RU2663626C1 - Hardware and software complex for diagnosis and treatment of cardiovascular diseases - Google Patents

Abstract

FIELD: medicine.SUBSTANCE: invention relates to the medical equipment. In the method, the hardware-software complex for diagnosis and treatment of cardiovascular diseases contains a channel for testing and determining the mode of patient’s exposure, diagnostic and treatment channels, a control and information storage unit with a power supply unit. Said channel of testing and determining the mode of patient’s exposure includes an ECG electrode unit connected via a switch with a serially connected data input unit and a D / A converter, whose first output is connected to the third input of the information management and storage unit, as well as the drug selector. Further, the diagnostic channel contains a block of electrodes for recording ECG signals, photoplethysmogram sensors, and an analog-to-digital converter. And the treatment channel consists of an inductor connected via a switch to the therapeutic signal generation unit, whose output and input are connected to the information management and storage unit. Also, the complex includes a vest, a multi-channel and bi-directional switch control unit and a channel selection unit. Said vest consists of a shoulder part, two belts of equal width and a detachable corset part, having the same dimensions in the front and back, connected along the shoulder and side plates with the possibility of attaching a set of additional pairs of parts, each having a discretely increasing width, respectively. Said corset part is made conformal from a composite material. Also, the first layer of the composite material has connectors for placing ECG electrodes in them, combined into regular sections with an amount of no more than 10 electrodes per section. In the second layer, an inductor is attached over the electrodes. And the second layer of the composite material contains a flexible printed circuit board, to which microcontrollers are connected. And the third layer of the composite material is protective.EFFECT: it is possible to use a large number of electrodes (up to 300, depending on the size of a patient's chest) built into the vest and wirelessly transmitting the ECG signal to the computer, due to which the diagnostic capabilities of the method are improved, allowing to receive synchronous information about the state of all parts of the heart.1 cl, 5 dwg

Description

The invention relates to medical equipment, namely to equipment for cardiovascular surgery and cardiology, and can be used for diagnostics and complex treatment, due to exposure to a patient with low-intensity electromagnetic radiation in cardiovascular diseases, including remotely online.

There is a known system of transcontinental electrocardiography (Patent for a utility model of the Russian Federation No. RU 125832, dated 10.24.2012 IPC АВВ 5/02) in which the system for diagnosing the state of the cardiovascular system of a person containing portable systems for collecting cardiometric data associated with data transmission channels of a computer network a data processing system, portable cardiometric data acquisition systems are configured to input user identification data and transmit it to a data processing system.

The system for diagnosing the state of the human cardiovascular system contains portable cardiometric data collection systems connected by computer network data transmission channels to a data processing system, each portable cardiometric data collection system containing electrodes connected through a multi-channel amplifier to the inputs of a multi-channel analog-to-digital conversion device the output of which is connected to the microprocessor device of the mobile phone to which the device is connected is displayed Information, made in the form of a display of a mobile phone, and a communication device with a computer network, a data processing system is configured to automatically or automatically process cardiometric data from portable cardiometric data collection systems configured to display the processing results received from the data processing system, the human cardiovascular system diagnostic system is configured to identify a user of portable systems it kardiometricheskih data collection. At the same time, portable cardiometric data acquisition systems are configured to input user identification data and transmit it to a data processing system.

A technical solution is known according to the patent of the Russian Federation No. RU 2577466, (with a convention priority of 08.04.2010, IPC H04L 29/08) describing medical monitoring of patients over heterogeneous networks, the result of which is to ensure uninterrupted data delivery using wireless and wired infrastructures. The method comprises the steps of: establishing a communication link between a multi-mode patient monitoring device and a plurality of Internet Protocol (IP) networks; collecting physiological data collected by a patient monitoring device; generate data packets from the collected physiological data; duplicate generated data packets; transmit duplicate data packets over multiple networks; receive transmitted duplicate data packets; and forward a single data set from duplicated data packets to the final application.

Known electrocardiotograph (ECTG-60), which is a 60-channel electrocardiotograph designed for in-depth functional studies, with the aim of determining ischemic injuries and the state of blood circulation of the heart in patients with coronary artery disease in conditions of cardiology clinics, cardiological dispensaries, diagnostic centers and clinics. The device allows conducting topical analysis - determining the localization of ischemic lesions in different parts of the left and right ventricles of the heart, amplitude-time analysis of the morphology of the QRS complex, with the aim of diagnosing ischemic lesions of the myocardium, diagnostic monitoring the size of ischemia necrotization, the state of ionotropic excitation and compensatory myocardial hypertrophy; cartographic analysis to determine the size of ischemic lesions, as well as a comprehensive analysis - differential diagnosis of ischemic myocardial damage, prediction of the course of the disease, graphic visualization of the focus of necrosis. (see http://cardian.by/cpm.html, http://cardian.by/sigma.html.)

There is also a device for non-invasive electrophysiological examination of the heart (see RF patent No. RU 2417051 dated November 27, 2008 IPC AB 5/0402), including a system for collecting electrocardiographic (ECG) signals and a hardware-software complex that records and processes ECG signals in the mode real-time, retrospective processing of the obtained ECG signal data. The system for collecting ECG signals consists of glued disposable electrodes on the surface of the chest in the form of horizontal five to eight belts located at equal distances vertically and around the circumference of the chest.

The disadvantage of this device is the individual disposable electrodes glued to the surface of the chest. Since these electrodes are glued by hand, it is not always possible to maintain an equal distance between them, which causes certain difficulties in processing the recorded signals. Each disposable electrode is connected to the hardware-software complex via a cable, which makes the device cumbersome.

The main diagnostic method for electrophysiological processes of the heart, routinely used in clinical practice, is electrocardiography (ECG) in 12 standard leads. However, this method has fundamental limitations. For example, using this method, it seems difficult to ECG diagnosis of myocardial infarction of the posterior basal parts of the left ventricle.

Due to the fact that electrophysiological processes occur in different parts of the heart muscle at the same time, it is difficult to determine the local electrical activity of the myocardium by standard ECG. So, for example, a wave of atrial repolarization in humans under conditions of normal rhythm is not detected on the ECG, since it is “hidden” by a high-amplitude QRS complex, which reflects ventricular depolarization. The electrocardiography vector also has similar limitations.

Compared with the methods described above, the method of surface electrocardiographic mapping of the chest, which consists in synchronously recording the set (from 40 to 250 or more) of unipolar ECG leads from the surface of the chest and constructing by means of interpolation for each time point a cardiocycle, has more wide possibilities. maps of the distribution of electric potential on the surface of the chest (Polyakova I.P. Diagnostic capabilities of multichannel ECG - mapping // Creative Cardiology. - 2007, No. 1-2. - S. 256-268).

