 nm, then OND druses is diagnosed.
EFFECT: method enables higher information value and reliable diagnosis of optic nerve disc druses, reduce labour intensity of diagnosis ensured by using optical coherence tomography.
1 cl, 2 ex

Description

The invention relates to medicine, in particular to ophthalmology, and can be used to diagnose friends of the optic nerve. Druzes of the optic nerve disk (optic nerve disc) are found from 0.3% to 2.4% in the population, often they are bilateral. They are hyaline-like calcifications located inside the optic nerve head (ZN). Druzes of optic discs can be both superficial and deep, and therefore their diagnosis is difficult. The ophthalmological method is subjective, since in each particular case the shape and size of the prominence of optic discs by different ophthalmologists are stated differently.

There are various objective diagnostic methods for the diagnosis of DZN drusen: fluorescence angiography (FAG), computed tomography (CT) of the orbits, ultrasound examination (ultrasound) of the eyeball. However, the above methods alone or in their various combinations, not in all clinical cases, can confirm the diagnosis of friends of the optic nerve head.

The closest analogue is a method for differential diagnosis of drusen optic nerve head and congestive optic nerve head (Ioyleva E.E., Marchenkova T.A., RF patent No. 2203000), which is carried out using the video ophthalmological method on the optic head analyzer. This method allows you to determine objectively non-invasively the topography of the optic head, namely the following diagnostic criteria: excavation area, excavation volume, rim (neuroretinal girdle) area, rim volume, ratio of excavation area to the area of optic disc.

The disadvantages of the method is the complexity of the diagnostic process, a significant number of parameters to obtain a complete diagnostic picture, most of which must be calculated manually.

With the advent of optical coherence tomography (OCT), the process of visualization of optic discs with obtaining high-resolution scans has become less time-consuming, for comprehensive diagnostics of the status of discs, fewer digital indicators are required, all of them are calculated automatically.

The objective of the invention is to create a reliable method for the diagnosis of Druze disabilities using a modern imaging method - optical coherence tomography.

The technical result is to increase the information content and reliability of the method for diagnosing friends of the optic nerve disc, as well as reducing the complexity of diagnosis.

The technical result is achieved by the fact that in the method for the diagnosis of friends of the optic disc, including measuring the area of the neuroretinal girdle of the optic nerve (Rim Aria), the volume of excavation of the optic disc, according to the invention, the diagnosis is carried out by optical coherence tomography according to the Optic Disc Cube 200 × 200 protocol, at the same time, the area of the optic nerve disk (Disk Aria), as well as the thickness of the layer of nerve fibers of the retina in four quadrants (RNFL Thickness) are additionally determined, and if the excavation volume is zero, the area of the spectator disk Foot area neuroretinal nerve and optic nerve girdle equal to each other, the thickness of the retinal nerve fiber layer in at least two quadrants ONH is less than 80 nm, the optic disc drusen diagnosed.

A theoretical prerequisite for the development of the proposed method was observation during examination of somatically healthy patients aged 18 to 30 years who were complaining of narrowing of the visual fields in the nasal segment, similar to glaucomatous.

The method is as follows. OCT is performed on a Cirrus HD-OCT spectral optical coherent tomography scanner (Carl Zeiss Meditec Inc.; software version 4.5.1.11). Pupil dilation is not required. The survey is conducted according to standard methods. The scanning of the optic disc region is carried out according to the Optic Disc Cube 200 × 200 protocol, followed by the analysis of peripapillary START using the RNFL Thickness Analysis program, according to which the START thickness is measured around a circumference with a diameter of 3.46 mm. The circle is centered automatically relative to the optic disc; if necessary, its position is adjusted in manual mode. Determine the average thickness of the START (around the entire circumference) and the thickness in 4 quadrants - temporal, superior, nasal and inferior. Measurements of excavation volume are carried out in mm 3 , the area of the optic nerve disk and the area of the neuroretinal girdle in mm 2 , the thickness of the layer of nerve fibers in nm. In addition, a mapping is underway, showing for illustrative purposes the change in these values by color.

