RU2611346C1 - Method of treating demodectosis - Google Patents

Abstract

FIELD: pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, namely to method of treating demodecosis. Method consists in application of care and prevention agents, means of local and systemic therapeutic agent. As agent for care and prevention and local therapy shampoo is used, containing following ingredients in wt%: sodium laureth sulfate 8.0–10; Chegina K 40GLO 1.5–2.0; Emanon XLf SAS 2.1–2.5; Amidet N 2.1–2.2; Amidet B 112, 1.0–1.5; Mikroker DH 1.4–1.7; Sodium chloride 2.0–2.5; Apricot perfume 2.4–2.6; Chamomile extract 2.9–3.1; tickseed herb extract 2.9–3.1; birch tar 0.28–0.32; tansy extract 0.28–0.32; verbena extract 0.28–0.32 and water to 100, and antibiotics and/or metronidazole are used as system agent. Shampoo is applied daily on problem skin areas, as well as hair and skin of face, neck and low neck zone, in external auditory passages rubbed in processed sections, kept 1–2 minutes, and then washed with warm water.

EFFECT: invention provides obtaining of high therapeutic effect in form of reducing length of treatment due to higher acaricide effect.

1 cl, 1 tbl, 2 ex

Description

The invention relates to medicine and can be used in the combined treatment of demodicosis of the body, face, eyelids and scalp.

Demodecosis is a chronic parasitic disease of the skin of humans and mammals, widespread in all climatic zones of the globe, caused by the tick demodex folliculorum and demodex brevis. Parasitizing in the sebaceous, meibomian glands of the eyelids and eyelash follicles, the tick causes, in addition to blepharitis, symptoms such as blepharoconjunctivitis, episcleritis and even keratitis, eyelash loss. The penetration of a tick into the hair follicles of the skin is accompanied by the phenomena of dermatitis of various intensities and localizations.

Demodecosis of the eyelids is often combined with demodicosis of the skin of the face, demodecosis of the skin of the face with damage to the scalp. One of the characteristics of the physiology of ticks is the ability to migrate. Often, ticks from their main reservoir - the external auditory canal of the ears, earwax migrate to the eyelids, eyebrows and to adjacent areas of the skin of the face, neck and head. Such migration helps maintain local foci of demodicosis, and non-compliance with basic personal hygiene measures promotes repeated self-infection, as there is no immunity to demodicosis in humans.

There are many methods for treating demodicosis using local therapies containing metronidazole, for example, Demalon ointment as a treatment for blepharitis (patent RU 2126668). This ointment has a significant drawback - a high concentration of metronidazole (up to 50%), which leads to side effects in the form of hyperemia and edema of the skin of the eyelids and conjunctival mucosa, itching or heaviness in the eyes of patients. The patent (RU 2192860) describes an ointment, including metronidazole (5.0-15.0%), proteoglycan aggregates (APGs), disaccharides, lanolin, vegetable oil, distilled water. However, these ointments based on metronidazole in the complex treatment of demodicosis showed weak acaricidal activity, and also led to irritation and toxic-allergic reactions. In addition, these ointments cannot be used to treat demodecosis of the scalp. Good acaricidal efficacy was found in herbal formulations (see, for example, patents: RU 2313356, 2007; RU 2315614, 2006; RU 2227025, 2004). These funds are also recommended only for the complex treatment of demodicosis of the eyelids and face and cannot be used to treat scalp.

Known methods for treating demodicosis by using shampoos containing tar for skin care for the scalp "Tar Shampoo" for oily hair (http://www.dermosil.ru/ru/products/), Dermozil shampoo http: //www.dermosil. com / blog / = 3063, Shampoo “DUST” http://librederm.ru/shampun-degot/. These funds can also be used to care for the scalp with demodicosis of the scalp. However, none of these shampoos is recommended as a topical treatment for facial demodicosis.

It is known that the treatment of demodicosis should be comprehensive, including both local effects and effects on the patient’s body (see Sirmays N.S., Abesadze G.A., Ustinov M.V. “Demodecosis: pathogenetic aspects in various dermatoses of the face” Moscow 2013, pp. 17-22). According to this source of information, 3 groups of drugs are used to treat demodicosis: 1 - care and prevention products (Demoten gel, soap, sulfur, cream, ointment); 2 - local therapy (antibacterial agents, antiprotozoal agents, glucocorticosteroids); 3 - systemic drugs - antibiotics, antiprotozoal drugs (metronidazole). The choice of care and prevention is determined by the localization of the pathological process. For demodecosis of the skin of the face, Demoten gel is used, for blepharic demodecosis - Blefarogel gel, for demodecosis of the scalp - soaps, shampoos, gels.