However, this method does not allow to accurately determine the local electrical activity of the myocardium. If the electrode is located on the surface of the chest, the contributions to the ECG signal from the nearest and most remote segment of the myocardium with respect to the recording electrode differ by about one order of magnitude.

For an electrode placed on the surface of the heart, this difference is three orders of magnitude. In this regard, to identify the local electrical activity of the heart using methods of invasive ECG registration, trying to bring as close as possible. electrodes to the surface of the heart.

The closest known technical solution is a device for the diagnosis and complex treatment of cardiovascular diseases included in the hardware and software complex (see patent on the PM of the Russian Federation No. RU 157740, 05.25.2015, IPC АВВ 5/0295) used for diagnostics and complex treatment, due to exposure to the patient with low-intensity electromagnetic radiation of cardiovascular diseases, including online remotely, and if necessary, make adjustments to the treatment regimen. A device for diagnosing and treating cardiovascular diseases, contains a channel for testing and determining the mode of exposure to the patient, channels for diagnosis and treatment, a control and information storage unit with a power supply, while the channel for testing and determining the mode of exposure to the patient includes an electrode block connected through the first switch is connected in series with the data input unit and the digital-to-analog converter (DAC), while the first inputs and outputs of the first switch and the data input unit are connected with the first and second inputs of the control and information storage unit, the first DAC output is connected to the third input of the control and information storage unit, the second DAC output is connected to the third output of the first switch, the medical selector, the output of the medical selector is connected to the fourth input of the control and information storage unit, the third the output of the control unit and information storage is connected to the first inputs of the DAC and the medical selector, the second input of the medical selector is connected to the second input of the first switch, the second output of the first switch is connected to the second input of the DAC, the diagnostic channel contains a block of electrodes for taking ECG signals, sensors for taking a photoplethysmogram (PPG), and the electrodes for taking ECG signals through a second switch and a first analog-to-digital converter connected in series are connected to the fifth the input of the control unit and information storage, FPG sensors through the second ADC is connected to the sixth input of the control unit and information storage, the treatment channel consists of an inductor connected to the unit a medical signal connected by inputs and outputs to the first switch, and a control unit and information storage.

The disadvantage of this device is that the ECG signal block consists of 5-6 electrodes, with which it is impossible to obtain complete information about the lesion, for example, in the diagnosis of myocardial infarction of the posterior basal parts of the left ventricle. Disposable ECG electrodes, in the amount of 5-6, are attached to the front surface of the chest.

The technical task of the proposed solution is the use of a large number of electrodes (up to 300, depending on the size of the patient’s chest), built-in to the vest and wirelessly transmitting the ECG signal to the computer, thereby improving the diagnostic capabilities of the method, which allow synchronous information on the status of all departments hearts.

To accomplish this task, a hardware and software complex for the diagnosis and treatment of cardiovascular diseases, containing a test channel and determine the mode of exposure to the patient, diagnostic and treatment channels, a control and information storage unit with a power supply, while the test channel determines the mode of exposure to the patient includes a block of electrodes connected through a switch to a series-connected data input unit and a digital-to-analog converter (DAC), a medical selector, the first output of the DAC is connected to the third input of the control and information storage unit, the output of the drug selector is connected to the fourth input of the control and information storage unit, the third output of the control and storage of information is connected to the first inputs of the DAC and the medical selector diagnostic channel, contains an electrode block for ECG removal signals, sensors for taking photoplethysmograms (PPG), ADC, treatment channel, consists of an inductor connected via a switch to the unit for generating a therapeutic signal output and input of which о is connected to the control and information storage unit, a vest is additionally introduced, a switch control device made of multichannel and bi-directional channels and a channel selection unit, the vest consists of a shoulder part of two belts of the same width and a detachable corset part with the same size in front and back connected by shoulder and side pads with the ability to be equipped with a set of additional paired parts having a discretely increasing width, while the corset part t conformal from a composite material, the first layer of the composite material has connectors for placing electrodes and an inductor in them, while electrodes of no more than 10 are combined in the form of regular sections, each electrode in the section is connected by means of conductors to the microcontroller, in the second layer on top of the electrodes at least one inductor is attached, the second layer of composite material contains a flexible printed circuit board to which microcontrollers are connected, the third layer of composite material the third layer of composite material is protective, the multi-channel switch is connected to the control unit of the switch, the output of which through the channel selection unit is connected to the inputs of the test channel and determine the patient exposure mode, the diagnostic and treatment channel, the first channel of the multi-channel switch is connected to the test channel and determine the patient exposure mode, the second the channel is connected to the output of the flexible working board of the diagnostic channel, the third channel is connected to the treatment channel, the sensor / and PPG through the fourth channel of the switch and the second ADC it is connected to the sixth input of the control and information storage unit, while the first inputs and outputs of the first channel of the switch and data input unit are connected to the first and second inputs of the control and information storage unit, the third output of the first channel of the switch is connected to the second input of the DAC, the second input of the first the channel of the switch is connected to the second input of the drug selector, a flexible printed circuit board of the diagnostic channel through the second channel of the switch and the first analog-to-digital converter connected in series are connected to the input of the control unit and information storage, PPG sensors through the fourth channel of the switch and the second ADC are connected to the sixth input of the control unit and information storage.

The inductor can be made in the form of a microstrip radiator Vivaldi - a multilayer printed structure, which allows it to be integrated into the vest.

The invention is illustrated in the drawing, where

- in FIG. 1 - shows a hardware-software complex for the diagnosis and treatment of cardiovascular diseases,

- in FIG. 2 - performance and equipment of the vest are presented,

- in FIG. 3 - presents the appearance of the vest,

- in FIG. 4 is a diagram of a connection of electrodes to a section, and an ECG signal collection line to a flexible printed circuit board,

in FIG. 5 - implementation of the second layer of the vest with the connection diagram of the electrodes. The hardware-software complex for the diagnosis and treatment of cardiovascular diseases contains a vest 1, a multi-channel bi-directional switch 2 with a control unit 3 connected to a channel selection unit 4 (specifying a signal source) connected to the output of the flexible printed circuit board of vest 1, data input unit 5, digital-to-analog converter (DAC) 6, drug selector 7, first ADC 8 for ECG signal conversion, FPG 9 sensor, second ADC 10 for si conversion FIGs catch block 11 forming a therapeutic signal, and the control unit 12 information storage, power supply 13 (as which can be used lithium-ion battery). (Fig. 1)