The method is illustrated by clinical examples:

Example 1. Patient S., 18 years old. Visual acuity of the right eye 1.0. Computer perimetry revealed a narrowing of the visual field in the nasal segment by 10 °. The threshold of electrical sensitivity of the right one was 45 μA, and the electrical lability was 40 imp / s. Fundus: optic nerve head monotonous, borders fused. When conducting OCT according to the proposed method, it was determined: the absence of excavation of the optic nerve disk of the right eye with an excavation volume equal to zero, the area of the optic nerve disk (Disk Aria) and the area of the neuroretinal girdle (Rim Aria) are equal and have values of 2.6 mm 2 , layer thickness nerve fibers in the upper and nasal segments are 77 and 45 nm, respectively. Given that all parameters are within the declared range, a diagnosis was made of Druze DZN.

To confirm the diagnosis, computed tomography of the orbits was performed, in which calcifications were found in the projection of the optic nerves.

Example 2. Patient X., 24 years old. Visual acuity with correction of the right eye - 1.0. With computer perimetry, peripheral narrowing of the visual field in the inferior temporal segment by 10 °. The threshold of electrical sensitivity is 60 μA, the electrical lability is 30 pulses / sec. Fundus: optic nerve disc monotonous, borders fused. When conducting OCT according to the proposed method, it was determined: the excavation volume is 1.2 mm 3 , the area of the neuroretinal girdle (Rim Aria) is 1.7 mm 2 , the area of the optic disc (Disk Aria) is 2.3 mm 2 , the thickness of the layer of nerve fibers the retina in all segments is: in the temporal - 89 nm, in the nasal - 132 nm, in the upper - 162 nm, in the lower 190 nm). Given that the parameters are not in the declared range, the diagnosis of Druze DZN was not made.

When a patient undergoes magnetic resonance imaging of the brain for the purpose of further examination, signs of increased intracranial pressure are identified. The presumptive diagnosis of Druze disabilities has not been confirmed.

Claims (1)

  1. A method for diagnosing friends of the optic nerve disk (DZN), including measuring the area of the neuroretinal girdle of the optic nerve (Rim Aria), the volume of excavation of the optic nerve disk, characterized in that the diagnosis is carried out by optical coherence tomography according to the Optic Disc Cube 200 × 200 protocol, while additionally determine the area of the disk of the optic nerve (Disk Aria), as well as the thickness of the layer of nerve fibers of the retina in four quadrants (RNFL Thickness), and if the excavation volume is zero, the area of the disk of the optic nerve and the area of neuroretinal p Yaska optic equal to each other, the thickness of the retinal nerve fiber layer in at least two quadrants ONH is less than 80 nm, the optic disc drusen diagnosed.
RU2014152569/14A 2014-12-25 2014-12-25 Method of diagnosing optic nerve disc druses RU2576810C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2014152569/14A RU2576810C1 (en) 2014-12-25 2014-12-25 Method of diagnosing optic nerve disc druses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2014152569/14A RU2576810C1 (en) 2014-12-25 2014-12-25 Method of diagnosing optic nerve disc druses

Publications (1)

Publication Number Publication Date
RU2576810C1 true RU2576810C1 (en) 2016-03-10

Family

ID=55654154

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014152569/14A RU2576810C1 (en) 2014-12-25 2014-12-25 Method of diagnosing optic nerve disc druses

Country Status (1)

Country Link
RU (1) RU2576810C1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2654783C1 (en) * 2017-07-13 2018-05-22 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Method for diagnosis of the optic nerve drusen by optical coherence tomography-angiography
RU2672391C1 (en) * 2018-02-08 2018-11-14 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Method for diagnosis of drusen of the optic nerve disc using the method of optical coherence tomography - angiography
RU2687651C2 (en) * 2017-08-09 2019-05-15 Дмитрий Юрьевич Самсонов Diagnostic and monitoring method of optic nerve disc drusen
RU2693115C1 (en) * 2018-03-06 2019-07-01 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Method for determining the position of drusen disk of optic nerve in children