This method of the authors Sirmays N.S., Abesadze G.A., Ustinov M.V. "Demodecosis: pathogenetic aspects of various dermatoses of the face", Moscow, 2013, pp. 17-22, was chosen by us as a prototype.

The disadvantage of this method is that when it is implemented, the vicious chain is not broken - the ticks survive on large areas of the scalp, neck, chest and the possibility of re-infection of already cured skin areas is not leveled. The known method does not include treatment with a care agent by means of local therapy having acaricidal properties of large areas of the patient’s body: scalp, décolleté, face and external auditory canals. In the compositions of the known means of care and prevention there are no substances that contribute to the expansion of the pores of the skin and thereby increase the transport of active components deep into the skin to create increased concentrations of active substances. Offered by the known method of care and prevention (Demoten gel, soap, sulfur, cream, ointment) have only a weak anti-inflammatory effect, but do not have a detrimental antiparasitic effect on the Demodex tick.

The technical result of the claimed invention is the development of a method for the treatment of demodicosis, which provides a high therapeutic effect, in the form of a reduction in treatment time due to the fact that a break in the vicious chain is achieved - the experience of ticks on large areas of the skin of the head, neck, chest and thereby eliminates re-infection of already cured areas of the skin, as well as due to the higher acaricidal effect of the agent used, which is not only a means of care and prevention, but also environments Twomey local therapy. The higher acaricidal therapeutic effect of the proposed method is due to the better penetration of therapeutic components to the localization of Demodex ticks - in the follicles and sebaceous glands of the skin.

This technical result is achieved by the fact that in the known method of treating demodicosis, including the use of care and prophylaxis, local therapy and systemic drugs, shampoo is used as a care and prophylaxis and local therapy, containing the following ingredients in wt%: sodium laureth sulfate 8.0-10 Chegina K 40GLO 1.5-2.0 Emanon XLf SAW 2.1-2.5, Amidet N 2.1-2.2, Amidet B 112, 1.0-1.5, - Microker DH 1.4-1.7, Sodium chloride 2.0-2.5, perfume Apricot. 2.4-2.6, chamomile herb extract 2.9-3.1, successive herb extract 2.9-3.1, birch tar 0.28-0.32, tansy extract 0.28-0.32, verbena extract 0.28-0.32, water up to 100, antibiotics and / or metronidazole are used as a systemic agent, shampoo is applied daily to problem areas of the skin, as well as to the hair and skin of the face, neck and decollete, to the external auditory passages, rub it into the treated areas, stand for 1-2 minutes, and then rinse with warm water, the procedures are carried out until a stable clinical cure of the patients is obtained.

The shampoo used in the method for treating demodicosis - as a solvent, contains a foaming agent in the form of sodium sulfate detergent laureate, wood tar, Chegina K 40GLO detergent, as an Emanon XLf foam and thickener enhancer, as an emulsifier, thickener, and Amidet N and Amidet detergent. In 112, as a preservative - Microker DH, as a flavoring - perfume Apricot, chamomile herb extract, succession herb extract, birch tar, tansy extract, verbena extract in the following ratio of ingredients

wt%:

sodium laureth sulfate 8.0-10

Chegina K 40GLO 1.5-2.0

Emanon XLf SAW 2.1-2.5

Amidet N 2.1-2.2

Amidet B 112, 1.0-1.5

- Microker DH 1.4-1.7

Sodium chloride 2.0-2.5

perfume Apricot. 2.4-2.6

chamomile herb extract 2.9-3.1

Herb extract 2.9-3.1

tar birch 0.28-0.32

tansy extract 0.28-0.32

verbena extract 0.28-0.32

water to 100.

We believe that the action of the proposed method using the above means is based on the combined use of components that have a multilateral combined synergistic effect:

- Birch tar has an antiparasitic effect, destroying adult individuals, larvae and eggs of the tick, showing an antibacterial effect. At the same time, skin turgor improves, the production of sebum, oiliness of the skin decreases, the effects of hyperkeratosis and inflammation are leveled.