The vest 1 (Fig. 2) is made of a composite material having a conformal shape. The vest consists of a shoulder part from two belts 14 and 15 of the same width, and a detachable corset part: having front 16 and a back 17 of the same size, connected along the shoulder side pads with the possibility of completing with a set of additional paired parts 18 and 19, which have a correspondingly discretely increasing width (details 20 and 21). The connection on the shoulder and side pads is carried out using a wide elastic braid 22 and fasteners 23 and 24, which allow for joint adjustment of the parameters of the vest 1 to ensure its exact and tight fit to the surface of the torso of the figure, thereby achieving conformity. In the shoulder and lateral areas, a snug fit is achieved by buckles - 25 fasteks on each side. The vest 1 is equipped with a set of additional paired parts 18 and 19, having a discretely increasing width, respectively, after connecting with the vest, ensuring the appropriate size of the product along the chest line. To increase or decrease the coverage parameters (increase or decrease the size), the vest 1 has on the sides of the front stitched halves of the fasteners 23 and 24 (detachable tape-zippers), to which additional parts 18 and 19 can be added or removed by fastening (Fig. 2 )

In this case, the first layer of the composite material of the corset part has connectors for placement of electrodes 26 _i in them. (Fig. 3) where i = from 1 to n (n-number of electrodes)

The appearance of the electrode system 26 _{i and} their numbering are shown in FIG. 3. The numbering of the electrodes is necessary for the exact coordination of the location of the electrodes with the areas of the intercostal space of the chest during non-invasive examination and diagnosis of the heart, as well as their treatment.

Sets of electrodes in an amount of not more than 10 are made in the form of regular sections (Fig. 4). The electrodes 26 _{i are} connected by conductors 27 to microcontrollers 28.

The second layer of the vest 1 contains a conductive structure in the form of a flexible printed circuit board 29. Each electrode 26 _i in the section is connected with a microcontroller 28 using conductors 27. The microcontrollers 28 are connected to a flexible printed circuit board (GPP) 29, each output of the GPP 29 is connected to the input-output the second channel of the switch ..

Channels are formed depending on the task:

The first cycle: the study of the patient - the channel for testing and determining the mode of exposure to the patient is turned on. The channel for testing and determining the mode contains a block of electrodes connected through the first channel of the switch 2 with the data input unit 5, the DAC 6 with the control and information storage unit 11, and the drug selector 7.

Preliminarily, on the basis of the results of laboratory and instrumental methods for examining a specific patient, the attending physician performs programming of the device based on multifactor modeling of the therapy algorithm for ischemic disease of the myocardial focus, selects the optimal exposure regimen that affects the repair processes in acute myocardial infarction.

The second cycle is diagnostics. The diagnostic channel consists of a structural grid of electrodes 26 _i distributed over the entire surface of the vest, sensors 9 for taking a photoplethysmogram (PPG), and electrodes for taking ECG signals through a second channel of a switch 2 and a first analog-to-digital converter 8 connected in series to a fifth input block 12 control and storage of information, the sensor / and 9 PPG through the fourth channel of the switch 2 and the second ADC 10 is connected to the sixth input of block 12 of the control and storage of information.

The third cycle is a comprehensive treatment. At the signal of block 4, a block is turned on, consisting of the required number of electrodes, on top of which at least one inductor is fixed. The treatment channel is connected to the third channel of the switch 2 and then to one of the inputs of the medical selector 7, through the block 11 of the formation of the treatment signal with the block 12 of the control and information storage. As an inductor, a radiator - a Vivaldi antenna can be used.

The third layer of the composite material of the vest 1 is protective.

A corset vest is put on the patient, covering the entire chest so that 1 row of electrodes is located at the level of the 1st intercostal space.

It is known that various parts of the heart are projected onto the surface of the chest, therefore, when removing ECG signals from these areas, it is possible to determine the location of myocardial ischemia. So, the projection of the anterior part of the interventricular septum (MZHP) is located from the right to the left parasternal line from I to VI intercostal space. The posterior part of the MJP is from the level of the angle of the left scapula to the right paravertebral line at the level of III-V intercostal space. The projection of the apex of the left ventricle (LV) is located from the left parasternal line to the left anterior axillary line, at the level of the V-VI intercostal space. The front wall of the LV is projected from the left parasternal line to the left middle axillary line at the level of I-VI intercostal space, with the exception of the projection of the apex of the LV. The projection of the LV lateral wall is located from the left middle axillary line to the vertebral line at the level of I-VI intercostal space with the exception of the projection of the posterior part of the interventricular septum (MZHP). The back wall of the LV - is projected from the vertebral line, to the right posterior axillary line and from the right middle axillary line to the right parasternal line at the level of V-VI intercostal space. The projection of the right ventricle is located from the vertebral line to the right rear axillary line and from the right middle axillary line to the right parasternal line at the level of I-IV intercostal space with the exception of the projection of the posterior part of the MJP.

After putting on the corset-vest, the numbered electrodes on the vest in the indicated zones of projections of various departments of the heart record the name of the corresponding departments of the heart.

The first stage is a bicycle ergometric test at rest, against the background of synchronous ECG registration from each electrode of the vest-corset. For each electrode overlay point, the integral of the ECG curve is calculated over the QRST interval. An iso-integral rest map is constructed.

The second stage, the patient undergoes a bicycle ergometric test at maximum load, also synchronously recording an ECG from each of the electrodes of the vest-corset at maximum load. In case of patient complaints (shortness of breath, headache, fatigue, increased blood pressure, etc.), the load is stopped. Similarly to the first stage, the integral of the ECG curve is calculated on the QRST interval. An iso-integral map of maximum load is built.

Next, the patient undergoes a bicycle ergometric test at 1, 3, 5, and 7 minutes of the recovery period, simultaneously recording the ECG from each of the electrodes of the vest-corset at 1, 3, 5, and 7 minutes of the recovery period. Iso-integrated maps of 1, 3, 5, 7 minutes of recovery are constructed in a similar way. For each iso-integral map, the difference index (IR) is calculated (IR = (P-N) / σ),

where P is the value of the integral of the ECG curve at the corresponding points of application of electrodes in the studied patient, N and σ are the average value and the mean square deviation of the integral of the ECG curve at the corresponding points of application of electrodes in patients in the normal group.