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2000127867A (en) * 2000-11-09 2002-08-27 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" A method of determining indications for irrigation therapy for optic nerve drusen disc
RU2203000C2 (en) * 2001-07-04 2003-04-27 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" Method for setting diagnosis by differentiating optic nerve disk drusen and stagnating optic nerve disk cases
RU2392863C1 (en) * 2009-03-12 2010-06-27 Учреждение Российской академии медицинских наук Научно-исследовательский институт глазных болезней РАМН (НИИГБ РАМН) Method of functional state assessment for optic nerve with druse of optic nerve disc

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2195155C2 (en) * 2000-11-09 2002-12-27 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" Method for detecting indications for irrigation therapy at treating drusen of optic nerve

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2000127867A (en) * 2000-11-09 2002-08-27 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" A method of determining indications for irrigation therapy for optic nerve drusen disc
RU2203000C2 (en) * 2001-07-04 2003-04-27 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" Method for setting diagnosis by differentiating optic nerve disk drusen and stagnating optic nerve disk cases
RU2392863C1 (en) * 2009-03-12 2010-06-27 Учреждение Российской академии медицинских наук Научно-исследовательский институт глазных болезней РАМН (НИИГБ РАМН) Method of functional state assessment for optic nerve with druse of optic nerve disc

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ШЕРЕМЕТ Н.Л. и др. Друзы диска зрительного нерва. Сообщение 3. Возможности оптической когерентной томографии. Вестник офтальмологии 2010 N2 с.15-19. SHAN A and el. Optic disc drusen in a child: diagnosis using noninvasive imaging tools. Optom Vis Sci. 2013 Oct;90(10):e269-73 abstract. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2654783C1 (en) * 2017-07-13 2018-05-22 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Method for diagnosis of the optic nerve drusen by optical coherence tomography-angiography
RU2687651C2 (en) * 2017-08-09 2019-05-15 Дмитрий Юрьевич Самсонов Diagnostic and monitoring method of optic nerve disc drusen
RU2672391C1 (en) * 2018-02-08 2018-11-14 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Method for diagnosis of drusen of the optic nerve disc using the method of optical coherence tomography - angiography
RU2693115C1 (en) * 2018-03-06 2019-07-01 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Method for determining the position of drusen disk of optic nerve in children

Similar Documents

Publication Publication Date Title
Leung et al. Comparison of macular thickness measurements between time domain and spectral domain optical coherence tomography
Garas et al. Reproducibility of retinal nerve fiber layer and macular thickness measurement with the RTVue-100 optical coherence tomograph
Marziani et al. Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography
Ergun et al. Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography
Costa et al. Optical coherence tomography 3: automatic delineation of the outer neural retinal boundary and its influence on retinal thickness measurements
Scott et al. Imaging the infant retina with a hand-held spectral-domain optical coherence tomography device
Menke et al. Reproducibility of retinal thickness measurements in healthy subjects using spectralis optical coherence tomography
Kim et al. Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia
Grover et al. Normative data for macular thickness by high-definition spectral-domain optical coherence tomography (Spectralis)
Jaffe et al. Optical coherence tomography to detect and manage retinal disease and glaucoma
Coscas et al. Optical coherence tomography angiography in retinal vein occlusion: evaluation of superficial and deep capillary plexa
Ikuno et al. Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography
Lee et al. Differentiation of optic nerve head drusen and optic disc edema with spectral-domain optical coherence tomography
Schmidt-Erfurth et al. Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases
Archibald et al. Retinal thickness in Parkinson's disease
Dayani et al. Intraoperative use of handheld spectral domain optical coherence tomography imaging in macular surgery
Duan et al. Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons: the Handan Eye Study
Wolf-Schnurrbusch et al. Macular thickness measurements in healthy eyes using six different optical coherence tomography instruments
Baumal Clinical applications of optical coherence tomography
Takayama et al. A novel method to detect local ganglion cell loss in early glaucoma using spectral-domain optical coherence tomography
Querques et al. Choroidal changes associated with reticular pseudodrusen
Thorell et al. Swept-source OCT angiography of macular telangiectasia type 2
Huang et al. Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms
Bellmann et al. Fixation stability using central and pericentral fixation targets in patients with age-related macular degeneration
Mwanza et al. Reproducibility of peripapillary retinal nerve fiber layer thickness and optic nerve head parameters measured with cirrus HD-OCT in glaucomatous eyes

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20161226