- The extract of tansy ordinary has antiparasitic, antibacterial and insecticidal effects, eliminating pustular skin lesions, destroying mature mites and associated bacteria.

- The grass string and its extract are famous for their anti-allergic effect. Its pronounced dermatropia is known: it is effective for diathesis in children, psoriasis, various dermatoses, and promotes the healing of small wounds. The extract of the series cleanses the surface of the skin and promotes the healing of affected areas of the scalp.

- Verbena extract has therapeutic efficacy in dermatoses - scabies, psoriasis, eczema, as well as a wound healing effect due to the normalization of cell metabolism.

- Chamomile extract helps to subside inflammatory phenomena on the skin and at the same time has an insecticidal effect. Chamomile extract cleanses and softens the surface of the skin.

The tool was used in patients suffering from various forms of demodicosis.

Example 1

Patient B., 45 years old. Diagnosis: seborrheic demodicosis. Complaints of redness of the face, eyelids, scalp, itching. According to the patient, the duration of the disease is 2 years. Objectively: T-shaped hyperemia of the face, teleangectasia, combs. Around the mouth intense redness, isolated pustules. A scraping was taken from the surface of the skin of the forehead, cheeks, near-mouth, scalp, and ear passages. Microscopy of scraping the skin of the forehead, cheeks, near-mouth, scalp. Investigated for the presence of demodicosis eyelashes. The study found a large number of mature individuals (from 3 to 12) in all samples, including those taken from the scalp and eyelids. Diagnosis: demodicosis.

Shampoo containing 2.9 wt.% Chamomile herb extract, 3.1% succession herb extract, 0.32% birch tar, 0.28% tansy herb extract, 0.32% wt. Verbena herb extract, applied to the scalp , face, décolleté and external auditory canals, rubbed intensively into the skin, and then washed off with warm water. The edges of the eyelids were treated with an alcohol-containing solution of eucalyptus and cream "Demazol". Additionally, antibiotics and metronidazole were prescribed. The treatment was carried out for 45 days.

After the end of treatment it was stated: Hyperemia of the skin of the face and scalp, eyelids disappeared. Under microscopy, the number of ticks in scrapings of the scalp ranged from 0 to 1, the skin of the forehead - 0-1, the external auditory canals -1-2.

It was concluded that a good clinical outcome was achieved.

Example 2

Patient S., 55 years old. Complaints of dandruff and itching of the scalp, behind the ear, forehead, cheeks. Sick for more than 2 years. She was treated with sulfur talkers. Objectively: Investigated for the presence of the Demodex folliculorum tick and eyelashes. The study found a large number of mature individuals (from 3 to 5) in all samples, including those taken from the scalp and eyelids.

Shampoo was applied to all the zones listed in Example 1, rubbed into the skin, and then washed off with warm water. The edges of the eyelids were treated with an alcohol-containing solution of eucalyptus and cream "Demazol". The treatment was carried out for 45 days. Additionally, the patient took metronidazole.

The number of ticks after treatment in the scrapings of the scalp was 0-1, in the scrapings of the behind-the-ear areas - 0, in the scrapings of the forehead and eyelids 0-1 and 0, respectively.

Comparative tests of the therapeutic effect of the claimed method were carried out using a systemic drug, metronidazole, a care and prevention drug, and a local therapy drug based on the Stop Demodex complex in 2 groups of patients with common demodecosis of the scalp, face and eyelids. Each group included 7-8 people.

1 group of patients was daily treated with shampoo based on the claimed agent. To do this, shampoo was applied daily to the hair and skin of the face, neck and décolleté, and into the external auditory canals. They rubbed the product well into the treated areas. Maintained for 1-2 minutes and then washed off with warm water. The tool was used to obtain a persistent clinical cure for patients. The edges of the eyelids were treated with an alcohol-containing solution of eucalyptus and cream "Demazol". Additionally, metronidazole was prescribed.