The minimum IR and the size of the region of negative values of IR are determined. A decrease in the minimum IR by 10% or more and / or an increase in the region of negative values of IR by 18% or more for any of the iso-integrated maps of the maximum load and 1, 3, 5, and 7 minutes of the recovery period relative to the iso-integral resting map indicates that the patient has coronary heart disease (CHD).

The advantage of the described device is that by analyzing the physiological parameters of the patient’s body while simultaneously studying photoplethysmography and electrocardiography, it is possible to diagnose a cardiovascular disease, in addition, in parallel with the treatment with low-intensity electromagnetic fields with an individual algorithm, it is possible to evaluate the treatment, as well as , if necessary, make adjustments to the current treatment regimen. The next advantage of using the device is the ability to remotely monitor and correct the treatment if necessary.

The antenna inductor is a radiator, for which you can use the Vivaldi radiator, which is a multilayer printed antenna operating in several wavelength ranges and having small mass and size parameters. The structure of the multilayer construction provides comparative ease of manufacture, which ensures its integration with other elements of the vest.

An electrocardiographic (ECG) study made it possible to record cardiac abnormalities, the effectiveness of antiarrhythmic therapy, and the diagnosis of myocardial ischemia.

These photoplethysmograms (PPG) made it possible to draw a conclusion about the adaptive capabilities of the body, the level of mobilizing potential, the level of hormonal modulation of regulatory mechanisms, the balance of anabolic and catabolic processes, the optimal or non-optimal mode of functioning of the rhythm control centralization system, stress index, and to assess the state of endothelial function.

Each GLP can conduct up to 10 electrical signals, that is, serve 10 ECG electrodes. The upper section is served by one microcontroller 28 (10 lines), the second together with the first section - 20 lines, the lower section is connected by the previous two sections of the GPP 29-30 lines (Fig. 5)

In microcontrollers 28, on 2 opposite sides there are connectors for connecting the cable, on the other two - up to 5 wires are fixed for attaching to the electrodes. The electrodes are mounted with standard riveted connectors. On the back of each microcontroller there is a fastener for fastening to the base of the vest. Each vertical row of electrode sections with a microcontroller 28 is one-piece, each has its own position on the basis of the vest - due to the different number of contacts for the electrodes and the number of microcontrollers.

The device operates as follows.

The described device allows both the diagnosis of cardiovascular disease, followed by treatment, due to exposure to the patient with low-intensity electromagnetic radiation, and in parallel with the treatment with low-intensity electromagnetic fields with an individual algorithm, to evaluate the treatment and, if necessary, make adjustments to ongoing treatment regimen.

Prior to work, the device is tested. Upon completion of the self-diagnosis, the device is ready for operation or a message about detected errors, and the device goes into standby mode. In the diagnosis, before treatment and in monitoring the treatment, a study of PPG and ECG is performed. To do this, electrodes for recording ECG signals and FPG sensors are connected wirelessly to the apparatus; using the virtual keyboard, information is entered from the control and information storage unit 12 and the corresponding actions are carried out: to remove the PPG, the optical sensor 9 is attached to the index finger (can be any) of the patient. The recorded signal is transmitted through the ADC 10 FPG and enters the block 12 control and storage of information.

If necessary, assess the endothelial function using 2 optical sensors 9 FPG, attached to the index fingers of both hands. Analysis of PPG taken from both fingers before and after an occlusion test allows us to judge the state of endothelial function.

In parallel with this, electrodes 26 _i for measuring ECG signals are attached in the region of the heart in an amount of 8-12, the signals from which enter the second channel of the multi-channel switch 2 and through the ADC 8 enters the control and information storage unit 12. At the same time, ECG and PPG recording is turned on.

For screening studies, recording within 5-6 minutes is sufficient. If necessary, this study can be carried out up to 24 hours. After the end of the study, the results are transmitted via a USB port of the computer to the doctor (remote transmission), possibly online. The latter evaluates the results and, if necessary, adjusts the therapy algorithm.

If it is necessary to conduct a more accurate diagnosis of coronary heart disease (CHD), identify a focus of ischemia, or heart rhythm disturbance in patients with contraindications for cardiac catheterization, a non-invasive activation heart mapping is performed to electrophysiologically and topically diagnose rhythm disturbances, identify a coronary heart disease, which it is impossible to implement by applying 8-12 electrodes, for example, in patients with complete blockade of the left or right leg of the bundle of His, two-beam blockade.

In the presence of IHD, the localization of the focus of ischemia is determined by the coincidence of the region of negative IR values with the projection of the myocardial zones

A non-invasive diagnostic study of the heart consists in the fact that a corset vest is put on the patient, covering the entire chest from level 1 to XII intercostal space, so that 1 row of electrodes is located at the level of the 1st intercostal space.

It is known that various parts of the heart are projected onto the surface of the chest, therefore, when removing ECG signals from these areas, it is possible to determine the location of myocardial ischemia. So, the projection of the anterior part of the interventricular septum (MZHP) is located from the right to the left parasternal line from I to VI intercostal space. The posterior part of the MJP is from the level of the angle of the left scapula to the right paravertebral line at the level of III-V intercostal space. The projection of the apex of the left ventricle (LV) is located from the left parasternal line to the left anterior axillary line, at the level of the V-VI intercostal space. The front wall of the LV is projected from the left parasternal line to the left middle axillary line at the level of I-VI intercostal space, with the exception of the projection of the apex of the LV. The projection of the LV lateral wall is located from the left middle axillary line to the vertebral line at the level of I-VI intercostal space with the exception of the projection of the posterior part of the interventricular septum (MZHP). The back wall of the LV - is projected from the vertebral line, to the right posterior axillary line and from the right middle axillary line to the right parasternal line at the level of V-VI intercostal space. The projection of the right ventricle is located from the vertebral line to the right rear axillary line and from the right middle axillary line to the right parasternal line at the level of I-IV intercostal space with the exception of the projection of the posterior part of the MJP.

After putting on the corset-vest, the numbered electrodes on the vest in the indicated zones of projections of various departments of the heart record the name of the corresponding departments of the heart.

The first stage is a bicycle ergometric test at rest, against the background of synchronous ECG recording from each electrode of the vest. For each electrode overlay point, the integral of the ECG curve is calculated over the QRST interval. An iso-integral rest map is constructed.

The second stage, the patient undergoes a bicycle ergometric test at maximum load, also synchronously recording an ECG from each of the electrodes of the vest-corset at maximum load. In case of patient complaints (shortness of breath, headache, fatigue, increased blood pressure, etc.), the load is stopped. Similarly to the first stage, the integral of the ECG curve is calculated on the QRST interval. An iso-integral map of maximum load is built.

Next, the patient undergoes a bicycle ergometric test at 1, 3, 5, and 7 minutes of the recovery period, simultaneously recording the ECG from each of the electrodes of the vest-corset at 1, 3, 5, and 7 minutes of the recovery period. Iso-integrated maps of 1, 3, 5, 7 minutes of recovery are constructed in a similar way.

For each iso-integral map, the index of the difference of the IR (IR = (P-N) / σ) is calculated, the minimum IR and the size of the region of negative values of the IR are determined.

A decrease in the minimum IR by 10% or more and / or an increase in the region of negative IR by 18% or more for any of the iso-integrated maps of the maximum load and 1, 3, 5, and 7 minutes of the recovery period relative to the iso-integral resting map indicates that the patient has Ischemic heart disease

If it is necessary to reverse the action through identified pathologically changed ECG signals, it is possible to connect an additional sensor, a magnetic inductor, to the electrodes of the ECG for treatment with low-intensity electromagnetic fields.

The therapeutic effect algorithm, developed individually for each patient, with the selection of the exposure mode through the multi-channel switch 2 is entered into the information input unit 5 and set by the information management and storage unit 12. Remote adjustment of the therapy algorithm is possible when connecting the device via a USB port to a remote computer.

Studies have confirmed good results in the treatment of cardiovascular diseases due to exposure to the patient with low-intensity electromagnetic radiation, as evidenced by numerous studies.

Then, the doctor, or the patient himself, at the direction of the doctor, selects the necessary therapeutic effect, connects the necessary external devices - electrodes made in the form of an induction coil, the working side adjacent to the patient’s body, and test strips, or uses an inductor antenna.

The treatment signal generating unit 11 is a radio transmitting device operating at a frequency carrying from 16 to 30 MHz and with amplitude modulation of the carrier. The modulating signal parameters are selected according to the therapy algorithm. Radiation power no more than 5 MW.

The device operates as follows.

In the diagnosis, before treatment and in monitoring the treatment, a study of PPG and ECG is performed. For this, electrodes for removing ECG signals and a PPG sensor are connected to the apparatus; using the virtual keyboard, information is entered from the control and information storage unit 11 and the corresponding actions are carried out: to remove the PPG, the optical sensor 9 is attached to the index finger (can be any) of the patient. The removed signal is transmitted through the ADC 10 of the PPG signal and enters the control unit 12 and information storage.

If it is necessary to evaluate endothelial function, 2 optical PPG sensors are used, attached to the index fingers of both hands. Analysis of PPG taken from both fingers before and after an occlusion test allows us to judge the state of endothelial function.

In parallel with this, standard electrodes 26 _i for ECG measurement are attached in the heart region in an amount of 5-10, the signals from which are fed to the multi-channel switch 2 (second channel) and through the ADC 8 signals from the ECG are fed to the control and information storage unit 12. It simultaneously turns on ECG and PPG recording.

For screening studies, recording within 5-6 minutes is sufficient. If necessary, this study can be carried out up to 24 hours. After the end of the study, the results are transmitted via a USB port of the computer to the doctor (remote transmission), possibly online. The latter evaluates the results and, if necessary, adjusts the therapy algorithm.

The therapeutic effect algorithm, developed individually for each patient, with the selection of the exposure mode is entered into the information input unit 5 and adjusted from the information management and storage unit 12. Remote adjustment of the therapy algorithm is possible when connecting the device via a USB port to a remote computer.

Studies have confirmed good results in the treatment of cardiovascular diseases due to exposure to the patient with low-intensity electromagnetic radiation.

The unit for generating the treatment signal 11 is a radio transmitting device operating at a frequency carrying from 16 to 30 MHz and with amplitude modulation of the carrier. The modulating signal parameters are selected according to the therapy algorithm. Radiation power no more than 5 MW.

In operation with connected electrodes:

since human vibrations (signals) are of an electromagnetic nature, they are registered using the electrode block 26 _i, the control and information storage unit 12 carries out coordinated connection of the electrodes and also connects the channel of the switch 2 and the drug selector 7 to the block for generating the treatment signal 11, according to the algorithm therapeutic effects stored in block 12 control and storage of information. Having undergone special processing (spatio-temporal, frequency, non-linear filtering, separation), the oscillations with the help of conductors, contacts and electrodes are returned to the patient. The patient’s electromagnetic field immediately responds to these therapeutic signals, and the corrected vibrations are sent back to the device, etc. During therapy, the patient and the device form a closed loop of adaptive regulation, as a result of which the processed oscillations return to the patient again and again. Upon completion of the therapeutic effect, relevant information is displayed on the display device, and the device enters standby mode.

In the operating mode with the inductor connected, for example, the Vivaldi antenna emitter, a treatment signal is generated with the parameters according to the information received from the control and information storage unit 12, then this signal is fed to the inductor antenna.

Thus, when using this device, the parameters of electromagnetic stimulation are determined by the state of the patient himself, while the effect is maximally individualized, which suggests that this device provides an optimally controlled treatment option.

After a treatment session, the data of the physiological parameters of the patient’s body, with the simultaneous examination of the PPG and ECG are processed, and, if necessary, appropriate changes are made to the therapy algorithm. In addition, there is the possibility of remote online correction of treatment and monitoring of treatment, by connecting the device via the computer’s USB port and via the Internet, the device is connected to the remote computer (with the doctor).

Example. 1. ACUTE CORONARY SYNDROME

An electrocardiographic and photoplethysmographic study is carried out for a patient with acute coronary syndrome, along with a laboratory (general blood test, blood biochemistry, coagulogram, spectrometric characteristics of the blood) and instrumental (echocardiogram) studies. To do this, connect the ECG sensor block and the sensor block to remove the FIG and connect the device to the on / off button. At the same time, the device monitors its functioning from the control and information storage unit 12. Upon completion of the self-diagnosis, the device displays the device ready for operation or a message about detected errors, and the device goes into standby mode. To take a photoplethysmogram, the optical sensor 9 is attached to the index finger (can be any) of the patient. The removed signal is transmitted through the ADC 10 of the PPG signal and enters the control unit 12 and information storage. If it is necessary to evaluate endothelial function, 2 optical PPG sensors are used, attached to the index fingers of both hands. Analysis of PPG taken from both fingers before and after an occlusion test allows us to judge the state of endothelial function.

In parallel with this, standard electrodes 26 _i for ECG measurement are attached in the heart region in an amount of 5-6, the signals from which are fed to the multi-channel switch 2 and through the ADC 8 signals from the ECG are sent to the control and information storage unit 12. At the same time, ECG and PPG recording is turned on.