In 2 groups of patients, Stop Demodex line products were used. Stop Demodex is a therapeutic cosmetic line, which is based on components traditionally used to treat demodicosis - metronidazole, sulfur, birch tar. It includes Shampoo Lotion Stop Demodex (skin care product), Shampoo Stop Demodex - for the care and local treatment of the scalp, Balm Stop Demodex and Gel Stop Demodex. Balm Stop Demodex (also called "cream" or "ointment") is a therapeutic drug against demodicosis (a local therapy drug), the action of which is based on a combination of birch tar, metronidazole and a number of plant components (chamomile, apple tree leaves, willow bark, rose petals, calendula). Gel Stop Demodex is used to treat demodecosis of the eyelids and to treat blepharitis that develops against the background of demodecosis (as a means of local therapy). Its main active ingredients are metronidazole, chamomile extract and hyaluronic acid, peppermint extract and glycerin. Stop Demodex lotion was used as a means of care and prevention for demodecosis in order to cleanse the skin, and also as a base before applying other means of the treatment line - balm or gel. They were daily rubbed on their face and other affected areas with a cotton pad.

Patients with advanced demodecosis of the scalp, face and eyelids were prescribed: daily shampooing with Stop Demodex shampoo, daily face skin rubbing with Stop Demodex Lotion and Balsam, and gel wiping with Stop Demodex Gel. Additionally, metronidazole was prescribed.

As follows from table 1, the duration of treatment of patients of group 1 was an average of 45 days, and the duration of treatment of patients in group 2 was 60 days.

The number of ticks on the 10th, 20th, and 30th day of treatment in the scrapings taken was also less in patients who used the claimed agent than the Stop Demodex complex.

Treatment of the eyelids with an alcohol-containing solution of eucalyptus and cream "Demazol" due to the peculiarity of the structure of this area. The rupture of the "vicious circle" in the form of "experiencing a tick in other parts of the body" also has a positive effect in the treatment of eyelid demodicosis.

This can be explained by the fact that the proposed method using shampoo, which has anti-inflammatory, antibacterial and anti-allergic effects, helps to reduce exudative phenomena, soften the crusts of dried mucous secretions on the skin of the eyelids and “clutches” in the mouths of the eyelashes and their subsequent removal and release of the mouths of the eyelashes, thereby ensuring better penetration through these stomata to the place of mite localization of the main acaricidal ingredients - tansy and tar. In addition, an agent containing acaricidal and detergents (detergents) not only has an enveloping effect on living individuals, leading to the cessation of their breathing and their death, but also provides mechanical removal of mature and immature individuals, as well as their larvae, and foaming agents eggs with a large surface of the skin of the body and the skin of the eyelids, and the best penetration of the active ingredients into the deep layers of the skin. It was found that the absence in the claimed tool of any of the ingredients: chamomile, string, tansy or verbena, even if tar is present in it, does not provide the therapeutic acaricidal effect that is associated with their combined use. The same acaricidal effect was expressed much weaker if the amount of tar, chamomile, string, tansy or verbena was taken less than the declared.

It is known that since ticks migrate over the entire surface of a person’s body, when applying only traditional local treatment, for example, with demodicosis of the eyelids, they easily re-enter the “treated” places and re-infect. The possibility of processing with the declared means a large area of the body and head with one hygienic means allows you to break this vicious circle. The above observations clearly demonstrate the effectiveness of the use of the claimed means for the treatment of demodicosis of the skin of the face, scalp and eyelids, as well as its advantages over previously known methods for a similar purpose.

Claims (1)

A method for the treatment of demodicosis, including the use of a means of care and prophylaxis of a local therapy and systemic drugs, characterized in that a shampoo containing the following ingredients, wt.%: Sodium laureth sulfate 8.0-10 is used as a care and prophylaxis and local therapy. ; Chegina K 40 GLO 1.5-2.0; Emanon XLf surfactant 2.1-2.5; Amidet N 2.1-2.2; Amidet B 112, 1.0-1.5; Microker DH 1.4-1.7; Sodium chloride 2.0-2.5; perfume Apricot 2.4-2.6; chamomile herb extract 2.9-3.1; an extract of grass of a series of 2.9-3.1; tar birch 0.28-0.32; tansy extract 0.28-0.32; verbena extract 0.28-0.32; water up to 100, antibiotics and / or metronidazole are used as a systemic agent, shampoo is applied daily to problem areas of the skin, as well as to the hair and skin of the face, neck and décolleté, in the external auditory canals, rubbed into the treated areas, kept for 1- 2 minutes, and then washed off with warm water, the procedures are carried out until a stable clinical cure for patients is obtained.