Using the virtual keyboard, information on the results of laboratory (general blood analysis, blood biochemistry, coagulogram, spectrometric characteristics of the blood) and instrumental (echocardiogram) studies of patient N., who had acute myocardial infarction, is entered from the control and information storage unit 12.

Based on the results of the study, the attending physician conducts programming of the device, based on multifactor modeling of the therapy algorithm for acute myocardial infarction. Treatment is aimed at reducing the risk of thrombosis, relieving spasm of coronary vessels, and reducing pain. Programming is performed using the developed software, which allows to individualize the treatment algorithm for a specific patient.

The therapeutic effect algorithm, developed individually, is downloaded by the doctor from the personal computer via the computer’s USB port to the data input unit 5 through the control and information storage unit 12. To conduct a therapeutic effect, an electrode block is connected to the device and the device is turned on using the on / off button, while the device monitors its functioning from the control and information storage unit 12 and the state of the connected external electrodes. Upon completion of the self-diagnosis, the device’s indicating device 12 indicates the device is ready for operation or a message about detected errors is entered, and the device enters standby mode, then, from the indicating device of unit 12, the therapeutic effect necessary for the patient is selected to reduce coagulation, taking into account its individual indicators, 2 electrodes are fixed on the patient’s body, on which the inductors are attached, the working side adjacent to the patient’s body, and the test strip with the patient’s blood is connected to rrektirovki individual treatment algorithm issued by the program, and then launch a therapeutic impact on execution. During therapy, the control and information storage unit 12 coordinates the external test strip, as well as the medical selector 7 to the treatment signal generating unit 11 according to the therapeutic effect algorithm in the range from 1 to 100 Hz stored in the control and information storage unit 12. The choice of the optimal exposure regimen that affects the repair processes in acute myocardial infarction is carried out in accordance with the recommendations for patients after acute myocardial infarction.

Upon completion of the therapeutic effect, the corresponding information is displayed on the indicating device of block 12 and the device goes into standby mode.

The second treatment option is possible without the use of electrodes, but with the inclusion of an antenna inductor. At home or in the hospital, the device is turned on using the on / off button. At the same time, the apparatus monitors its functioning from the control and information storage unit 12. Upon completion of the self-diagnosis on the display device of unit 12, the device is ready for operation or a message about detected errors, and the device goes into standby mode. To carry out therapy from the indicating device of block 12, using the selected command typed using the virtual keyboard from the control and information storage unit 12, the therapeutic effect necessary for the patient is selected to reduce coagulation, taking into account its individual indicators. At the same time, the apparatus is positioned so that the apparatus body with the antenna-inductor is located on the surface of the body, on the projection of the heart. During therapy, the control and information storage unit 12 generates an electromagnetic signal with the necessary parameters, and then this signal is fed to the antenna inductor.

When adjusting the therapeutic effect, after a treatment session, a photoplethysmographic and electrocardiographic study is repeated, the indicators of which are sent to the information management and storage unit 12, the data of which are displayed on the display device. The doctor analyzes the results and decides on the need for treatment adjustment. The correction data is also entered into the data block 12 of the control and information storage device using the virtual keyboard.

Example 2. Hypertension. Diagnosis and treatment.

Hypertension is one of the most common diseases of the cardiovascular system. The causes of hypertension can be different. These include dysfunctions of the internal organs: liver, adrenal kidneys, etc. One of the main causes of hypertension is the overstrain of higher nervous activity under the influence of psychoemotional influences.

The use of low-intensity electromagnetic fields as part of the complex therapy of hypertension is possible at all stages of the disease, which will contribute to more effective treatment, reduction of side effects of drug therapy, due to lower doses of drugs, and in the initial stage of the course of the disease, there is no need to prescribe drug therapy.

The advisability of using low-intensity electromagnetic fields as part of the complex treatment of hypertension is also that in the presence of a not deeply developed endothelial dysfunction, there is the possibility of its correction.

At present, it is generally recognized that successful treatment of hypertension is possible with the help of agents that reduce the activity of the sympathetic nervous system by improving the functions of the higher parts of the brain. So, for example, the inclusion in the complex therapy of low-intensity electromagnetic oscillations of frequencies 5.5, 9.5 Hz, contributes to the antiangiospastic effect. The parasympathetic effect is achieved by using a frequency of 6 Hz. If it is necessary to obtain a diuretic effect, it is possible to connect the frequency spectrum in the range of 8.10, 86 Hz, the hypotensive effect of 3.3-9.5 Hz. For the regulation of diuresis, the balance of potassium, sodium, it is possible to use a frequency of 8.1 Hz. In magnesium deficiency - the use of a frequency of 62.5 Hz.

A patient with hypertension, along with laboratory and instrumental studies, conduct electrocardiographic and photoplethysmographic studies. To do this, connect the ECG electrode block 26 _i to the apparatus, connecting them through a flexible printed circuit board 29 and the sensor block 9 for removing the PPG and turn on the apparatus. In this case, the device monitors its operation from the unit 12 of the control and storage of information. Upon completion of the self-diagnosis, the device is ready for operation or a message about detected errors, and the device goes into standby mode. To take a photoplethysmogram, the optical sensor 9 is attached to the index finger (can be any) of the patient. The removed signal is transmitted through the ADC 10 of the PPG signal and enters the control unit 12 and storage. If it is necessary to evaluate endothelial function, 2 optical PPG sensors are used, attached to the index fingers of both hands. Analysis of PPG taken from both fingers before and after an occlusion test allows us to judge the state of endothelial function.

In parallel with this, standard electrodes 26 _i for measuring ECG signals are attached in the region of the heart in an amount of 5-6, the signals from which enter the switching unit 2 and through the ADC 8 enters the control and information storage unit 12. At the same time, ECG and PPG recording is turned on.

Using the virtual keyboard, information on the results of laboratory (general blood analysis, blood biochemistry, coagulogram, spectrometric blood characteristics) and instrumental (echocardiogram) studies of patient A., with hypertension, is entered from the control and information storage unit 12.

Based on the results of the study, the attending physician performs programming of the device based on multifactor modeling of the therapy algorithm for hypertension. The treatment is aimed at correcting psychoemotional overstrain and disturbances in the trophism of the central nervous system, leading to pathologically increased excitability of the hypothalamic structures and the reticular formation of the brain is to include the hypothalamus frequency spectrum (7.5, 15, 100 Hz, pituitary gland (92.5, 99, 91.5, 98 Hz), the limbic system (5, 26.5 Hz), the use of programs in the rhythms of the brain, and our previous experimental studies on the influence of low-intensity electromagnetic fields (bi resonance therapy) for the normalization of morphological and functional changes in the rat hippocampus during inhalation anesthetic halothane and SHAM showed positive effects on normalization of morphofunctional state in fields CA1 neurons / CA3 rat hippocampus after sham-operation under halothane anesthesia.

Programming is performed using the developed software, which allows to individualize the treatment algorithm for a specific patient.

The therapeutic effect algorithm, developed individually, is downloaded, as directed by the doctor, from the personal computer via the USB port to the data input unit 5 through the control and information storage unit 12. To conduct a therapeutic intervention, a vest is connected to the device and the unit 12 is turned on. Upon completion of the self-diagnosis, the device 12 indicates the device is ready for operation or a message about detected errors is displayed, and the device goes into standby mode, then the therapeutic effect necessary for the patient is selected, taking into account its of individual indicators, 2 inductors are fixed on the patient’s body with the working side adjacent to the patient’s body and the test strip is connected with the patient’s blood for adjustment Individual treatment algorithm issued by the program, and then launch a therapeutic impact on execution. During therapy, the control and information storage unit 12 makes a coordinated connection of the external test strip, as well as the medical selector 7 to the therapeutic signal generating device 11 according to the therapeutic effect algorithm, in the range from 1 to 100 Hz, stored in the control and information storage unit 12. Upon completion of the therapeutic effect, the corresponding information is displayed on the indicating device of block 12 and the device goes into standby mode.

The second treatment option is possible without the use of electrodes, but with the inclusion of an antenna inductor. At home or in the hospital, the apparatus is turned on, while the apparatus monitors its functioning from the control and information storage unit 12. Upon completion of the self-diagnosis, the readiness of the device for operation or a message about detected errors is indicated on the display device, and the device goes into standby mode. To carry out therapy from the display device using the selected command typed using the virtual keyboard from the control and information storage unit 12, the therapeutic effect necessary for the patient is selected to correct the psychoemotional overstrain and trophic disturbance of the central nervous system, leading to pathologically increased excitability of hypothalamic structures and the reticular formation the brain is to include in the regimen of complex therapy the frequency spectrum of the hypothalamus (7.5, 15, 100 Hz, hyp physics (92.5, 99, 91.5, 98 Hz), limbic system (5, 26.5 Hz), the use of programs in the rhythms of the brain, correction of endothelial dysfunction, taking into account its individual indicators. the inductor was located on the surface of the body (for example, in a pocket). The antenna-inductor operates in the near zone. During therapy, the control and information storage unit 12 generates an electromagnetic signal with the necessary parameters and then this signal is fed to the antenna ctor.

When adjusting the therapeutic effect, after the treatment session, the PPG and ECG tests are repeated, the indicators of which are sent to the control and information storage unit 12, the data of which are displayed on the display device. The doctor analyzes the results and decides on the need for treatment adjustment. Correction data is also entered into the data block of the control and information storage device using the virtual keyboard.

An individual approach to treatment is achieved by the fact that, if it is necessary to achieve the effect necessary in a particular case (hypotensive, antihistamine hypoglycemic, anti-stress, antiarrhythmic, parasympathetic, etc.), frequency spectra with the desired effect are included in the complex of treatment programs.

Example 3. Chronic heart failure

According to the Guideline study, the prevalence of chronic heart failure (CHF) in the United States and Western Europe is between 1% and 3%. In Russia, mortality rates from heart and vascular diseases are 3.5 times higher than in developed European countries. Endothelial vasomotor dysfunction is an early sign of endothelial cell dysfunction, characterized by a decrease in nitric oxide production. It is believed that the progression of heart failure may be the result of a sharp decrease in the synthesis of nitric oxide (NO) by vascular endothelial cells. Therefore, the possibility of correcting endothelial dysfunction using low-intensity electromagnetic fields in patients with chronic heart failure seems to us an important and promising direction.

We conducted a study to study the effect of low-intensity electromagnetic fields of endogenous origin on endothelial function in patients with chronic heart failure with FC II NYHA. As a result of the study, it was found that in this group of patients the vasomotor function of the endothelium is impaired, indicating a decrease in vasodilating substances (nitric oxide synthesis) by endothelial cells. Under the influence of low-intensity electromagnetic fields of endogenous origin (endogenous bioresonance therapy), an improvement in microcirculation parameters was observed, indicating a vasodilator effect. A decrease in the parameter of neurogenic tone to normal values indicates a possible regulatory effect of this type of treatment.

A patient with heart failure, along with laboratory and instrumental studies, conduct ECG and PPG study. To do this, connect the ECG electrodes 26i and the sensor unit 9 to remove the PPG to the apparatus and turn on the apparatus. In this case, the device monitors its operation from the unit 12 of the control and storage of information. Upon completion of the self-diagnosis, the readiness of the device for operation or a message about detected errors is indicated on the display device, and the device goes into standby mode. To remove the PPG, the optical sensor 9 is attached to the index finger (can be any) of the patient. The removed signal is transmitted through the ADC 10 of the PPG signal and enters the control unit 12 and information storage. If necessary, assess the endothelial function using 2 optical sensors 9 FPG, attached to the index fingers of both hands. Analysis of PPG taken from both fingers before and after an occlusion test allows us to judge the state of endothelial function.

In parallel with this, standard electrodes 26 _i for ECG measurement are attached in the region of the heart. The numbers of the electrodes in the vest are determined in accordance with standard Holter monitoring and include those that are responsible for certain projections of the departments of the heart. ECG signals are supplied to the switch 2 and through the ADC 8 are supplied to the control unit 12 and information storage. At the same time, ECG and PPG recording is turned on.

Using the virtual keyboard from the control and information storage unit 12, the results are entered, laboratory (general blood analysis, blood biochemistry, coagulogram, spectrometric blood characteristics) and instrumental (echocardiogram) studies of patient B., with chronic heart failure.

Based on the results of the study, the attending physician performs programming of the device based on multifactor modeling of the algorithm for the treatment of chronic heart failure.

The treatment is aimed at correcting psychoemotional overstrain and disturbances in the trophism of the central nervous system, leading to pathologically increased excitability of hypothalamic structures and the reticular formation of the brain consists in including the hypothalamus (7.5, 15, 100 Hz, pituitary gland (92.5, 99, 91.5, 98 Hz), limbic system (5, 26.5 Hz), the use of programs in the rhythms of the brain, correction of endothelial dysfunction, taking into account its individual indicators.

Programming is performed using the developed software, which allows to individualize the treatment algorithm for a specific patient.

The therapeutic effect algorithm, developed individually, is downloaded by the doctor from the personal computer via USB to the data input unit 5 through the control and information storage unit 12. To conduct a therapeutic effect, the electrodes 26 _{i are} connected to the apparatus and include a hardware-software complex that monitors its functioning from the control and information storage unit 12 and the state of the electrodes, inductor and PPG connected to the vest. Upon completion of the self-diagnosis, the device is ready for operation or a message about detected errors is entered, and the device goes into standby mode, then the therapeutic effect necessary for the patient is selected, taking into account its individual indicators, 2 inductors are fixed on the patient’s body and, with the working side adjacent to the patient’s body, connecting a test strip with the patient’s blood to adjust the individual treatment algorithm issued by the program, after which the therapeutic effect on execution. During therapy, the control and information storage unit 12 coordinates the external test strip, as well as the medical selector 7 to the therapeutic signal generation unit 11, in accordance with the therapeutic effect algorithm, in the range from 1 to 100 Hz stored in the information control and storage unit 12 . Upon completion of the therapeutic effect, the corresponding information is displayed on the display device of unit 2 and the device goes into standby mode.

The second treatment option is possible without the use of electrodes, but with the inclusion of an antenna inductor. At home or in the hospital, the apparatus is turned on, the operation is monitored from the control and information storage unit 12. Upon completion of the self-diagnosis, the readiness of the device for operation or a message about detected errors is indicated on the display device, and the device goes into standby mode. For the treatment, the therapeutic effect necessary for the patient is selected, aimed at correcting psychoemotional overstrain and impaired trophism of the central nervous system, leading to pathologically increased excitability of hypothalamic structures and the reticular formation of the brain is to include in the complex therapy regimen the frequency spectrum of the hypothalamus (7.5, 15, 100 Hz, pituitary gland (92.5, 99, 91.5, 98 Hz), limbic system (5, 26.5 Hz), the use of programs in the rhythms of the brain, correction of endothelial dysfunction, taking into account volume of its individual indicators.

At the same time, the apparatus is positioned so that the apparatus body with the inductor antenna is located on the surface of the body on the projection of the target organ (heart). Since the antenna operates in the near field, the effect on the patient is mainly the magnetic component of the electromagnetic field. During therapy, the control and information storage unit 12 generates an electromagnetic signal with the necessary parameters, and then this signal is fed to the antenna inductor.

When adjusting the therapeutic effect, after the treatment session, the PPG and ECG tests are repeated, the indicators of which are sent to the control and information storage unit 12, the data of which are displayed on the screen. The doctor analyzes the results and decides whether treatment should be adjusted. The correction data is also entered into the data block 12 of the control and information storage device using the virtual keyboard.

An individual approach to treatment is achieved by the fact that if it is necessary to achieve the effect required in a particular case (hypotensive, antihistamine, hypoglycemic, anti-stress, antiarrhythmic, parasympathetic, etc.), frequency spectra with the desired effect are included in the complex of treatment programs.

In all cases of conducting a therapy session, the data of the physiological parameters of the patient’s body, with the simultaneous study of PPG and ECG, are processed, and if necessary, the necessary changes are made to the therapy algorithm. In addition, it is possible to remotely consult online about the correction and control of the treatment, by connecting the device via the computer’s USB port and connecting the device to the remote computer via the Internet.

Thus, the use of a large number of electrodes (up to 300, depending on the size of the patient’s chest), built-in to the vest and wirelessly transmitting the ECG signal to the computer, thereby improving the diagnostic capabilities of the method, allowing you to synchronously receive information about the state of all parts of the heart.

Claims (2)

1. A hardware-software complex for the diagnosis and treatment of cardiovascular diseases, comprising a testing channel and determining a mode of exposure to a patient, diagnostic and treatment channels, a control and information storage unit with a power supply, the channel for testing and determining a mode of exposure to a patient includes ECG electrode block connected through a switch to a data input unit and a digital-to-analog converter connected in series; the first output of the digital-to-analog converter is connected to a third the input of the control and information storage unit, the drug selector, the output of the drug selector is connected to the fourth input of the control and information storage unit, the third output of the control and information storage unit is connected to the first inputs of the digital-to-analog converter and the drug selector, the diagnostic channel contains a block of electrodes for removal ECG signals, sensors for taking photoplethysmograms, analog-to-digital converter, the treatment channel consists of at least one inductor connected to through a switch to a medical signal generating unit, the output and input of which is connected to a control and information storage unit, characterized in that a vest is additionally introduced into the hardware-software complex, a control device for the switch is multi-channel and bi-directional, and a channel selection unit, while the vest consists of a shoulder part of two belts of the same width and a detachable corset part, which has a front and back of the same size, connected to the shoulder and side pads with the possibility of picking boron of additional paired parts having a discretely increasing width, the corset part being conformal made of composite material, the first layer of the composite material has connectors for placing ECG electrodes in them, while the electrodes are combined into regular sections with no more than 10 electrodes per section, each the electrode in the section is connected to the microcontroller using conductors, in the second layer at least one inductor is attached over the electrodes, the second layer of the composite material contains it is a flexible printed circuit board to which microcontrollers are connected, the third layer of composite material is protective, the multichannel switch is connected to the switch control unit, the output of which is connected through the channel selection block to the inputs of the testing channel, selecting and determining the mode of exposure to the patient, diagnostic and treatment channel, the first channel of the multi-channel switch is connected to the channel for testing and determining the mode of exposure to the patient, the second channel is connected to the output of the flexible working board of the channel diagnostics sticks, the third channel is connected to the treatment channel, photoplethysmogram sensors through the fourth channel of the switch and the second analog-to-digital converter are connected to the sixth input of the control and information storage unit, while the first inputs and outputs of the first channel of the switch and the data input unit are connected to the first and second inputs control and information storage unit, the third output of the first channel of the switch is connected to the second input of the digital-to-analog converter, the second input of the first channel of the switch is connected to the second input of copper of a stone substitute selector, a flexible printed circuit board of the diagnostic channel through a second channel of the switch and the first analog-to-digital converter connected in series to the fifth input of the control and information storage unit, photoplethysmogram sensors through the fourth channel of the switch and the second analog-to-digital converter are connected to the sixth input of the control and storage unit information. 2. Hardware-software complex for the diagnosis and treatment of cardiovascular diseases according to claim 1, characterized in that the inductor is made in the form of a microstrip radiator Vivaldi.

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